Article
Microbiology
Tianqiong He, Mingshu Wang, Anchun Cheng, Qiao Yang, Renyong Jia, Ying Wu, Juan Huang, Bin Tian, Mafeng Liu, Shun Chen, Xin-Xin Zhao, Dekang Zhu, Shaqiu Zhang, Xuming Ou, Sai Mao, Qun Gao, Di Sun
Summary: The protein encoded by the DPV UL41 gene degrades RNA and induces protein synthesis shutdown, affecting viral replication and spread.
VETERINARY MICROBIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Le Yu, Pengda Liu
Summary: cGAS is a major cytosolic DNA sensor that, when hyperactivated, contributes to autoimmune diseases but serves as an adjuvant for anticancer immune therapy; inactivation of cGAS signaling causes difficulty in sensing and clearing infections, as well as facilitating tumor immune evasion, therefore cGAS activation is tightly controlled.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Review
Biochemistry & Molecular Biology
Wangli Zheng, Nanhua Chen, Francois Meurens, Wanglong Zheng, Jianzhong Zhu
Summary: This study summarizes the mechanisms by which cGAS avoids sensing self-DNA under normal physiological conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Chemistry, Medicinal
Jin Kyung Seok, Minhyuk Kim, Han Chang Kang, Yong-Yeon Cho, Hye Suk Lee, Joo Young Lee
Summary: cGAS is a DNA sensor that triggers a strong immune response, and its signaling pathway plays important roles in autoimmunity, inflammation, and cancer progression, making it an attractive therapeutic target. This review provides insights into the prevention and treatment of cGAS-related chronic immune and inflammatory diseases based on accumulated evidence.
ARCHIVES OF PHARMACAL RESEARCH
(2023)
Review
Immunology
Debipreeta Bhowmik, Fanxiu Zhu
Summary: Sensing viral constituents is crucial for host immune defense against viruses. Host DNA sensors have been discovered and their mechanisms elucidated, but herpesviruses employ diverse strategies to evade host DNA sensing.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Review
Cell Biology
Zhilei Wang, Nian Chen, Zhiyong Li, Guang Xu, Xiaoyan Zhan, Jianyuan Tang, Xiaohe Xiao, Zhaofang Bai
Summary: Inflammation is a protective response regulated by the host, with cGAS-STING pathway playing a crucial role in immune defense, viral infections, fatty liver, and cancer metastasis. The potential impact of this pathway in liver diseases has attracted widespread attention, with pharmacological agonists and antagonists offering new therapeutic possibilities. Understanding the mechanisms of cGAS-STING pathway may lead to the development of effective treatments for liver diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Immunology
Nina Kessler, Susanne F. Viehmann, Calvin Krollmann, Karola Mai, Katharina M. Kirschner, Hella Luksch, Prasanti Kotagiri, Alexander M. C. Boehner, Dennis Huugen, Carina C. de Oliveira Mann, Simon Otten, Stefanie A. Weiss, Thomas Zillinger, Kristiyana Dobrikova, Dieter E. Jenne, Rayk Behrendt, Andrea Ablasser, Eva Bartok, Gunther Hartmann, Karl-Peter Hopfner, Paul A. Lyons, Peter Boor, Angela Roesen-Wolff, Lino L. Teichmann, Peter Heeringa, Christian Kurts, Natalio Garbi
Summary: The study identifies abnormal DNA recognition and IFN-I production as drivers of severe ANCA-associated vasculitis, and demonstrates that blocking this pathway can ameliorate the disease and accelerate recovery, suggesting potential therapeutic targets for patients.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Wanglong Zheng, Anjing Liu, Nengwen Xia, Nanhua Chen, Francois Meurens, Jianzhong Zhu
Summary: The cGAS-STING signaling axis is activated by cytosolic DNA, both non-self and self DNA. This pathway is used by the innate immune system to monitor invading pathogens and/or damage. It not only facilitates inflammatory responses and IFN production, but also activates other cellular processes like apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Wanglong Zheng, Nengwen Xia, Jiajia Zhang, Nanhua Chen, Francois Meurens, Zongping Liu, Jianzhong Zhu
Summary: The cGAS-STING pathway is involved in triggering both canonical and non-canonical autophagy, which plays crucial roles in balancing innate immune responses, maintaining intracellular environmental homeostasis, alleviating liver injury, and limiting tumor growth and transformation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Virology
Haowen Qiao, Yuanpu Chiu, Xinyan Liang, Shangzhou Xia, Mariam Ayrapetyan, Siqi Liu, Cuiling He, Ruocen Song, Jianxiong Zeng, Xiangxue Deng, Weiming Yuan, Zhen Zhao
Summary: The ChP-CSF system provides cushioning for the brain and helps clear waste. During sepsis, pathogens and immune cells can breach the ChP barrier and lead to neurological dysfunction. The study found that the cGAS-STING pathway plays a crucial role in the antiviral response.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Wen Zhou, Lisa Mohr, John Maciejowski, Philip J. Kranzusch
Summary: The phase separation of cGAS-DNA is critical for efficient sensing of immunostimulatory DNA, as it limits the activity of the cytosolic exonuclease TREX1. This selective environment suppresses TREX1 function and restricts DNA degradation, balancing cytosolic DNA degradation and innate immune activation.
Review
Immunology
Roberto Amadio, Giulia Maria Piperno, Federica Benvenuti
Summary: The activation of cellular responses to DNA acts as a defense mechanism, but uncontrolled response can lead to autoimmune diseases. Dysregulated recognition of self-DNA is associated with type-I interferons and ISGs, while fine-tuned membrane trafficking and cytoskeletal dynamics play crucial roles.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Virology
Yulin Xu, Youwen Zhang, Shaohua Sun, Jia Luo, Sen Jiang, Jiajia Zhang, Xueliang Liu, Qi Shao, Qi Cao, Wanglong Zheng, Nanhua Chen, Francois Meurens, Jianzhong Zhu
Summary: The cGAS-STING signal plays an important antiviral role in PRRSV infection, as demonstrated by the suppression of infection with stable expression of STING or stimulation of cGAS-STING signaling, while the knockout of STING gene increases the level of infection.
Article
Immunology
Shisuo Du, Genwen Chen, Baoying Yuan, Yong Hu, Ping Yang, Yixing Chen, Qianqian Zhao, Jian Zhou, Jia Fan, Zhaochong Zeng
Summary: Liver damage caused by exposure to ionizing radiation can lead to liver dysfunction, particularly in cases of radiotherapy for cancers such as hepatocellular carcinoma. Experimental studies have shown that activation of the cGAS-STING pathway in non-parenchymal cells plays a key role in the development of radiation-induced liver disease (RILD) by triggering interferon production and release. Targeting the interferon signaling pathway may offer a potential protective strategy against RILD.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Virology
Li Gao, Rui Liu, Fuchun Yang, Xiaohan Li, Changjun Liu, Xiaole Qi, Hongyu Cui, Yanping Zhang, Suyan Wang, Xiaomei Wang, Yulong Gao, Kai Li
Summary: Duck enteritis virus (DEV) encodes multiple viral proteins to inhibit the cGAS-STING DNA-sensing pathway. The viral tegument protein UL41 selectively reduces the mRNA accumulation of interferon regulatory factor 7 (IRF7), thereby inhibiting the DNA-sensing pathway. Loss of UL41 enhances the immune response to DEV and impairs viral replication.
JOURNAL OF VIROLOGY
(2022)
Article
Virology
Xueping Yu, Yijuan Zheng, Dawu Zeng, Yongjun Zhou, Jian Sun, Milong Su, Huatang Zhang, Minhui Zheng, Zhipeng Huang, Wenwu Lin, Richeng Mao, Jiming Zhang, Chunfu Zheng, Zhijun Su
Summary: CD3(+)CD4(-)CD7(+)CD57(-) T cells are decreased in patients with end-stage liver disease, especially those with acute to chronic liver failure, and this decrease is associated with disease severity, prognosis, and complications. IL-22 stimulation promotes apoptosis and reduces the number of CD3(+)CD4(-)CD7(+)CD57(-) T cells. These cells exhibit an immunosuppressive phenotype and low expression levels of cytokines.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Review
Biochemistry & Molecular Biology
Jie Gao, Qiaoban Wang, Yan-Dong Tang, Jingbo Zhai, Wei Hu, Chunfu Zheng
Summary: Apoptosis, necrosis, and autophagy are different strategies used by host cells to defend against pathogens such as viruses, bacteria, or fungi. Ferroptosis is a newly discovered regulated cell death that pathogens can manipulate to promote their replication and pathogenesis. However, the interaction between ferroptosis and pathogenic infections is still not fully understood. This review summarizes the advances in understanding how pathogens exploit and regulate ferroptosis and discusses potential therapeutic approaches against pathogen-associated diseases.
TRENDS IN MICROBIOLOGY
(2023)
Review
Immunology
Changqing Yu, Guosheng Wang, Qiang Liu, Jingbo Zhai, Mengzhou Xue, Qiang Li, Yuanhua Xian, Chunfu Zheng
Summary: Viral envelope glycoproteins play a crucial role in viral infections. Host cells have developed counteracting mechanisms to suppress viral replication by targeting their envelope glycoproteins. Some host antiviral proteins have been found to inhibit furin cleavage of viral envelope glycoproteins, impairing viral infectivity. This review summarizes these host antiviral factors and their roles in reducing furin cleavage, providing insights for future antiviral studies.
EMERGING MICROBES & INFECTIONS
(2023)
Editorial Material
Biochemistry & Molecular Biology
Weizheng Liang, Xiushen Li, Hao Wang, Shuangqing Wang, Qingxue Meng, Ruoqing Feng, Jingbo Zhai, Mengzhou Xue, Chunfu Zheng
Letter
Virology
Shuai Zhang, Jianguo Ju, Fang Yang, Chunfu Zheng, Jingbo Zhai
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Virology
Yan Zhan, Ling Ye, Qianying Ouyang, Jiye Yin, Jiajia Cui, Ke Liu, Chengxian Guo, Haibo Zhang, Jingbo Zhai, Chunfu Zheng, Aoxiang Guo, Bao Sun
Summary: This study identified the binding affinity between different HLA proteins and SARS-CoV-2 strains, as well as 10 active binding sites that may contribute to immune evasion. Notably, the weak binding ability with HLA class I polymorphisms could promote immune evasion of Omicron. These findings have important implications for preventing immune evasion of SARS-CoV-2 and providing new insights for vaccine design.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Virology
Rongzhao Zhang, Wenxian Yang, Huifang Zhu, Jingbo Zhai, Mengzhou Xue, Chunfu Zheng
Summary: TBK1 activation is crucial for antiviral innate immunity. NLRC4 has been identified as a positive regulator of TBK1, enhancing the activity of the cGAS-STING signaling pathway and promoting antiviral immune response.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Letter
Virology
Chunfu Zheng
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Virology
Yao Bai, Li Shen, Minghao Sun, Zurong Yang, Zhijun Chen, Jingbo Zhai, Mengzhou Xue, Zhongjun Shao, Kun Liu, Chunfu Zheng
Summary: This study analyzed the epidemiological characteristics of varicella and investigated the impact of anti-COVID-19 nonpharmaceutical interventions (NPIs) on varicella in Xi'an, China. The results showed that the NPIs effectively reduced the incidence of varicella with spatiotemporal heterogeneity.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Correction
Virology
Chunfu Zheng
JOURNAL OF VIROLOGY
(2023)
Correction
Virology
Hui Yuan, Jia You, Hongjuan You, Chunfu Zheng
JOURNAL OF VIROLOGY
(2023)
Correction
Virology
Jie Gao, Yan-Dong Tang, Wei Hu, Chunfu Zheng
JOURNAL OF VIROLOGY
(2023)
Correction
Virology
Jian Huang, Hongjuan You, Chenhe Su, Yangxin Li, Shunhua Chen, Chunfu Zheng
JOURNAL OF VIROLOGY
(2023)
Correction
Microbiology
Huifang Zhu, Chunfu Zheng
MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS
(2023)
Review
Microbiology
Changqing Yu, Qiang Liu, Zhuo Zhao, Jingbo Zhai, Mengzhou Xue, Yan-Dong Tang, Chengbao Wang, Chunfu Zheng
Summary: MARCH8, a membrane-associated protein, regulates turnover of transmembrane proteins and exhibits antiviral activities. It functions through degradation and trapping of viral proteins, playing a role in antiviral defense.