Article
Orthopedics
Minghui Sun, Weijun Wang, Lingtian Min, Cheng Chen, Qing Li, Wenjie Weng
Summary: Overexpression of SFRP5 in ATDC5 cells inhibits LPS-induced inflammation and apoptosis by repressing Wnt5a/JNK signaling. The inhibitory effect of SFRP5 on inflammation and apoptosis is weakened by overexpressing Wnt5a, suggesting that Wnt5a/JNK activation may play a role in mediating the protective actions of SFRP5.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2021)
Article
Physiology
Jiarui Cui, Yo Shibata, Keiji Itaka, Jun Zhou, Jiaming Zhang
Summary: This study used bioinformatic analyses to identify the impact of exercise on cartilage transcriptome, revealing that exercise suppressed genes related to various cellular functions and inflammatory responses, with downregulated genes being more stable over time. Additionally, the study identified time-related signaling pathways and clusters of genes responsive to exercise duration, advancing the understanding of cartilage homeostasis.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Nutrition & Dietetics
Chun-De Liao, Shih-Wei Huang, Hung-Chou Chen, Yu-Yun Huang, Tsan-Hon Liou, Che-Li Lin
Summary: This study investigated the treatment efficiency of protein supplementation combined with resistance exercise training on walking speed recovery in older adults with knee osteoarthritis and sarcopenia. The results showed that the combination of protein supplementation and resistance exercise training was more effective in promoting walking speed recovery.
Article
Biochemistry & Molecular Biology
Colombe Otis, Emilie Bouet, Sokhna Keita-Alassane, Marilyn Frezier, Alienor Delsart, Martin Guillot, Agathe Bedard, Jean-Pierre Pelletier, Johanne Martel-Pelletier, Bertrand Lussier, Francis Beaudry, Eric Troncy
Summary: Validating animal pain models is crucial for enhancing translational research and pharmacological treatment response. This study found that a calibrated slight exercise protocol combined with multimodal analgesia had positive effects on the MI-RAT model, particularly when used in conjunction with positive analgesics, reducing sensitivity to pain and improving joint structure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Yang Gu, Ying Ding, Xin Zhang, Yong Li, Zhenglu Shang
Summary: The upregulation of SFRP3 can inhibit cardiac remodeling and oxidative stress, thereby improving the adverse outcomes of heart failure.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Orthopedics
J. J. Bjerre-Bastos, H. B. Nielsen, J. R. Andersen, M. Karsdal, A. -C. Bay-Jensen, M. Boesen, A. L. Mackey, I. Byrjalsen, A. R. Bihlet
Summary: The study found that moderate intensity exercise in knee osteoarthritis patients led to acute changes in biochemical markers of cartilage turnover, with cycling and running impacting the degradation of type II and type VI collagen differently.
OSTEOARTHRITIS AND CARTILAGE
(2021)
Article
Medicine, General & Internal
Yukun Yin, Yuanyu Zhang, Li Guo, Pengcui Li, Dongming Wang, Lingan Huang, Xiaoqin Zhao, Gaige Wu, Lu Li, Xiaochun Wei
Summary: This study aimed to evaluate the effect of exercise on the superficial zone of the osteoarticular cartilage during osteoarthritis progression. The results showed that exercise increased the number of cells and the content of proteoglycan in the superficial zone, changed the distribution of collagen, improved the Young's modulus of the cartilage, and reduced abnormal subchondral bone remodeling. Moreover, exercise also played a role in delaying the degeneration of articular cartilage through the TGF beta/pSmad2/3 signaling pathway and Prg4 expression.
Article
Endocrinology & Metabolism
Senxin Cai, Yuchun Zou, Yong Zhao, Hanyu Lin, Dali Zheng, Linyu Xu, Youguang Lu
Summary: This study found that mechanical stress plays a significant role in the growth and development of the tempormandibular joint (TMJ), and is involved in the progression of TMJ osteoarthritis (TMJOA) through the regulation of Wnt/β-catenin signaling and secreted frizzled-related proteins (SFRPs).
Article
Orthopedics
B. Bodic, M. A. Boutet, C. Boyer, B. Metayer, C. Vignes, J. Lesoeur, J. Veziers, V. Daguin, F. Haspot, Y. Maugars, F. Djouad, J. Guicheux, C. Vinatier
Summary: This study demonstrated the feasibility of inducing osteoarthritis (OA) in immunologically humanized mice by destabilization of the medial meniscus (DMM). The developed OA model could serve as a useful tool for bridging the gap between preclinical and clinical evaluation of immune interacting disease-modifying osteoarthritis drugs (DMOADs) and cell-based therapies.
OSTEOARTHRITIS AND CARTILAGE
(2022)
Article
Orthopedics
Xiaobin Huang, Leilei Zhong, Eefje van Helvoort, Floris Lafeber, Simon Mastbergen, Jan Hendriks, Janine N. Post, Marcel Karperien
Summary: The study suggests that DKK1 and FRZB are negatively correlated with the severity of osteoarthritis (OA) and multiple proinflammatory cytokines, indicating their potential as joint disease-specific biomarkers.
Article
Endocrinology & Metabolism
Yu Bai, Qiang Du, Ranhua Jiang, Le Zhang, Runyu Du, Na Wu, Ping Li, Ling Li
Summary: In adolescents from Northeast China, lower levels of plasma SFRP5 are strongly associated with increased risk of high fasting plasma glucose and high total cholesterol. This suggests a close relationship between SFRP5 and lipid and glucose metabolism in adolescents.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2021)
Article
Biology
Blagovesta Boneva, Nikola Ralchev, Petya Ganova, Andrey Tchorbanov, Nikolina Mihaylova
Summary: This study investigated the role of different types of immune cells in the development of osteoarthritis, finding infiltration of B lymphocytes and effector T cells, activation of cytotoxic T cells and NK cell populations, and differentiation of NK cells from a cytotoxic phenotype to an effector phenotype in different stages of the disease.
Article
Cell Biology
Jae Min Cho, Seul-Ki Park, Rajeshwary Ghosh, Kellsey Ly, Caroline Ramous, Lauren Thompson, Michele Hansen, Maria Sara de Lima Coutinho Mattera, Karla Maria Pires, Maroua Ferhat, Sohom Mookherjee, Kevin J. Whitehead, Kandis Carter, Marcio Buffolo, Sihem Boudina, J. David Symons
Summary: Protein quality control mechanisms decline during cardiac aging, leading to accumulation of protein aggregates and organelle damage. However, late-in-life exercise training can improve autophagy, protein aggregate clearance, and overall heart function in old mice.
Article
Biotechnology & Applied Microbiology
Hao Hu, Xu Huang, Yankun Dai, Kairun Zhu, Xuwen Ye, Shengdong Meng, Qing Zhang, Xueguan Xie
Summary: In this study, a novel nanomaterial strategy was applied to overcome osteoarthritis (OA) in a mouse model. Mil-88a nanozyme, a Fe-MOF, was synthesized and its toxic effects were evaluated. The results showed that Mil-88a could promote the expression of OA anabolism-related genes and inhibit the expression of OA catabolism-related genes. Moreover, treatment with Mil-88a nano-enzyme on organic metal matrix significantly improved the OARSI score in the animal model.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Lyudmila Belenska-Todorova, Sevdalina Nikolova Lambova, Stela Stoyanova, Elenka Georgieva, Tsvetelina Batsalova, Dzhemal Moten, Desislava Kolchakova, Balik Dzhambazov
Summary: The study investigated the effects of metformin, alendronate, and their combination in the treatment of osteoarthritis. It was found that treatment with either metformin, alendronate, or their combination could inhibit some pathological changes, reduce the levels of inflammatory mediators in the serum, and alleviate the degree of cartilage degeneration.
Article
Rheumatology
Kevin L. Winthrop, John D. Isaacs, Philip J. Mease, Dimitrios T. Boumpas, Xenofon Baraliakos, Jacques-Eric Gottenberg, Stefan Siebert, Marta Mosca, Neil Basu, Dana Orange, R. Lories, Daniel Aletaha, Iain B. McInnes, Tom W. J. Huizinga, Reinhard E. Voll, Ellen M. Gravallese, Ferry C. Breedveld, Josef S. Smolen
Summary: This article summarizes the unmet clinical and scientific needs in the field of rheumatology. It highlights the importance of clinical trial design innovation and the need to better understand the natural history of rheumatic diseases. The article also identifies the specific unmet needs in different rheumatological disease-specific groups and emphasizes the importance of developing therapies and therapeutic strategies for treatment-refractory disease.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Orthopedics
S. A. Elahi, R. Castro-Vinuelas, P. Tanska, R. K. Korhonen, R. Lories, N. Famaey, I. Jonkers
Summary: In silico approach was used to study the main mechanisms of cartilage degeneration in osteoarthritis. Collagen degradation drives degenerative changes in intact and degenerated cartilage, while mechanical loading initially causes proteoglycans depletion in the presence of a focal cartilage defect.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Article
Orthopedics
J. Quintiens, A. De Roover, F. M. F. Cornelis, A. Escribano-Nun, A. Sermon, S. Pazmino, S. Monteagudo, R. J. Lories
Summary: This study identified the hypoxia and Wnt signaling pathways as regulators of ANP32A expression. Hypoxia increased ANP32A levels, while Wnt hyper-activation decreased ANP32A levels. The modulation of the ATM gene by hypoxia and Wnt was also observed. Maintaining hypoxia and limiting Wnt activation are important for protecting against osteoarthritis.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Review
Rheumatology
Jonas J. W. Kuiper, Joerg C. Prinz, Efstratios Stratikos, Piotr Kusnierczyk, Akiko Arakawa, Sebastian Springer, Dillon Mintoff, Ivan Padjen, Russka Shumnalieva, Secil Vural, Ina Koetter, Marleen G. van de Sande, Ayse Boyvat, Joke H. de Boer, George Bertsias, Niek de Vries, Charlotte L. M. Krieckaert, Ines Leal, Natasa Vidovic Valentincic, Ilknur Tugal-Tutkun, Hanane el Khaldi Ahanach, Felicie Costantino, Simon Glatigny, Danijela Mrazovac Zimak, Fabian Loetscher, Floor G. Kerstens, Marija Bakula, Elsa Viera Sousa, Peter Boehm, Kees Bosman, Tony J. Kenna, Simon J. Powis, Maxime Breban, Ahmet Gul, John Bowes, Rik J. U. Lories, Johannes Nowatzky, Gerrit Jan Wolbink, Dennis G. McGonagle, Franktien Turkstra
Summary: The 'MHC-I-opathy' concept describes a group of inflammatory diseases with overlapping clinical manifestations and a strong genetic link to the MHC-I antigen presentation pathway. However, the understanding and treatment of these disorders is limited due to patient heterogeneity and lack of systematic investigation. Therefore, interdisciplinary collaboration is needed to decipher the underlying disease mechanisms.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Reem Assi, Chahrazad Cherifi, Frederique M. F. Cornelis, Qiongfei Zhou, Lies Storms, Sofia Pazmino, Rodrigo Coutinho de Almeida, Ingrid Meulenbelt, Rik J. J. Lories, Silvia Monteagudo
Summary: The methylation of H3K79me is reduced in osteoarthritis. Histone demethylase families, such as Jumonji-C and KDM2/7, can increase the levels of H3K79me and targeting KDM2/7 can protect joints against osteoarthritis.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Pharmacology & Pharmacy
Reem Assi, Jolien Quintiens, Silvia Monteagudo, Rik J. J. Lories
Summary: Osteoarthritis is a chronic joint disease characterized by progressive damage to the joints, causing pain and loss of function. Intra-articular drug therapy has emerged as a potential treatment option, with drugs being injected directly into affected joints to optimize drug bioavailability and reduce systemic toxicity. This review explores the current landscape of intra-articular drug therapies for osteoarthritis, including established approaches and those in clinical development. Despite challenges in defining outcome measures and optimizing clinical trial set-ups, advancements in drug development and clinical trial design hold promise for successful therapies for this important disease.
Article
Cardiac & Cardiovascular Systems
Ruben De Bosscher, Christophe Dausin, Piet Claus, Jan Bogaert, Steven Dymarkowski, Kaatje Goetschalckx, Olivier Ghekiere, Caroline M. van de Heyning, Paul Van Herck, Bernard Paelinck, Haroun El Addouli, Andre La Gerche, Lieven Herbots, Rik Willems, Hein Heidbuchel, Guido Claessen, Mathias Claeys, Peter Hespel, Tom Dresselaers, Hielko Miljoen, Ann Belmans, Kasper Favere, Dorien Vermeulen, Isabel Witvrouwen, Dominique Hansen, Bert Op't Eijnde, Daisy Thijs, Peter Vanvoorden, Sofie Van Soest
Summary: The impact of long-term endurance sport participation on coronary atherosclerosis and acute cardiac events remains controversial. A study found that lifelong endurance athletes had a higher prevalence of coronary plaques compared to healthy individuals. Further research is needed to understand the risk of cardiovascular events in high-intensity endurance exercise.
EUROPEAN HEART JOURNAL
(2023)
Article
Physiology
Chiel Poff, Ruben Robberechts, Myrthe Stalmans, Jan Vanderroost, Stijn Bogaerts, Peter Hespel
Summary: Exogenous ketosis improves psychocognitive functioning and stimulates muscular recovery during exercise. Ketone ester supplementation counters the decline in psychocognitive functioning and promotes postexercise muscular recovery in ultra-endurance exercise.
JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Article
Neurosciences
Chiel Poffe, Ruben Robberechts, Ruud Van Thienen, Peter Hespel
Summary: During a 3-week endurance training overload period, the ingestion of ketone ester can increase pro-angiogenic factors and stimulate muscular angiogenesis, potentially improving the adaptation to endurance training.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Orthopedics
Stijn Arnaert, Paul Byttebier, Sam Van Rossom, Evie Vereecke, Ilse Jonkers, Edwin Oei, Sita M. A. Bierma-Zeinstra, Rik Lories, Marienke van Middelkoop, Stefan Clockaerts
Summary: This study investigates the characteristics of the anterior tibiotalar fat pad (ATFP) in the ankle joint after one year of an ankle sprain and its correlation with systemic factors and local articular pathology. The results suggest that age, body mass index (BMI), and sex are significantly associated with the T1 intensity of ATFP. Age, diffuse cartilage loss in the lateral talus, and Kellgren and Lawrence score in the tibiotalar joint are negatively associated with the area of ATFP. BMI is positively associated with the ATFP area.
Article
Rheumatology
Manouk de Hooge, Alla Ishchenko, Ann-Sophie De Craemer, Serge Steinfeld, Adrien Nzeusseu, Dirk Elewaut, Rik Lories, Kurt de Vlam, Filip van den Bosch
Summary: This study aimed to examine radiographic axial damage of the sacroiliac joints and spine in patients with psoriatic arthritis (PsA) and spondyloarthritis (SpA) in private and academic Belgian practices. The data comparison between the two patient groups found that patients with SpA tend to have more severe spinal damage compared to those with PsA. In patients with PsA, the cervical spine is more often affected, while in patients with SpA, the location of syndesmophytes is more evenly distributed.
Article
Rheumatology
Manouk de Hooge, Alla Ischenko, Serge Steinfeld, Adrien Nzeusseu, Dirk Elewaut, Rik Lories, Filip van den Bosch, Kurt De Vlam
Summary: This study investigates the association between different definitions of axial involvement and syndesmophytes development in patients with Psoriatic Arthritis (PsA). The results show that the probability of developing syndesmophytes is much higher when axial involvement is determined radiographically rather than clinically, particularly in the context of high CRP.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Immunology
Mariia Dzhus, Lisa Ehlers, Marjon Wouters, Katrien Jansen, Rik Schrijvers, Lien De Somer, Steven Vanderschueren, Marco Baggio, Leen Moens, Benjamin Verhaaren, Rik Lories, Giorgia Bucciol, Isabelle Meyts
Summary: Deficiency of human adenosine deaminase type 2 (DADA2) is a rare autoimmune disorder characterized by vasculopathy, immune dysregulation, and hematologic abnormalities. Neurological manifestations, particularly strokes, are a significant feature of DADA2, with brain stem and deep gray matter being commonly affected. Other neurological involvements include neuropathies, focal deficits, ophthalmological findings, convulsions, and headaches. Recognizing the diverse neurological manifestations of DADA2 is crucial for accurate diagnosis and appropriate management.
JOURNAL OF CLINICAL IMMUNOLOGY
(2023)
Review
Rheumatology
Ennio Lubrano, Silvia Scriffignano, Kurt de Vlam, Mario Ronga, Fabio Massimo Perrotta, Rik Lories
Summary: Psoriatic arthritis (PsA) is a complex and chronic inflammatory disease that combines arthritis and psoriasis with other conditions and comorbidities. Non-pharmacological approaches such as diet modifications, improved sleep quality, and physical activity have been shown to improve the quality of life for PsA patients.
Article
Nutrition & Dietetics
Ruben Robberechts, Chiel Poffe, Noemie Ampe, Stijn Bogaerts, Peter Hespel
Summary: This study compared the effects of collagen peptide and whey protein supplementation on muscle damage and recovery during eccentric exercise training. The results showed that substituting a portion of whey protein for collagen peptide within a similar total protein dose did not improve indices of muscle damage or functional outcomes during eccentric training.
INTERNATIONAL JOURNAL OF SPORT NUTRITION AND EXERCISE METABOLISM
(2023)