A Dynamic Network Model of mTOR Signaling Reveals TSC-Independent mTORC2 Regulation

Blocking the mTOR pathway: a drug discovery perspective

(2011) Carlos Garcia-Echeverria   BIOCHEMICAL SOCIETY TRANSACTIONS

Parameter estimation in systems biology models using spline approximation

(2011) Choujun Zhan et al.   BMC Systems Biology

Activation of mTORC2 by Association with the Ribosome

(2011) Vittoria Zinzalla et al.   CELL

Evidence for Direct Activation of mTORC2 Kinase Activity by Phosphatidylinositol 3,4,5-Trisphosphate

(2011) Xiaoqing Gan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

mTORC2 Is Required for Proliferation and Survival of TSC2-Null Cells

(2011) E. A. Goncharova et al.   MOLECULAR AND CELLULAR BIOLOGY

The long and winding road to rational treatment of cancer associated with LKB1/AMPK/TSC/mTORC1 signaling

(2011) W van Veelen et al.   ONCOGENE

Phosphoproteomic Analysis Identifies Grb10 as an mTORC1 Substrate That Negatively Regulates Insulin Signaling

(2011) Y. Yu et al.   SCIENCE

The mTOR-Regulated Phosphoproteome Reveals a Mechanism of mTORC1-Mediated Inhibition of Growth Factor Signaling

(2011) P. P. Hsu et al.   SCIENCE

mTOR couples cellular nutrient sensing to organismal metabolic homeostasis

(2011) Jessica J. Howell et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

(2010) Yasemin Sancak et al.   CELL

A Ras Signaling Complex Controls the RasC-TORC2 Pathway and Directed Cell Migration

(2010) Pascale G. Charest et al.   DEVELOPMENTAL CELL

Classic and contemporary approaches to modeling biochemical reactions

(2010) W. W. Chen et al.   GENES & DEVELOPMENT

Second AKT: The rise of SGK in cancer signalling

(2010) Maressa A. Bruhn et al.   GROWTH FACTORS

Mass and Information Feedbacks through Receptor Endocytosis Govern Insulin Signaling as Revealed Using a Parameter-free Modeling Framework

(2010) Cecilia Brännmark et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amino Acids Activate Mammalian Target of Rapamycin Complex 2 (mTORC2) via PI3K/Akt Signaling

(2010) Irantzu Tato et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ras-mediated activation of the TORC2–PKB pathway is critical for chemotaxis

(2010) Huaqing Cai et al.   JOURNAL OF CELL BIOLOGY

Involvement of the Cytoskeleton in Controlling Leading-Edge Function during Chemotaxis

(2010) Susan Lee et al.   MOLECULAR BIOLOGY OF THE CELL

Regulation of the mTOR Complex 1 Pathway by Nutrients, Growth Factors, and Stress

(2010) Shomit Sengupta et al.   MOLECULAR CELL

A comprehensive map of the mTOR signaling network

(2010) Etienne Caron et al.   Molecular Systems Biology

The emerging mechanisms of isoform-specific PI3K signalling

(2010) Bart Vanhaesebroeck et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Modelling the Response of FOXO Transcription Factors to Multiple Post-Translational Modifications Made by Ageing-Related Signalling Pathways

(2010) Graham R. Smith et al.   PLoS One

Inferring Signaling Pathway Topologies from Multiple Perturbation Measurements of Specific Biochemical Species

(2010) T.-R. Xu et al.   Science Signaling

Rapamycin inhibits mTORC1, but not completely

(2009) Carson C. Thoreen et al.   Autophagy

Activation of mTORC1 in two steps: Rheb-GTP activation of catalytic function and increased binding of substrates to raptor1

(2009) Joseph Avruch et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Rag proteins regulate amino-acid-induced mTORC1 signalling

(2009) Yasemin Sancak et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

A complex interplay between Akt, TSC2 and the two mTOR complexes: Figure 1

(2009) Jingxiang Huang et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

TORC-Specific Phosphorylation of Mammalian Target of Rapamycin (mTOR): Phospho-Ser2481 Is a Marker for Intact mTOR Signaling Complex 2

(2009) J. Copp et al.   CANCER RESEARCH

Systems Biology Reveals New Strategies for Personalizing Cancer Medicine and Confirms the Role of PTEN in Resistance to Trastuzumab

(2009) D. Faratian et al.   CANCER RESEARCH

Signaling Events Downstream of Mammalian Target of Rapamycin Complex 2 Are Attenuated in Cells and Tumors Deficient for the Tuberous Sclerosis Complex Tumor Suppressors

(2009) J. Huang et al.   CANCER RESEARCH

mTOR and the control of whole body metabolism

(2009) Pazit Polak et al.   CURRENT OPINION IN CELL BIOLOGY

mTOR Ser-2481 Autophosphorylation Monitors mTORC-specific Catalytic Activity and Clarifies Rapamycin Mechanism of Action

(2009) Ghada A. Soliman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1

(2009) Carson C. Thoreen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Improved semiquantitative Western blot technique with increased quantification range

(2009) F. Heidebrecht et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Site-Specific mTOR Phosphorylation Promotes mTORC1-Mediated Signaling and Cell Growth

(2009) H. A. Acosta-Jaquez et al.   MOLECULAR AND CELLULAR BIOLOGY

Quantification of the effect of amino acids on an integrated mTOR and insulin signaling pathway

(2009) Palakkad Krishnan Unni Vinod et al.   Molecular BioSystems

Systems-level interactions between insulin–EGF networks amplify mitogenic signaling

(2009) Nikolay Borisov et al.   Molecular Systems Biology

Harmonic oscillator model of the insulin and IGF1 receptors’ allosteric binding and activation

(2009) Vladislav V Kiselyov et al.   Molecular Systems Biology

The Systems Biology Graphical Notation

(2009) Nicolas Le Novère et al.   NATURE BIOTECHNOLOGY

The nuts and bolts of AGC protein kinases

(2009) Laura R. Pearce et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

TOR complex 2: a signaling pathway of its own

(2009) Nadine Cybulski et al.   TRENDS IN BIOCHEMICAL SCIENCES

Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2

(2009) Morris E Feldman et al.   PLOS BIOLOGY

Signaling Logic of Activity-Triggered Dendritic Protein Synthesis: An mTOR Gate But Not a Feedback Switch

(2009) Pragati Jain et al.   PLoS Computational Biology

TOR regulation of AGC kinases in yeast and mammals

(2008) Estela Jacinto et al.   BIOCHEMICAL JOURNAL

mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

(2008) Juan M. García-Martínez et al.   BIOCHEMICAL JOURNAL

PIP3-Independent Activation of TorC2 and PKB at the Cell's Leading Edge Mediates Chemotaxis

(2008) Yoichiro Kamimura et al.   CURRENT BIOLOGY

Regulation of Proline-rich Akt Substrate of 40 kDa (PRAS40) Function by Mammalian Target of Rapamycin Complex 1 (mTORC1)-mediated Phosphorylation

(2008) Lifu Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The TSC1-TSC2 Complex Is Required for Proper Activation of mTOR Complex 2

(2008) J. Huang et al.   MOLECULAR AND CELLULAR BIOLOGY

PKBα/Akt1 Acts Downstream of DNA-PK in the DNA Double-Strand Break Response and Promotes Survival

(2008) Lana Bozulic et al.   MOLECULAR CELL

Models from experiments: combinatorial drug perturbations of cancer cells

(2008) Sven Nelander et al.   Molecular Systems Biology

Model-Based Hypothesis Testing of Key Mechanisms in Initial Phase of Insulin Signaling

(2008) Gunnar Cedersund et al.   PLoS Computational Biology

The Signaling Petri Net-Based Simulator: A Non-Parametric Strategy for Characterizing the Dynamics of Cell-Specific Signaling Networks

(2008) Derek Ruths et al.   PLoS Computational Biology

Regulation of Akt/PKB activity by P21-activated kinase in cardiomyocytes

(2007) Kai Mao et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY