Neuro-psychopharmacological perspective of Orphan receptors of Rhodopsin (class A) family of G protein-coupled receptors

The role of polyunsaturated fatty acids and GPR40 receptor in brain

(2017) Muhammad Zahid Khan et al.   NEUROPHARMACOLOGY

The emerging pharmacology and function of GPR35 in the nervous system

(2017) Amanda E. Mackenzie et al.   NEUROPHARMACOLOGY

Mice Lacking GPR88 Show Motor Deficit, Improved Spatial Learning, and Low Anxiety Reversed by Delta Opioid Antagonist

(2016) Aura C. Meirsman et al.   BIOLOGICAL PSYCHIATRY

The emerging role of GPR50 receptor in brain

(2016) Muhammad zahid Khan et al.   BIOMEDICINE & PHARMACOTHERAPY

The emerging roles of human trace amines and human trace amine-associated receptors (hTAARs) in central nervous system

(2016) Muhammad zahid khan et al.   BIOMEDICINE & PHARMACOTHERAPY

mRNA GPR162 changes are associated with decreased food intake in rat, and its human genetic variants with impairments in glucose homeostasis in two Swedish cohorts

(2016) Vanni Caruso et al.   GENE

Identification and molecular docking studies for novel inverse agonists of SREB, super conserved receptor expressed in brain

(2016) Toshihiro Yanai et al.   GENES TO CELLS

Potential antidepressant-like properties of the TC G-1008, a GPR39 (zinc receptor) agonist

(2016) Katarzyna Młyniec et al.   JOURNAL OF AFFECTIVE DISORDERS

Developmental and adult expression patterns of the G-protein-coupled receptor GPR88 in the rat: Establishment of a dual nuclear-cytoplasmic localization

(2016) Renaud Massart et al.   JOURNAL OF COMPARATIVE NEUROLOGY

GPR40 receptor activation leads to CREB phosphorylation and improves cognitive performance in an Alzheimer’s disease mouse model

(2016) Muhammad Zahid Khan et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

CNS remyelination as a novel reparative approach to neurodegenerative diseases: The roles of purinergic signaling and the P2Y-like receptor GPR17

(2016) Marta Fumagalli et al.   NEUROPHARMACOLOGY

Kynurenic acid and zaprinast induce analgesia by modulating HCN channels through GPR35 activation

(2016) Francesco Resta et al.   NEUROPHARMACOLOGY

A new role for the P2Y-like GPR17 receptor in the modulation of multipotency of oligodendrocyte precursor cells in vitro

(2016) Marta Boccazzi et al.   Purinergic Signalling

Identification of GPR83 as the receptor for the neuroendocrine peptide PEN

(2016) Ivone Gomes et al.   Science Signaling

Identification of a small-molecule ligand that activates the neuropeptide receptor GPR171 and increases food intake

(2016) Jonathan H. Wardman et al.   Science Signaling

Design and Synthesis of 2-Alkylpyrimidine-4,6-diol and 6-Alkylpyridine-2,4-diol as Potent GPR84 Agonists

(2016) Yang Liu et al.   ACS Medicinal Chemistry Letters

Identification of GPR83 as the receptor for the neuroendocrine peptide PEN

(2016) Ivone Gomes et al.   Science Signaling

Identification of a small-molecule ligand that activates the neuropeptide receptor GPR171 and increases food intake

(2016) Jonathan H. Wardman et al.   Science Signaling

Neuronal Orphan G-Protein Coupled Receptor Proteins Mediate Plasmalogens-Induced Activation of ERK and Akt Signaling

(2016) Md. Shamim Hossain et al.   PLoS One

The Subcellular Dynamics of the Gs-Linked Receptor GPR3 Contribute to the Local Activation of PKA in Cerebellar Granular Neurons

(2016) Tatsuhiro Miyagi et al.   PLoS One

Study of antidepressant drugs in GPR39 (zinc receptor−/−) knockout mice, showing no effect of conventional antidepressants, but effectiveness of NMDA antagonists

(2015) Katarzyna Młyniec et al.   BEHAVIOURAL BRAIN RESEARCH

G protein coupled receptor 50 promotes self-renewal and neuronal differentiation of embryonic neural progenitor cells through regulation of notch and wnt/β-catenin signalings

(2015) Yan-Xia Ma et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Functional G-protein-coupled receptor 35 is expressed by neurons in the CA1 field of the hippocampus

(2015) Manickavasagom Alkondon et al.   BIOCHEMICAL PHARMACOLOGY

GPR84 deficiency reduces microgliosis, but accelerates dendritic degeneration and cognitive decline in a mouse model of Alzheimer’s disease

(2015) Julie Audoy-Rémus et al.   BRAIN BEHAVIOR AND IMMUNITY

Investigation of the GPR39 zinc receptor following inhibition of monoaminergic neurotransmission and potentialization of glutamatergic neurotransmission

(2015) Katarzyna Młyniec et al.   BRAIN RESEARCH BULLETIN

The Concise Guide to PHARMACOLOGY 2015/16: G protein-coupled receptors

(2015) Stephen PH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

Novel Therapeutic GPCRs for Psychiatric Disorders

(2015) Hidetoshi Komatsu   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

GPR39 Zn2+-sensing receptor: A new target in antidepressant development?

(2015) Katarzyna Młyniec et al.   JOURNAL OF AFFECTIVE DISORDERS

Integrated Approaches for Genome-wide Interrogation of the Druggable Non-olfactory G Protein-coupled Receptor Superfamily

(2015) Bryan L. Roth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Role of G-Protein Receptor 84 in Experimental Neuropathic Pain

(2015) L. S. C. Nicol et al.   JOURNAL OF NEUROSCIENCE

Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65

(2015) Xi-Ping Huang et al.   NATURE

Homeostatic regulation of KCC2 activity by the zinc receptor mZnR/GPR39 during seizures

(2015) David Gilad et al.   NEUROBIOLOGY OF DISEASE

G protein-coupled receptor 26 immunoreactivity in intranuclear inclusions associated with polyglutamine and intranuclear inclusion body diseases

(2015) Fumiaki Mori et al.   NEUROPATHOLOGY

LGR5/GPR49 is implicated in motor neuron specification in nervous system

(2015) Shao-jun Song et al.   NEUROSCIENCE LETTERS

Glycerophospholipid regulation of modality-specific sensory axon guidance in the spinal cord

(2015) A. T. Guy et al.   SCIENCE

Loss of GPR3 reduces the amyloid plaque burden and improves memory in Alzheimer’s disease mouse models

(2015) Yunhong Huang et al.   Science Translational Medicine

The association of GPR85 with PSD-95-neuroligin complex and autism spectrum disorder: a molecular analysis

(2015) Eriko Fujita-Jimbo et al.   Molecular Autism

Involvement of GPR50 polymorphisms in depression: independent replication in a prospective elderly cohort

(2015) Joanne Ryan et al.   Brain and Behavior

Editorial: Orphan GPCRs As Emerging Drug Targets

(2015) Ye Fang et al.   Frontiers in Pharmacology

The therapeutic potential of orphan GPCRs, GPR35 and GPR55

(2015) Derek M. Shore et al.   Frontiers in Pharmacology

G protein-coupled receptor 35: an emerging target in inflammatory and cardiovascular disease

(2015) Nina Divorty et al.   Frontiers in Pharmacology

Synthesis, Pharmacological Characterization, and Structure–Activity Relationship Studies of Small Molecular Agonists for the Orphan GPR88 Receptor

(2014) Chunyang Jin et al.   ACS Chemical Neuroscience

Proton receptor GPR68 expression in dendritic-cell-like S100β-positive cells of rat anterior pituitary gland: GPR68 induces interleukin-6 gene expression in extracellular acidification

(2014) Kotaro Horiguchi et al.   CELL AND TISSUE RESEARCH

G-protein coupled receptor 6 deficiency alters striatal dopamine and cAMP concentrations and reduces dyskinesia in a mouse model of Parkinson's disease

(2014) Patrick Oeckl et al.   EXPERIMENTAL NEUROLOGY

The G protein-coupled receptor GPR162 is widely distributed in the CNS and highly expressed in the hypothalamus and in hedonic feeding areas

(2014) Vanni Caruso et al.   GENE

LGR4/GPR48 Inactivation Leads to Aniridia-Genitourinary Anomalies-Mental Retardation Syndrome Defects

(2014) Tingfang Yi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lgr4 Protein Deficiency Induces Ataxia-like Phenotype in Mice and Impairs Long Term Depression at Cerebellar Parallel Fiber-Purkinje Cell Synapses

(2014) Xin Guan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cutting Edge: GPR35/CXCR8 Is the Receptor of the Mucosal Chemokine CXCL17

(2014) José L. Maravillas-Montero et al.   JOURNAL OF IMMUNOLOGY

Discovery of the First Potent and Orally Available Agonist of the Orphan G-Protein-Coupled Receptor 52

(2014) Masaki Setoh et al.   JOURNAL OF MEDICINAL CHEMISTRY

Local inactivation of Gpr88 in the nucleus accumbens attenuates behavioral deficits elicited by the neonatal administration of phencyclidine in rats

(2014) M Ingallinesi et al.   MOLECULAR PSYCHIATRY

Developmental expression of GPR3 in rodent cerebellar granule neurons is associated with cell survival and protects neurons from various apoptotic stimuli

(2014) Shigeru Tanaka et al.   NEUROBIOLOGY OF DISEASE

Anatomical Transcriptome of G Protein-Coupled Receptors Leads to the Identification of a Novel Therapeutic Candidate GPR52 for Psychiatric Disorders

(2014) Hidetoshi Komatsu et al.   PLoS One

The Top Prescription Drugs of 2012 Globally: Biologics Dominate, But Small Molecule CNS Drugs Hold on to Top Spots

(2013) Craig W. Lindsley   ACS Chemical Neuroscience

LGR5 is a Proneural Factor and is Regulated by OLIG2 in Glioma Stem-Like Cells

(2013) Xing-gang Mao et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

The G Protein-Coupled Receptor 55 Ligandl-α-Lysophosphatidylinositol Exerts Microglia-Dependent Neuroprotection After Excitotoxic Lesion

(2013) Sonja Kallendrusch et al.   GLIA

Melatonin Receptor Genes in Vertebrates

(2013) Di Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Medium-chain Fatty Acid-sensing Receptor, GPR84, Is a Proinflammatory Receptor

(2013) Masakatsu Suzuki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LGR4 acts as a link between the peripheral circadian clock and lipid metabolism in liver

(2013) Feng Wang et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

NG2 Regulates Directional Migration of Oligodendrocyte Precursor Cells via Rho GTPases and Polarity Complex Proteins

(2013) F. Biname et al.   JOURNAL OF NEUROSCIENCE

Ascl1/Mash1 Promotes Brain Oligodendrogenesis during Myelination and Remyelination

(2013) H. Nakatani et al.   JOURNAL OF NEUROSCIENCE

The involvement of the GPR39-Zn(2+)-sensing receptor in the pathophysiology of depression. Studies in rodent models and suicide victims

(2013) Katarzyna Młyniec et al.   NEUROPHARMACOLOGY

Mechanisms regulating the development of oligodendrocytes and central nervous system myelin

(2013) S. Mitew et al.   NEUROSCIENCE

G-Protein Coupled Receptor 83 (GPR83) Signaling Determined by Constitutive and Zinc(II)-Induced Activity

(2013) Anne Müller et al.   PLoS One

Cellular and Molecular Characterization of Multipolar Map5-Expressing Cells: A Subset of Newly Generated, Stage-Specific Parenchymal Cells in the Mammalian Central Nervous System

(2013) Paola Crociara et al.   PLoS One

GPR55, a G-Protein Coupled Receptor for Lysophosphatidylinositol, Plays a Role in Motor Coordination

(2013) Chia-Shan Wu et al.   PLoS One

Plasmalogens Rescue Neuronal Cell Death through an Activation of AKT and ERK Survival Signaling

(2013) Md. Shamim Hossain et al.   PLoS One

GPR35 Activation Reduces Ca2+ Transients and Contributes to the Kynurenic Acid-Dependent Reduction of Synaptic Activity at CA3-CA1 Synapses

(2013) Rolando Berlinguer-Palmini et al.   PLoS One

Rod Photoreceptors Express GPR55 in the Adult Vervet Monkey Retina

(2013) Joseph Bouskila et al.   PLoS One

GPR171 is a hypothalamic G protein-coupled receptor for BigLEN, a neuropeptide involved in feeding

(2013) I. Gomes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cannabinoid- and lysophosphatidylinositol-sensitive receptor GPR55 boosts neurotransmitter release at central synapses

(2013) S. Sylantyev et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Changes of the GPR17 receptor, a new target for neurorepair, in neurons and glial cells in patients with traumatic brain injury

(2013) Heike Franke et al.   Purinergic Signalling

Chemical Probe Identification Platform for Orphan GPCRs Using Focused Compound Screening: GPR39 as a Case Example

(2013) Markus Boehm et al.   ACS Medicinal Chemistry Letters

Association study in three different populations between the GPR88 gene and major psychoses

(2013) Maria Del Zompo et al.   Molecular Genetics & Genomic Medicine

Regulated Expression of pH Sensing G Protein-Coupled Receptor-68 Identified through Chemical Biology Defines a New Drug Target for Ischemic Heart Disease

(2012) Jamie L. Russell et al.   ACS Chemical Biology

Coupling Hippocampal Neurogenesis to Brain pH through Proneurogenic Small Molecules That Regulate Proton Sensing G Protein-Coupled Receptors

(2012) Jay W. Schneider et al.   ACS Chemical Neuroscience

Developmental Expression of Orphan G Protein-Coupled Receptor 50 in the Mouse Brain

(2012) Ellen Grünewald et al.   ACS Chemical Neuroscience

The role of the GPR39 receptor in zinc deficient-animal model of depression

(2012) Katarzyna Młyniec et al.   BEHAVIOURAL BRAIN RESEARCH

Functions of plasmalogen lipids in health and disease

(2012) Nancy E. Braverman et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The orphan receptor GPR3 modulates the early phases of cocaine reinforcement

(2012) Clara Tourino et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Proton-activated G Protein Coupled Receptor OGR1 Acutely Regulates the Activity of Epithelial Proton Transport Proteins

(2012) Nilufar Mohebbi et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

SREB2/GPR85, a schizophrenia risk factor, negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent learning and memory

(2012) Qian Chen et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

How much of reinforcement learning is working memory, not reinforcement learning? A behavioral, computational, and neurogenetic analysis

(2012) Anne G. E. Collins et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Gpr171, a putative P2Y-like receptor, negatively regulates myeloid differentiation in murine hematopoietic progenitors

(2012) Lara Rossi et al.   EXPERIMENTAL HEMATOLOGY

Attenuated stress-evoked anxiety, increased sucrose preference and delayed spatial learning in glucocorticoid-induced receptor-deficient mice

(2012) L. E. Vollmer et al.   GENES BRAIN AND BEHAVIOR

The Chemokine Superfamily Revisited

(2012) Albert Zlotnik et al.   IMMUNITY

Neuroanatomical distribution of the orphan GPR50 receptor in adult sheep and rodent brains

(2012) M. Batailler et al.   JOURNAL OF NEUROENDOCRINOLOGY

Anti-inflammatory/anti-amyloidogenic effects of plasmalogens in lipopolysaccharide-induced neuroinflammation in adult mice

(2012) Masataka Ifuku et al.   Journal of Neuroinflammation

Downregulation of GPR83 in the hypothalamic preoptic area reduces core body temperature and elevates circulating levels of adiponectin

(2012) Jeffrey S. Dubins et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

β-arrestin 2 regulates Aβ generation and γ-secretase activity in Alzheimer's disease

(2012) Amantha Thathiah et al.   NATURE MEDICINE

Lack of GPR88 enhances medium spiny neuron activity and alters motor- and cue-dependent behaviors

(2012) Albert Quintana et al.   NATURE NEUROSCIENCE

Synaptic plasticity in neuronal circuits regulating energy balance

(2012) Lori M Zeltser et al.   NATURE NEUROSCIENCE

SNARE-dependent upregulation of potassium chloride co-transporter 2 activity after metabotropic zinc receptor activation in rat cortical neurons in vitro

(2012) R.A. Saadi et al.   NEUROSCIENCE

Targeted Inactivation of GPR26 Leads to Hyperphagia and Adiposity by Activating AMPK in the Hypothalamus

(2012) Daohong Chen et al.   PLoS One

Multiple tyrosine metabolites are GPR35 agonists

(2012) Huayun Deng et al.   Scientific Reports

Dorsal root ganglion – a potential new therapeutic target for neuropathic pain

(2012) Damir Sapunar et al.   Journal of Pain Research

Involvement of GPR12 in the induction of neurite outgrowth in PC12 cells

(2011) Xiaoming Lu et al.   BRAIN RESEARCH BULLETIN

A Role for the Melatonin-Related Receptor GPR50 in Leptin Signaling, Adaptive Thermogenesis, and Torpor

(2011) David A. Bechtold et al.   CURRENT BIOLOGY

The G protein coupled receptor Gpr153 shares common evolutionary origin with Gpr162 and is highly expressed in central regions including the thalamus, cerebellum and the arcuate nucleus

(2011) Smitha Sreedharan et al.   FEBS Journal

The GPR17 receptor in NG2 expressing cells: Focus on in vivocell maturation and participation in acute trauma and chronic damage

(2011) Enrica Boda et al.   GLIA

Insulin-like Growth Factor 1-mediated Hyperthermia Involves Anterior Hypothalamic Insulin Receptors

(2011) Manuel Sanchez-Alavez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phenotypic Changes, Signaling Pathway, and Functional Correlates of GPR17-expressing Neural Precursor Cells during Oligodendrocyte Differentiation

(2011) Marta Fumagalli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TLR4 mutation reduces microglial activation, increases Aβ deposits and exacerbates cognitive deficits in a mouse model of Alzheimer's disease

(2011) Min Song et al.   Journal of Neuroinflammation

Upregulation of KCC2 Activity by Zinc-Mediated Neurotransmission via the mZnR/GPR39 Receptor

(2011) E. Chorin et al.   JOURNAL OF NEUROSCIENCE

CC Chemokine Receptor 2 Deficiency Aggravates Cognitive Impairments and Amyloid Pathology in a Transgenic Mouse Model of Alzheimer's Disease

(2011) G. Naert et al.   JOURNAL OF NEUROSCIENCE

Distinct and Non-Redundant Roles of Microglia and Myeloid Subsets in Mouse Models of Alzheimer's Disease

(2011) A. Mildner et al.   JOURNAL OF NEUROSCIENCE

Characterization of metabolic phenotypes of mice lacking GPR61, an orphan G-protein coupled receptor

(2011) Hirohide Nambu et al.   LIFE SCIENCES

Minireview: Recent Developments in the Physiology and Pathology of the Lysophosphatidylinositol-Sensitive Receptor GPR55

(2011) Christopher M. Henstridge et al.   MOLECULAR ENDOCRINOLOGY

Genetic Approaches to Investigate the Role of CREB in Neuronal Plasticity and Memory

(2011) Angel Barco et al.   MOLECULAR NEUROBIOLOGY

Trends in the exploitation of novel drug targets

(2011) Mathias Rask-Andersen et al.   NATURE REVIEWS DRUG DISCOVERY

GPR3 orphan receptor is involved in neuropathic pain after peripheral nerve injury and regulates morphine-induced antinociception

(2011) Jessica Ruiz-Medina et al.   NEUROPHARMACOLOGY

GPR26-deficient mice display increased anxiety- and depression-like behaviors accompanied by reduced phosphorylated cyclic AMP responsive element-binding protein level in central amygdala

(2011) L.-L. Zhang et al.   NEUROSCIENCE

The new P2Y-like receptor G protein-coupled receptor 17 mediates acute neuronal injury and late microgliosis after focal cerebral ischemia in rats

(2011) B. Zhao et al.   NEUROSCIENCE

Lysophosphatidylinositol Causes Neurite Retraction via GPR55, G13 and RhoA in PC12 Cells

(2011) Yutaro Obara et al.   PLoS One

R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/ -catenin signaling

(2011) K. S. Carmon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Emerging role of extracellular nucleotides and adenosine in multiple sclerosis

(2011) Marek Cieślak et al.   Purinergic Signalling

Orthologue selectivity and ligand bias: translating the pharmacology of GPR35

(2011) Graeme Milligan   TRENDS IN PHARMACOLOGICAL SCIENCES

GPR35 as a Novel Therapeutic Target

(2011) A. E. MacKenzie et al.   Frontiers in Endocrinology

GPR35 is a novel lysophosphatidic acid receptor

(2010) Saori Oka et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Expression of functional GPR35 in human iNKT cells

(2010) Silvia Fallarini et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

GPR55 ligands promote receptor coupling to multiple signalling pathways

(2010) Christopher M Henstridge et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cardiolipin Remodeling by ALCAT1 Links Oxidative Stress and Mitochondrial Dysfunction to Obesity

(2010) Jia Li et al.   Cell Metabolism

TNF-α and neuropathic pain - a review

(2010) Lawrence Leung et al.   Journal of Neuroinflammation

The K+-Cl−cotransporter KCC2 promotes GABAergic excitation in the mature rat hippocampus

(2010) Tero Viitanen et al.   JOURNAL OF PHYSIOLOGY-LONDON

Expression of the orphan GPR50 protein in rodent and human dorsomedial hypothalamus, tanycytes and median eminence

(2010) Anissa Sidibe et al.   JOURNAL OF PINEAL RESEARCH

Circulating plasmalogen levels and Alzheimer Disease Assessment Scale–Cognitive scores in Alzheimer patients

(2010) Paul Wood   JOURNAL OF PSYCHIATRY & NEUROSCIENCE

O2 regulates stem cells through Wnt/β-catenin signalling

(2010) Jolly Mazumdar et al.   NATURE CELL BIOLOGY

G-protein coupled receptor 35 (GPR35) activation and inflammatory pain: Studies on the antinociceptive effects of kynurenic acid and zaprinast

(2010) Cristina Cosi et al.   NEUROPHARMACOLOGY

Association of GPR50, an X-linked orphan G protein-coupled receptor, and affective disorder in an independent sample of the Scottish population

(2010) Donald J. MacIntyre et al.   NEUROSCIENCE LETTERS

G-Protein-Coupled Receptor 35 Is a Target of the Asthma Drugs Cromolyn Disodium and Nedocromil Sodium

(2010) Yuhua Yang et al.   PHARMACOLOGY

Single cell transcriptomics of hypothalamic warm sensitive neurons that control core body temperature and fever response

(2010) James Eberwine et al.   PHARMACOLOGY & THERAPEUTICS

TAAR6 variations possibly associated with antidepressant response and suicidal behavior

(2010) Chi-Un Pae et al.   PSYCHIATRY RESEARCH

The P2Y-like receptor GPR17 as a sensor of damage and a new potential target in spinal cord injury

(2009) Stefania Ceruti et al.   BRAIN

AMPK: An Emerging Drug Target for Diabetes and the Metabolic Syndrome

(2009) Bei B. Zhang et al.   Cell Metabolism

Stable Expression of Neurogenin 1 Induces LGR5, a Novel Stem Cell Marker, in an Immortalized Human Neural Stem Cell Line HB1.F3

(2009) Jun-ichi Satoh et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Cerebellar ataxias

(2009) Mario Manto et al.   CURRENT OPINION IN NEUROLOGY

Regulation of bone formation and remodeling by G-protein-coupled receptor 48

(2009) J. Luo et al.   DEVELOPMENT

Insulin Causes Hyperthermia by Direct Inhibition of Warm-Sensitive Neurons

(2009) M. Sanchez-Alavez et al.   DIABETES

Differential changes in GPR55 during microglial cell activation

(2009) Maciej Pietr et al.   FEBS LETTERS

Role of the oligodendroglial cytoskeleton in differentiation and myelination

(2009) Nina G. Bauer et al.   GLIA

Lipid G Protein-coupled Receptor Ligand Identification Using β-Arrestin PathHunter™ Assay

(2009) Hong Yin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kynurenic Acid Triggers Firm Arrest of Leukocytes to Vascular Endothelium under Flow Conditions

(2009) Marita C. Barth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inflammation and Microglia Actions in Alzheimer’s Disease

(2009) Colin K. Combs   Journal of Neuroimmune Pharmacology

Synaptically Released Zinc Triggers Metabotropic Signaling via a Zinc-Sensing Receptor in the Hippocampus

(2009) L. Besser et al.   JOURNAL OF NEUROSCIENCE

The orphan GPCR, GPR88, modulates function of the striatal dopamine system: A possible therapeutic target for psychiatric disorders?

(2009) Sheree F. Logue et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

The oligodendrocyte-specific G protein–coupled receptor GPR17 is a cell-intrinsic timer of myelination

(2009) Ying Chen et al.   NATURE NEUROSCIENCE

Formation and maintenance of Alzheimer's disease β-amyloid plaques in the absence of microglia

(2009) Stefan A Grathwohl et al.   NATURE NEUROSCIENCE

Cation-Chloride Cotransporters and Neuronal Function

(2009) Peter Blaesse et al.   NEURON

Computational Influence of Adult Neurogenesis on Memory Encoding

(2009) James B. Aimone et al.   NEURON

The neurobiology of memory based predictions

(2009) H. Eichenbaum et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

GPR3 Receptor, a Novel Actor in the Emotional-Like Responses

(2009) Olga Valverde et al.   PLoS One

The Gs-Linked Receptor GPR3 Inhibits the Proliferation of Cerebellar Granule Cells during Postnatal Development

(2009) Shigeru Tanaka et al.   PLoS One

Lipid levels in female patients with affective disorders

(2009) Marina Sagud et al.   PSYCHIATRY RESEARCH

The Orphan G Protein-Coupled Receptor 3 Modulates Amyloid-Beta Peptide Generation in Neurons

(2009) A. Thathiah et al.   SCIENCE

GPR12 Selections of the metabolites from an endophytic Streptomyces sp. Asociated with Cistanches deserticola

(2008) Zhen-Jian Lin et al.   ARCHIVES OF PHARMACAL RESEARCH

Anatomical Profiling of G Protein-Coupled Receptor Expression

(2008) Jean B. Regard et al.   CELL

Mechanisms and Functional Implications of Adult Neurogenesis

(2008) Chunmei Zhao et al.   CELL

The contribution of failing adult hippocampal neurogenesis to psychiatric disorders

(2008) Gerd Kempermann et al.   CURRENT OPINION IN PSYCHIATRY

Mu-opioid receptor activation induces transcriptional plasticity in the central extended amygdala

(2008) K. Befort et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

The GPR55 ligand l-α-lysophosphatidylinositol promotes RhoA-dependent Ca2+ signaling and NFAT activation

(2008) Christopher M. Henstridge et al.   FASEB JOURNAL

2-Arachidonoyl-sn-glycero-3-phosphoinositol: A Possible Natural Ligand for GPR55

(2008) S. Oka et al.   JOURNAL OF BIOCHEMISTRY

Metabolic Acidosis Increases Intracellular Calcium in Bone Cells Through Activation of the Proton Receptor OGR1

(2008) Kevin K Frick et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Integrin clustering enables anandamide-induced Ca2+ signaling in endothelial cells via GPR55 by protection against CB1-receptor-triggered repression

(2008) M. Waldeck-Weiermair et al.   JOURNAL OF CELL SCIENCE

Role of AMP-Activated Protein Kinase in the Control of Appetite

(2008) B. Kola   JOURNAL OF NEUROENDOCRINOLOGY

G-Protein-Coupled Receptor Screen Reveals a Role for Chemokine Receptor CCR5 in Suppressing Microglial Neurotoxicity

(2008) K. Gamo et al.   JOURNAL OF NEUROSCIENCE

Persistence of abnormal cortisol levels in elderly persons after recovery from major depression

(2008) Isabelle Beluche et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation

(2008) Liqin Zhu et al.   NATURE

Crypt stem cells as the cells-of-origin of intestinal cancer

(2008) Nick Barker et al.   NATURE

Lgr5 marks cycling, yet long-lived, hair follicle stem cells

(2008) Viljar Jaks et al.   NATURE GENETICS

Cell type–specific regulation of DARPP-32 phosphorylation by psychostimulant and antipsychotic drugs

(2008) Helen S Bateup et al.   NATURE NEUROSCIENCE

A2A adenosine receptor regulates glia proliferation and pain after peripheral nerve injury

(2008) Andreea S. Bura et al.   PAIN

The Recently Identified P2Y-Like Receptor GPR17 Is a Sensor of Brain Damage and a New Target for Brain Repair

(2008) Davide Lecca et al.   PLoS One

GPR55 is a cannabinoid receptor that increases intracellular calcium and inhibits M current

(2008) J. E. Lauckner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The evolutionarily conserved G protein-coupled receptor SREB2/GPR85 influences brain size, behavior, and vulnerability to schizophrenia

(2008) M. Matsumoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Altered metabolism in the melatonin-related receptor (GPR50) knockout mouse

(2007) Elena A. Ivanova et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

GPR35 is a functional receptor in rat dorsal root ganglion neurons

(2007) Hiroyuki Ohshiro et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

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