Article
Oncology
Kerstin Menck, Saskia Heinrichs, Darius Wlochowitz, Maren Sitte, Helen Noeding, Andreas Janshoff, Hannes Treiber, Torben Ruhwedel, Bawarjan Schatlo, Christian von der Brelie, Stefan Wiemann, Tobias Pukrop, Tim Beissbarth, Claudia Binder, Annalen Bleckmann
Summary: Our study identified a novel auto-stimulatory loop in which ROR2 triggers the expression of its own ligand, WNT11, resulting in enhanced tumor invasion associated with breast cancer metastasis. The overexpression of ROR2 induced a BRCAness-like phenotype and resistance to PARP inhibition in a cell-context specific manner. High levels of ROR2 were also associated with defects in cell morphology and cell-cell-contacts leading to increased tumor invasiveness.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Dongli Liu, Luis Enriquez, Caroline E. Ford
Summary: This study investigated the role of the Wnt signalling receptor ROR2 in endometrial cancer and found that low expression was associated with unfavorable outcomes and reduced overall survival. Epigenetic repression of ROR2 expression was observed in cancer cell lines and patient samples, and ectopic expression inhibited invasive ability. The findings suggest that ROR2 may serve as a diagnostic or therapeutic candidate for endometrial cancer.
Article
Multidisciplinary Sciences
Anthony Veltri, Christopher M. R. Lang, Gaia Cangiotti, Chim Kei Chan, Wen-Hui Lien
Summary: The study reveals the important roles of the Wnt receptor ROR2 in the activation, self-renewal, and maintenance of hair follicle stem cells (HFSCs), through both transducing Wnt signaling and regulating DNA damage response.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Pablo Lopez-Bergami
Summary: ROR2 plays a dual role in cancer, with contradictory effects on cell proliferation and migration. In melanoma, it impairs cell proliferation while promoting migration, EMT, and chemoresistance. It is proposed to be a major driver of phenotype switching in melanoma, providing therapeutic opportunities for targeting invasive and drug-resistant phenotypes.
CANCER CELL INTERNATIONAL
(2022)
Article
Developmental Biology
Yuanyuan Ma, Junjun Jing, Jifan Feng, Yuan Yuan, Quan Wen, Xia Han, Jinzhi He, Shuo Chen, Thach-Vu Ho, Yang Chai
Summary: The control of size and shape is crucial during organogenesis, and tooth formation is a complex process that fine-tunes the size and shape of teeth. Ror2-mediated noncanonical Wnt signaling plays a crucial role in regulating root development size in mouse molars, with Cdc42 potentially acting as a downstream mediator. Activation of Cdc42 can restore cell proliferation and partially rescue root development size defects in Ror2 mutant mice.
Article
Biochemistry & Molecular Biology
Cheng-Fa Yeh, Ti-Chun Chan, Hung-Lung Ke, Tzu-Ju Chen, Li-Ching Wu, Hsiang-Ying Lee, Yu-Ching Wei, Wen-Jeng Wu, Chien-Feng Li, Wei-Ming Li
Summary: The study revealed that high ROR2 expression is associated with aggressive pathological characteristics in UC and independently predicts worse prognosis, suggesting its potential role in clinical risk stratification and treatment decisions.
Article
Biochemistry & Molecular Biology
Elena F. Boer, Hannah F. Van Hollebeke, Emily T. Maclary, Carson Holt, Mark Yandell, Michael D. Shapiro
Summary: Research on craniofacial morphogenesis in pigeons has identified a Z chromosome locus linked to beak morphology variation, with an amino acid substitution in the ROR2 gene potentially regulating beak length. Comparative genomic analyses suggest significant differentiation in related loci between breeds with different beak lengths. The non-canonical Wnt pathway plays a critical role in vertebrate neural crest cell migration and craniofacial morphogenesis.
Article
Dentistry, Oral Surgery & Medicine
Haixia Liu, Xu Zhang, Qixiang Yang, Xueqin Zhu, Fubo Chen, Jing Yue, Rong Zhou, Yuanzhi Xu, Shengcai Qi
Summary: The study revealed that knockout of NRAGE induces autophagy-related gene expression and accelerates the progression of periodontitis by increasing the activity and differentiation of osteoclasts.
Article
Cell Biology
Baoheng Gui, Chenxi Yu, Xiaoxin Li, Sen Zhao, Hengqiang Zhao, Zihui Yan, Xi Cheng, Jiachen Lin, Haiyang Zheng, Jiashen Shao, Zhengye Zhao, Lina Zhao, Yuchen Niu, Zhi Zhao, Huizi Wang, Bobo Xie, Xianda Wei, Chunrong Gui, Chuan Li, Shaoke Chen, Yi Wang, Yanning Song, Chunxiu Gong, Terry Jianguo Zhang, Xin Fan, Zhihong Wu, Yujun Chen, Nan Wu
Summary: This study investigated the mutational spectrum of ROR2 in children with short stature and identified several mutations that potentially disrupt the expression of downstream genes in the Wnt5a-ROR2 pathway by affecting protein subcellular localization and expression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Kazuki Wakizaka, Toshiya Kamiyama, Tatsuhiko Kakisaka, Tatsuya Orimo, Akihisa Nagatsu, Takeshi Aiyama, Shunsuke Shichi, Akinobu Taketomi
Summary: This study investigated the significance of ROR2 expression in hepatocellular carcinoma (HCC) by examining ROR2 expression in liver cancer cell lines and performing immunohistochemical staining of ROR2 on 243 resected HCC specimens. The study also investigated the association between ROR2 expression and clinicopathologic factors and prognosis.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Developmental Biology
Daniel B. Dranow, Pierre Le Pabic, Thomas F. Schilling
Summary: Non-canonical/beta-catenin-independent Wnt signaling is crucial for tissue/cell polarity in epithelia, but its role in mesenchymal tissues like the skeleton is not well studied. Mutations in non-canonical Wnt signaling pathway genes cause skeletal diseases in humans, disrupting bone growth. Ror2 is a non-canonical Wnt receptor/co-receptor. Zebrafish with ror2-/- mutation show craniofacial skeletal defects and chondrocyte polarity disruptions. The proline-rich domain of Ror2 is required for its function in rescuing the defects.
Article
Medicine, Research & Experimental
Eman M. Awad, Al-Shaimaa F. Ahmed, Mahmoud El-Daly, Ali H. Amin, Nashwa F. G. El-Tahawy, AlShimaa Wagdy, Morley D. Hollenberg, Ashraf Taye
Summary: The study found that dihydromyricetin (DHM) can prevent vascular endothelial dysfunction caused by hyperglycaemia, inhibiting vasoconstriction, improving endothelial vasodilation, and reducing inflammation and oxidative stress.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Raul Riquelme, Laura Li, Abigail Gambrill, Andres Barria
Summary: Wnt signaling is crucial for regulating synaptic and neuronal function in the mature CNS. Our study demonstrates that the Wnt receptor ROR2 can independently activate downstream signaling and regulate key synaptic components through homodimerization. Understanding ROR2 signaling is important for comprehending the regulation of synaptic and neuronal function in normal brain processes.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2023)
Article
Cell Biology
Nakisa Tabrizian, Shaghayegh Nouruzi, Cassandra Jingjing Cui, Maxim Kobelev, Takeshi Namekawa, Ishana Lodhia, Amina Talal, Olena Sivak, Dwaipayan Ganguli, Amina Zoubeidi
Summary: This study identifies ROR2 as a potential therapeutic target to reverse the lineage plasticity induced by AR pathway inhibition in prostate cancer. ROR2 promotes stem-cell-like and neuronal networks by activating the ERK/CREB signaling pathway.
Article
Cell Biology
Barnabas Irmer, Janes Efing, Lea Elisabeth Reitnauer, Allegra Angenendt, Saskia Heinrichs, Antonia Schubert, Matthias Schulz, Claudia Binder, Joke Tio, Uwe Hansen, Christiane Geyer, Mirjam Gerwing, Annalen Bleckmann, Kerstin Menck
Summary: EVs can transfer oncogenic Wnt receptors ROR1/2 to the surface of ROR-negative cancer cells, inducing an aggressive phenotype that supports tumor progression. This transfer was observed both in vitro and in vivo, and ROR-positive EVs were also found to be significantly elevated in the plasma of breast cancer patients.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Biochemistry & Molecular Biology
Shanshan Lai, Jun Yuan, Dandan Zhao, Ning Shen, Weibo Chen, Yao Ding, Decai Yu, Jing Lie, Feiyan Pan, Minsheng Zhu, Chaojun Li, Bin Xue
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2015)
Article
Endocrinology & Metabolism
Lu Zhou, Hang Sun, Ran Cheng, Xiujun Fan, Shanshan Lai, Cheng Deng
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2019)
Letter
Endocrinology & Metabolism
Shanshan Lai
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2019)