Structure–activity relationships for ruthenium and osmium anticancer agents – towards clinical development
出版年份 2018 全文链接
标题
Structure–activity relationships for ruthenium and osmium anticancer agents – towards clinical development
作者
关键词
-
出版物
CHEMICAL SOCIETY REVIEWS
Volume 47, Issue 3, Pages 909-928
出版商
Royal Society of Chemistry (RSC)
发表日期
2017-11-24
DOI
10.1039/c7cs00332c
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Characterizing activation mechanisms and binding preferences of ruthenium metallo-prodrugs by a competitive binding assay
- (2017) Christian Artner et al. JOURNAL OF INORGANIC BIOCHEMISTRY
- A phase I dose-escalation study of NKP-1339 in patients with advanced solid tumors refractory to treatment.
- (2017) N. R. Dickson et al. JOURNAL OF CLINICAL ONCOLOGY
- Electronic State of Sodium trans-[Tetrachloridobis(1H-indazole)ruthenate(III)] (NKP-1339) in Tumor, Liver and Kidney Tissue of a SW480-bearing Mouse
- (2017) Amir Blazevic et al. Scientific Reports
- Combination of ruthenium(II)-arene complex [Ru(η6-p-cymene)Cl2(pta)] (RAPTA-C) and the epidermal growth factor receptor inhibitor erlotinib results in efficient angiostatic and antitumor activity
- (2017) Robert H. Berndsen et al. Scientific Reports
- A Macrocyclic Ruthenium(III) Complex Inhibits Angiogenesis with Down-Regulation of Vascular Endothelial Growth Factor Receptor-2 and Suppresses Tumor Growth In Vivo
- (2016) Wai-Lun Kwong et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Thiomaltol-Based Organometallic Complexes with 1-Methylimidazole as Leaving Group: Synthesis, Stability, and Biological Behavior
- (2016) Carmen M. Hackl et al. CHEMISTRY-A EUROPEAN JOURNAL
- Cytotoxicity and preliminary mode of action studies of novel 2-aryl-4-thiopyrone-based organometallics
- (2016) Melanie Schmidlehner et al. DALTON TRANSACTIONS
- Introducing the 4-Phenyl-1,2,3-Triazole Moiety as a Versatile Scaffold for the Development of Cytotoxic Ruthenium(II) and Osmium(II) Arene Cyclometalates
- (2016) Christoph A. Riedl et al. INORGANIC CHEMISTRY
- Biodistribution of the novel anticancer drug sodium trans -[tetrachloridobis(1 H -indazole)ruthenate(III)] KP-1339/IT139 in nude BALB/c mice and implications on its mode of action
- (2016) Anna K. Bytzek et al. JOURNAL OF INORGANIC BIOCHEMISTRY
- X-ray Structure Analysis of Indazolium trans-[Tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019) Bound to Human Serum Albumin Reveals Two Ruthenium Binding Sites and Provides Insights into the Drug Binding Mechanism
- (2016) Aleksandar Bijelic et al. JOURNAL OF MEDICINAL CHEMISTRY
- Expression of GRP78, Master Regulator of the Unfolded Protein Response, Increases Chemoresistance in Pancreatic Ductal Adenocarcinoma
- (2016) J. B. Gifford et al. MOLECULAR CANCER THERAPEUTICS
- Upregulation of Glucose-Regulated Protein 78 in Metastatic Cancer Cells Is Necessary for Lung Metastasis Progression
- (2016) Michael M. Lizardo et al. NEOPLASIA
- Anticancer Gold(III) Porphyrins Target Mitochondrial Chaperone Hsp60
- (2015) Di Hu et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Ru(II) dyads derived from α -oligothiophenes: A new class of potent and versatile photosensitizers for PDT
- (2015) Ge Shi et al. COORDINATION CHEMISTRY REVIEWS
- Approaches to the design of catalytic metallodrugs
- (2015) Joan J Soldevila-Barreda et al. CURRENT OPINION IN CHEMICAL BIOLOGY
- Three-dimensional and co-culture models for preclinical evaluation of metal-based anticancer drugs
- (2015) Ekaterina Schreiber-Brynzak et al. INVESTIGATIONAL NEW DRUGS
- RNA-seq analysis of the whole transcriptome of MDA-MB-231 mammary carcinoma cells exposed to the antimetastatic drug NAMI-A
- (2015) Alberta Bergamo et al. Metallomics
- A Mixed-Methods Feasibility Trial of Protein Kinase C Iota Inhibition with Auranofin in Asymptomatic Ovarian Cancer Patients
- (2015) Aminah Jatoi et al. ONCOLOGY
- Potent organo-osmium compound shifts metabolism in epithelial ovarian cancer cells
- (2015) Jessica M. Hearn et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- In vivo evaluation of small-molecule thermoresponsive anticancer drugs potentiated by hyperthermia
- (2015) Catherine M. Clavel et al. Chemical Science
- Target profiling of an antimetastatic RAPTA agent by chemical proteomics: relevance to the mode of action
- (2015) Maria V. Babak et al. Chemical Science
- Auranofin: Repurposing an Old Drug for a Golden New Age
- (2015) Christine Roder et al. Drugs in research & development
- Metal-based anticancer chemotherapeutic agents
- (2014) Nafees Muhammad et al. CURRENT OPINION IN CHEMICAL BIOLOGY
- Development of anticancer agents: wizardry with osmium
- (2014) Muhammad Hanif et al. DRUG DISCOVERY TODAY
- Caffeine-Based Gold(I) N-Heterocyclic Carbenes as Possible Anticancer Agents: Synthesis and Biological Properties
- (2014) Benoît Bertrand et al. INORGANIC CHEMISTRY
- Phase I/II study with ruthenium compound NAMI-A and gemcitabine in patients with non-small cell lung cancer after first line therapy
- (2014) Suzanne Leijen et al. INVESTIGATIONAL NEW DRUGS
- NKP-1339, the first ruthenium-based anticancer drug on the edge to clinical application
- (2014) Robert Trondl et al. Chemical Science
- Ligand substitutions between ruthenium–cymene compounds can control protein versus DNA targeting and anticancer activity
- (2014) Zenita Adhireksan et al. Nature Communications
- Identification of Metal-Associated Proteins in Cells by Using Continuous-Flow Gel Electrophoresis and Inductively Coupled Plasma Mass Spectrometry
- (2013) Ligang Hu et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Application of mass spectrometric techniques to delineate the modes-of-action of anticancer metallodrugs
- (2013) Christian G. Hartinger et al. CHEMICAL SOCIETY REVIEWS
- Identification of the Structural Determinants for Anticancer Activity of a Ruthenium Arene Peptide Conjugate
- (2013) Samuel M. Meier et al. CHEMISTRY-A EUROPEAN JOURNAL
- Next-Generation Metal Anticancer Complexes: Multitargeting via Redox Modulation
- (2013) Isolda Romero-Canelón et al. INORGANIC CHEMISTRY
- Metal–Arene Complexes with Indolo[3,2-c]-quinolines: Effects of Ruthenium vs Osmium and Modifications of the Lactam Unit on Intermolecular Interactions, Anticancer Activity, Cell Cycle, and Cellular Accumulation
- (2013) Lukas K. Filak et al. ORGANOMETALLICS
- Novel metal(ii) arene 2-pyridinecarbothioamides: a rationale to orally active organometallic anticancer agents
- (2013) Samuel M. Meier et al. Chemical Science
- Global Proteome Analysis of the NCI-60 Cell Line Panel
- (2013) Amin Moghaddas Gholami et al. Cell Reports
- Targeting the DNA-topoisomerase complex in a double-strike approach with a topoisomerase inhibiting moiety and covalent DNA binder
- (2012) Andrea Kurzwernhart et al. CHEMICAL COMMUNICATIONS
- Designing organometallic compounds for catalysis and therapy
- (2012) Anna Louisa Noffke et al. CHEMICAL COMMUNICATIONS
- Bipyrimidine ruthenium(II) arene complexes: structure, reactivity and cytotoxicity
- (2012) Soledad Betanzos-Lara et al. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
- The molecular mechanisms of antimetastatic ruthenium compounds explored through DIGE proteomics
- (2012) Francesca Guidi et al. JOURNAL OF INORGANIC BIOCHEMISTRY
- Structure–Activity Relationships of Targeted RuII(η6-p-Cymene) Anticancer Complexes with Flavonol-Derived Ligands
- (2012) Andrea Kurzwernhart et al. JOURNAL OF MEDICINAL CHEMISTRY
- A SAR Study of Novel Antiproliferative Ruthenium and Osmium Complexes with Quinoxalinone Ligands in Human Cancer Cell Lines
- (2012) Werner Ginzinger et al. JOURNAL OF MEDICINAL CHEMISTRY
- Systems biology approach for in vivo photodynamic therapy optimization of ruthenium-porphyrin compounds
- (2012) Marlène Pernot et al. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
- Combination of metallomics and proteomics to study the effects of the metallodrug RAPTA-T on human cancer cells
- (2012) Dirk A. Wolters et al. Metallomics
- Challenges and Opportunities in the Development of Organometallic Anticancer Drugs
- (2012) Christian G. Hartinger et al. ORGANOMETALLICS
- Metabolite Profiling Identifies a Key Role for Glycine in Rapid Cancer Cell Proliferation
- (2012) M. Jain et al. SCIENCE
- The contrasting chemical reactivity of potent isoelectronic iminopyridine and azopyridine osmium(ii) arene anticancer complexes
- (2012) Ying Fu et al. Chemical Science
- Outcome in disappearing colorectal cancer liver metastases during oxaliplatin-based chemotherapy
- (2012) TOMOJIRO ONO et al. Oncology Letters
- A Ruthenium Antimetastasis Agent Forms Specific Histone Protein Adducts in the Nucleosome Core
- (2011) Bin Wu et al. CHEMISTRY-A EUROPEAN JOURNAL
- Structure–activity relationships for organometallic osmium arene phenylazopyridine complexes with potent anticancer activity
- (2011) Ying Fu et al. DALTON TRANSACTIONS
- Targeted and multifunctional arene ruthenium chemotherapeutics
- (2011) Gregory S. Smith et al. DALTON TRANSACTIONS
- Bridging solubility between drug discovery and development
- (2011) Li Di et al. DRUG DISCOVERY TODAY
- En Route to Osmium Analogues of KP1019: Synthesis, Structure, Spectroscopic Properties and Antiproliferative Activity oftrans-[OsIVCl4(Hazole)2]
- (2011) Gabriel E. Büchel et al. INORGANIC CHEMISTRY
- Approaching tumour therapy beyond platinum drugs
- (2011) A. Bergamo et al. JOURNAL OF INORGANIC BIOCHEMISTRY
- Organometallic Ruthenium(II) Arene Compounds with Antiangiogenic Activity
- (2011) Patrycja Nowak-Sliwinska et al. JOURNAL OF MEDICINAL CHEMISTRY
- Organometallic Cages as Vehicles for Intracellular Release of Photosensitizers
- (2011) Frédéric Schmitt et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- LC– and CZE–ICP-MS approaches for the in vivo analysis of the anticancer drug candidate sodium trans-[tetrachloridobis(1H-indazole)ruthenate(iii)] (KP1339) in mouse plasma
- (2011) Anna K. Bytzek et al. Metallomics
- Anti-colorectal cancer activity of an organometallic osmium arene azopyridine complex
- (2011) Steve D. Shnyder et al. MedChemComm
- Influence of the Arene Ligand and the Leaving Group on the Anticancer Activity of (Thio)maltol Ruthenium(II)?(η6-Arene) Complexes
- (2010) Muhammad Hanif et al. AUSTRALIAN JOURNAL OF CHEMISTRY
- The X-ray Structure of the Adduct between NAMI-A and Carbonic Anhydrase Provides Insights into the Reactivity of this Metallodrug with Proteins
- (2010) Angela Casini et al. ChemMedChem
- Osmium(ii)–versus ruthenium(ii)–arene carbohydrate-based anticancer compounds: similarities and differences
- (2010) Muhammad Hanif et al. DALTON TRANSACTIONS
- Is the Reactivity of M(II)−Arene Complexes of 3-Hydroxy-2(1H)-pyridones to Biomolecules the Anticancer Activity Determining Parameter?
- (2010) Muhammad Hanif et al. INORGANIC CHEMISTRY
- Organometallic indolo[3,2-c]quinolines versus indolo[3,2-d]benzazepines: synthesis, structural and spectroscopic characterization, and biological efficacy
- (2010) Lukas K. Filak et al. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
- From hydrolytically labile to hydrolytically stable RuII–arene anticancer complexes with carbohydrate-derived co-ligands
- (2010) Muhammad Hanif et al. JOURNAL OF INORGANIC BIOCHEMISTRY
- Organometallic Osmium Arene Complexes with Potent Cancer Cell Cytotoxicity
- (2010) Ying Fu et al. JOURNAL OF MEDICINAL CHEMISTRY
- Organometallic Anticancer Compounds
- (2010) Gilles Gasser et al. JOURNAL OF MEDICINAL CHEMISTRY
- Mannich products of kojic acid and N-heterocycles and their Ru(II)–arene complexes: Synthesis, characterization and stability
- (2010) Johanna H. Kasser et al. JOURNAL OF ORGANOMETALLIC CHEMISTRY
- Lectin–Gd-Loaded Chitosan Hydrogel Nanoparticles: A New Biospecific Contrast Agent for MRI
- (2010) Irena Pashkunova-Martic et al. MOLECULAR IMAGING AND BIOLOGY
- Ruthenium− and Osmium−Arene Complexes of 2-Substituted Indolo[3,2-c]quinolines: Synthesis, Structure, Spectroscopic Properties, and Antiproliferative Activity
- (2010) Lukas K. Filak et al. ORGANOMETALLICS
- Pharmacokinetics of a novel anticancer ruthenium complex (KP1019, FFC14A) in a phase I dose-escalation study
- (2009) Frederike Lentz et al. ANTI-CANCER DRUGS
- A Ruthenium-Containing Organometallic Compound Reduces Tumor Growth through Induction of the Endoplasmic Reticulum Stress Gene CHOP
- (2009) Xiangjun Meng et al. CANCER RESEARCH
- Maltol-Derived Ruthenium-Cymene Complexes with Tumor Inhibiting Properties: The Impact of Ligand-Metal Bond Stability on Anticancer Activity In Vitro
- (2009) Wolfgang Kandioller et al. CHEMISTRY-A EUROPEAN JOURNAL
- Areneruthenium complexes as anticancer agents
- (2009) Georg Süss-Fink DALTON TRANSACTIONS
- Organometallic Osmium(II) Arene Anticancer Complexes Containing Picolinate Derivatives
- (2009) Sabine H. van Rijt et al. INORGANIC CHEMISTRY
- Serum-protein interactions with anticancer Ru(III) complexes KP1019 and KP418 characterized by EPR
- (2009) Naniye Cetinbas et al. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
- In vivo tumour and metastasis reduction and in vitro effects on invasion assays of the ruthenium RM175 and osmium AFAP51 organometallics in the mammary cancer model
- (2009) A. Bergamo et al. JOURNAL OF INORGANIC BIOCHEMISTRY
- Transferring the Concept of Multinuclearity to Ruthenium Complexes for Improvement of Anticancer Activity
- (2009) Maria G. Mendoza-Ferri et al. JOURNAL OF MEDICINAL CHEMISTRY
- Amide Linkage Isomerism As an Activity Switch for Organometallic Osmium and Ruthenium Anticancer Complexes
- (2009) Sabine H. van Rijt et al. JOURNAL OF MEDICINAL CHEMISTRY
- Cytotoxicity, Hydrophobicity, Uptake, and Distribution of Osmium(II) Anticancer Complexes in Ovarian Cancer Cells
- (2009) Sabine H. van Rijt et al. JOURNAL OF MEDICINAL CHEMISTRY
- From Pyrone to Thiopyrone Ligands−Rendering Maltol-Derived Ruthenium(II)−Arene Complexes That Are Anticancer Active in Vitro
- (2009) Wolfgang Kandioller et al. ORGANOMETALLICS
- Influence of the Arene Ligand, the Number and Type of Metal Centers, and the Leaving Group on thein VitroAntitumor Activity of Polynuclear Organometallic Compounds
- (2009) Maria G. Mendoza-Ferri et al. ORGANOMETALLICS
- Bioorganometallic chemistry—from teaching paradigms to medicinal applications
- (2008) Christian G. Hartinger et al. CHEMICAL SOCIETY REVIEWS
- KP1019, A New Redox-Active Anticancer Agent - Preclinical Development and Results of a Clinical Phase I Study in Tumor Patients
- (2008) Christian G. Hartinger et al. CHEMISTRY & BIODIVERSITY
- In Vitro Anticancer Activity and Biologically Relevant Metabolization of Organometallic Ruthenium Complexes with Carbohydrate-Based Ligands
- (2008) Isabella Berger et al. CHEMISTRY-A EUROPEAN JOURNAL
- Capillary electrophoresis hyphenated to inductively coupled plasma-mass spectrometry: A novel approach for the analysis of anticancer metallodrugs in human serum and plasma
- (2008) Michael Groessl et al. ELECTROPHORESIS
- The ruthenium(II)–arene compound RAPTA-C induces apoptosis in EAC cells through mitochondrial and p53–JNK pathways
- (2008) Soumya Chatterjee et al. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
- DNA Interactions of Monofunctional Organometallic Osmium(II) Antitumor Complexes in Cell-Free Media
- (2008) Hana Kostrhunova et al. JOURNAL OF MEDICINAL CHEMISTRY
- Tuning the anticancer activity of maltol-derived ruthenium complexes by derivatization of the 3-hydroxy-4-pyrone moiety
- (2008) Wolfgang Kandioller et al. JOURNAL OF ORGANOMETALLIC CHEMISTRY
- Catalytic organometallic anticancer complexes
- (2008) S. J. Dougan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started