Article
Chemistry, Inorganic & Nuclear
Angelina Z. Petrovic, Dusan C. Cocic, Dirk Bockfeld, Marko Zivanovic, Nevena Milivojevic, Katarina Virijevic, Nenad Jankovic, Andreas Scheurer, Milan Vranes, Jovana V. Bogojeski
Summary: This paper presents the synthesis and structural characterization of three newly synthesized osmium(ii) complexes; investigates the kinetics of substitution reactions, binding properties, and interactions with biomolecules such as CT-DNA and HSA; further explores the binding mechanism through fluorescence competition experiments and molecular docking studies. In vitro cytotoxicity and redox status experiments on cancer cell lines provide insight into the potential molecular mechanisms of these complexes.
INORGANIC CHEMISTRY FRONTIERS
(2021)
Review
Chemistry, Inorganic & Nuclear
Thimma Subramanian Prathima, Badruzzaman Choudhury, Md. Gulzar Ahmad, Kaushik Chanda, M. M. Balamurali
Summary: Numerous biologically active metal complexes have been reported for their unique features and enhanced functions in inhibiting cancer progression. However, many of these drugs have failed at various levels of clinical trials despite performing well in the laboratory.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Chemistry, Inorganic & Nuclear
Rajeh Alotaibi, Amy Booth, Edmund Little, Adam Brookfield, Amritroop Achari, Selena J. Lockyer, Grigore A. Timco, George F. S. Whitehead, Inigo J. Vitorica-Yrezabal, Nicholas F. Chilton, Rahul R. Nair, David Collison, Richard E. P. Winpenny
Summary: We synthesized and characterized a series of heterometallic rings using alkylammonium or imidazolium cations as templates. The structure of these rings can be controlled by the template and the coordination geometry preference of each metal, resulting in rings with eight, nine, ten, twelve, and fourteen metals. The compounds were analyzed using various techniques, including X-ray diffraction, elemental analysis, magnetometry, and EPR measurements. The magnetic measurements showed antiferromagnetic exchange coupling between the metal centers, while the EPR spectroscopy revealed different ground and excited states for different ring structures. These findings provide insights into the transferability of magnetic parameters among related compounds.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Inorganic & Nuclear
Sonia Infante-Tadeo, Vanessa Rodriguez-Fanjul, Cintia C. Vequi-Suplicy, Ana M. Pizarro
Summary: The passage describes the rapid hydrolysis and high basicity of complexes [Os(eta 6-arene)(C,N-phenylpyridine)Z] with chlorido or tethered oxygen as the ligand. It also reveals the structure-activity relationship between Os-CN and Os-NN complexes.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Lukas Masaryk, Darina Muthna, Petr Halas, Pavel Zoufaly, Eva Peterova, Radim Havelek, Bohuslav Drahos, David Milde, Alena Mrkvicova, Pavel Starha
Summary: In the presence of carboxypeptidase, the hydrolytically stable complex partially released the bioactive substituent indomethacin, which was bound through the amide bond to the chelating moiety. The stability in the presence of other relevant biomolecules and cancer cell viability were also investigated in this study.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Inorganic & Nuclear
Wen-Rui Lv, Rong-Jian Li, Zhen-Jiang Liu, Yan Jin, Zi-Jian Yao
Summary: A series of N,O-coordinate iridium(III) complexes with Schiff base ligands were synthesized for catalytic hydrogenation of nitro and carbonyl substrates, showing efficient catalytic activity and high yields. The molecular structures of the complexes were well characterized and the highest TON values were achieved for the hydrogenation reactions of carbonyl and nitro substrates.
INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Asma Hasil, Daniel Beck, Daniel Schroder, Sebastien Pillet, Emmanuel Wenger, Theo Woike, Peter Klufers, Dominik Schaniel
Summary: This study discovered a special phenomenon of photo-induced linkage isomerism, confirmed experimentally and computationally, revealing a synchronous 50-degree turn of the two nitrosyl ligands during the GS/MS transition. Although the usual redshift of the N-O stretch was observed during the process, there was no increased charge transfer from Ru to NO.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Inorganic & Nuclear
Binoy Kar, Utpal Das, Sourav De, Sudhindra Pete, Ajay S. Sharma, Nilmadhab Roy, Ashok S. K. Kumar, Debashis Panda, Priyankar Paira
Summary: Researchers have been trying to design Ru(ii)-arene complexes resistant to GSH as potential anticancer agents to overcome the side effects of platinum-based drugs, and luminescent ruthenium(ii)-p-cymene-imidazophenanthroline complexes show promise as highly cytoselective cancer therapeutic agents for HeLa and Caco-2 cells.
DALTON TRANSACTIONS
(2021)
Article
Chemistry, Multidisciplinary
Zhouyang Huang, A. Paden King, James Lovett, Barry Lai, Joshua J. Woods, Hugh H. Harris, Justin J. Wilson
Summary: The photophysical and photochemical properties of two Pt(iv)Re(i) conjugates were studied and found to exhibit modest photocytotoxicity against ovarian cancer cells. X-ray fluorescence microscopy revealed colocalization of Pt and Re in cells, whether or not they had been irradiated. This work highlights the potential of photoactivated multilimetallic agents for cancer treatment.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Applied
Carolane M. Almeida, Pedro H. S. Marcon, Erica C. M. Nascimento, Joao B. L. Martins, Marcio A. S. Chagas, Mahmi Fujimori, Patricia G. F. De Marchi, Eduardo L. Franca, Adenilda C. Honorio-Franca, Claudia C. Gatto
Summary: This study documented the synthesis and characterization of two new organometallic Au (III) and Pt (II) complexes with 2-acetylthiophene-N(3)-methylthiosemicarbazone (HL). The compounds were characterized using various spectroscopic techniques including X-ray diffraction and MS. The results revealed the coordination of the thiosemicarbazone ligand to the Au (III) and Pt (II) metal atoms in a tridentate mode. The compounds exhibited interactions in their molecular packing, as demonstrated by quantitative analysis of the 3D Hirshfeld surface and 2D fingerprint results. The biological activity of the compounds against MCF-7 human cancer cells was evaluated, and their inhibitory activity was predicted using molecular docking.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Mark Stitch, Rayhaan Z. Boota, Alannah S. Chalkley, Tony D. Keene, Jeremy C. Simpson, Paul A. Scattergood, Paul I. P. Elliott, Susan J. Quinn
Summary: The synthesis and photophysical characterization of two osmium(II) polypyridyl complexes containing dppz or dppp2 ligands and TAP ancillary ligands are reported. These complexes exhibit complex electrochemistry, bind to and stabilize DNA, and are internalized by mammalian cells and localize in the nucleus.
INORGANIC CHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Kacper Poblocki, Joanna Drzezdzon, Tomasz Kostrzewa, Dagmara Jacewicz
Summary: Photodynamic therapy (PDT) is an alternative cancer treatment method that utilizes photosensitizers to convert light emission into radical oxygen-derived species (ROS), and can interact with compounds such as metal organic frameworks (MOFs). The interaction between DNA and metal-based complexes plays a key role in the development of new anti-cancer drugs, affecting the amount of ROS generated, quantum emission efficiency, and phototoxic index.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Inorganic & Nuclear
Marzena Fandzloch, Tomasz Jedrzejewski, Liliana Dobrzanska, Gines M. Esteban-Parra, Joanna Wisniewska, Agata Paneth, Piotr Paneth, Jerzy Sitkowski
Summary: Three half-sandwich organometallic ruthenium(II) complexes containing purine analogs have been synthesized and characterized. The most active complex, [(eta(6)-p-cym)Ru(HmtpO)Cl-2], showed high cytotoxicity against HeLa cells and lower toxicity to normal fibroblast cells. This complex also exhibited antimetastatic activity and high antiparasitic effect, making it a promising candidate for further research.
DALTON TRANSACTIONS
(2021)
Article
Chemistry, Multidisciplinary
Qi-Yuan Yang, Rui Ma, Yun-Qiong Gu, Xiao-Fang Xu, Zhen-Feng Chen, Hong Liang
Summary: Targeting metabolic reprogramming to treat cancer, by using arene-ruthenium(II)/osmium(II) complexes to potentiate the anticancer effect of metformin (Met.) via glucose metabolism reprogramming, could increase overall survival and reduce side effects.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Rong-Jian Li, Yang Wang, Yan Jin, Wei Deng, Zhen-Jiang Liu, Zi-Jian Yao
Summary: Neutral C,C-chelate half-sandwich iridium(iii) complexes with NHC ligands containing pendant aromatic rings show excellent catalytic activity for acceptorless dehydrogenation reactions and transfer hydrogenation reactions of alcohols and ketones. These complexes are efficient in producing aldehydes from primary alcohols and alcohols from ketones and aldehydes under mild conditions. The exact structure and bonding mode of these NHC-based iridium complexes have been identified using various spectroscopic methods and single crystal X-ray analysis.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Organic
Jonathan Barrios-Rivera, Yingjian Xu, Guy J. Clarkson, Martin Wills
Summary: The application of enantiomerically-pure ruthenium(II) catalysts containing N - functionalised TsDPEN ligand to the asymmetric transfer hydrogenation of 15 examples of alpha-heterocyclic acetophenone derivatives is reported, with products of up to 99% ee formed. (C) 2021 Elsevier Ltd. All rights reserved.
Article
Chemistry, Multidisciplinary
Adedibu C. Tella, Adetola C. Oladipo, Victoria T. Olayemi, Allen Gordon, Adeniyi S. Ogunlaja, Lukman O. Alimi, Stephen P. Argent, Robert Mokaya, Guy J. Clarkson, Richard I. Walton
Summary: Two calcium coordination compounds were grown at room temperature and characterized. The structures of the compounds are stabilized by a network of hydrogen bonds. Compound 1 exhibits high excitation energies and chemical hardness, making it a better electron acceptor. Compound 2 is softer with better polarizability and reactivity.
STRUCTURAL CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Satarupa Das, Jinfang Zhang, Thomas W. Chamberlain, Guy J. Clarkson, Richard I. Walton
Summary: CO2 epoxidation to cyclic carbonates under mild, solvent-free conditions is a promising pathway for sustainable CO2 utilization. However, previous metal-organic frameworks (MOFs) used for this purpose are not suitable for commercial utilization due to the nonrenewable ligands used. This study presents new yttrium MOFs based on renewable 2,5-furandicarboxylate (FDC) ligands, which exhibit high catalytic activity and conversion efficiency for CO2 epoxidation reactions.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Organic
Guy J. Clarkson, Stefan Roesner
Summary: An efficient methodology for the synthesis of benzofuropyridines and dibenzofurans from fluoropyridines or fluoroarenes and 2-bromophenyl acetates is presented. The streamlined one-pot procedure involves four-step directed ortho-lithiation, zincation, Negishi cross-coupling, and intramolecular nucleophilic aromatic substitution, enabling the easy assembly of a diverse set of fused benzofuro heterocycles.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Jiangping Liu, Andrew W. Prentice, Guy J. Clarkson, Jack M. Woolley, Vasilios G. Stavros, Martin J. Paterson, Peter J. Sadler
Summary: This study reports a Ru(II) polypyridyl prodrug, RuAzNM, functionalized with azo and nitrogen mustard, which exhibits multimodal theranostic properties towards hypoxic cancer cells. Reduction of the azo group in hypoxic cell microenvironments leads to the generation of reactive oxygen species and mtDNA crosslinking, while the resulting phosphorescent RuNH2 serves as a diagnostic signal and activates phototherapy. This unique strategy allows controlled multimodal theranostics to be realized in hypoxic cells, making RuAzNM a highly selective and effective cancer-cell-selective theranostic agent.
ADVANCED MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Xingzhen Zhang, Zeynep Karagoz, Sangita Swapnasrita, Pamela Habibovic, Aureilie Carlier, Sabine van Rijt
Summary: This study investigated the effect of RGD adhesion ligand global density, spacing, and clustering levels on stem cell adhesion and differentiation. It was found that highly clustered RGD-MSN-based films with increased RGD global density promoted cell adhesion and spreading. Moreover, a higher RGD ligand clustering level also promoted the expression of alkaline phosphatase in hMSCs.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Materials Science, Biomaterials
Aygul Zengin, Filipa Castro Teixeira, Tony Feliciano, Pamela Habibovic, Carlos Domingues Mota, Matthew B. Baker, Sabine van Rijt
Summary: In this study, a new type of nanocomposite bioinks containing thiolated mesoporous silica nanoparticles (MSN) was developed. The MSNs could rapidly crosslink hydrogels upon exposure to UV light, and modification of the MSNs' surface resulted in enzyme-responsive biodegradable bioinks. Addition of specific peptides enhanced cell-matrix interactions. The nanocomposite bioinks could be printed using extrusion-based bioprinting, and showed tunable mechanical and degradation properties.
BIOMATERIALS ADVANCES
(2023)
Meeting Abstract
Ophthalmology
A. J. H. van Velthoven, D. Crosbie, C. A. Trayford, S. Ferrari, S. van Rijt, M. M. Dickman, V. L. S. LaPointe
ACTA OPHTHALMOLOGICA
(2023)
Article
Materials Science, Multidisciplinary
Pichaporn Sutthavas, Matthias Schumacher, Martyna Nikody, Vaijayanthi Ramesh, Jurij Jakobi, Elizabeth R. R. Balmayor, Pamela Habibovic, Christoph Rehbock, Stephan Barcikowski, Sabine van Rijt
Summary: Bioactive glass nanoparticles (nBGs) have been successfully doped with iron, strontium, and/or copper ions using pulsed laser techniques. The laser-doped nBGs maintained their morphology and showed biocompatibility. Furthermore, the presence of specific ions in the nBGs enhanced bone repair and vessel formation.
MATERIALS ADVANCES
(2023)
Article
Materials Science, Biomaterials
Lei He, Pamela Habibovic, Sabine van Rijt
Summary: Three types of mesoporous silica nanoparticles (MSNs) were developed and investigated for their ability to deliver selenium. The nanoparticles showed cytotoxicity towards cancer cells and lower toxicity towards healthy osteoblasts. Additionally, the nanoparticles induced reactive oxygen species generation and cell apoptosis. These findings highlight the potential of MSNs as selenium delivery carriers for osteosarcoma therapy.
BIOMATERIALS SCIENCE
(2023)
Proceedings Paper
Engineering, Biomedical
J. Krieger, B. Niessing, N. Koenig, C. Mota, V. La Pointe, S. Van Rijt, D. Kondro, M. Hiatt, B. Viellerobe, B. Brisson, M. Marechal, L. Geris, F. P. Luyten, I. Papantoniou, R. H. Schmitt
Summary: The EU Horizon 2020 project JointPromise aims to develop and implement an automated production platform for three-dimensional joint implants that can regenerate deep osteochondral defects. The project utilizes spheroid-based implants and 3D bioprinting technology to create functional joint implants. The platform includes devices for cell and microtissue cultivation, harvest and implant production, as well as control software and testing in large animal models.
V CIRP CONFERENCE ON BIOMANUFACTURING
(2022)
Article
Materials Science, Biomaterials
Mar Bonany, Ana Joaquina Perez-Berna, Tanja Ducic, Eva Pereiro, Helena Martin-Gomez, Carlos Mas-Moruno, Sabine van Rijt, Zhitong Zhao, Montserrat Espanol, Maria-Pau Ginebra
Summary: This study aimed to investigate the importance of nanoparticle membrane interactions in the cytotoxicity of MG-63 cells. By comparing different types of nanoparticles and their interaction with cells, the direct interaction of cell membrane with the material was ruled out as the main mechanism of nanoparticle toxicity. Conventional techniques for assessing nanoparticle toxicity were inconclusive, while the combination of fluorescent calcium probes and cryo-soft X-ray imaging was effective in studying soluble calcium inside the cells.
BIOMATERIALS ADVANCES
(2022)
Article
Chemistry, Inorganic & Nuclear
Noha Khamis, Guy J. Clarkson, Martin Wills
Summary: The synthesis of a variety of N-(heterocyclesulfonyl)-functionalized Noyori-Ikariya catalysts was described in this study. These complexes were prepared from C2-symmetric 1,2-diphenylethylene-1,2-diamine (DPEN) and characterized using multiple methods including X-ray crystallography. The complexes exhibited catalytic activity in the asymmetric transfer hydrogenation (ATH) of various acetophenone derivatives, yielding products with high enantioselectivity in most cases, especially for ortho-substituted acetophenones.
DALTON TRANSACTIONS
(2022)
Meeting Abstract
Cell & Tissue Engineering
Xingzhen Zhang, Pamela Habibovic, Sabine van Rijt
TISSUE ENGINEERING PART A
(2022)
Article
Chemistry, Inorganic & Nuclear
Feng Chen, Isolda Romero-Canelon, Abraha Habtemariam, Ji-Inn Song, Samya Banerjee, Guy J. Clarkson, Lijiang Song, Ivan Prokes, Peter J. Sadler
Summary: We synthesized a series of novel substituted sulfonyl ethylenediamine (en) Ru-II arene complexes, which showed antiproliferative activity against cancer cells and exhibited catalytic activity in transfer hydrogenation reactions and reactions with thiols.
DALTON TRANSACTIONS
(2022)