Class III PI-3-kinase activates phospholipase D in an amino acid–sensing mTORC1 pathway

mTOR signaling: PLD takes center stage

(2011) Yuting Sun et al.   CELL CYCLE

Phosphatidic Acid Activates Mammalian Target of Rapamycin Complex 1 (mTORC1) Kinase by Displacing FK506 Binding Protein 38 (FKBP38) and Exerting an Allosteric Effect

(2011) Mee-Sup Yoon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phospholipase D Mediates Nutrient Input to Mammalian Target of Rapamycin Complex 1 (mTORC1)

(2011) Limei Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Mammalian Class 3 PI3K (PIK3C3) Is Required for Early Embryogenesis and Cell Proliferation

(2011) Xiang Zhou et al.   PLoS One

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

(2010) Yasemin Sancak et al.   CELL

The Late Endosome is Essential for mTORC1 Signaling

(2010) Rory J. Flinn et al.   MOLECULAR BIOLOGY OF THE CELL

PP2AT61ɛ Is an Inhibitor of MAP4K3 in Nutrient Signaling to mTOR

(2010) Lijun Yan et al.   MOLECULAR CELL

Shaping Development of Autophagy Inhibitors with the Structure of the Lipid Kinase Vps34

(2010) S. Miller et al.   SCIENCE

The phospholipase D1 pathway modulates macroautophagy

(2010) Claudia Dall'Armi et al.   Nature Communications

The regulation and function of Class III PI3Ks: novel roles for Vps34

(2008) Jonathan M. Backer   BIOCHEMICAL JOURNAL

hVps15, but not Ca2+/CaM, is required for the activity and regulation of hVps34 in mammalian cells

(2008) Ying Yan et al.   BIOCHEMICAL JOURNAL

Amino Acids Activate mTOR Complex 1 via Ca2+/CaM Signaling to hVps34

(2008) Pawan Gulati et al.   Cell Metabolism

The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling inDrosophila

(2008) Gábor Juhász et al.   JOURNAL OF CELL BIOLOGY

PLD regulates myoblast differentiation through the mTOR-IGF2 pathway

(2008) M.-S. Yoon et al.   JOURNAL OF CELL SCIENCE

Regulation of mTORC1 and mTORC2 Complex Assembly by Phosphatidic Acid: Competition with Rapamycin

(2008) A. Toschi et al.   MOLECULAR AND CELLULAR BIOLOGY

Beclin 1 Forms Two Distinct Phosphatidylinositol 3-Kinase Complexes with Mammalian Atg14 and UVRAG

(2008) Eisuke Itakura et al.   MOLECULAR BIOLOGY OF THE CELL

Regulation of TORC1 by Rag GTPases in nutrient response

(2008) Eunjung Kim et al.   NATURE CELL BIOLOGY

Phospholipase D1 is an effector of Rheb in the mTOR pathway

(2008) Y. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

(2008) Y. Sancak et al.   SCIENCE