期刊
CURRENT OPINION IN CHEMICAL BIOLOGY
卷 25, 期 -, 页码 172-183出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2015.01.024
关键词
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资金
- ERC [247450]
- EPSRC [EP/F034210/1]
- University of Warwick Institute of Advanced Studies and Science City (ERDF/AWM)
- Engineering and Physical Sciences Research Council [EP/F034210/1] Funding Source: researchfish
- EPSRC [EP/F034210/1] Funding Source: UKRI
Metal ions are known to act as catalytic centres in metalloenzymes. On the other hand, low-molecular-weight metal complexes are widely used as catalysts in chemical systems. However, small catalysts do not have a large protein ligand to provide substrate selectivity and minimize catalyst poisoning. Despite the challenges that the lack of a protein ligand might pose, some success in the use of metal catalysts for biochemical transformations has been reported. Here, we present a brief overview of such reports, especially involving catalytic reactions in cells. Examples include C-C bond formation, deprotection and functional group modification, degradation of biomolecules, and redox modulation. We discuss four classes of catalytic redox modulators: photosensitizers, superoxide dismutase mimics, thiol oxidants, and transfer hydrogenation catalysts. Catalytic metallodrugs offer the prospect of low-dose therapy and a challenging new design strategy for future exploration.
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