标题
Oncometabolites: linking altered metabolism with cancer
作者
关键词
-
出版物
JOURNAL OF CLINICAL INVESTIGATION
Volume 123, Issue 9, Pages 3652-3658
出版商
American Society for Clinical Investigation
发表日期
2013-09-02
DOI
10.1172/jci67228
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- SDH Mutations Establish a Hypermethylator Phenotype in Paraganglioma
- (2013) Eric Letouzé et al. CANCER CELL
- CUL3 and NRF2 Mutations Confer an NRF2 Activation Phenotype in a Sporadic Form of Papillary Renal Cell Carcinoma
- (2013) A. Ooi et al. CANCER RESEARCH
- The Proto-oncometabolite Fumarate Binds Glutathione to Amplify ROS-Dependent Signaling
- (2013) Lucas B. Sullivan et al. MOLECULAR CELL
- Succinate is an inflammatory signal that induces IL-1β through HIF-1α
- (2013) G. M. Tannahill et al. NATURE
- Silencing a Metabolic Oncogene
- (2013) J. Kim et al. SCIENCE
- (R)-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible
- (2013) J.-A. Losman et al. SCIENCE
- An Inhibitor of Mutant IDH1 Delays Growth and Promotes Differentiation of Glioma Cells
- (2013) D. Rohle et al. SCIENCE
- Targeted Inhibition of Mutant IDH2 in Leukemia Cells Induces Cellular Differentiation
- (2013) F. Wang et al. SCIENCE
- Succinate Dehydrogenase Mutation Underlies Global Epigenomic Divergence in Gastrointestinal Stromal Tumor
- (2013) J. Keith Killian et al. Cancer Discovery
- A Role for Cytosolic Fumarate Hydratase in Urea Cycle Metabolism and Renal Neoplasia
- (2013) Julie Adam et al. Cell Reports
- Inhibition of Mitochondrial Aconitase by Succination in Fumarate Hydratase Deficiency
- (2013) Nicola Ternette et al. Cell Reports
- Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate
- (2012) Patrick S. Ward et al. CANCER CELL
- Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming
- (2012) Yoichiro Mitsuishi et al. CANCER CELL
- Cellular Metabolism and Disease: What Do Metabolic Outliers Teach Us?
- (2012) Ralph J. DeBerardinis et al. CELL
- D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function
- (2012) M. Sasaki et al. GENES & DEVELOPMENT
- Inhibition of -KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors
- (2012) M. Xiao et al. GENES & DEVELOPMENT
- Cancer-associated Isocitrate Dehydrogenase Mutations Inactivate NADPH-dependent Reductive Carboxylation
- (2012) Roberta Leonardi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- TET2 Mutations in Acute Myeloid Leukemia (AML): Results From a Comprehensive Genetic and Clinical Analysis of the AML Study Group
- (2012) Verena I. Gaidzik et al. JOURNAL OF CLINICAL ONCOLOGY
- Progress in understanding 2-hydroxyglutaric acidurias
- (2012) Martijn Kranendijk et al. JOURNAL OF INHERITED METABOLIC DISEASE
- 2-Hydroxyglutarate inIDHmutant acute myeloid leukemia: predicting patient responses, minimal residual disease and correlations with methylcytosine and hydroxymethylcytosine levels
- (2012) Daniel A. Pollyea et al. LEUKEMIA & LYMPHOMA
- IDH mutation impairs histone demethylation and results in a block to cell differentiation
- (2012) Chao Lu et al. NATURE
- Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation
- (2012) Peppi Koivunen et al. NATURE
- IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype
- (2012) Sevin Turcan et al. NATURE
- How cancer metabolism is tuned for proliferation and vulnerable to disruption
- (2012) Almut Schulze et al. NATURE
- IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics
- (2012) Masato Sasaki et al. NATURE
- Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans
- (2012) Wei Ge et al. Nature Chemical Biology
- Untuning the tumor metabolic machine: HIF-α: pro- and antitumorigenic?
- (2012) Regina M Young et al. NATURE MEDICINE
- 2-hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas
- (2012) Changho Choi et al. NATURE MEDICINE
- Systems Biology, Metabolomics, and Cancer Metabolism
- (2012) M. Tomita et al. SCIENCE
- Metabolite Profiling Identifies a Key Role for Glycine in Rapid Cancer Cell Proliferation
- (2012) M. Jain et al. SCIENCE
- Detection of 2-Hydroxyglutarate in IDH-Mutated Glioma Patients by In Vivo Spectral-Editing and 2D Correlation Magnetic Resonance Spectroscopy
- (2012) O. C. Andronesi et al. Science Translational Medicine
- Magnetic Resonance of 2-Hydroxyglutarate in IDH1-Mutated Low-Grade Gliomas
- (2012) A. Elkhaled et al. Science Translational Medicine
- Genetically-defined metabolic reprogramming in cancer
- (2012) Andrew R. Mullen et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- The emerging role of fumarate as an oncometabolite
- (2012) Ming Yang et al. Frontiers in Oncology
- SDH mutations in cancer
- (2011) Chiara Bardella et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
- Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases
- (2011) Wei Xu et al. CANCER CELL
- An Antioxidant Response Phenotype Shared between Hereditary and Sporadic Type 2 Papillary Renal Cell Carcinoma
- (2011) Aikseng Ooi et al. CANCER CELL
- Renal Cyst Formation in Fh1-Deficient Mice Is Independent of the Hif/Phd Pathway: Roles for Fumarate in KEAP1 Succination and Nrf2 Signaling
- (2011) Julie Adam et al. CANCER CELL
- Metabolic Regulation of Hematopoietic Stem Cells in the Hypoxic Niche
- (2011) Toshio Suda et al. Cell Stem Cell
- Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells
- (2011) Yoshihiro Inami et al. JOURNAL OF CELL BIOLOGY
- SDHA Immunohistochemistry Detects GermlineSDHAGene Mutations in Apparently Sporadic Paragangliomas and Pheochromocytomas
- (2011) Esther Korpershoek et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Inborn and acquired metabolic defects in cancer
- (2011) Christian Frezza et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Non-invasive detection of 2-hydroxyglutarate and other metabolites in IDH1 mutant glioma patients using magnetic resonance spectroscopy
- (2011) Whitney B. Pope et al. JOURNAL OF NEURO-ONCOLOGY
- IDH mutation status impact on in vivo hypoxia biomarkers expression: new insights from a clinical, nuclear imaging and immunohistochemical study in 33 glioma patients
- (2011) Philippe Metellus et al. JOURNAL OF NEURO-ONCOLOGY
- Value and Limitations of Immunohistochemistry and Gene Sequencing for Detection of theIDH1-R132HMutation in Diffuse Glioma Biopsy Specimens
- (2011) Matthias Preusser et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- Seeing the smoking gun: a sensitive and specific method to visualize loss of the tumour suppressor, fumarate hydratase, in human tissues
- (2011) Patrick H. Maxwell JOURNAL OF PATHOLOGY
- Aberrant succination of proteins in fumarate hydratase-deficient mice and HLRCC patients is a robust biomarker of mutation status
- (2011) Chiara Bardella et al. JOURNAL OF PATHOLOGY
- IDH1 and IDH2 mutations are frequent events in central chondrosarcoma and central and periosteal chondromas but not in other mesenchymal tumours
- (2011) M Fernanda Amary et al. JOURNAL OF PATHOLOGY
- Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis
- (2011) Gina M. DeNicola et al. NATURE
- Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma
- (2011) Ignacio Varela et al. NATURE
- Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase
- (2011) Christian Frezza et al. NATURE
- Identification of additional IDH mutations associated with oncometabolite R(−)-2-hydroxyglutarate production
- (2011) P S Ward et al. ONCOGENE
- Frequent Mutation of Isocitrate Dehydrogenase (IDH)1 and IDH2 in Cholangiocarcinoma Identified Through Broad-Based Tumor Genotyping
- (2011) D. R. Borger et al. ONCOLOGIST
- Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome
- (2011) Z. J. Reitman et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of -ketoglutarate to citrate to support cell growth and viability
- (2011) D. R. Wise et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Acquired mutations in the genes encoding IDH1 and IDH2 both are recurrent aberrations in acute myeloid leukemia: prevalence and prognostic value
- (2010) S. Abbas et al. BLOOD
- The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate
- (2010) Patrick S. Ward et al. CANCER CELL
- Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation
- (2010) Maria E. Figueroa et al. CANCER CELL
- Hypoxia Signaling in Hematopoietic Stem Cells: A Double-Edged Sword
- (2010) Patrick J. Pollard et al. Cell Stem Cell
- Warburg tumours and the mechanisms of mitochondrial tumour suppressor genes. Barking up the right tree?
- (2010) Jean-Pierre Bayley et al. CURRENT OPINION IN GENETICS & DEVELOPMENT
- Succination of proteins in diabetes
- (2010) Norma Frizzell et al. FREE RADICAL RESEARCH
- Dysregulation of hypoxia pathways in fumarate hydratase-deficient cells is independent of defective mitochondrial metabolism
- (2010) Linda O'Flaherty et al. HUMAN MOLECULAR GENETICS
- IDH1 and IDH2 Mutations Are Frequent Genetic Alterations in Acute Myeloid Leukemia and Confer Adverse Prognosis in Cytogenetically Normal Acute Myeloid Leukemia With NPM1 Mutation Without FLT3 Internal Tandem Duplication
- (2010) Peter Paschka et al. JOURNAL OF CLINICAL ONCOLOGY
- Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations
- (2010) Stefan Gross et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Erratum: Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
- (2010) Lenny Dang et al. NATURE
- Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes
- (2010) Gillian L. Dalgliesh et al. NATURE
- Identification of lysine succinylation as a new post-translational modification
- (2010) Zhihong Zhang et al. Nature Chemical Biology
- IDH2 Mutations in Patients with D-2-Hydroxyglutaric Aciduria
- (2010) M. Kranendijk et al. SCIENCE
- Type and frequency of IDH1 and IDH2 mutations are related to astrocytic and oligodendroglial differentiation and age: a study of 1,010 diffuse gliomas
- (2009) Christian Hartmann et al. ACTA NEUROPATHOLOGICA
- An immunohistochemical procedure to detect patients with paraganglioma and phaeochromocytoma with germline SDHB, SDHC, or SDHD gene mutations: a retrospective and prospective analysis
- (2009) Francien H van Nederveen et al. LANCET ONCOLOGY
- Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer
- (2009) Gijs van Haaften et al. NATURE GENETICS
- Metabolic Enzymes as Oncogenes or Tumor Suppressors
- (2009) Craig B. Thompson NEW ENGLAND JOURNAL OF MEDICINE
- Mutation inTET2in Myeloid Cancers
- (2009) François Delhommeau et al. NEW ENGLAND JOURNAL OF MEDICINE
- Recurring Mutations Found by Sequencing an Acute Myeloid Leukemia Genome
- (2009) Elaine R. Mardis et al. NEW ENGLAND JOURNAL OF MEDICINE
- IDH1andIDH2Mutations in Gliomas
- (2009) Hai Yan et al. NEW ENGLAND JOURNAL OF MEDICINE
- Glioma-Derived Mutations in IDH1 Dominantly Inhibit IDH1 Catalytic Activity and Induce HIF-1
- (2009) S. Zhao et al. SCIENCE
- Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
- (2009) M. G. Vander Heiden et al. SCIENCE
- NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer
- (2009) John D. Hayes et al. TRENDS IN BIOCHEMICAL SCIENCES
- Dual roles of Nrf2 in cancer
- (2008) A LAU et al. PHARMACOLOGICAL RESEARCH
- An Integrated Genomic Analysis of Human Glioblastoma Multiforme
- (2008) D. W. Parsons et al. SCIENCE
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