期刊
PROTEIN & CELL
卷 1, 期 1, 页码 22-32出版社
SPRINGEROPEN
DOI: 10.1007/s13238-010-0014-1
关键词
telomerase; transcriptional regulation; chromatin; epigenetic regulation; cancer
类别
资金
- NIH [GM071725]
- Pennsylvania State College of Medicine
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM071725] Funding Source: NIH RePORTER
Telomerase expression and telomere maintenance are critical for long-term cell proliferation and survival, and they play important roles in development, aging, and cancer. Cumulating evidence has indicated that regulation of the rate-limiting subunit of human telomerase reverse transcriptase gene (hTERT) is a complex process in normal cells and many cancer cells. In addition to a number of transcriptional activators and repressors, the chromatin environment and epigenetic status of the endogenous hTERT locus are also pivotal for its regulation in normal human somatic cells and in tumorigenesis.
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