Article
Oncology
Jun Li, Gang Peng, Kuikui Zhu, Xiaohua Jie, Yingzhuo Xu, Xinrui Rao, Yunhong Xu, Yunshang Chen, Biyuan Xing, Gang Wu, Liangliang Shi
Summary: This study found that mast cells are poor prognostic factors associated with resistance to anti-PD-1 immunotherapy. The PD-1 antibody can activate PD-1(+) mast cells to release histamine and cytokines, thereby playing a negative role in the tumor microenvironment. Inhibition of mast cells may provide a new solution to improve the response rate of anti-PD-1 immunotherapy.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Pharmacology & Pharmacy
Pier Giorgio Puzzovio, Thayse R. Brueggemann, Hadas Pahima, David Mankuta, Bruce D. Levy, Francesca Levi-Schaffer
Summary: The study found that Cromolyn Sodium has immunomodulatory actions in allergic inflammation that go beyond just stabilizing mast cells, indicating broader mechanisms at play.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Multidisciplinary Sciences
Gregory A. Wyant, Wenyu Yu, IIias P. Doulamis, Rio S. Nomoto, Mossab Y. Saeed, Thomas Duignan, James D. McCully, William G. Kaelin Jr
Summary: Kynurenic acid (KynA) has tissue-protective effects in ischemia models, and this study demonstrates that activation of GPR35 and interaction with ATPIF1 may be the underlying mechanism. These findings provide a rationale for developing specific GPR35 agonists for the treatment of ischemic diseases.
Article
Pharmacology & Pharmacy
Xiaoli Wei, Fan Yin, Miaomiao Wu, Qianqian Xie, Xueqin Zhao, Cheng Zhu, Ruiqian Xie, Chongqing Chen, Menghua Liu, Xueying Wang, Ruixue Ren, Guijie Kang, Chenwen Zhu, Jingjing Cong, Hua Wang, Xuefu Wang
Summary: Nonalcoholic fatty liver disease (NAFLD) is a common chronic liver disease worldwide. G protein-coupled receptor 35 (GPR35) plays a role in metabolic stresses, but its role in NAFLD has been unknown. In this study, we found that hepatocyte GPR35 regulates hepatic cholesterol homeostasis and mitigates NASH. Overexpression of GPR35 protected against diet-induced steatohepatitis, while loss of GPR35 had the opposite effect. Activation of GPR35 with the agonist kynurenic acid (Kyna) suppressed steatohepatitis in mice.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Instruments & Instrumentation
Shereen Kesserwan, Li Mao, Roshanak Sharafieh, Donald L. Kreutzer, Ulrike Klueh
Summary: The study focused on stabilizing mast cells to mitigate the inflammatory response caused by insulin phenolic preservatives, using Cromolyn sodium (CS). Results showed that CS can reduce inflammation triggered by insulin phenolic preservatives, potentially extending the longevity of insulin infusion sets. Further research may confirm the importance of mast cells in insulin infusion therapy through different models.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Article
Gastroenterology & Hepatology
Hanife Yurdakul Ertan, Gunnur Ozbakis Dengiz, Figen Barut, Yonca Yilmaz Urun, Murat Can, Shemsu Umer Hussen, Yucel Ustundag
Summary: The study aimed to compare the effects of cromolyn sodium and other medications on cholestatic pruritus and related parameters in an experimental cholestasis model. Cromolyn sodium showed significant improvements in serum histamine and autotaxin levels, total bile acids, bilirubin, and biliary enzymes compared to the control group. Furthermore, it demonstrated promising antipruritic efficacy and histopathological recovery. Peribiliary mast cells were found to produce autotaxin, an important pruritogenic signal in cholestasis.
TURKISH JOURNAL OF GASTROENTEROLOGY
(2023)