Possible repurposing of pyrvinium pamoate for the treatment of mesothelioma: A pre-clinical assessment

RBL2/p130 is a direct AKT target and is required to induce apoptosis upon AKT inhibition in lung cancer and mesothelioma cell lines

(2018) Francesca Pentimalli et al.   ONCOGENE

The Wnt regulator SFRP4 inhibits mesothelioma cell proliferation, migration, and antagonizes Wnt3a via its netrin-like domain

(2017) Vanathi Perumal et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

The novel role of pyrvinium in cancer therapy

(2017) Amir A. Momtazi-borojeni et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Drug repurposing for the treatment of glioblastoma multiforme

(2017) Claudia Abbruzzese et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Pharmacologic Inhibition of β-Catenin With Pyrvinium Inhibits Murine and Human Models of Wilms Tumor

(2017) Dina Polosukhina et al.   ONCOLOGY RESEARCH

Ror2, a Developmentally Regulated Kinase, Is Associated With Tumor Growth, Apoptosis, Migration, and Invasion in Renal Cell Carcinoma

(2017) Chun-ming Yang et al.   ONCOLOGY RESEARCH

Targeting of Wnt/β-Catenin by Anthelmintic Drug Pyrvinium Enhances Sensitivity of Ovarian Cancer Cells to Chemotherapy

(2017) Chongyuan Zhang et al.   MEDICAL SCIENCE MONITOR

c-Met expression and MET amplification in malignant pleural mesothelioma

(2016) Melanie C. Bois et al.   Annals of Diagnostic Pathology

Pyrvinium selectively induces apoptosis of lymphoma cells through impairing mitochondrial functions and JAK2/STAT5

(2016) Meifang Xiao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

WNT5A–ROR2 is induced by inflammatory mediators and is involved in the migration of human ovarian cancer cell line SKOV-3

(2016) Somayeh Arabzadeh et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

Cyclin D1, cancer progression, and opportunities in cancer treatment

(2016) Shuo Qie et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Computational drugs repositioning identifies inhibitors of oncogenic PI3K/AKT/P70S6K-dependent pathways among FDA-approved compounds

(2016) Diego Carrella et al.   Oncotarget

Secreted HMGB1 from Wnt activated intestinal cells is required to maintain a crypt progenitor phenotype

(2016) Karen R. Reed et al.   Oncotarget

Carcinogenic potential of high aspect ratio carbon nanomaterials

(2016) Sudjit Luanpitpong et al.   Environmental Science-Nano

Migration and invasion is inhibited by silencing ROR1 and ROR2 in chemoresistant ovarian cancer

(2016) C E Henry et al.   Oncogenesis

MWCNTs Induce ROS Generation, ERK Phosphorylation, and SOD-2 Expression in Human Mesothelial Cells

(2015) Min Yu et al.   INTERNATIONAL JOURNAL OF TOXICOLOGY

Ror2 as a Therapeutic Target in Cancer

(2015) Zufan Debebe et al.   PHARMACOLOGY & THERAPEUTICS

Pyrvinium selectively targets blast phase-chronic myeloid leukemia through inhibition of mitochondrial respiration

(2015) Wei Xiang et al.   Oncotarget

The impact of pyrvinium pamoate on colon cancer cell viability

(2014) Armin Wiegering et al.   INTERNATIONAL JOURNAL OF COLORECTAL DISEASE

Overview of the biochemical and genetic processes in malignant mesothelioma

(2014) Leonardo Vinícius Monteiro de Assis et al.   Jornal Brasileiro de Pneumologia

Occupational and non-occupational attributable risk of asbestos exposure for malignant pleural mesothelioma

(2014) A Lacourt et al.   THORAX

Ligand-Independent and Tissue-Selective Androgen Receptor Inhibition by Pyrvinium

(2013) Minyoung Lim et al.   ACS Chemical Biology

Genotoxic and carcinogenic potential of engineered nanoparticles: an update

(2013) Ashutosh Kumar et al.   ARCHIVES OF TOXICOLOGY

Expression profile and function of Wnt signaling mechanisms in malignant mesothelioma cells

(2013) Simon A. Fox et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Pyrvinium pamoate does not activate protein kinase CK1, but promotes Akt/PKB down-regulation and GSK3 activation

(2013) Andrea Venerando et al.   BIOCHEMICAL JOURNAL

The Antihelmintic Drug Pyrvinium Pamoate Targets Aggressive Breast Cancer

(2013) Wei Xu et al.   PLoS One

Cancer Cell Secretion of the DAMP Protein HMGB1 Supports Progression in Malignant Mesothelioma

(2012) S. Jube et al.   CANCER RESEARCH

The dual role of the novel Wnt receptor tyrosine kinase, ROR2, in human carcinogenesis

(2012) Caroline E. Ford et al.   INTERNATIONAL JOURNAL OF CANCER

Ror2-Src signaling in metastasis of mouse melanoma cells is inhibited by NRAGE

(2012) Shan-shan Lai et al.   Cancer Genetics

Reprofiling a classical anthelmintic, pyrvinium pamoate, as an anti-cancer drug targeting mitochondrial respiration

(2012) Isao Ishii et al.   Frontiers in Oncology

Pyrvinium pamoate inhibits proliferation of myeloma/erythroleukemia cells by suppressing mitochondrial respiratory complex I and STAT3

(2011) Yasuo Harada et al.   CANCER LETTERS

Malignant mesothelioma: Facts, Myths, and Hypotheses

(2011) Michele Carbone et al.   JOURNAL OF CELLULAR PHYSIOLOGY

New pyrazolo[3,4-d]pyrimidine SRC inhibitors induce apoptosis in mesothelioma cell lines through p27 nuclear stabilization

(2011) P Indovina et al.   ONCOGENE

Facts, rumours and speculations about the mesothelioma epidemic

(2011) Jan P. van Meerbeeck et al.   RESPIROLOGY

Induction of Wnt/β-Catenin Signaling in Mouse Mesenchymal Stem Cells Is Associated with Activation of the p130 and E2f4 and Formation of the p130/Gsk3β/β-Catenin Complex

(2011) Nikolay Petrov et al.   STEM CELLS AND DEVELOPMENT

Clinical Significance of Serum Vascular Endothelial Growth Factor in Malignant Pleural Mesothelioma

(2010) Akihiro Yasumitsu et al.   Journal of Thoracic Oncology

Pleural effusion VEGF levels as a prognostic factor of malignant pleural mesothelioma

(2010) Noriko Hirayama et al.   RESPIRATORY MEDICINE

Malignant Pleural Mesothelioma

(2009) Anne S. Tsao et al.   JOURNAL OF CLINICAL ONCOLOGY

Non-competitive androgen receptor inhibition in vitro and in vivo

(2009) J. O. Jones et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA