Targeting Nrf2-Mediated Gene Transcription by Extremely Potent Synthetic Triterpenoids Attenuate Dopaminergic Neurotoxicity in the MPTP Mouse Model of Parkinson's Disease

Antioxidants in Central Nervous System Diseases: Preclinical Promise and Translational Challenges

(2017) Chandrashekhar D. Kamat et al.   JOURNAL OF ALZHEIMERS DISEASE

Insights into the Disappointing Clinical Trials of Antioxidants in Neurodegenerative Diseases

(2017) Liang Shen et al.   JOURNAL OF ALZHEIMERS DISEASE

Pharmacological Targeting of the Transcription Factor Nrf2 at the Basal Ganglia Provides Disease Modifying Therapy for Experimental Parkinsonism

(2011) Agnieszka Jazwa et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial Permeability Transition Pore Component Cyclophilin D Distinguishes Nigrostriatal Dopaminergic Death Paradigms in the MPTP Mouse Model of Parkinson's Disease

(2011) Bobby Thomas et al.   ANTIOXIDANTS & REDOX SIGNALING

Development of Neh2-Luciferase Reporter and Its Application for High Throughput Screening and Real-Time Monitoring of Nrf2 Activators

(2011) Natalya A. Smirnova et al.   CHEMISTRY & BIOLOGY

Neuroprotective effect of Nrf2/ARE activators, CDDO ethylamide and CDDO trifluoroethylamide, in a mouse model of amyotrophic lateral sclerosis

(2011) Arie Neymotin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Electrophilic Nitro-fatty Acids Activate NRF2 by a KEAP1 Cysteine 151-independent Mechanism

(2011) Emilia Kansanen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dietary and Synthetic Activators of the Antistress Gene Response in Treatment of Renal Disease

(2011) Paul J. Thornalley et al.   JOURNAL OF RENAL NUTRITION

Caspase signalling controls microglia activation and neurotoxicity

(2011) Miguel A. Burguillos et al.   NATURE

Participation of covalent modification of Keap1 in the activation of Nrf2 by tert-butylbenzoquinone, an electrophilic metabolite of butylated hydroxyanisole

(2011) Yumi Abiko et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Association of Nrf2-encoding NFE2L2 haplotypes with Parkinson's disease

(2010) Malin von Otter et al.   BMC Medical Genetics

Identification and Characterization of Novel Nrf2 Inducers Designed to Target the Intervening Region of Keap1

(2010) Jian H. Wu et al.   Chemical Biology & Drug Design

Behavioral deficits and progressive neuropathology in progranulin-deficient mice: a mouse model of frontotemporal dementia

(2010) Fangfang Yin et al.   FASEB JOURNAL

Triterpenoids CDDO-ethyl amide and CDDO-trifluoroethyl amide improve the behavioral phenotype and brain pathology in a transgenic mouse model of Huntington's disease

(2010) Cliona Stack et al.   FREE RADICAL BIOLOGY AND MEDICINE

An Exceptionally Potent Inducer of Cytoprotective Enzymes

(2010) Albena T. Dinkova-Kostova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of NRF2 by Nitrosative Agents and H2O2Involves KEAP1 Disulfide Formation

(2010) Simon Fourquet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stress-Activated Cap'n'collar Transcription Factors in Aging and Human Disease

(2010) G. P. Sykiotis et al.   Science Signaling

Nrf2 regulates microglial dynamics and neuroinflammation in experimental Parkinson's disease

(2009) Ana I. Rojo et al.   GLIA

Antioxidant-induced modification of INrf2 cysteine 151 and PKC-δ-mediated phosphorylation of Nrf2 serine 40 are both required for stabilization and nuclear translocation of Nrf2 and increased drug resistance

(2009) Suryakant K. Niture et al.   JOURNAL OF CELL SCIENCE

Triterpenoid CDDO-methylamide improves memory and decreases amyloid plaques in a transgenic mouse model of Alzheimer’s disease

(2009) Magali Dumont et al.   JOURNAL OF NEUROCHEMISTRY

Neuroprotective Effects of the Triterpenoid, CDDO Methyl Amide, a Potent Inducer of Nrf2-Mediated Transcription

(2009) Lichuan Yang et al.   PLoS One

Nrf2-mediated neuroprotection in the MPTP mouse model of Parkinson's disease: Critical role for the astrocyte

(2009) Pei-Chun Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Interaction between Andrographolide and Glutathione Follows Second Order Kinetics

(2008) Zhiqiang Zhang et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

The synthetic triterpenoid CDDO-methyl ester modulates microglial activities, inhibits TNF production, and provides dopaminergic neuroprotection

(2008) Thi A Tran et al.   Journal of Neuroinflammation

Induction of the Phase II Detoxification Pathway Suppresses Neuron Loss in Drosophila Models of Parkinson's Disease

(2008) K. Trinh et al.   JOURNAL OF NEUROSCIENCE