Article
Biochemistry & Molecular Biology
May Meltzer, Noam Eliash, Ziv Azoulay, Uzi Hadad, Niv Papo
Summary: The study focuses on the importance of Tie1 and Tie2 receptor tyrosine kinases in various diseases, especially cancer. Using non-immune nanobodies, the researchers discovered a highly expressive and specific nanobody that binds to Tie1, with potential therapeutic effects on cancer.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Cell Biology
Barnabas Irmer, Janes Efing, Lea Elisabeth Reitnauer, Allegra Angenendt, Saskia Heinrichs, Antonia Schubert, Matthias Schulz, Claudia Binder, Joke Tio, Uwe Hansen, Christiane Geyer, Mirjam Gerwing, Annalen Bleckmann, Kerstin Menck
Summary: EVs can transfer oncogenic Wnt receptors ROR1/2 to the surface of ROR-negative cancer cells, inducing an aggressive phenotype that supports tumor progression. This transfer was observed both in vitro and in vivo, and ROR-positive EVs were also found to be significantly elevated in the plasma of breast cancer patients.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Biochemistry & Molecular Biology
Silvia Martina Ferrari, Giusy Elia, Francesca Ragusa, Sabrina Rosaria Paparo, Valeria Mazzi, Armando Patrizio, Simona Piaggi, Enke Baldini, Marco Centanni, Concettina La Motta, Alessandro Antonelli, Poupak Fallahi
Summary: This study evaluated the antineoplastic effect of multitarget tyrosine kinase inhibitor pazopanib in primary human anaplastic thyroid cancer cells in vitro. The results showed that pazopanib inhibited cell proliferation, migration, and invasion, and increased apoptosis. Moreover, pazopanib significantly decreased the expression of VEGF in the cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Fabio Turco, Marcello Tucci, Rosario Francesco Di Stefano, Alessandro Samuelly, Maristella Bungaro, Marco Audisio, Chiara Pisano, Massimo Di Maio, Giorgio Vittorio Scagliotti, Consuelo Buttigliero
Summary: Obesity is a well-known risk factor for renal cell carcinoma development, but studies have found that it may actually be associated with a better prognosis in patients with this type of cancer, a phenomenon known as the obesity paradox. The purpose of research in this area is to better understand the mechanisms behind this paradoxical relationship.
ENDOCRINE-RELATED CANCER
(2021)
Article
Cell Biology
Chaoqun Liu, Le Shen, Li Xu, Afang Zhu, Yuguang Huang
Summary: The study indicates that the role of Ror2 in spinal cord astrocytes can affect the development of CPTP by regulating the transformation of A1/A2 reactive astrocytes, and suppressing Ror2 may help prevent the occurrence of CPTP.
CELLULAR SIGNALLING
(2022)
Article
Multidisciplinary Sciences
Anthony Veltri, Christopher M. R. Lang, Gaia Cangiotti, Chim Kei Chan, Wen-Hui Lien
Summary: The study reveals the important roles of the Wnt receptor ROR2 in the activation, self-renewal, and maintenance of hair follicle stem cells (HFSCs), through both transducing Wnt signaling and regulating DNA damage response.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Hanshuang Shao, Alan Wells
Summary: Abnormal expression and mutagenesis of EGFR drive the development and progression of human cancers, and further mutations within the tyrosine kinase region contribute to resistance to targeted drugs. However, the effect of these mutations on cancer cell progression behaviors is unknown.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biology
Qingyu Meng, Luya Pu, Mingran Qi, Shuai Li, Banghao Sun, Yaru Wang, Bin Liu, Fan Li
Summary: The study reveals that laminar shear stress inhibits inflammatory response in human aortic endothelial cells through autophagy induction. EPHB2 and the LOC107986345/miR-128-3p/EPHB2 axis play crucial roles in laminar shear stress-mediated anti-atherosclerotic development.
COMMUNICATIONS BIOLOGY
(2022)
Review
Hematology
Thomas J. Kipps
Summary: ROR1 is a cell receptor with significant importance in embryonic development and cancer. It plays a crucial role in the pathophysiology of CLL and has distinctive expression in this malignancy. Researchers have conducted studies on the expression, biology, and therapeutic strategies targeting ROR1.
Article
Cell Biology
Corina M. Borza, Gema Bolas, Xiuqi Zhang, Mary Beth Browning Monroe, Ming-Zhi Zhang, Jens Meiler, Marcin J. Skwark, Raymond C. Harris, Lynne A. Lapierre, James R. Goldenring, Magnus Hook, Jose Rivera, Kyle L. Brown, Birgit Leitinger, Matthew J. Tyska, Markus Moser, Ralph T. Boettcher, Roy Zent, Ambra Pozzi
Summary: This study identifies DDR1b as a major driver of cell migration and talin and BCR as key players in the interplay between integrins and DDR1b in regulating cell migration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Raul Riquelme, Laura Li, Abigail Gambrill, Andres Barria
Summary: Wnt signaling is crucial for regulating synaptic and neuronal function in the mature CNS. Our study demonstrates that the Wnt receptor ROR2 can independently activate downstream signaling and regulate key synaptic components through homodimerization. Understanding ROR2 signaling is important for comprehending the regulation of synaptic and neuronal function in normal brain processes.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2023)
Article
Oncology
Simona Gallo, Annapia Vitacolonna, Paolo Comoglio, Tiziana Crepaldi
Summary: The MET oncogene interacts with glutamate receptors in breast cancer cells, promoting migration and invasion. Inhibition of glutamate receptors can reduce the effects of hepatocyte growth factor (HGF) on cell migration and invasion. In triple-negative breast cancer cells, the NMDAR2B subunit is coexpressed with the MET protein, and inhibiting NMDAR can weaken the effects of HGF.
Article
Biochemistry & Molecular Biology
Elena F. Boer, Hannah F. Van Hollebeke, Emily T. Maclary, Carson Holt, Mark Yandell, Michael D. Shapiro
Summary: Research on craniofacial morphogenesis in pigeons has identified a Z chromosome locus linked to beak morphology variation, with an amino acid substitution in the ROR2 gene potentially regulating beak length. Comparative genomic analyses suggest significant differentiation in related loci between breeds with different beak lengths. The non-canonical Wnt pathway plays a critical role in vertebrate neural crest cell migration and craniofacial morphogenesis.
Article
Biotechnology & Applied Microbiology
Dewang Fu, Ben Liu, Huamao Jiang, Zhaowei Li, Chenghui Fan, Li'e Zang
Summary: The research demonstrates that exosomal miR-19b-1-5p can suppress bladder cancer growth by decreasing ABL2, and it also inhibits malignant behaviors of bladder cancer cells.
Article
Oncology
Juan Li, Nan Yang, Xiaolei Tian, Linglong Ouyang, Man Jiang, Shufang Zhang
Summary: The study demonstrates the significant role of Protein tyrosine kinase 6 (PTK6) in the malignant progression of cervical cancer, particularly through its interaction with GRB2-associated binding 1 (GAB1).
MOLECULAR MEDICINE REPORTS
(2022)