标题
mTOR, metabolism, and the regulation of T-cell differentiation and function
作者
关键词
-
出版物
IMMUNOLOGICAL REVIEWS
Volume 249, Issue 1, Pages 43-58
出版商
Wiley
发表日期
2012-08-14
DOI
10.1111/j.1600-065x.2012.01152.x
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- ICOS Ligation Recruits the p50 PI3K Regulatory Subunit to the Immunological Synapse
- (2014) C. Fos et al. JOURNAL OF IMMUNOLOGY
- mTOR Signaling in Growth Control and Disease
- (2012) Mathieu Laplante et al. CELL
- Connecting mTORC1 signaling to SREBP-1 activation
- (2012) Inan Bakan et al. CURRENT OPINION IN LIPIDOLOGY
- Vital roles of mTOR complex 2 in Notch-driven thymocyte differentiation and leukemia
- (2012) Keunwook Lee et al. JOURNAL OF EXPERIMENTAL MEDICINE
- The translational landscape of mTOR signalling steers cancer initiation and metastasis
- (2012) Andrew C. Hsieh et al. NATURE
- How the TCR balances sensitivity and specificity for the recognition of self and pathogens
- (2012) Gerald P Morris et al. NATURE IMMUNOLOGY
- Impaired autophagy due to constitutive mTOR activation sensitizes TSC2-null cells to cell death under stress
- (2011) Shukie Ng et al. Autophagy
- Activation of mTORC2 by Association with the Ribosome
- (2011) Vittoria Zinzalla et al. CELL
- mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway
- (2011) Timothy R. Peterson et al. CELL
- Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1
- (2011) Eric V. Dang et al. CELL
- Growth controls connect: Interactions between c-myc and the tuberous sclerosis complex-mTOR pathway
- (2011) Emmett V. Schmidt et al. CELL CYCLE
- Akt Stimulates Hepatic SREBP1c and Lipogenesis through Parallel mTORC1-Dependent and Independent Pathways
- (2011) Jessica L. Yecies et al. Cell Metabolism
- The many faces of Th17 cells
- (2011) Anneli Peters et al. CURRENT OPINION IN IMMUNOLOGY
- Regulation of T-cell survival and mitochondrial homeostasis by TSC1
- (2011) Thomas F. O'Brien et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Integrated T-cell receptor and costimulatory signals determine TGF-β-dependent differentiation and maintenance of Foxp3+ regulatory T cells
- (2011) Leona Gabryšová et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation
- (2011) Ruoning Wang et al. IMMUNITY
- A Central Role for mTOR Kinase in Homeostatic Proliferation Induced CD8+ T Cell Memory and Tumor Immunity
- (2011) Qingsheng Li et al. IMMUNITY
- Mitochondrial Respiratory Capacity Is a Critical Regulator of CD8+ T Cell Memory Development
- (2011) Gerritje J.W. van der Windt et al. IMMUNITY
- Regulatory T cells and Foxp3
- (2011) Alexander Y. Rudensky IMMUNOLOGICAL REVIEWS
- Liver X receptor (LXR) mediates negative regulation of mouse and human Th17 differentiation
- (2011) Guoliang Cui et al. JOURNAL OF CLINICAL INVESTIGATION
- HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Tregcells
- (2011) Lewis Z. Shi et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Peroxisome Proliferator-Activated Receptor γ Is Required for CD4 + T Cell-Mediated Lymphopenia-Associated Autoimmunity
- (2011) William J. Housley et al. JOURNAL OF IMMUNOLOGY
- Temporal Regulation of Intracellular Organelle Homeostasis in T Lymphocytes by Autophagy
- (2011) W. Jia et al. JOURNAL OF IMMUNOLOGY
- OX40 Complexes with Phosphoinositide 3-Kinase and Protein Kinase B (PKB) To Augment TCR-Dependent PKB Signaling
- (2011) T. So et al. JOURNAL OF IMMUNOLOGY
- The Tuberous Sclerosis Complex-Mammalian Target of Rapamycin Pathway Maintains the Quiescence and Survival of Naive T Cells
- (2011) Q. Wu et al. JOURNAL OF IMMUNOLOGY
- New Insights on OX40 in the Control of T Cell Immunity and Immune Tolerance In Vivo
- (2011) X. Xiao et al. JOURNAL OF IMMUNOLOGY
- Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets
- (2011) R. D. Michalek et al. JOURNAL OF IMMUNOLOGY
- The tumor suppressor Tsc1 enforces quiescence of naive T cells to promote immune homeostasis and function
- (2011) Kai Yang et al. NATURE IMMUNOLOGY
- The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2
- (2011) Greg M Delgoffe et al. NATURE IMMUNOLOGY
- Characterization of the Metabolic Phenotype of Rapamycin-Treated CD8+ T Cells with Augmented Ability to Generate Long-Lasting Memory Cells
- (2011) Shan He et al. PLoS One
- Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth
- (2011) Q. Sun et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- ER Stress Inhibits mTORC2 and Akt Signaling Through GSK-3 -Mediated Phosphorylation of Rictor
- (2011) C.-H. Chen et al. Science Signaling
- Manipulating the Bioenergetics of Alloreactive T Cells Causes Their Selective Apoptosis and Arrests Graft-Versus-Host Disease
- (2011) E. Gatza et al. Science Translational Medicine
- Constitutive reductions in mTOR alter cell size, immune cell development, and antibody production
- (2010) S. Zhang et al. BLOOD
- Induction of T cell anergy: integration of environmental cues and infectious tolerance
- (2010) Pascal Chappert et al. CURRENT OPINION IN IMMUNOLOGY
- Mammalian Target of Rapamycin Controls Dendritic Cell Development Downstream of Flt3 Ligand Signaling
- (2010) Taheri Sathaliyawala et al. IMMUNITY
- An Oscillatory Switch in mTOR Kinase Activity Sets Regulatory T Cell Responsiveness
- (2010) Claudio Procaccini et al. IMMUNITY
- The Mammalian Target of Rapamycin: Linking T Cell Differentiation, Function, and Metabolism
- (2010) Jonathan D. Powell et al. IMMUNITY
- Mammalian Target of Rapamycin Protein Complex 2 Regulates Differentiation of Th1 and Th2 Cell Subsets via Distinct Signaling Pathways
- (2010) Keunwook Lee et al. IMMUNITY
- The mTOR Kinase Determines Effector versus Memory CD8 + T Cell Fate by Regulating the Expression of Transcription Factors T-bet and Eomesodermin
- (2010) Rajesh R. Rao et al. IMMUNITY
- TCR ligand density and affinity determine peripheral induction of Foxp3 in vivo
- (2010) Rachel A. Gottschalk et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Autophagy Regulates Endoplasmic Reticulum Homeostasis and Calcium Mobilization in T Lymphocytes
- (2010) W. Jia et al. JOURNAL OF IMMUNOLOGY
- Peroxisome Proliferator-Activated Receptor and Agonists Together with TGF- Convert Human CD4+CD25- T Cells into Functional Foxp3+ Regulatory T Cells
- (2010) J. Lei et al. JOURNAL OF IMMUNOLOGY
- Leptin Modulates the Survival of Autoreactive CD4+ T Cells through the Nutrient/Energy-Sensing Mammalian Target of Rapamycin Signaling Pathway
- (2010) M. Galgani et al. JOURNAL OF IMMUNOLOGY
- Glutamine Uptake and Metabolism Are Coordinately Regulated by ERK/MAPK during T Lymphocyte Activation
- (2010) E. L. Carr et al. JOURNAL OF IMMUNOLOGY
- Characterization of the metabolic phenotype of chronically activated lymphocytes
- (2010) DR Wahl et al. LUPUS
- AP-1 Regulates Cyclin D1 and c-MYC Transcription in an AKT-Dependent Manner in Response to mTOR Inhibition: Role of AIP4/Itch-Mediated JUNB Degradation
- (2010) R. Vartanian et al. MOLECULAR CANCER RESEARCH
- Sin1-mTORC2 Suppresses rag and il7r Gene Expression through Akt2 in B Cells
- (2010) Adam S. Lazorchak et al. MOLECULAR CELL
- Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1
- (2010) Katrin Düvel et al. MOLECULAR CELL
- Regulation of the mTOR Complex 1 Pathway by Nutrients, Growth Factors, and Stress
- (2010) Shomit Sengupta et al. MOLECULAR CELL
- mTORC1 controls fasting-induced ketogenesis and its modulation by ageing
- (2010) Shomit Sengupta et al. NATURE
- The S1P1-mTOR axis directs the reciprocal differentiation of TH1 and Treg cells
- (2010) Guangwei Liu et al. NATURE IMMUNOLOGY
- IL-35-mediated induction of a potent regulatory T cell population
- (2010) Lauren W Collison et al. NATURE IMMUNOLOGY
- Duration of antigen receptor signaling determines T-cell tolerance or activation
- (2010) S. D. Katzman et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- CCL5 promotes proliferation of MCF-7 cells through mTOR-dependent mRNA translation
- (2009) Thomas T. Murooka et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- An Amino Acid Shuffle Activates mTORC1
- (2009) Adiel Cohen et al. CELL
- Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy
- (2009) Paul Nicklin et al. CELL
- LKB1 is essential for the proliferation of T-cell progenitors and mature peripheral T cells
- (2009) Peter Tamás et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Tumor suppressors and cell metabolism: a recipe for cancer growth
- (2009) R. G. Jones et al. GENES & DEVELOPMENT
- Control of Regulatory T Cell Lineage Commitment and Maintenance
- (2009) Steven Z. Josefowicz et al. IMMUNITY
- The mTOR Kinase Differentially Regulates Effector and Regulatory T Cell Lineage Commitment
- (2009) Greg M. Delgoffe et al. IMMUNITY
- mTOR: taking cues from the immune microenvironment
- (2009) Greg M. Delgoffe et al. IMMUNOLOGY
- Th9 and allergic disease
- (2009) Pejman Soroosh et al. IMMUNOLOGY
- Enhanced Interferon-γ Gene Expression in T Cells and Reduced Ovalbumin-Dependent Lung Eosinophilia in Hypoxia-Inducible Factor-1-α-Deficient Mice
- (2009) Jia Guo et al. INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
- ULK1·ATG13·FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy
- (2009) Ian G. Ganley et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- mTOR signaling at a glance
- (2009) M. Laplante et al. JOURNAL OF CELL SCIENCE
- The nuclear receptor PPARγ selectively inhibits Th17 differentiation in a T cell–intrinsic fashion and suppresses CNS autoimmunity
- (2009) Luisa Klotz et al. JOURNAL OF EXPERIMENTAL MEDICINE
- PD-L1 regulates the development, maintenance, and function of induced regulatory T cells
- (2009) Loise M. Francisco et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Anergic T Cells Are Metabolically Anergic
- (2009) Y. Zheng et al. JOURNAL OF IMMUNOLOGY
- Memory-Like CD8+ T Cells Generated during Homeostatic Proliferation Defer to Antigen-Experienced Memory Cells
- (2009) K. P. Cheung et al. JOURNAL OF IMMUNOLOGY
- Autophagy Is Essential for Mitochondrial Clearance in Mature T Lymphocytes
- (2009) H. H. Pua et al. JOURNAL OF IMMUNOLOGY
- ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery
- (2009) Chang Hwa Jung et al. MOLECULAR BIOLOGY OF THE CELL
- Enhancing CD8 T-cell memory by modulating fatty acid metabolism
- (2009) Erika L. Pearce et al. NATURE
- mTOR regulates memory CD8 T-cell differentiation
- (2009) Koichi Araki et al. NATURE
- The receptor S1P1 overrides regulatory T cell–mediated immune suppression through Akt-mTOR
- (2009) Guangwei Liu et al. NATURE IMMUNOLOGY
- Dynamics and diversity in autophagy mechanisms: lessons from yeast
- (2009) Hitoshi Nakatogawa et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Insulin Stimulates Adipogenesis through the Akt-TSC2-mTORC1 Pathway
- (2009) Hui H. Zhang et al. PLoS One
- mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)
- (2008) Juan M. García-Martínez et al. BIOCHEMICAL JOURNAL
- SREBP Activity Is Regulated by mTORC1 and Contributes to Akt-Dependent Cell Growth
- (2008) Thomas Porstmann et al. Cell Metabolism
- Hypoxia regulates TSC1/2 mTOR signaling and tumor suppression through REDD1-mediated 14 3 3 shuttling
- (2008) M. P. DeYoung et al. GENES & DEVELOPMENT
- The TSC-mTOR Signaling Pathway Regulates the Innate Inflammatory Response
- (2008) Thomas Weichhart et al. IMMUNITY
- Heterogeneous Nuclear Ribonucleoprotein A1 Regulates Cyclin D1 and c-mycInternal Ribosome Entry Site Function through Akt Signaling
- (2008) Oak D. Jo et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The AKT–mTOR axis regulates de novo differentiation of CD4+Foxp3+cells
- (2008) Sokol Haxhinasto et al. JOURNAL OF EXPERIMENTAL MEDICINE
- De novo induction of antigen-specific CD4+CD25+Foxp3+ regulatory T cells in vivo following systemic antigen administration accompanied by blockade of mTOR
- (2008) Johnthomas Kang et al. JOURNAL OF LEUKOCYTE BIOLOGY
- AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint
- (2008) Dana M. Gwinn et al. MOLECULAR CELL
- Regulation of TORC1 by Rag GTPases in nutrient response
- (2008) Eunjung Kim et al. NATURE CELL BIOLOGY
- T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR
- (2008) S. Sauer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1
- (2008) Y. Sancak et al. SCIENCE
- Regulation of macroautophagy by mTOR and Beclin 1 complexes
- (2007) Sophie Pattingre et al. BIOCHIMIE
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExplorePublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More