Article
Immunology
Huimin Hu, Ming Fu, Chuntian Li, Binman Zhang, Yuncheng Li, Qinxue Hu, Mudan Zhang
Summary: HSV-2 inhibits the activation of NF-kappa B through the immediate early protein ICP22, suggesting a novel mechanism by which HSV-2 evades the host antiviral responses.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Microbiology
Huichao Huang, Jun Zhao, Ting-Yu Wang, Shu Zhang, Yuzheng Zhou, Youliang Rao, Chao Qin, Yongzhen Liu, Yongheng Chen, Zanxian Xia, Pinghui Feng
Summary: The study found that mouse RIG-I is resistant to evasion by HSV-1, while the N495 of human RIG-I determines species-specific deamidation by HSV-1.
Article
Biochemistry & Molecular Biology
Gerard Kian-Meng Goh, Vladimir N. Uversky
Summary: This article discusses the significant impact of intrinsic disorder in the outer shell of HIV on vaccine development and proposes a new model for vaccine design. Traditional viruses typically do not have high levels of intrinsic disorder in their outer shells, allowing for successful establishment of effective vaccines.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Review
Virology
Emily Greenan, Sophie Gallagher, Rana Khalil, Conor C. Murphy, Joan Ni Gabhann-Dromgoole
Summary: HSK is a common eye disease caused by HSV-1, for which there is currently no cure or vaccine available. Treatments aim to control inflammation caused by the virus. There is a need for more effective treatments to reduce reliance on steroids and prevent disease recurrence.
Review
Microbiology
Yonathan Arfi, Carole Lartigue, Pascal Sirand-Pugnet, Alain Blanchard
Summary: Mycoplasmas are small, genome-reduced bacteria with the ability to colonize a wide range of host species. They can exist as commensal microbiota or cause pathogenic inflammatory diseases. These bacteria have evolved strategies to evade the host's immune response, including the expression of immunoglobulin-binding proteins to prevent antibody-antigen interaction. Understanding these immune evasion mechanisms is crucial for studying mycoplasma diseases and improving vaccine efficacy.
Review
Immunology
Luisa F. Duarte, Antonia Reyes, Monica A. Farias, Claudia A. Riedel, Susan M. Bueno, Alexis M. Kalergis, Pablo A. Gonzalez
Summary: HSV-1 infection is widespread globally, with only a small fraction of carriers developing into latent infections. The virus causes damage in the skin and mucosae upon infection, while also remaining latent in neurons and can cause new infections upon reactivation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Microbiology
Ayano Fukui, Yuhei Maruzuru, Shiho Ohno, Moeka Nobe, Shuji Iwata, Kosuke Takeshima, Naoto Koyanagi, Akihisa Kato, Shinobu Kitazume, Yoshiki Yamaguchi, Yasushi Kawaguchi
Summary: The N-glycan shield on the envelope glycoprotein B of HSV-1 plays a crucial role in evading human antibodies, both in cell cultures and mice. This finding has significant implications for understanding viral pathogenesis and developing vaccines.
Article
Immunology
Chaohu Pan, Qiaomei Cai, Xiaorong Li, Lili Li, Liping Yang, Yu Chen, Junxiao Liu, Wancheng Liu, Meiling Gao, Tianqi Sui, Xiaoyang Wang, Huiming Fan, Jiayin Ruan, Yueyue Shi, Saihua Chen, Lucy S. Cheng, Jiayong Liu, Heng Yang, Genhong Cheng
Summary: This study uncovered a novel antiviral activity of BACH1 and provided a new strategy for improving the clinical efficiency of the oncolytic virus HSV-1.
CELLULAR & MOLECULAR IMMUNOLOGY
(2022)
Review
Immunology
Farias Ma, Duarte Lf, Tognarelli Ei, Gonzalez Pa
Summary: HSV-1 and HSV-2 are highly prevalent in humans, causing lifelong infections by establishing latency in neurons and undergoing sporadic reactivations. These viruses possess molecular determinants that help them evade host antiviral and immune responses, including modulating the function of dendritic cells. The interactions between HSVs and DCs play a crucial role in determining optimal antiviral immunity.
Article
Gastroenterology & Hepatology
Ayumu Kanbe, Tetsuya Ishikawa, Akira Hara, Hiroshi Suemizu, Eri Nanizawa, Yuki Tamaki, Hiroyasu Ito
Summary: A novel HBV infection mouse model was established in this study, which successfully transplanted hepatocytes from HBV-transgenic mice into HSV-TK mice. The results showed that HBsAg-positive areas persisted for at least 20 weeks in replaced mice, immune response was detected, and HBsAg levels increased 4 weeks after transplantation.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Dong-Liang Chen, Hui Sheng, Dong-Sheng Zhang, Ying Jin, Bai-Tian Zhao, Nuo Chen, Kang Song, Rui-Hua Xu
Summary: The study highlights the upregulation of circDLG1 in distant metastatic lesions and gastric cancer tissues resistant to anti-PD-1 therapy, correlating with aggressive tumor phenotype and poor prognosis. Ectopic circDLG1 expression promotes proliferation, migration, invasion, and immune evasion of gastric cancer cells. Mechanistically, circDLG1 interacts with miR-141-3p as a miRNA sponge to increase CXCL12 expression, promoting gastric cancer progression and resistance to anti-PD-1 therapy.
Review
Microbiology
Kathlyn Laval, Katrien C. K. Poelaert, Jolien Van Cleemput, Jing Zhao, Annelies P. Vandekerckhove, Annick C. Gryspeerdt, Barbara Garre, Karen van der Meulen, Hossein B. Baghi, Haileleul N. Dubale, Ines Zarak, Eline Van Crombrugge, Hans J. Nauwynck
Summary: EHV-1, related to PRV and VZV, is a major pathogen affecting horses worldwide, causing various diseases and significant economic losses. Effective therapies are lacking, highlighting the urgent need for a better understanding of its pathogenesis and development of novel treatments.
FRONTIERS IN MICROBIOLOGY
(2021)
Review
Microbiology
Suchitra Mohanty, Edward W. Harhaj
Summary: Human T lymphotropic virus-1 (HTLV-1) is an oncoretrovirus that infects and establishes a persistent infection in approximately 10-20 million people worldwide. The immune response to HTLV-1 infection and the mechanisms of innate immune detection are not well understood. This review highlights the roles of immune sensors in recognizing HTLV-1 infection and the strategies employed by HTLV-1 to subvert the innate immune response.
Review
Chemistry, Medicinal
Li You, Wenda Wu, Xu Wang, Liurong Fang, Vojtech Adam, Eugenie Nepovimova, Qinghua Wu, Kamil Kuca
Summary: Hypoxia and HIF-1 are crucial in tumor immune evasion, suppressing the immune system to promote tumor growth and metastasis.
MEDICINAL RESEARCH REVIEWS
(2021)
Article
Immunology
Haiyue Dai, Jianan Wu, Hongshu Yang, Yongli Guo, Haoqing Di, Mingchun Gao, Junwei Wang
Summary: Bovine herpesvirus type 1 (BHV-1) is a neurotropic herpesvirus that causes infectious rhinotracheitis and vulvovaginitis in cattle. The BHV-1 UL41 gene encodes a protein that is highly conserved and plays a crucial role in interrupting host defense and facilitating viral replication. This study successfully constructed a BHV-1 UL41-deficient strain using the CRISPR/Cas9 system, which showed slowed viral replication and enhanced sensitivity to temperature and acidic environments.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Virology
Chowdhury Nusaiba Binte Sayed Prapty, Raad Rahmat, Yusha Araf, Samiha Kamal Shounak, Noor-A-Afrin, Tanjim Ishraq Rahaman, Mohammad Jakir Hosen, Chunfu Zheng, Md. Golzar Hossain
Summary: The co-infection of SARS-CoV-2 and dengue virus is increasing in dengue-endemic regions, posing a threat of a co-epidemic. The comorbidity risk in co-infection cases is greater than that of a single viral infection. Although the pathophysiologies of the two infections differ, they have similar effects in the body, resulting in identical clinical symptoms in the case of co-infection. Proper differentiation and diagnosis of the infections are important, and specific biomarkers can be used for precise results. However, the treatment of co-infection cases is more complicated. Therefore, confirmation diagnosis of both COVID-19 and dengue should be mandatory to prevent health deterioration in individuals treated for a single infection. The literature on the epidemiology, pathophysiology, diagnosis, therapy, and management of SARS-CoV-2 and dengue virus co-infection is scarce. This review provides a summary of the epidemiology, pathogenesis, diagnosis, treatment, and management of co-infection cases, shedding light on appropriate approaches for patients.
REVIEWS IN MEDICAL VIROLOGY
(2023)
Article
Virology
Xueping Yu, Yijuan Zheng, Dawu Zeng, Yongjun Zhou, Jian Sun, Milong Su, Huatang Zhang, Minhui Zheng, Zhipeng Huang, Wenwu Lin, Richeng Mao, Jiming Zhang, Chunfu Zheng, Zhijun Su
Summary: CD3(+)CD4(-)CD7(+)CD57(-) T cells are decreased in patients with end-stage liver disease, especially those with acute to chronic liver failure, and this decrease is associated with disease severity, prognosis, and complications. IL-22 stimulation promotes apoptosis and reduces the number of CD3(+)CD4(-)CD7(+)CD57(-) T cells. These cells exhibit an immunosuppressive phenotype and low expression levels of cytokines.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Virology
Yimin Xue, Jun Ke, Jiuyun Zhang, Mingguang Chen, Lijuan Zeng, Qiaolian Fan, Chunfu Zheng, Feng Chen
Summary: This study investigates the expression profiles of lncRNAs and mRNAs associated with AVMC. It identifies differentially expressed genes involved in metabolic and immune-related processes and explores the molecular interactions between these molecules. These findings shed light on the roles of lncRNAs in disease pathogenesis and provide insights for discovering new therapeutic targets.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Letter
Virology
Zipeng Yang, Hao Yuan, Xiu-Xiang Zhang, Jingbo Zhai, Mengzhou Xue, Chunfu Zheng, Zi-Guo Yuan
JOURNAL OF MEDICAL VIROLOGY
(2023)
Review
Biochemistry & Molecular Biology
Jie Gao, Qiaoban Wang, Yan-Dong Tang, Jingbo Zhai, Wei Hu, Chunfu Zheng
Summary: Apoptosis, necrosis, and autophagy are different strategies used by host cells to defend against pathogens such as viruses, bacteria, or fungi. Ferroptosis is a newly discovered regulated cell death that pathogens can manipulate to promote their replication and pathogenesis. However, the interaction between ferroptosis and pathogenic infections is still not fully understood. This review summarizes the advances in understanding how pathogens exploit and regulate ferroptosis and discusses potential therapeutic approaches against pathogen-associated diseases.
TRENDS IN MICROBIOLOGY
(2023)
Review
Immunology
Changqing Yu, Guosheng Wang, Qiang Liu, Jingbo Zhai, Mengzhou Xue, Qiang Li, Yuanhua Xian, Chunfu Zheng
Summary: Viral envelope glycoproteins play a crucial role in viral infections. Host cells have developed counteracting mechanisms to suppress viral replication by targeting their envelope glycoproteins. Some host antiviral proteins have been found to inhibit furin cleavage of viral envelope glycoproteins, impairing viral infectivity. This review summarizes these host antiviral factors and their roles in reducing furin cleavage, providing insights for future antiviral studies.
EMERGING MICROBES & INFECTIONS
(2023)
Editorial Material
Biochemistry & Molecular Biology
Weizheng Liang, Xiushen Li, Hao Wang, Shuangqing Wang, Qingxue Meng, Ruoqing Feng, Jingbo Zhai, Mengzhou Xue, Chunfu Zheng
Review
Virology
Xinhua Cui, Yang Wang, Jingbo Zhai, Mengzhou Xue, Chunfu Zheng, Lu Yu
Summary: SARS-CoV-2, the virus causing a global public health crisis, particularly with the emergence of the Omicron variants, has garnered significant attention from the WHO. As of February 1st, 2023, there have been 671,016,135 confirmed cases and 6,835,595 deaths worldwide. Despite available vaccines and treatments, complete eradication of SARS-CoV-2 remains elusive. Additionally, animal-to-human transmission of the virus has been observed, suggesting the need for rational prevention and control strategies for COVID-19.
Article
Virology
Yan Zhan, Ling Ye, Qianying Ouyang, Jiye Yin, Jiajia Cui, Ke Liu, Chengxian Guo, Haibo Zhang, Jingbo Zhai, Chunfu Zheng, Aoxiang Guo, Bao Sun
Summary: This study identified the binding affinity between different HLA proteins and SARS-CoV-2 strains, as well as 10 active binding sites that may contribute to immune evasion. Notably, the weak binding ability with HLA class I polymorphisms could promote immune evasion of Omicron. These findings have important implications for preventing immune evasion of SARS-CoV-2 and providing new insights for vaccine design.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Virology
Rongzhao Zhang, Wenxian Yang, Huifang Zhu, Jingbo Zhai, Mengzhou Xue, Chunfu Zheng
Summary: TBK1 activation is crucial for antiviral innate immunity. NLRC4 has been identified as a positive regulator of TBK1, enhancing the activity of the cGAS-STING signaling pathway and promoting antiviral immune response.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Letter
Virology
Chunfu Zheng
JOURNAL OF MEDICAL VIROLOGY
(2023)
Correction
Microbiology
Huifang Zhu, Chunfu Zheng
MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS
(2023)
Correction
Microbiology
Hongjuan You, Sisilia Zheng, Zhiming Huang, Yingying Lin, Qingtang Shen, Chunfu Zheng
Review
Microbiology
Changqing Yu, Qiang Liu, Zhuo Zhao, Jingbo Zhai, Mengzhou Xue, Yan-Dong Tang, Chengbao Wang, Chunfu Zheng
Summary: MARCH8, a membrane-associated protein, regulates turnover of transmembrane proteins and exhibits antiviral activities. It functions through degradation and trapping of viral proteins, playing a role in antiviral defense.
Article
Public, Environmental & Occupational Health
Chiranjib Chakraborty, Manojit Bhattacharya, Abdulrahman Alshammari, Metab Alharbi, Thamer H. Albekairi, Chunfu Zheng
Summary: This study examines the structural and molecular interaction of the Mpro-nirmatrelvir complex. The results provide insights into the characteristics and dynamics of the complex, which can aid in the design of broad-spectrum antiviral molecules and the fight against SARS-CoV-2 and other infectious viruses.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2023)
