Article
Cell Biology
Giovanni Risato, Rudy Celeghin, Raquel Branas Casas, Alberto Dinarello, Alessandro Zuppardo, Andrea Vettori, Kalliopi Pilichou, Gaetano Thiene, Cristina Basso, Francesco Argenton, Silvia Visentin, Erich Cosmi, Natascia Tiso, Giorgia Beffagna
Summary: This study identified the Wnt/β-catenin and Jak/Stat3 pathways as key players in the development of Fetal Growth Restriction (FGR). By using drugs targeting these pathways, the researchers were able to rescue FGR phenotypes in zebrafish models. This data suggests the potential of targeting the Wnt/β-catenin pathway for pharmacological intervention in FGR.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Linda Campos-Fernandez, Rocio Ortiz-Muniz, Edith Cortes-Barberena, Sergio Mares-Samano, Ramon Garduno-Juarez, Catalina Soriano-Correa
Summary: This study used quantum chemistry methods to design and characterize the electronic structure of imidazole and nitroimidazole derivatives, and analyze the molecular docking and interactions of NADH-fumarate reductase. Molecules with the best physicochemical properties and lowest toxicity were selected, and a high-quality three-dimensional structure of NADH-fumarate reductase was obtained through homology modeling.
JOURNAL OF COMPUTATIONAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Jessica B. Spinelli, Paul C. Rosen, Hans-Georg Sprenger, Anna M. Puszynska, Jessica L. Mann, Julian M. Roessler, Andrew L. Cangelosi, Antonia Henne, Kendall J. Condon, Tong Zhang, Tenzin Kunchok, Caroline A. Lewis, Navdeep S. Chandel, David M. Sabatini
Summary: Research has shown that cells can deposit electrons into the mitochondrial electron transport chain through alternative pathways when oxygen reduction is impeded, with the succinate dehydrogenase complex playing a crucial role in the process. By reversing the succinate dehydrogenase complex, mitochondrial functions are maintained even under conditions of inhibited oxygen reduction.
Article
Parasitology
Shinzaburo Takamiya, Takeshi Nakamura, Daigo Tsubokawa, Naotoshi Tsuji, Koichi Fukuda, Hiroshi Yamasaki, Tsutomu Fujimura, Hikari Taka, Naoko Kaga, Momoko Kobayashi-Tanabe, Motoo Matsuda, Toshihiro Mita
Summary: The mitochondria of adult and plerocercoid Spirometra mansoni were studied to understand their respiratory function and physicochemical properties. It was found that adult mitochondria had higher specific activities of succinate oxidase and NADH-FRD compared to plerocercoid mitochondria. Both adult and plerocercoid mitochondria contained rhodoquinone-10 and ubiquinone-10, with higher concentrations in adult mitochondria. Inhibition studies showed that adult mitochondria had both cyanide-sensitive and -insensitive succinate oxidases, and could produce hydrogen peroxide. The specific activities of NADH-fumarate reductase and cytochrome c oxidase were higher in mature proglottids. Isopycnic density-gradient centrifugation analyses and in situ electron microscopic histochemistry revealed the heterogeneity of both adult and plerocercoid mitochondria.
PARASITOLOGY INTERNATIONAL
(2023)
Article
Chemistry, Physical
Hiroaki Mitsuizumi, Seiji Mori
Summary: 3α-HSD enzyme plays a crucial role in regulating the concentration of 5α-DHT in the prostate. Understanding the mechanism of 5α-DHT hydride reduction by 3α-HSD could lead to the development of effective drugs for prostate cancer treatment. The study conducted comprehensive evaluation of human 3α-HSD type 3 crystal structure, revealing key interactions and mechanisms involved in the reaction process.
JOURNAL OF PHYSICAL CHEMISTRY B
(2021)
Article
Integrative & Complementary Medicine
Xiaojin Liu, Tiancheng Ji, Haoya Hu, Xiaobing Lv, Guoping Zhu
Summary: This study was the first to investigate the effects of Gardenia florida fruit extract (GFFE) on hair growth. Both in vitro and in vivo experiments were conducted to examine the effects of GFFE on human dermal papilla cells (hDPCs) and C57BL/6 mice. The results showed that GFFE promoted cell proliferation, stimulated hair growth-promoting genes, and suppressed hair loss-related genes. Additionally, GFFE treatment increased the number, size, and depth of hair follicles in mice.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Haruka Kono, Satoshi Hara, Tadaomi Furuta, Hiroshi Ichinose
Summary: In this study, the binding profile of quinonoid-form dihydrobiopterin (qBH2) to quinonoid dihydropteridine reductase (QDPR) was analyzed using in vitro and in silico methods. It was found that qBH2 and quinonoid-form dihydrofolate (qDHF) could be potential physiological substrates for QDPR, suggesting that QDPR may have a bifunctional role. These findings provide important insights into biopterin and folate metabolism and have implications for drug development.
JOURNAL OF BIOCHEMISTRY
(2023)