The dual role of the novel Wnt receptor tyrosine kinase, ROR2, in human carcinogenesis

Three decades of Wnts: a personal perspective on how a scientific field developed

(2012) Roel Nusse et al.   EMBO JOURNAL

Ror family receptor tyrosine kinases regulate the maintenance of neural progenitor cells in the developing neocortex

(2012) M. Endo et al.   JOURNAL OF CELL SCIENCE

ROR2 is a novel prognostic biomarker and a potential therapeutic target in leiomyosarcoma and gastrointestinal stromal tumour

(2012) Badreddin Edris et al.   JOURNAL OF PATHOLOGY

Monoclonal antibodies against ROR1 induce apoptosis of chronic lymphocytic leukemia (CLL) cells

(2012) A H Daneshmanesh et al.   LEUKEMIA

Wnt5a-Ror2 signaling between osteoblast-lineage cells and osteoclast precursors enhances osteoclastogenesis

(2012) Kazuhiro Maeda et al.   NATURE MEDICINE

ROR1 Is Expressed in Human Breast Cancer and Associated with Enhanced Tumor-Cell Growth

(2012) Suping Zhang et al.   PLoS One

Loss of Wnt5a and Ror2 protein in hepatocellular carcinoma associated with poor prognosis

(2012) Ming Geng   WORLD JOURNAL OF GASTROENTEROLOGY

Ror1 Is a Pseudokinase That Is Crucial for Met-Driven Tumorigenesis

(2011) A. Gentile et al.   CANCER RESEARCH

Critical role of Wnt5a-Ror2 signaling in motility and invasiveness of carcinoma cells following Snail-mediated epithelial-mesenchymal transition

(2011) Dayong Ren et al.   GENES TO CELLS

Dissection of Wnt5a-Ror2 Signaling Leading to Matrix Metalloproteinase (MMP-13) Expression

(2011) Kaoru Yamagata et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Use of the receptor tyrosine kinase-like orphan receptor 1 (ROR1) as a diagnostic tool in chronic lymphocytic leukemia (CLL)

(2011) Sabrina Uhrmacher et al.   LEUKEMIA RESEARCH

Therapeutic Potential and Challenges of Targeting Receptor Tyrosine Kinase ROR1 with Monoclonal Antibodies in B-Cell Malignancies

(2011) Jiahui Yang et al.   PLoS One

Emerging role of Notch signaling in epidermal differentiation and skin cancer

(2010) John Panelos et al.   CANCER BIOLOGY & THERAPY

WNT5A antagonizes WNT/β-catenin signaling and is frequently silenced by promoter CpG methylation in esophageal squamous cell carcinoma

(2010) Jisheng Li et al.   CANCER BIOLOGY & THERAPY

β-catenin-independent WNT signaling in basal-like breast cancer and brain metastasis

(2010) F. Klemm et al.   CARCINOGENESIS

Epigenetic disruption of the WNT/ß-catenin signaling pathway in human cancers

(2010) Ying Ying et al.   Epigenetics

Canonical and noncanonical Wnts use a common mechanism to activate completely unrelated coreceptors

(2010) L. Grumolato et al.   GENES & DEVELOPMENT

ROR1 expression is not a unique marker of CLL

(2010) Gábor Barna et al.   HEMATOLOGICAL ONCOLOGY

Ror2/Frizzled Complex Mediates Wnt5a-Induced AP-1 Activation by Regulating Dishevelled Polymerization

(2010) M. Nishita et al.   MOLECULAR AND CELLULAR BIOLOGY

Epigenetic repression of ROR2 has a Wnt-mediated, pro-tumourigenic role in colon cancer

(2010) Ester Lara et al.   Molecular Cancer

Wnt5a signaling is involved in the aggressiveness of prostate cancer and expression of metalloproteinase

(2010) H Yamamoto et al.   ONCOGENE

Orphan receptor tyrosine kinase ROR2 as a potential therapeutic target for osteosarcoma

(2009) Kazuhito Morioka et al.   CANCER SCIENCE

Resequencing and copy number analysis of the human tyrosine kinase gene family in poorly differentiated gastric cancer

(2009) Takashi Kubo et al.   CARCINOGENESIS

Wnt5a regulates distinct signalling pathways by binding to Frizzled2

(2009) Akira Sato et al.   EMBO JOURNAL

Ror2 Receptor Requires Tyrosine Kinase Activity to Mediate Wnt5A Signaling

(2009) Amanda Mikels et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Wnt Survival Guide: From Flies to Human Disease

(2009) Andy J. Chien et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Autonomous regulation of osteosarcoma cell invasiveness by Wnt5a/Ror2 signaling

(2009) M Enomoto et al.   ONCOGENE

Ror2, a developmentally regulated kinase, promotes tumor growth potential in renal cell carcinoma

(2009) T M Wright et al.   ONCOGENE

The orphan tyrosine kinase receptor, ROR2, mediates Wnt5A signaling in metastatic melanoma

(2009) M P O’Connell et al.   ONCOGENE

Ror2 expression in squamous cell carcinoma and epithelial dysplasia of the oral cavity

(2009) Masaki Kobayashi et al.   ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTICS

Unique Cell Surface Expression of Receptor Tyrosine Kinase ROR1 in Human B-Cell Chronic Lymphocytic Leukemia

(2008) S. Baskar et al.   CLINICAL CANCER RESEARCH

Ror1, a cell surface receptor tyrosine kinase is expressed in chronic lymphocytic leukemia and may serve as a putative target for therapy

(2008) Amir H. DaneshManesh et al.   INTERNATIONAL JOURNAL OF CANCER

Expression profile of orphan receptor tyrosine kinase (ROR1) and Wilms' tumor gene 1 (WT1) in different subsets of B-cell acute lymphoblastic leukemia

(2008) Mahdi Shabani et al.   LEUKEMIA & LYMPHOMA

Alternative Wnt Signaling Is Initiated by Distinct Receptors

(2008) R. van Amerongen et al.   Science Signaling