Construction of giant glycosidase inhibitors from iminosugar-substituted fullerene macromonomers

The antimicrobial activity of nanoparticles: present situation and prospects for the future

(2017) Linlin Wang et al.   International Journal of Nanomedicine

Fluorinated Chaperone−β-Cyclodextrin Formulations for β-Glucocerebrosidase Activity Enhancement in Neuronopathic Gaucher Disease

(2017) M. Isabel García-Moreno et al.   JOURNAL OF MEDICINAL CHEMISTRY

Modulation of microglia polarization dynamics during diabetic retinopathy in db / db mice

(2016) Ana I. Arroba et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Influence of the configurational pattern of sp2-iminosugar pseudo N-, S-, O- and C-glycosides on their glycoside inhibitory and antitumor properties

(2016) Elena M. Sánchez-Fernández et al.   CARBOHYDRATE RESEARCH

Potent Glycosidase Inhibition with Heterovalent Fullerenes: Unveiling the Binding Modes Triggering Multivalent Inhibition

(2016) Marta Abellán Flos et al.   CHEMISTRY-A EUROPEAN JOURNAL

Pillar[5]arene-Based Glycoclusters: Synthesis and Multivalent Binding to Pathogenic Bacterial Lectins

(2016) Kevin Buffet et al.   CHEMISTRY-A EUROPEAN JOURNAL

Mechanistic Insight into Heptosyltransferase Inhibition by using Kdo Multivalent Glycoclusters

(2016) Abdellatif Tikad et al.   CHEMISTRY-A EUROPEAN JOURNAL

Iminosugar-Cyclopeptoid Conjugates Raise Multivalent Effect in Glycosidase Inhibition at Unprecedented High Levels

(2016) Mathieu L. Lepage et al.   CHEMISTRY-A EUROPEAN JOURNAL

Ultra-Fast Dendritic Growth Based on the Grafting of Fullerene Hexa-Adduct Macromonomers onto a Fullerene Core

(2016) David Sigwalt et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Future prospects of antibacterial metal nanoparticles as enzyme inhibitor

(2016) Khan Behlol Ayaz Ahmed et al.   Materials Science & Engineering C-Materials for Biological Applications

Understanding multivalent effects in glycosidase inhibition using C-glycoside click clusters as molecular probes

(2016) Fabien Stauffert et al.   NEW JOURNAL OF CHEMISTRY

Pentavalent pillar[5]arene-based glycoclusters and their multivalent binding to pathogenic bacterial lectins

(2016) Nicolas Galanos et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Tn Antigen Mimics Based on sp2-Iminosugars with Affinity for an anti-MUC1 Antibody

(2016) Elena M. Sánchez Fernández et al.   ORGANIC LETTERS

Are enzymes sensitive to the multivalent effect? Emerging evidence with glycosidases

(2016) Camilla Matassini et al.   TETRAHEDRON LETTERS

Shape-Dependent Biomimetic Inhibition of Enzyme by Nanoparticles and Their Antibacterial Activity

(2015) Sang-Ho Cha et al.   ACS Nano

pH-Responsive Pharmacological Chaperones for Rescuing Mutant Glycosidases

(2015) Teresa Mena-Barragán et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Glyconanosynthons as powerful scaffolds and building blocks for the rapid construction of multifaceted, dense and chiral dendrimers

(2015) René Roy et al.   CHEMICAL SOCIETY REVIEWS

Dendritic glycopolymers based on dendritic polyamine scaffolds: view on their synthetic approaches, characteristics and potential for biomedical applications

(2015) Dietmar Appelhans et al.   CHEMICAL SOCIETY REVIEWS

The dendritic effect illustrated with phosphorus dendrimers

(2015) Anne-Marie Caminade et al.   CHEMICAL SOCIETY REVIEWS

Biologically Active Heteroglycoclusters Constructed on a Pillar[5]arene-Containing [2]Rotaxane Scaffold

(2015) Stéphane P. Vincent et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synthesis of novel flavone hydrazones: In-vitro evaluation of α-glucosidase inhibition, QSAR analysis and docking studies

(2015) Syahrul Imran et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Evaluation of silver-doped indium oxide nanoparticles as in vitro α-amylase and α-glucosidase inhibitors

(2015) M. Z. Naik et al.   MEDICINAL CHEMISTRY RESEARCH

Synthesis of giant globular multivalent glycofullerenes as potent inhibitors in a model of Ebola virus infection

(2015) Antonio Muñoz et al.   Nature Chemistry

Synthesis and biological properties of multivalent iminosugars

(2015) Renaud Zelli et al.   NEW JOURNAL OF CHEMISTRY

Fucofullerenes as tight ligands of RSL and LecB, two bacterial lectins

(2015) Kevin Buffet et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Investigation of glycofullerene dynamics by NMR spectroscopy

(2015) Olof Engström et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Emerging trends in enzyme inhibition by multivalent nanoconstructs

(2015) Nasreddine Kanfar et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

2.2 A resolution cryo-EM structure of  -galactosidase in complex with a cell-permeant inhibitor

(2015) A. Bartesaghi et al.   SCIENCE

Unprecedented inhibition of glycosidase-catalyzed substrate hydrolysis by nanodiamond-grafted O-glycosides

(2015) Aloysius Siriwardena et al.   RSC Advances

The Multivalent Effect in Glycosidase Inhibition: A New, Rapidly Emerging Topic in Glycoscience

(2014) Philippe Compain et al.   CHEMBIOCHEM

The Impact of Copper-Catalyzed Alkyne-Azide 1,3-Dipolar Cycloaddition in Fullerene Chemistry

(2014) Iwona Nierengarten et al.   CHEMICAL RECORD

Glycomimetics versus Multivalent Glycoconjugates for the Design of High Affinity Lectin Ligands

(2014) Samy Cecioni et al.   CHEMICAL REVIEWS

Multivalent Inhibitors for Carbohydrate-Processing Enzymes: Beyond the “Lock-and-Key” Concept

(2014) Sébastien G. Gouin   CHEMISTRY-A EUROPEAN JOURNAL

Fullerene Sugar Balls: A New Class of Biologically Active Fullerene Derivatives

(2014) Iwona Nierengarten et al.   Chemistry-An Asian Journal

Synthesis and glycosidase inhibition properties of triazole-linked calixarene–iminosugar clusters

(2014) Alberto Marra et al.   TETRAHEDRON

Glycofullerenes Inhibit Viral Infection

(2013) Joanna Luczkowiak et al.   BIOMACROMOLECULES

The Multivalent Effect in Glycosidase Inhibition: Probing the Influence of Valency, Peripheral Ligand Structure, and Topology with Cyclodextrin-Based Iminosugar Click Clusters

(2013) Camille Decroocq et al.   CHEMBIOCHEM

Cyclodextrin-based multivalent glycodisplays: covalent and supramolecular conjugates to assess carbohydrate–protein interactions

(2013) Álvaro Martínez et al.   CHEMICAL SOCIETY REVIEWS

Bridging lectin binding sites by multivalent carbohydrates

(2013) Valentin Wittmann et al.   CHEMICAL SOCIETY REVIEWS

Multivalent glycoconjugate syntheses and applications using aromatic scaffolds

(2013) Yoann M. Chabre et al.   CHEMICAL SOCIETY REVIEWS

A Supramolecular Photosynthetic Model Made of a Multiporphyrinic Array Constructed around a C60Core and a C60-Imidazole Derivative

(2013) K. Yoosaf et al.   CHEMISTRY-A EUROPEAN JOURNAL

Fullerene-sp2-Iminosugar Balls as Multimodal Ligands for Lectins and Glycosidases: A Mechanistic Hypothesis for the Inhibitory Multivalent Effect

(2013) Rocío Rísquez-Cuadro et al.   CHEMISTRY-A EUROPEAN JOURNAL

Thiyl Glycosylation of Propargylated Octasilsesquioxane: Synthesis and Lectin-Binding Properties of Densely Glycosylated Clusters on a Cubic Platform

(2013) Alberto Marra et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Topological Effects and Binding Modes Operating with Multivalent Iminosugar-Based Glycoclusters and Mannosidases

(2013) Yoan Brissonnet et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Sugar-Functionalized Amphiphilic Pillar[5]arene: Synthesis, Self-Assembly in Water, and Application in Bacterial Cell Agglutination

(2013) Guocan Yu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A mannosylated pillar[5]arene derivative: chiral information transfer and antiadhesive properties against uropathogenic bacteria

(2013) Iwona Nierengarten et al.   TETRAHEDRON LETTERS

Cyclodextrin-Based Iminosugar Click Clusters: The First Examples of Multivalent Pharmacological Chaperones for the Treatment of Lysosomal Storage Disorders

(2012) Camille Decroocq et al.   CHEMBIOCHEM

Carbosilane glycodendrimers

(2012) Ken Hatano et al.   CHEMICAL SOCIETY REVIEWS

Bacterial toxininhibitors based on multivalent scaffolds

(2012) Thomas R. Branson et al.   CHEMICAL SOCIETY REVIEWS

Multivalent glycoconjugates as anti-pathogenic agents

(2012) Anna Bernardi et al.   CHEMICAL SOCIETY REVIEWS

Multivalency in heterogeneous glycoenvironments: hetero-glycoclusters, -glycopolymers and -glycoassemblies

(2012) José L. Jiménez Blanco et al.   CHEMICAL SOCIETY REVIEWS

Quantifying the rebinding effect in multivalent chemical ligand-receptor systems

(2012) Marcus Weber et al.   JOURNAL OF CHEMICAL PHYSICS

Glycoside and peptide clustering around the octasilsesquioxane scaffold via photoinduced free-radical thiol–ene coupling. The observation of a striking glycoside cluster effect

(2012) Mauro Lo Conte et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

The Inhibition of Liposaccharide Heptosyltransferase WaaC with Multivalent Glycosylated Fullerenes: A New Mode of Glycosyltransferase Inhibition

(2011) Maxime Durka et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synthesis of Dodecavalent Fullerene-Based Glycoclusters and Evaluation of Their Binding Properties towards a Bacterial Lectin

(2011) Samy Cecioni et al.   CHEMISTRY-A EUROPEAN JOURNAL

The Multivalent Effect in Glycosidase Inhibition: Probing the Influence of Architectural Parameters with Cyclodextrin-based Iminosugar Click Clusters

(2011) Camille Decroocq et al.   CHEMISTRY-A EUROPEAN JOURNAL

Selectivity among Two Lectins: Probing the Effect of Topology, Multivalency and Flexibility of “Clicked” Multivalent Glycoclusters

(2011) Samy Cecioni et al.   CHEMISTRY-A EUROPEAN JOURNAL

Artificial Light-Harvesting Arrays: Electronic Energy Migration and Trapping on a Sphere and between Spheres

(2011) Julien Iehl et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Glycodendrimers as functional antigens and antitumor vaccines

(2011) Tze Chieh Shiao et al.   NEW JOURNAL OF CHEMISTRY

Glycosidase Inhibition with Fullerene Iminosugar Balls: A Dramatic Multivalent Effect

(2010) Philippe Compain et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Sequential copper catalyzed alkyne–azide and thiol–ene click reactions for the multiple functionalization of fullerene hexaadducts

(2010) Julien Iehl et al.   CHEMICAL COMMUNICATIONS

Fullerene sugar balls

(2010) Jean-François Nierengarten et al.   CHEMICAL COMMUNICATIONS

The functional valency of dodecamannosylated fullerenes with Escherichia coli FimH—towards novel bacterial antiadhesives

(2010) Maxime Durka et al.   CHEMICAL COMMUNICATIONS

Octakis(3-azidopropyl)octasilsesquioxane: A Versatile Nanobuilding Block for the Efficient Preparation of Highly Functionalized Cube-Octameric Polyhedral Oligosilsesquioxane Frameworks Through Click Assembly

(2010) Beatriz Trastoy et al.   CHEMISTRY-A EUROPEAN JOURNAL

[60]Fullerene as Multivalent Scaffold: Efficient Molecular Recognition of Globular Glycofullerenes by Concanavalin A

(2010) Macarena Sánchez-Navarro et al.   CHEMISTRY-A EUROPEAN JOURNAL

Design, synthesis and biological evaluation of carbohydrate-functionalized cyclodextrins and liposomes for hepatocyte-specific targeting

(2010) Gonçalo J. L. Bernardes et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Inorganic Nanoparticles as Protein Mimics

(2010) Nicholas A. Kotov   SCIENCE

Effects of pH and Iminosugar Pharmacological Chaperones on Lysosomal Glycosidase Structure and Stability

(2009) Raquel L. Lieberman et al.   BIOCHEMISTRY

Thermodynamics of Multivalent Carbohydrate−Lectin Cross-Linking Interactions: Importance of Entropy in the Bind and Jump Mechanism

(2009) Tarun K. Dam et al.   BIOCHEMISTRY

Understanding How Diverse β-Mannanases Recognize Heterogeneous Substrates

(2009) Louise E. Tailford et al.   BIOCHEMISTRY

A Click-Click Approach for the Preparation of Functionalized [5:1]-Hexaadducts of C60

(2009) Julien Iehl et al.   CHEMISTRY-A EUROPEAN JOURNAL

Catalytic Mechanism of Human α-Galactosidase

(2009) Abigail I. Guce et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tuning Charge Transfer Energetics in Reaction Center Mimics viaTh-Functionalization of Fullerenes

(2009) Fabian Spänig et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis and biological evaluation of multivalent carbohydrate ligands obtained by click assembly of pseudo-rotaxanes

(2009) Martin Chwalek et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Click chemistry for the efficient preparation of functionalized [60]fullerene hexakis-adducts

(2008) Julien Iehl et al.   CHEMICAL COMMUNICATIONS

The Carbohydrate-Active EnZymes database (CAZy): an expert resource for Glycogenomics

(2008) B. L. Cantarel et al.   NUCLEIC ACIDS RESEARCH