Herpes Simplex Virus 1 Tegument Protein VP22 Abrogates cGAS/STING-Mediated Antiviral Innate Immunity

Herpes Simplex Virus 1 VP22 Inhibits AIM2-Dependent Inflammasome Activation to Enable Efficient Viral Replication

(2018) Yuhei Maruzuru et al.   Cell Host & Microbe

Evasion of Cytosolic DNA-Stimulated Innate Immune Responses by Herpes Simplex Virus 1

(2018) Chunfu Zheng   JOURNAL OF VIROLOGY

Herpes Simplex Virus 1 Abrogates the cGAS/STING-Mediated Cytosolic DNA-Sensing Pathway via Its Virion Host Shutoff Protein, UL41

(2017) Chenhe Su et al.   JOURNAL OF VIROLOGY

Herpes Simplex Virus 1 UL24 Abrogates the DNA Sensing Signal Pathway by Inhibiting NF-κB Activation

(2017) Haiyan Xu et al.   JOURNAL OF VIROLOGY

Human Cytomegalovirus Tegument Protein pp65 (pUL83) Dampens Type I Interferon Production by Inactivating the DNA Sensor cGAS without Affecting STING

(2017) Matteo Biolatti et al.   JOURNAL OF VIROLOGY

Evasion of the STING DNA-Sensing Pathway by VP11/12 of Herpes Simplex Virus 1

(2017) Thibaut Deschamps et al.   JOURNAL OF VIROLOGY

HSV‐1 ICP27 targets the TBK1‐activated STING signalsome to inhibit virus‐induced type I IFN expression

(2016) Maria H Christensen et al.   EMBO JOURNAL

Herpes Simplex Virus 1 Tegument Protein UL41 Counteracts IFIT3 Antiviral Innate Immunity

(2016) Zhangtao Jiang et al.   JOURNAL OF VIROLOGY

Herpes Simplex Virus 1 Serine Protease VP24 Blocks the DNA-Sensing Signal Pathway by Abrogating Activation of Interferon Regulatory Factor 3

(2016) Dandan Zhang et al.   JOURNAL OF VIROLOGY

Herpes Simplex Virus 1 Ubiquitin-Specific Protease UL36 Abrogates NF-κB Activation in DNA Sensing Signal Pathway

(2016) Ruijie Ye et al.   JOURNAL OF VIROLOGY

Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing

(2016) Qi Chen et al.   NATURE IMMUNOLOGY

Evasion of host antiviral innate immunity by HSV-1, an update

(2016) Chenhe Su et al.   Virology Journal

cGAS Senses Human Cytomegalovirus and Induces Type I Interferon Responses in Human Monocyte-Derived Cells

(2016) Jennifer Paijo et al.   PLoS Pathogens

Inhibition of cGAS DNA Sensing by a Herpesvirus Virion Protein

(2015) Jian-jun Wu et al.   Cell Host & Microbe

The cyclic GMP-AMP synthetase-STING signaling pathway is required for both the innate immune response against HBV and the suppression of HBV assembly

(2015) Hiromichi Dansako et al.   FEBS Journal

Mitochondrial DNA stress primes the antiviral innate immune response

(2015) A. Phillip West et al.   NATURE

Control of adaptive immunity by the innate immune system

(2015) Akiko Iwasaki et al.   NATURE IMMUNOLOGY

Modulation of the cGAS-STING DNA sensing pathway by gammaherpesviruses

(2015) Zhe Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

cGAS-mediated stabilization of IFI16 promotes innate signaling during herpes simplex virus infection

(2015) Megan H. Orzalli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA tumor virus oncogenes antagonize the cGAS-STING DNA-sensing pathway

(2015) L. Lau et al.   SCIENCE

Herpes simplex virus 1 UL41 protein abrogates the antiviral activity of hZAP by degrading its mRNA

(2015) Chenhe Su et al.   Virology Journal

Mitochondrial DNA in the regulation of innate immune responses

(2015) Chunju Fang et al.   Protein & Cell

Innate Immune Sensing and Signaling of Cytosolic Nucleic Acids

(2014) Jiaxi Wu et al.   Annual Review of Immunology

SnapShot: Nucleic Acid Immune Sensors, Part 1

(2014) Veit Hornung   IMMUNITY

Herpes Simplex Virus 1 Counteracts Viperin via Its Virion Host Shutoff Protein UL41

(2014) G. Shen et al.   JOURNAL OF VIROLOGY

The cGAS-cGAMP-STING Pathway of Cytosolic DNA Sensing and Signaling

(2014) Xin Cai et al.   MOLECULAR CELL

Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase

(2013) Pu Gao et al.   CELL

Cyclic GMP-AMP Synthase Is Activated by Double-Stranded DNA-Induced Oligomerization

(2013) Xin Li et al.   IMMUNITY

The Capsids of HIV-1 and HIV-2 Determine Immune Detection of the Viral cDNA by the Innate Sensor cGAS in Dendritic Cells

(2013) Xavier Lahaye et al.   IMMUNITY

The interferon response to intracellular DNA: Why so many receptors?

(2013) Leonie Unterholzner   IMMUNOBIOLOGY

Herpes Simplex Virus 1 Serine/Threonine Kinase US3 Hyperphosphorylates IRF3 and Inhibits Beta Interferon Production

(2013) Shuai Wang et al.   JOURNAL OF VIROLOGY

Herpes Simplex Virus 1-Encoded Tegument Protein VP16 Abrogates the Production of Beta Interferon (IFN) by Inhibiting NF- B Activation and Blocking IFN Regulatory Factor 3 To Recruit Its Coactivator CBP

(2013) J. Xing et al.   JOURNAL OF VIROLOGY

Herpes Simplex Virus 1 E3 Ubiquitin Ligase ICP0 Protein Inhibits Tumor Necrosis Factor Alpha-Induced NF-κB Activation by Interacting with p65/RelA and p50/NF-κB1

(2013) Jie Zhang et al.   JOURNAL OF VIROLOGY

Herpes Simplex Virus 1 Counteracts Tetherin Restriction via Its Virion Host Shutoff Activity

(2013) H. L. Zenner et al.   JOURNAL OF VIROLOGY

Herpes simplex virus 1 DNA polymerase processivity factor UL42 inhibits TNF-α-induced NF-κB activation by interacting with p65/RelA and p50/NF-κB1

(2013) Jie Zhang et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING

(2013) Xu Zhang et al.   MOLECULAR CELL

cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING

(2013) Andrea Ablasser et al.   NATURE

Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity

(2013) John W. Schoggins et al.   NATURE

Cyclic GMP-AMP Synthase Is an Innate Immune Sensor of HIV and Other Retroviruses

(2013) D. Gao et al.   SCIENCE

The Innate Immune DNA Sensor cGAS Produces a Noncanonical Cyclic Dinucleotide that Activates Human STING

(2013) Elie J. Diner et al.   Cell Reports

Herpes Simplex Virus 1 Tegument Protein US11 Downmodulates the RLR Signaling Pathway via Direct Interaction with RIG-I and MDA-5

(2012) J. Xing et al.   JOURNAL OF VIROLOGY

Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA

(2012) J. Wu et al.   SCIENCE

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

Varicella-Zoster Virus Immediate-Early Protein ORF61 Abrogates the IRF3-Mediated Innate Immune Response through Degradation of Activated IRF3

(2011) H. Zhu et al.   JOURNAL OF VIROLOGY

The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells

(2011) Zhiqiang Zhang et al.   NATURE IMMUNOLOGY

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

The STING pathway and regulation of innate immune signaling in response to DNA pathogens

(2010) Hiroki Ishikawa et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

IFI16 is an innate immune sensor for intracellular DNA

(2010) Leonie Unterholzner et al.   NATURE IMMUNOLOGY

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

c-di-AMP Secreted by Intracellular Listeria monocytogenes Activates a Host Type I Interferon Response

(2010) J. J. Woodward et al.   SCIENCE

RNA Polymerase III Detects Cytosolic DNA and Induces Type I Interferons through the RIG-I Pathway

(2009) Yu-Hsin Chiu et al.   CELL

Ubiquitin-Regulated Recruitment of I B Kinase   to the MAVS Interferon Signaling Adapter

(2009) S. Paz et al.   MOLECULAR AND CELLULAR BIOLOGY

VP22 of Herpes Simplex Virus 1 Promotes Protein Synthesis at Late Times in Infection and Accumulation of a Subset of Viral mRNAs at Early Times in Infection

(2008) C. Duffy et al.   JOURNAL OF VIROLOGY

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

(2008) Hiroki Ishikawa et al.   NATURE