期刊
JOURNAL OF ORGANOMETALLIC CHEMISTRY
卷 694, 期 6, 页码 922-929出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jorganchem.2008.10.016
关键词
Antitumor agents; Bioorganometallic chemistry; Ruthenium(II)-arene complex; Pyrone; Hydrolysis; 5 '-GMP binding
Organometallic ruthenium(II)-arene complexes coordinated to maltol-derived ligands were prepared and their anticancer activity against human tumor cell lines was studied. In addition, their hydrolysis behavior and reaction with 5'-GMP was tested and compared to the parent compound chlorido[2-methyl-3-(oxo-kappa O)-pyran-4(1H)-onato-kappa O4](eta 6-p-cymene)ruthenium(II) (Ru-maltol). Improved stability and in vitro anticancer activity at maintained GMP binding capability were observed, in comparison to the Ru-maltol complex. (C) 2008 Elsevier B. V. All rights reserved.
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