Mitochondrial Dysfunction in Parkinson’s Disease: New Mechanistic Insights and Therapeutic Perspectives
出版年份 2018 全文链接
标题
Mitochondrial Dysfunction in Parkinson’s Disease: New Mechanistic Insights and Therapeutic Perspectives
作者
关键词
Parkinson’s disease, Neurodegeneration, Mitochondria, Bioenergetics, Mitophagy, Mitochondrial biogenesis, Therapy
出版物
Current Neurology and Neuroscience Reports
Volume 18, Issue 5, Pages -
出版商
Springer Nature
发表日期
2018-04-03
DOI
10.1007/s11910-018-0829-3
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Dimethyl fumarate mediates Nrf2-dependent mitochondrial biogenesis in mice and humans
- (2017) Genki Hayashi et al. HUMAN MOLECULAR GENETICS
- Varied pathological and therapeutic response effects associated with CHCHD2 mutant and risk variants
- (2017) Murni Tio et al. HUMAN MUTATION
- Proteinopathy, oxidative stress and mitochondrial dysfunction: cross talk in Alzheimer's disease and Parkinson's disease
- (2017) Gargi Ganguly et al. Drug Design Development and Therapy
- PINK1 Primes Parkin-Mediated Ubiquitination of PARIS in Dopaminergic Neuronal Survival
- (2017) Yunjong Lee et al. Cell Reports
- Nix restores mitophagy and mitochondrial function to protect against PINK1/Parkin-related Parkinson’s disease
- (2017) Brianada Koentjoro et al. Scientific Reports
- Mitochondrial DNA Depletion in Respiratory Chain-Deficient Parkinson Disease Neurons
- (2016) Anne Grünewald et al. ANNALS OF NEUROLOGY
- The Essential Role of Drp1 and Its Regulation by S-Nitrosylation of Parkin in Dopaminergic Neurodegeneration: Implications for Parkinson's Disease
- (2016) Zhenzhen Zhang et al. ANTIOXIDANTS & REDOX SIGNALING
- Functional Impairment in Miro Degradation and Mitophagy Is a Shared Feature in Familial and Sporadic Parkinson’s Disease
- (2016) Chung-Han Hsieh et al. Cell Stem Cell
- PINK1 disables the anti-fission machinery to segregate damaged mitochondria for mitophagy
- (2016) Kenneth R. Pryde et al. JOURNAL OF CELL BIOLOGY
- mito-QC illuminates mitophagy and mitochondrial architecture in vivo
- (2016) Thomas G. McWilliams et al. JOURNAL OF CELL BIOLOGY
- Mitochondrial DNA homeostasis is essential for nigrostriatal integrity
- (2016) Charalampos Tzoulis et al. MITOCHONDRION
- Genetics of Parkinson's disease
- (2016) Christina M. Lill MOLECULAR AND CELLULAR PROBES
- Understanding Dopaminergic Cell Death Pathways in Parkinson Disease
- (2016) Patrick P. Michel et al. NEURON
- Loss of ATP13A2 impairs glycolytic function in Kufor-Rakeb syndrome patient-derived cell models
- (2016) Jin-Sung Park et al. PARKINSONISM & RELATED DISORDERS
- Defective mitochondrial DNA homeostasis in the substantia nigra in Parkinson disease
- (2016) Christian Dölle et al. Nature Communications
- Mitophagy programs: mechanisms and physiological implications of mitochondrial targeting by autophagy
- (2015) Anne Hamacher-Brady et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Effect of Creatine Monohydrate on Clinical Progression in Patients With Parkinson Disease
- (2015) Karl Kieburtz et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- CHCHD2 mutations in autosomal dominant late-onset Parkinson's disease: a genome-wide linkage and sequencing study
- (2015) Manabu Funayama et al. LANCET NEUROLOGY
- Insights on the interaction of alpha-synuclein and metals in the pathophysiology of Parkinson's disease
- (2015) Eleonora Carboni et al. Metallomics
- MNRR1 (formerly CHCHD2) is a bi-organellar regulator of mitochondrial metabolism
- (2015) Siddhesh Aras et al. MITOCHONDRION
- Measuring In Vivo Mitophagy
- (2015) Nuo Sun et al. MOLECULAR CELL
- The role of ATP13A2 in Parkinson's disease: Clinical phenotypes and molecular mechanisms
- (2015) Jin-Sung Park et al. MOVEMENT DISORDERS
- The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy
- (2015) Michael Lazarou et al. NATURE
- Parkinson's disease–associated mutant VPS35 causes mitochondrial dysfunction by recycling DLP1 complexes
- (2015) Wenzhang Wang et al. NATURE MEDICINE
- Retromer in Alzheimer disease, Parkinson disease and other neurological disorders
- (2015) Scott A. Small et al. NATURE REVIEWS NEUROSCIENCE
- Progressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock-in mice
- (2015) M. Yue et al. NEUROBIOLOGY OF DISEASE
- PARK10 is a major locus for sporadic neuropathologically confirmed Parkinson disease
- (2015) G. W. Beecham et al. NEUROLOGY
- Endogenous Parkin Preserves Dopaminergic Substantia Nigral Neurons following Mitochondrial DNA Mutagenic Stress
- (2015) Alicia M. Pickrell et al. NEURON
- The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease
- (2015) Alicia M. Pickrell et al. NEURON
- Parkin loss leads to PARIS-dependent declines in mitochondrial mass and respiration
- (2015) Daniel A. Stevens et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Iron overload triggers mitochondrial fragmentation via calcineurin-sensitive signals in HT-22 hippocampal neuron cells
- (2015) Junghyung Park et al. TOXICOLOGY
- Mitochondrial dysfunction and mitophagy in Parkinson's: from familial to sporadic disease
- (2015) Brent J. Ryan et al. TRENDS IN BIOCHEMICAL SCIENCES
- VPS35 Deficiency or Mutation Causes Dopaminergic Neuronal Loss by Impairing Mitochondrial Fusion and Function
- (2015) Fu-Lei Tang et al. Cell Reports
- PKA Phosphorylation of NCLX Reverses Mitochondrial Calcium Overload and Depolarization, Promoting Survival of PINK1-Deficient Dopaminergic Neurons
- (2015) Marko Kostic et al. Cell Reports
- PGC-1α activity in nigral dopamine neurons determines vulnerability to α-synuclein
- (2015) Carine Ciron et al. Acta Neuropathologica Communications
- PGC−1α Promoter Methylation in Parkinson’s Disease
- (2015) Xiaomin Su et al. PLoS One
- Mutual exacerbation of peroxisome proliferator-activated receptor γ coactivator 1α deregulation and α-synuclein oligomerization
- (2014) Judith Eschbach et al. ANNALS OF NEUROLOGY
- SREBF1links lipogenesis to mitophagy and sporadic Parkinson disease
- (2014) Rachael M Ivatt et al. Autophagy
- Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65
- (2014) Agne Kazlauskaite et al. BIOCHEMICAL JOURNAL
- DUBs counteract parkin for efficient mitophagy
- (2014) I. Dikic et al. EMBO JOURNAL
- Parkinson's disease-associated human ATP13A2 (PARK9) deficiency causes zinc dyshomeostasis and mitochondrial dysfunction
- (2014) Jin-Sung Park et al. HUMAN MOLECULAR GENETICS
- Mitophagy of damaged mitochondria occurs locally in distal neuronal axons and requires PINK1 and Parkin
- (2014) Ghazaleh Ashrafi et al. JOURNAL OF CELL BIOLOGY
- PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity
- (2014) Lesley A. Kane et al. JOURNAL OF CELL BIOLOGY
- -Synuclein Is Localized to Mitochondria-Associated ER Membranes
- (2014) C. Guardia-Laguarta et al. JOURNAL OF NEUROSCIENCE
- The Impact of Mitochondrial Fusion and Fission Modulation in Sporadic Parkinson’s Disease
- (2014) Daniel Santos et al. MOLECULAR NEUROBIOLOGY
- Ubiquitin is phosphorylated by PINK1 to activate parkin
- (2014) Fumika Koyano et al. NATURE
- Abnormal alpha-synuclein reduces nigral voltage-dependent anion channel 1 in sporadic and experimental Parkinson's disease
- (2014) Yaping Chu et al. NEUROBIOLOGY OF DISEASE
- Mitochondrial DNA damage: Molecular marker of vulnerable nigral neurons in Parkinson's disease
- (2014) Laurie H. Sanders et al. NEUROBIOLOGY OF DISEASE
- Detailed analysis of mitochondrial respiratory chain defects caused by loss of PINK1
- (2014) Taku Amo et al. NEUROSCIENCE LETTERS
- Genome-wide RNAi screen identifies the Parkinson disease GWAS risk locus SREBF1 as a regulator of mitophagy
- (2014) R. M. Ivatt et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Parkin and PINK1: much more than mitophagy
- (2014) Leslie A. Scarffe et al. TRENDS IN NEUROSCIENCES
- The c-Abl inhibitor, Nilotinib, protects dopaminergic neurons in a preclinical animal model of Parkinson's disease
- (2014) Senthilkumar S. Karuppagounder et al. Scientific Reports
- A Randomized Clinical Trial of High-Dosage Coenzyme Q10 in Early Parkinson Disease
- (2014) et al. JAMA Neurology
- The rescue of microtubule-dependent traffic recovers mitochondrial function in Parkinson's disease
- (2013) A.R. Esteves et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Mitochondria-targeted antioxidants for treatment of Parkinson's disease: Preclinical and clinical outcomes
- (2013) Huajun Jin et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- A Neo-Substrate that Amplifies Catalytic Activity of Parkinson’s-Disease-Related Kinase PINK1
- (2013) Nicholas T. Hertz et al. CELL
- Isogenic Human iPSC Parkinson’s Model Shows Nitrosative Stress-Induced Dysfunction in MEF2-PGC1α Transcription
- (2013) Scott D. Ryan et al. CELL
- Genetic Correction of a LRRK2 Mutation in Human iPSCs Links Parkinsonian Neurodegeneration to ERK-Dependent Changes in Gene Expression
- (2013) Peter Reinhardt et al. Cell Stem Cell
- Dimethyl Fumarate for Treatment of Multiple Sclerosis: Mechanism of Action, Effectiveness, and Side Effects
- (2013) Ralf A. Linker et al. Current Neurology and Neuroscience Reports
- Zn2+ dyshomeostasis caused by loss of ATP13A2/PARK9 leads to lysosomal dysfunction and alpha-synuclein accumulation
- (2013) Taiji Tsunemi et al. HUMAN MOLECULAR GENETICS
- Functional interaction of Parkinson's disease-associated LRRK2 with members of the dynamin GTPase superfamily
- (2013) Klodjan Stafa et al. HUMAN MOLECULAR GENETICS
- Pathogenic Mutation in VPS35 Impairs Its Protection against MPP+ Cytotoxicity
- (2013) Fangfang Bi et al. International Journal of Biological Sciences
- The Impact of Pathogenic Mitochondrial DNA Mutations on Substantia Nigra Neurons
- (2013) A. Reeve et al. JOURNAL OF NEUROSCIENCE
- α-Synuclein and Mitochondrial Dysfunction in Parkinson’s Disease
- (2013) Stephen Mullin et al. MOLECULAR NEUROBIOLOGY
- The genetics of Parkinson's disease: Progress and therapeutic implications
- (2013) Andrew B. Singleton et al. MOVEMENT DISORDERS
- Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization
- (2013) Shireen A. Sarraf et al. NATURE
- Exposure to pesticides or solvents and risk of Parkinson disease
- (2013) G. Pezzoli et al. NEUROLOGY
- Role of iron in UPS impairment model of Parkinson's disease
- (2013) Weidong Le PARKINSONISM & RELATED DISORDERS
- Targeting Nrf2-Mediated Gene Transcription by Extremely Potent Synthetic Triterpenoids Attenuate Dopaminergic Neurotoxicity in the MPTP Mouse Model of Parkinson's Disease
- (2012) Navneet Ammal Kaidery et al. ANTIOXIDANTS & REDOX SIGNALING
- Alterations in axonal transport motor proteins in sporadic and experimental Parkinson’s disease
- (2012) Yaping Chu et al. BRAIN
- Revisiting oxidative stress and mitochondrial dysfunction in the pathogenesis of Parkinson disease—resemblance to the effect of amphetamine drugs of abuse
- (2012) Rita Perfeito et al. FREE RADICAL BIOLOGY AND MEDICINE
- Selective binding of nuclear alpha-synuclein to the PGC1alpha promoter under conditions of oxidative stress may contribute to losses in mitochondrial function: Implications for Parkinson’s disease
- (2012) Almas Siddiqui et al. FREE RADICAL BIOLOGY AND MEDICINE
- G2019S leucine-rich repeat kinase 2 causes uncoupling protein-mediated mitochondrial depolarization
- (2012) Tatiana D. Papkovskaia et al. HUMAN MOLECULAR GENETICS
- α-Synuclein and Neuronal Cell Death
- (2012) Toru Yasuda et al. MOLECULAR NEUROBIOLOGY
- Identifying prodromal Parkinson's disease: Pre-Motor disorders in Parkinson's disease
- (2012) Ronald B. Postuma et al. MOVEMENT DISORDERS
- Mitochondrial dysfunction and oxidative stress in Parkinson's disease and monogenic parkinsonism
- (2012) David N. Hauser et al. NEUROBIOLOGY OF DISEASE
- α-Synuclein expression is modulated at the translational level by iron
- (2012) Fabia Febbraro et al. NEUROREPORT
- PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65
- (2012) C. Kondapalli et al. Open Biology
- A Mutation in VPS35, Encoding a Subunit of the Retromer Complex, Causes Late-Onset Parkinson Disease
- (2011) Alexander Zimprich et al. AMERICAN JOURNAL OF HUMAN GENETICS
- VPS35 Mutations in Parkinson Disease
- (2011) Carles Vilariño-Güell et al. AMERICAN JOURNAL OF HUMAN GENETICS
- PARIS (ZNF746) Repression of PGC-1α Contributes to Neurodegeneration in Parkinson's Disease
- (2011) Joo-Ho Shin et al. CELL
- PINK1 and Parkin Target Miro for Phosphorylation and Degradation to Arrest Mitochondrial Motility
- (2011) Xinnan Wang et al. CELL
- PARK9-associated ATP13A2 localizes to intracellular acidic vesicles and regulates cation homeostasis and neuronal integrity
- (2011) David Ramonet et al. HUMAN MOLECULAR GENETICS
- Pharmacologic activation of mitochondrial biogenesis exerts widespread beneficial effects in a transgenic mouse model of Huntington's disease
- (2011) Ashu Johri et al. HUMAN MOLECULAR GENETICS
- Role of Mendelian genes in “sporadic” Parkinson's disease
- (2011) Suzanne Lesage et al. PARKINSONISM & RELATED DISORDERS
- Web-Based Genome-Wide Association Study Identifies Two Novel Loci and a Substantial Genetic Component for Parkinson's Disease
- (2011) Chuong B. Do et al. PLoS Genetics
- A Two-Stage Meta-Analysis Identifies Several New Loci for Parkinson's Disease
- (2011) et al. PLoS Genetics
- PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
- (2010) Sven Geisler et al. NATURE CELL BIOLOGY
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now