Potent Glycosidase Inhibition with Heterovalent Fullerenes: Unveiling the Binding Modes Triggering Multivalent Inhibition

Glycomimetic-based pharmacological chaperones for lysosomal storage disorders: lessons from Gaucher, GM1-gangliosidosis and Fabry diseases

(2016) Elena M. Sánchez-Fernández et al.   CHEMICAL COMMUNICATIONS

Pillar[5]arene-Based Glycoclusters: Synthesis and Multivalent Binding to Pathogenic Bacterial Lectins

(2016) Kevin Buffet et al.   CHEMISTRY-A EUROPEAN JOURNAL

Iminosugar-Cyclopeptoid Conjugates Raise Multivalent Effect in Glycosidase Inhibition at Unprecedented High Levels

(2016) Mathieu L. Lepage et al.   CHEMISTRY-A EUROPEAN JOURNAL

Force Nanoscopy as a Versatile Platform for Quantifying the Activity of Antiadhesion Compounds Targeting Bacterial Pathogens

(2016) Audrey Beaussart et al.   NANO LETTERS

Tuning of glyconanomaterial shape and size for selective bacterial cell agglutination

(2016) J. J. Cid Martín et al.   Journal of Materials Chemistry B

pH-Responsive Pharmacological Chaperones for Rescuing Mutant Glycosidases

(2015) Teresa Mena-Barragán et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Polymeric Iminosugars Improve the Activity of Carbohydrate-Processing Enzymes

(2015) Yoan Brissonnet et al.   BIOCONJUGATE CHEMISTRY

Fluorescent Silica Nanoparticles with Multivalent Inhibitory Effects towards Carbonic Anhydrases

(2015) Nadia Touisni et al.   CHEMISTRY-A EUROPEAN JOURNAL

Biologically Active Heteroglycoclusters Constructed on a Pillar[5]arene-Containing [2]Rotaxane Scaffold

(2015) Stéphane P. Vincent et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synthesis of novel flavone hydrazones: In-vitro evaluation of α-glucosidase inhibition, QSAR analysis and docking studies

(2015) Syahrul Imran et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Stereoselective Synthesis of Boat-Locked Glycosides Designed as Glycosyl Hydrolase Conformational Probes

(2015) Emilie Thiery et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Synthesis of giant globular multivalent glycofullerenes as potent inhibitors in a model of Ebola virus infection

(2015) Antonio Muñoz et al.   Nature Chemistry

Synthesis and biological properties of multivalent iminosugars

(2015) Renaud Zelli et al.   NEW JOURNAL OF CHEMISTRY

Fucofullerenes as tight ligands of RSL and LecB, two bacterial lectins

(2015) Kevin Buffet et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Exploring carbonic anhydrase inhibition with multimeric coumarins displayed on a fullerene scaffold

(2015) Marta Abellán-Flos et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthetic multivalency for biological applications

(2015) Eugene Mahon et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Emerging trends in enzyme inhibition by multivalent nanoconstructs

(2015) Nasreddine Kanfar et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

2.2 A resolution cryo-EM structure of  -galactosidase in complex with a cell-permeant inhibitor

(2015) A. Bartesaghi et al.   SCIENCE

Direct synthesis of imino-C-nucleoside analogues and other biologically active iminosugars

(2015) Milan Bergeron-Brlek et al.   Nature Communications

Antileishmanial activity of sp2-iminosugar derivatives

(2015) Elena M. Sánchez-Fernández et al.   RSC Advances

Unprecedented inhibition of glycosidase-catalyzed substrate hydrolysis by nanodiamond-grafted O-glycosides

(2015) Aloysius Siriwardena et al.   RSC Advances

Pharmacological Chaperones and Coenzyme Q10 Treatment Improves Mutant β-Glucocerebrosidase Activity and Mitochondrial Function in Neuronopathic Forms of Gaucher Disease

(2015) Mario de la Mata et al.   Scientific Reports

Synthesis of the first examples of iminosugar clusters based on cyclopeptoid cores

(2014) Mathieu L Lepage et al.   Beilstein Journal of Organic Chemistry

The Multivalent Effect in Glycosidase Inhibition: A New, Rapidly Emerging Topic in Glycoscience

(2014) Philippe Compain et al.   CHEMBIOCHEM

Iminosugar-based glycopolypeptides: glycosidase inhibition with bioinspired glycoprotein analogue micellar self-assemblies

(2014) Colin Bonduelle et al.   CHEMICAL COMMUNICATIONS

Glycomimetics versus Multivalent Glycoconjugates for the Design of High Affinity Lectin Ligands

(2014) Samy Cecioni et al.   CHEMICAL REVIEWS

O-GlcNAc and neurodegeneration: biochemical mechanisms and potential roles in Alzheimer's disease and beyond

(2014) Scott A. Yuzwa et al.   CHEMICAL SOCIETY REVIEWS

Multivalent Inhibitors for Carbohydrate-Processing Enzymes: Beyond the “Lock-and-Key” Concept

(2014) Sébastien G. Gouin   CHEMISTRY-A EUROPEAN JOURNAL

Synthesis of High-Mannose Oligosaccharide Analogues through Click Chemistry: True Functional Mimics of Their Natural Counterparts Against Lectins?

(2014) Marc François-Heude et al.   CHEMISTRY-A EUROPEAN JOURNAL

Fullerene Sugar Balls: A New Class of Biologically Active Fullerene Derivatives

(2014) Iwona Nierengarten et al.   Chemistry-An Asian Journal

A Convergent Strategy for the Synthesis of Second-Generation Iminosugar Clusters Using “Clickable” Trivalent Dendrons

(2014) Antoine Joosten et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

The Emerging Link betweenO-GlcNAc and Alzheimer Disease

(2014) Yanping Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synthesis of Multibranched Australine Derivatives from Reducing Castanospermine Analogues through the Amadori Rearrangement of gem-Diamine Intermediates: Selective Inhibitors of β-Glucosidase

(2014) Elena M. Sánchez-Fernández et al.   JOURNAL OF ORGANIC CHEMISTRY

Targeted delivery of pharmacological chaperones for Gaucher disease to macrophages by a mannosylated cyclodextrin carrier

(2014) Julio Rodríguez-Lavado et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Enzyme inhibition by iminosugars: Analysis and insight into the glycosidase–iminosugar dependency of pH

(2013) Óscar López et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The Multivalent Effect in Glycosidase Inhibition: Probing the Influence of Valency, Peripheral Ligand Structure, and Topology with Cyclodextrin-Based Iminosugar Click Clusters

(2013) Camille Decroocq et al.   CHEMBIOCHEM

A diversity oriented one-pot synthesis of novel iminosugar C-glycosides

(2013) Soundararasu Senthilkumar et al.   CHEMICAL COMMUNICATIONS

Glyconanotechnology

(2013) Niels C. Reichardt et al.   CHEMICAL SOCIETY REVIEWS

Multivalent scaffolds in glycoscience: an overview

(2013) Olivier Renaudet et al.   CHEMICAL SOCIETY REVIEWS

Fullerene-sp2-Iminosugar Balls as Multimodal Ligands for Lectins and Glycosidases: A Mechanistic Hypothesis for the Inhibitory Multivalent Effect

(2013) Rocío Rísquez-Cuadro et al.   CHEMISTRY-A EUROPEAN JOURNAL

Structural investigation of multivalent carbohydrate–protein interactions using synthetic biomolecules

(2013) Valentin Wittmann   CURRENT OPINION IN CHEMICAL BIOLOGY

Constrained 3,6-Anhydro-Heptosides: Synthesis by a DAST-Induced Debenzylative Reaction, and Reactivity Profile

(2013) Abdellatif Tikad et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Pharmacological Chaperones as Therapeutics for Lysosomal Storage Diseases

(2013) Robert E. Boyd et al.   JOURNAL OF MEDICINAL CHEMISTRY

Topological Effects and Binding Modes Operating with Multivalent Iminosugar-Based Glycoclusters and Mannosidases

(2013) Yoan Brissonnet et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Bicyclic 1-Deoxygalactonojirimycin Derivative as a Novel Pharmacological Chaperone for GM1 Gangliosidosis

(2013) Tomoko Takai et al.   MOLECULAR THERAPY

New Castanospermine Glycoside Analogues Inhibit Breast Cancer Cell Proliferation and Induce Apoptosis without Affecting Normal Cells

(2013) Ghada Allan et al.   PLoS One

Stereoselective synthesis of 1-C-alkyl iminogalactitol derivatives, potential chaperones for galactosidase-linked LSDs: a real challenge

(2013) Anna Biela-Banaś et al.   TETRAHEDRON LETTERS

Mini-Special Issue paper Management of diabetic patients with hypoglycemic agents α-Glucosidase inhibitors and their use in clinical practice

(2012) Giuseppe Derosa et al.   Archives of Medical Science

Cyclodextrin-Based Iminosugar Click Clusters: The First Examples of Multivalent Pharmacological Chaperones for the Treatment of Lysosomal Storage Disorders

(2012) Camille Decroocq et al.   CHEMBIOCHEM

Multivalent glycoconjugates as anti-pathogenic agents

(2012) Anna Bernardi et al.   CHEMICAL SOCIETY REVIEWS

Multivalency in heterogeneous glycoenvironments: hetero-glycoclusters, -glycopolymers and -glycoassemblies

(2012) José L. Jiménez Blanco et al.   CHEMICAL SOCIETY REVIEWS

sp2-Iminosugar O-, S-, and N-Glycosides as Conformational Mimics of α-Linked Disaccharides; Implications for Glycosidase Inhibition

(2012) Elena M. Sánchez-Fernández et al.   CHEMISTRY-A EUROPEAN JOURNAL

Probing the Nature of the Cluster Effect Observed with Synthetic Multivalent Galactosides and Peanut Agglutinin Lectin

(2012) Mehdi Almant et al.   CHEMISTRY-A EUROPEAN JOURNAL

The Development of an Aza-C-Glycoside Library Based on a Tandem Staudinger/Aza-Wittig/Ugi Three-Component Reaction

(2012) Tom Wennekes et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

LacZβ-galactosidase: Structure and function of an enzyme of historical and molecular biological importance

(2012) Douglas H. Juers et al.   PROTEIN SCIENCE

Molecular Motion Inside an Adsorbed [5:1] Fullerene Hexaadduct Observed by Ultrafast Cyclic Voltammetry

(2011) Philippe Fortgang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ser-796 of β-galactosidase (Escherichia coli) plays a key role in maintaining a balance between the opened and closed conformations of the catalytically important active site loop

(2011) Larisa J. Jancewicz et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

The Inhibition of Liposaccharide Heptosyltransferase WaaC with Multivalent Glycosylated Fullerenes: A New Mode of Glycosyltransferase Inhibition

(2011) Maxime Durka et al.   CHEMISTRY-A EUROPEAN JOURNAL

The Multivalent Effect in Glycosidase Inhibition: Probing the Influence of Architectural Parameters with Cyclodextrin-based Iminosugar Click Clusters

(2011) Camille Decroocq et al.   CHEMISTRY-A EUROPEAN JOURNAL

Probing Carbohydrate-Lectin Recognition in Heterogeneous Environments with Monodisperse Cyclodextrin-Based Glycoclusters

(2011) Marta Gómez-García et al.   JOURNAL OF ORGANIC CHEMISTRY

Glycosidase Inhibition with Fullerene Iminosugar Balls: A Dramatic Multivalent Effect

(2010) Philippe Compain et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Glycoside hydrolases: Catalytic base/nucleophile diversity

(2010) Thu V. Vuong et al.   BIOTECHNOLOGY AND BIOENGINEERING

Synthesis of N-, S-, and C-glycoside castanospermine analogues with selective neutral α-glucosidase inhibitory activity as antitumour agents

(2010) Elena M. Sánchez-Fernández et al.   CHEMICAL COMMUNICATIONS

Fullerene sugar balls

(2010) Jean-François Nierengarten et al.   CHEMICAL COMMUNICATIONS

The functional valency of dodecamannosylated fullerenes with Escherichia coli FimH—towards novel bacterial antiadhesives

(2010) Maxime Durka et al.   CHEMICAL COMMUNICATIONS

[60]Fullerene as Multivalent Scaffold: Efficient Molecular Recognition of Globular Glycofullerenes by Concanavalin A

(2010) Macarena Sánchez-Navarro et al.   CHEMISTRY-A EUROPEAN JOURNAL

Crystal structures of isomaltase from Saccharomyces cerevisiae and in complex with its competitive inhibitor maltose

(2010) Keizo Yamamoto et al.   FEBS Journal

Application of copper(I)-catalysed azide/alkyne cycloaddition (CuAAC) ‘click chemistry’ in carbohydrate drug and neoglycopolymer synthesis

(2010) Valquiria Aragão-Leoneti et al.   TETRAHEDRON

Glycosphingolipids-Nature, Function, and Pharmacological Modulation

(2009) Tom Wennekes et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Click-Click Approach for the Preparation of Functionalized [5:1]-Hexaadducts of C60

(2009) Julien Iehl et al.   CHEMISTRY-A EUROPEAN JOURNAL

Maximising multivalency effects in protein–carbohydrate interactions

(2009) Roland J. Pieters   ORGANIC & BIOMOLECULAR CHEMISTRY

Glycosidase inhibition: assessing mimicry of the transition state

(2009) Tracey M. Gloster et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Tactics and strategies for the synthesis of iminosugar C-glycosides: a review

(2009) Philippe Compain et al.   TETRAHEDRON-ASYMMETRY

Click chemistry for the efficient preparation of functionalized [60]fullerene hexakis-adducts

(2008) Julien Iehl et al.   CHEMICAL COMMUNICATIONS

Current Developments in the Synthesis and Biological Activity of Aza-C-Nucleosides:Immucillins and Related Compounds

(2008) Pedro Merino et al.   CURRENT MEDICINAL CHEMISTRY

Mechanistic insights into glycosidase chemistry

(2008) David J Vocadlo et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Carbonic Anhydrase Inhibitor Coated Gold Nanoparticles Selectively Inhibit the Tumor-Associated Isoform IX over the Cytosolic Isozymes I and II

(2008) Maamar Stiti et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Carbohydrate-Active EnZymes database (CAZy): an expert resource for Glycogenomics

(2008) B. L. Cantarel et al.   NUCLEIC ACIDS RESEARCH

Multivalent iminosugars to modulate affinity and selectivity for glycosidases

(2008) Jennifer Diot et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Golgi  -mannosidase II cleaves two sugars sequentially in the same catalytic site

(2008) N. Shah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA