Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65

Integrated Approaches for Genome-wide Interrogation of the Druggable Non-olfactory G Protein-coupled Receptor Superfamily

(2015) Bryan L. Roth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of inflammation by extracellular acidification and proton-sensing GPCRs

(2013) Fumikazu Okajima   CELLULAR SIGNALLING

Role of extracellular proton-sensing OGR1 in regulation of insulin secretion and pancreatic ^|^beta;-cell functions

(2013) Chihiro Mogi et al.   ENDOCRINE JOURNAL

Targeting Low-Druggability Bromodomains: Fragment Based Screening and Inhibitor Design against the BAZ2B Bromodomain

(2013) Fleur M. Ferguson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Regulated Expression of pH Sensing G Protein-Coupled Receptor-68 Identified through Chemical Biology Defines a New Drug Target for Ischemic Heart Disease

(2012) Jamie L. Russell et al.   ACS Chemical Biology

Coupling Hippocampal Neurogenesis to Brain pH through Proneurogenic Small Molecules That Regulate Proton Sensing G Protein-Coupled Receptors

(2012) Jay W. Schneider et al.   ACS Chemical Neuroscience

The Proton-activated G Protein Coupled Receptor OGR1 Acutely Regulates the Activity of Epithelial Proton Transport Proteins

(2012) Nilufar Mohebbi et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Activation of T cell death-associated gene 8 regulates the cytokine production of T cells and macrophages in vitro

(2012) Yoshiko Onozawa et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

A-kinase anchoring proteins regulate compartmentalized cAMP signaling in airway smooth muscle

(2012) Sarah J. Horvat et al.   FASEB JOURNAL

Ovarian cancer G-protein-coupled receptor 1 induces the expression of the pain mediator prostaglandin E2 in response to an acidic extracellular environment in human osteoblast-like cells

(2012) Juqiang Wang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Automated design of ligands to polypharmacological profiles

(2012) Jérémy Besnard et al.   NATURE

Extracellular acidification induces connective tissue growth factor production through proton-sensing receptor OGR1 in human airway smooth muscle cells

(2011) Shinichi Matsuzaki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The GPCR OGR1 (GPR68) mediates diverse signalling and contraction of airway smooth muscle in response to small reductions in extracellular pH

(2011) H Saxena et al.   BRITISH JOURNAL OF PHARMACOLOGY

Where will new neuroscience therapies come from?

(2011) Darryle D. Schoepp   NATURE REVIEWS DRUG DISCOVERY

ChEMBL: a large-scale bioactivity database for drug discovery

(2011) A. Gaulton et al.   NUCLEIC ACIDS RESEARCH

Ovarian cancer G protein-coupled receptor 1-dependent and -independent vascular actions to acidic pH in human aortic smooth muscle cells

(2010) Jin-Peng Liu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Extracellular acidification stimulates IL-6 production and Ca2+ mobilization through proton-sensing OGR1 receptors in human airway smooth muscle cells

(2010) Isao Ichimonji et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Identification of Human Ether-à-go-go Related Gene Modulators by Three Screening Platforms in an Academic Drug-Discovery Setting

(2010) Xi-Ping Huang et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Rapid Context-Dependent Ligand Desolvation in Molecular Docking

(2010) Michael M. Mysinger et al.   Journal of Chemical Information and Modeling

Directed molecular evolution of DREADDs: a generic approach to creating next-generation RASSLs

(2010) Shuyun Dong et al.   Nature Protocols

Expression and Function of Proton-Sensing G-Protein-Coupled Receptors in Inflammatory Pain

(2009) Ying-Ju Chen et al.   Molecular Pain

Predicting new molecular targets for known drugs

(2009) Michael J. Keiser et al.   NATURE

GPCR 3D homology models for ligand screening: Lessons learned from blind predictions of adenosine A2a receptor complex

(2009) Vsevolod Katritch et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Anatomical Profiling of G Protein-Coupled Receptor Expression

(2008) Jean B. Regard et al.   CELL

Metabolic Acidosis Increases Intracellular Calcium in Bone Cells Through Activation of the Proton Receptor OGR1

(2008) Kevin K Frick et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Quantifying the Relationships among Drug Classes

(2008) Jérôme Hert et al.   Journal of Chemical Information and Modeling

Discovery of Novel Chemotypes to a G-Protein-Coupled Receptor through Ligand-Steered Homology Modeling and Structure-Based Virtual Screening

(2008) Claudio N. Cavasotto et al.   JOURNAL OF MEDICINAL CHEMISTRY

Building alternate protein structures using the elastic network model

(2008) Qingyi Yang et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Orphan GPCR research

(2007) S Chung et al.   BRITISH JOURNAL OF PHARMACOLOGY

The adenosine A1 receptor antagonist SLV320 reduces myocardial fibrosis in rats with 5/6 nephrectomy without affecting blood pressure

(2007) P Kalk et al.   BRITISH JOURNAL OF PHARMACOLOGY