Novel Therapeutic GPCRs for Psychiatric Disorders

Schizophrenia drug discovery and development in an evolving era: Are new drug targets fulfilling expectations?

(2015) John Dunlop et al.   JOURNAL OF PSYCHOPHARMACOLOGY

A striatal-enriched intronic GPCR modulates huntingtin levels and toxicity

(2015) Yuwei Yao et al.   eLife

Temporal and Spatial Transcriptional Fingerprints by Antipsychotic or Propsychotic Drugs in Mouse Brain

(2015) Kensuke Sakuma et al.   PLoS One

Synthesis, Pharmacological Characterization, and Structure–Activity Relationship Studies of Small Molecular Agonists for the Orphan GPR88 Receptor

(2014) Chunyang Jin et al.   ACS Chemical Neuroscience

G-protein coupled receptor 6 deficiency alters striatal dopamine and cAMP concentrations and reduces dyskinesia in a mouse model of Parkinson's disease

(2014) Patrick Oeckl et al.   EXPERIMENTAL NEUROLOGY

Two new adenosine receptor antagonists for the treatment of Parkinson's disease: istradefylline versus tozadenant

(2014) Santiago Perez-Lloret et al.   EXPERT OPINION ON PHARMACOTHERAPY

Discovery of the First Potent and Orally Available Agonist of the Orphan G-Protein-Coupled Receptor 52

(2014) Masaki Setoh et al.   JOURNAL OF MEDICINAL CHEMISTRY

Local inactivation of Gpr88 in the nucleus accumbens attenuates behavioral deficits elicited by the neonatal administration of phencyclidine in rats

(2014) M Ingallinesi et al.   MOLECULAR PSYCHIATRY

Anatomical Transcriptome of G Protein-Coupled Receptors Leads to the Identification of a Novel Therapeutic Candidate GPR52 for Psychiatric Disorders

(2014) Hidetoshi Komatsu et al.   PLoS One

Local control of striatal dopamine release

(2014) Roger Cachope et al.   Frontiers in Behavioral Neuroscience

Antipsychotics in Adults With Schizophrenia: Comparative Effectiveness of First-Generation Versus Second-Generation Medications

(2013) Lisa Hartling et al.   ANNALS OF INTERNAL MEDICINE

Association study in three different populations between the GPR88 gene and major psychoses

(2013) Maria Del Zompo et al.   Molecular Genetics & Genomic Medicine

How much of reinforcement learning is working memory, not reinforcement learning? A behavioral, computational, and neurogenetic analysis

(2012) Anne G. E. Collins et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Lack of GPR88 enhances medium spiny neuron activity and alters motor- and cue-dependent behaviors

(2012) Albert Quintana et al.   NATURE NEUROSCIENCE

Unraveling the Differential Functions and Regulation of Striatal Neuron Sub-Populations in Motor Control, Reward, and Motivational Processes

(2011) Sabrina Ena et al.   Frontiers in Behavioral Neuroscience

Agonist-Trafficking and Hallucinogens

(2009) Javier Gonzalez-Maeso et al.   CURRENT MEDICINAL CHEMISTRY

Tuning and Fine-Tuning of Synapses with Adenosine

(2009) A. Sebastiao et al.   Current Neuropharmacology

Lipid G Protein-coupled Receptor Ligand Identification Using β-Arrestin PathHunter™ Assay

(2009) Hong Yin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The orphan GPCR, GPR88, modulates function of the striatal dopamine system: A possible therapeutic target for psychiatric disorders?

(2009) Sheree F. Logue et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Anatomical Profiling of G Protein-Coupled Receptor Expression

(2008) Jean B. Regard et al.   CELL

A Critical Role of the Adenosine A2A Receptor in Extrastriatal Neurons in Modulating Psychomotor Activity as Revealed by Opposite Phenotypes of Striatum and Forebrain A2A Receptor Knock-Outs

(2008) H.-Y. Shen et al.   JOURNAL OF NEUROSCIENCE

Cell type–specific regulation of DARPP-32 phosphorylation by psychostimulant and antipsychotic drugs

(2008) Helen S Bateup et al.   NATURE NEUROSCIENCE