Epigenetic Regulation of Telomere Maintenance for Therapeutic Interventions in Gliomas

Targeting noncoding RNAs in disease

(2017) Brian D. Adams et al.   JOURNAL OF CLINICAL INVESTIGATION

The role of histone modifications and telomere alterations in the pathogenesis of diffuse gliomas in adults and children

(2017) Julieann Lee et al.   JOURNAL OF NEURO-ONCOLOGY

The C-Circle Assay for alternative-lengthening-of-telomeres activity

(2017) Jeremy D. Henson et al.   METHODS

Whole-genome landscape of pancreatic neuroendocrine tumours

(2017) Aldo Scarpa et al.   NATURE

MicroRNA therapeutics: towards a new era for the management of cancer and other diseases

(2017) Rajesha Rupaimoole et al.   NATURE REVIEWS DRUG DISCOVERY

Advances in brain tumour classification and therapy

(2017) Matthias Preusser et al.   Nature Reviews Neurology

Targeting Epigenetic Pathways in the Treatment of Pediatric Diffuse (High Grade) Gliomas

(2017) Magimairajan Issai Vanan et al.   Neurotherapeutics

Alternative lengthening of telomeres can be maintained by preferential elongation of lagging strands

(2017) Jaewon Min et al.   NUCLEIC ACIDS RESEARCH

Epigenetics in cancer: Fundamentals and Beyond

(2017) Subhankar Biswas et al.   PHARMACOLOGY & THERAPEUTICS

Advances in epigenetic glioblastoma therapy

(2017) Dong Hoon Lee et al.   Oncotarget

Telomere Recognition and Assembly Mechanism of Mammalian Shelterin

(2017) Fabian Erdel et al.   Cell Reports

Therapeutic Targeting of Histone Modifications in Adult and Pediatric High-Grade Glioma

(2017) Maria J. Williams et al.   Frontiers in Oncology

The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary

(2016) David N. Louis et al.   ACTA NEUROPATHOLOGICA

HDAC9 regulates the alternative lengthening of telomere (ALT) pathway via the formation of ALT-associated PML bodies

(2016) Mohd. Raeed Jamiruddin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Evolving Molecular Genetics of Glioblastoma

(2016) Cheng-Yin Liu et al.   CHINESE MEDICAL JOURNAL

RNA as a fundamental component of interphase chromosomes: could repeats prove key?

(2016) Lisa L Hall et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Alternative lengthening of human telomeres is a conservative DNA replication process with features of break‐induced replication

(2016) Fani‐Marlen Roumelioti et al.   EMBO REPORTS

Telomere profiles and tumor-associated macrophages with different immune signatures affect prognosis in glioblastoma

(2016) Noelyn A Hung et al.   MODERN PATHOLOGY

Understanding TERT Promoter Mutations: A Common Path to Immortality

(2016) R. J. A. Bell et al.   MOLECULAR CANCER RESEARCH

Alternative lengthening of telomeres does exist in various canine sarcomas

(2016) Theresa Kreilmeier et al.   MOLECULAR CARCINOGENESIS

DNA methylation mediated up-regulation ofTERRAnon-coding RNA is coincident with elongated telomeres in the human placenta

(2016) Boris Novakovic et al.   MOLECULAR HUMAN REPRODUCTION

Break-induced telomere synthesis underlies alternative telomere maintenance

(2016) Robert L. Dilley et al.   NATURE

Advances in the molecular genetics of gliomas — implications for classification and therapy

(2016) Guido Reifenberger et al.   Nature Reviews Clinical Oncology

A balance between elongation and trimming regulates telomere stability in stem cells

(2016) Teresa Rivera et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

New players in heterochromatin silencing: histone variant H3.3 and the ATRX/DAXX chaperone

(2016) Hsiao P.J. Voon et al.   NUCLEIC ACIDS RESEARCH

The crosstalk of telomere dysfunction and inflammation through cell-free TERRA containing exosomes

(2016) Zhuo Wang et al.   RNA Biology

RNA-template dependent de novo telomere addition

(2016) Gloria Fuhrmann et al.   RNA Biology

ATRX loss promotes tumor growth and impairs nonhomologous end joining DNA repair in glioma

(2016) Carl Koschmann et al.   Science Translational Medicine

An update on the epigenetics of glioblastomas

(2016) Wallax Augusto Silva Ferreira et al.   Epigenomics

Telomeric RNAs are essential to maintain telomeres

(2016) Juan José Montero et al.   Nature Communications

Role of Telomeres and Telomerase in Aging and Cancer

(2016) J. W. Shay   Cancer Discovery

A balance between elongation and trimming regulates telomere stability in stem cells

(2016) Teresa Rivera et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Physiological and pathological implications of 5-hydroxymethylcytosine in diseases

(2016) Jing Liang et al.   Oncotarget

Telomerase Regulation from Beginning to the End

(2016) Deanna MacNeil et al.   Genes

Telomere Transcripts Target Telomerase in Human Cancer Cells

(2016) Theresa Kreilmeier et al.   Genes

The Role of ATRX in the Alternative Lengthening of Telomeres (ALT) Phenotype

(2016) João Amorim et al.   Genes

Regulation of the Telomerase Reverse Transcriptase Subunit through Epigenetic Mechanisms

(2016) Kayla A. Lewis et al.   Frontiers in Genetics

Nuclear respiratory factor 1 and endurance exercise promote human telomere transcription

(2016) A. Diman et al.   Science Advances

Switch telomerase to ALT mechanism by inducing telomeric DNA damages and dysfunction of ATRX and DAXX

(2016) Yang Hu et al.   Scientific Reports

TRF1 phosphorylation on T271 modulates telomerase-dependent telomere length maintenance as well as the formation of ALT-associated PML bodies

(2016) Angus Ho et al.   Scientific Reports

Nuclear-Receptor-Mediated Telomere Insertion Leads to Genome Instability in ALT Cancers

(2015) Paulina Marzec et al.   CELL

Histone deacetylation meets miRNA: epigenetics and post-transcriptional regulation in cancer and chronic diseases

(2015) Stefan Swierczynski et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

PML induces compaction, TRF2 depletion and DNA damage signaling at telomeres and promotes their alternative lengthening

(2015) S. Osterwald et al.   JOURNAL OF CELL SCIENCE

TERRA mimicking ssRNAs prevail over the DNA substrate for telomerasein vitrodue to interactions with the alternative binding site

(2015) Dulat Azhibek et al.   JOURNAL OF MOLECULAR RECOGNITION

Genetic Inactivation ofATRXLeads to a Decrease in the Amount of Telomeric Cohesin and Level of Telomere Transcription in Human Glioma Cells

(2015) Rita Eid et al.   MOLECULAR AND CELLULAR BIOLOGY

Functionally defined therapeutic targets in diffuse intrinsic pontine glioma

(2015) Catherine S Grasso et al.   NATURE MEDICINE

TERRA and the state of the telomere

(2015) Karsten Rippe et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Complex interactions between the DNA-damage response and mammalian telomeres

(2015) Nausica Arnoult et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Molecular mechanisms of activity and derepression of alternative lengthening of telomeres

(2015) Hilda A Pickett et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

CHK1-driven histone H3.3 serine 31 phosphorylation is important for chromatin maintenance and cell survival in human ALT cancer cells

(2015) Fiona T. M. Chang et al.   NUCLEIC ACIDS RESEARCH

LINE-1 induces hTERT and ensures telomere maintenance in tumour cell lines

(2015) T Aschacher et al.   ONCOGENE

Telomere biology: Rationale for diagnostics and therapeutics in cancer

(2015) Philippe Rousseau et al.   RNA Biology

Telomere elongation chooses TERRA ALTernatives

(2015) Rajika Arora et al.   RNA Biology

Alternative lengthening of telomeres renders cancer cells hypersensitive to ATR inhibitors

(2015) R. L. Flynn et al.   SCIENCE

Cell of Origin for Malignant Gliomas and Its Implication in Therapeutic Development

(2015) Hui Zong et al.   Cold Spring Harbor Perspectives in Biology

Suppression of the alternative lengthening of telomere pathway by the chromatin remodelling factor ATRX

(2015) David Clynes et al.   Nature Communications

TERRA and the state of the telomere

(2015) Karsten Rippe et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Complex interactions between the DNA-damage response and mammalian telomeres

(2015) Nausica Arnoult et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Molecular mechanisms of activity and derepression of alternative lengthening of telomeres

(2015) Hilda A Pickett et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

ATRX represses alternative lengthening of telomeres

(2015) Christine E. Napier et al.   Oncotarget

HDAC9 promotes glioblastoma growth via TAZ-mediated EGFR pathway activation

(2015) Rui Yang et al.   Oncotarget

Glioma

(2015) Michael Weller et al.   Nature Reviews Disease Primers

Non-coding RNA in neural function, disease, and aging

(2015) Kirk Szafranski   Frontiers in Genetics

Alternative Lengthening of Telomeres: Recurrent Cytogenetic Aberrations and Chromosome Stability under Extreme Telomere Dysfunction

(2015) Despoina Sakellariou et al.   NEOPLASIA

The Roles of Telomerase in the Generation of Polyploidy during Neoplastic Cell Growth

(2015) Agni Christodoulidou et al.   NEOPLASIA

L1 Retrotransposons and Somatic Mosaicism in the Brain

(2014) Sandra R. Richardson et al.   Annual Review of Genetics

Epidemiologic and Molecular Prognostic Review of Glioblastoma

(2014) J. P. Thakkar et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

MicroRNA-dependent Regulation of Telomere Maintenance Mechanisms: A Field as Much Unexplored as Potentially Promising

(2014) Francesca Santambrogio et al.   CURRENT PHARMACEUTICAL DESIGN

Telomere Maintenance Mechanisms in Cancer: Clinical Implications

(2014) Roger Reddel   CURRENT PHARMACEUTICAL DESIGN

Role of Tet proteins in enhancer activity and telomere elongation

(2014) Falong Lu et al.   GENES & DEVELOPMENT

A preclinical mouse model of glioma with an alternative mechanism of telomere maintenance (ALT)

(2014) Maya Jeitany et al.   INTERNATIONAL JOURNAL OF CANCER

Prognostic significance of telomere maintenance mechanisms in pediatric high-grade gliomas

(2014) Kathleen Dorris et al.   JOURNAL OF NEURO-ONCOLOGY

A model of a patient-derived IDH1 mutant anaplastic astrocytoma with alternative lengthening of telomeres

(2014) Alexandra Borodovsky et al.   JOURNAL OF NEURO-ONCOLOGY

Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma

(2014) Rintaro Hashizume et al.   NATURE MEDICINE

Mobile DNA elements in the generation of diversity and complexity in the brain

(2014) Jennifer A. Erwin et al.   NATURE REVIEWS NEUROSCIENCE

Rapid induction of alternative lengthening of telomeres by depletion of the histone chaperone ASF1

(2014) Roderick J O'Sullivan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

NuRD–ZNF827 recruitment to telomeres creates a molecular scaffold for homologous recombination

(2014) Dimitri Conomos et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Alternative Lengthening of Telomeres is characterized by reduced compaction of telomeric chromatin

(2014) Harikleia Episkopou et al.   NUCLEIC ACIDS RESEARCH

Expression of Telomeres in Astrocytoma WHO Grade 2 to 4: TERRA Level Correlates with Telomere Length, Telomerase Activity, and Advanced Clinical Grade

(2014) Sandra Sampl et al.   Translational Oncology

Assembly of telomeric chromatin to create ALTernative endings

(2014) Roderick J. O'Sullivan et al.   TRENDS IN CELL BIOLOGY

Histone deacetylase inhibitor AR42 regulates telomerase activity in human glioma cells via an Akt-dependent mechanism

(2013) Ya-Luen Yang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Endogenous Retrotransposition Activates Oncogenic Pathways in Hepatocellular Carcinoma

(2013) Ruchi Shukla et al.   CELL

A new role for histone deacetylase 5 in the maintenance of long telomeres

(2013) Clara Lopes Novo et al.   FASEB JOURNAL

Loss of DAXX and ATRX Are Associated With Chromosome Instability and Reduced Survival of Patients With Pancreatic Neuroendocrine Tumors

(2013) Ilaria Marinoni et al.   GASTROENTEROLOGY

Alternative lengthening of telomeres in normal mammalian somatic cells

(2013) A. A. Neumann et al.   GENES & DEVELOPMENT

Histone methyltransferaseSuv39h1deficiency preventsMyc-induced chromosomal instability in murine myeloid leukemias

(2013) Beate Vajen et al.   GENES CHROMOSOMES & CANCER

Telomerase-mediated telomere elongation from human blastocysts to embryonic stem cells

(2013) Sicong Zeng et al.   JOURNAL OF CELL SCIENCE

Antiproliferative effects of pomegranate extract in MCF-7 breast cancer cells are associated with reduced DNA repair gene expression and induction of double strand breaks

(2013) Amit B. Shirode et al.   MOLECULAR CARCINOGENESIS

A three-state model for the regulation of telomerase by TERRA and hnRNPA1

(2013) Sophie Redon et al.   NUCLEIC ACIDS RESEARCH

Telomerase: central regulator of all of the hallmarks of cancer

(2013) Kee Chung Low et al.   TRENDS IN BIOCHEMICAL SCIENCES

Alternative lengthening of telomeres: remodeling the telomere architecture

(2013) Dimitri Conomos et al.   Frontiers in Oncology

Cancer Genetics and Epigenetics: Two Sides of the Same Coin?

(2012) Jueng Soo You et al.   CANCER CELL

A role for CTCF and cohesin in subtelomere chromatin organization, TERRA transcription, and telomere end protection

(2012) Zhong Deng et al.   EMBO JOURNAL

Low values of 5-hydroxymethylcytosine (5hmC), the “sixth base,” are associated with anaplasia in human brain tumors

(2012) Theo F.J. Kraus et al.   INTERNATIONAL JOURNAL OF CANCER

Variant repeats are interspersed throughout the telomeres and recruit nuclear receptors in ALT cells

(2012) Dimitri Conomos et al.   JOURNAL OF CELL BIOLOGY

Alternative mechanisms of telomere lengthening: Permissive mutations, DNA repair proteins and tumorigenic progression

(2012) April Renee Sandy Gocha et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma

(2012) Jeremy Schwartzentruber et al.   NATURE

Telomere length regulates TERRA levels through increased trimethylation of telomeric H3K9 and HP1α

(2012) Nausica Arnoult et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

CBTRUS Statistical Report: Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2005-2009

(2012) T. A. Dolecek et al.   NEURO-ONCOLOGY

Cancer and Telomeres--An ALTernative to Telomerase

(2012) J. W. Shay et al.   SCIENCE

Loss of ATRX, Genome Instability, and an Altered DNA Damage Response Are Hallmarks of the Alternative Lengthening of Telomeres Pathway

(2012) Courtney A. Lovejoy et al.   PLoS Genetics

Current concepts and management of glioblastoma

(2011) Matthias Preusser et al.   ANNALS OF NEUROLOGY

Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases

(2011) Wei Xu et al.   CANCER CELL

A functional polymorphism at microRNA-629-binding site in the 3′-untranslated region of NBS1 gene confers an increased risk of lung cancer in Southern and Eastern Chinese population

(2011) Lei Yang et al.   CARCINOGENESIS

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

A challenging epigenetic message: telomerase activity is associated with complex changes in lifestyle

(2011) András Falus et al.   CELL BIOLOGY INTERNATIONAL

The origins of glioma: E Pluribus Unum?

(2011) F. A. Siebzehnrubl et al.   GLIA

Medical genetics and epigenetics of telomerase

(2011) Jillian E. Koziel et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The alternative lengthening of telomeres pathway may operate in non-neoplastic human cells

(2011) Tania L Slatter et al.   JOURNAL OF PATHOLOGY

MicroRNA therapeutics in preclinical cancer models

(2011) Minlee Kim et al.   LANCET ONCOLOGY

The CDKN2A G500 Allele Is More Frequent in GBM Patients with No Defined Telomere Maintenance Mechanism Tumors and Is Associated with Poorer Survival

(2011) Janice A. Royds et al.   PLoS One

Altered Telomeres in Tumors with ATRX and DAXX Mutations

(2011) C. M. Heaphy et al.   SCIENCE

Alternative Lengthening of Telomeres in Human Glioma Stem Cells

(2011) David C. Silvestre et al.   STEM CELLS

Identification of a CpG Island Methylator Phenotype that Defines a Distinct Subgroup of Glioma

(2010) Houtan Noushmehr et al.   CANCER CELL

Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1

(2010) Roel G.W. Verhaak et al.   CANCER CELL

Assaying and investigating Alternative Lengthening of Telomeres activity in human cells and cancers

(2010) Jeremy D. Henson et al.   FEBS LETTERS

ATRX interacts with H3.3 in maintaining telomere structural integrity in pluripotent embryonic stem cells

(2010) L. H. Wong et al.   GENOME RESEARCH

Alternative lengthening of telomeres pathway: Recombination-mediated telomere maintenance mechanism in human cells

(2010) A. Nabetani et al.   JOURNAL OF BIOCHEMISTRY

Presence of Alternative Lengthening of Telomeres Mechanism in Patients With Glioblastoma Identifies a Less Aggressive Tumor Type With Longer Survival

(2010) Kerrie L. McDonald et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Molecular Dissection of Telomeric Repeat-Containing RNA Biogenesis Unveils the Presence of Distinct and Multiple Regulatory Pathways

(2010) A. Porro et al.   MOLECULAR AND CELLULAR BIOLOGY

Alternative lengthening of telomeres: models, mechanisms and implications

(2010) Anthony J. Cesare et al.   NATURE REVIEWS GENETICS

The non-coding RNA TERRA is a natural ligand and direct inhibitor of human telomerase

(2010) Sophie Redon et al.   NUCLEIC ACIDS RESEARCH

Chromatin and epigenetic regulation of the telomerase reverse transcriptase gene

(2010) Jiyue Zhu et al.   Protein & Cell

Senescence: an antiviral defense that is tumor suppressive?

(2009) R. R. Reddel   CARCINOGENESIS

The Austrian Brain Tumour Registry: a cooperative way to establish a population-based brain tumour registry

(2009) Adelheid Wöhrer et al.   JOURNAL OF NEURO-ONCOLOGY

Telomerase activity is associated with an increase in DNA methylation at the proximal subtelomere and a reduction in telomeric transcription

(2009) Laura J. Ng et al.   NUCLEIC ACIDS RESEARCH

Subtelomeric DNA hypomethylation is not required for telomeric sister chromatid exchanges in ALT cells

(2009) G Tilman et al.   ONCOGENE

CpG-island promoters drive transcription of human telomeres

(2009) S. G. Nergadze et al.   RNA

Hypomethylation of subtelomeric regions in ICF syndrome is associated with abnormally short telomeres and enhanced transcription from telomeric regions

(2008) Shiran Yehezkel et al.   HUMAN MOLECULAR GENETICS

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

(2008) Roger McLendon et al.   NATURE

A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases

(2008) Roberta Benetti et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Malignant Gliomas in Adults

(2008) Patrick Y. Wen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Telomerase redefined: Integrated regulation of hTR and hTERT for telomere maintenance and telomerase activity

(2007) C.J. Cairney et al.   BIOCHIMIE

Alternative lengthening of telomeres (ALT) and chromatin: Is there a connection?

(2007) Thalia Nittis et al.   BIOCHIMIE