Article
Cell Biology
Rui Sun, Lixiazi He, Hyeyoon Lee, Andrey Glinka, Carolin Andresen, Daniel Huebschmann, Irmela Jeremias, Karin Mueller-Decker, Caroline Pabst, Christof Niehrs
Summary: RSPO2 promotes self-renewal of AML cells and may serve as a marker for poor prognosis. It maintains AML self-renewal independently of WNT by inhibiting BMP receptor signaling.
Article
Developmental Biology
Sho Tsukamoto, Mai Kuratani, Shinya Tanaka, Eijiro Jimi, Hiromi Oda, Takenobu Katagiri
Summary: Endochondral ossification is important for longitudinal skeletal growth. Osteoblasts, near hypertrophic chondrocytes, contribute to bone formation during this process. Smad4 knockout mice showed increased bone volume due to enhanced osteoblast-mediated bone formation via the Wnt7b-ft-catenin axis. Wnt7b, expressed in differentiated chondrocytes, was suppressed by BMP4 stimulation. Deletion of Wnt7b reduced bone increase in Smad4 knockout mice and inhibited skeletal growth in juveniles, highlighting its role in initiating endochondral ossification.
Article
Multidisciplinary Sciences
Kosei Nagata, Hironori Hojo, Song Ho Chang, Hiroyuki Okada, Fumiko Yano, Ryota Chijimatsu, Yasunori Omata, Daisuke Mori, Yuma Makii, Manabu Kawata, Taizo Kaneko, Yasuhide Iwanaga, Hideki Nakamoto, Yuji Maenohara, Naohiro Tachibana, Hisatoshi Ishikura, Junya Higuchi, Yuki Taniguchi, Shinsuke Ohba, Ung-il Chung, Sakae Tanaka, Taku Saito
Summary: The transcription factors Runx2 and Runx3 play different roles in the development of osteoarthritis. Runx3 protects articular cartilage by regulating the expression of lubricin and aggrecan, while Runx2 exerts biphasic effects on osteoarthritis development under different conditions.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Alice H. Reis, Sergei Y. Sokol
Summary: In Xenopus anteroposterior axis specification, Rspo2 acts as a Wnt antagonist by inhibiting TCF3/TCF7L1 phosphorylation, therefore suppressing target gene activation. This mechanism suggests that Rspo2 is a context-specific regulator of TCF3 phosphorylation and Wnt signaling.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Xiaofeng Zhou, Yingting He, Nian Li, Guofeng Bai, Xiangchun Pan, Zhe Zhang, Hao Zhang, Jiaqi Li, Xiaolong Yuan
Summary: In female mammals, the proliferation, apoptosis, and estradiol-17 beta (E2) secretion of granulosa cells (GCs) have a crucial role in determining the fate of follicles. The Wnt signaling pathway, specifically the DNA methylation and RSPO2 gene, are involved in GC survival and follicular development. Hypomethylation of specific regions in the RSPO2 promoter enhances the transcription of RSPO2, which promotes GC proliferation and E2 secretion while inhibiting apoptosis, ultimately benefiting follicular development via the Wnt signaling pathway.
CELL DEATH & DISEASE
(2021)
Article
Cell Biology
Chunhui Zhu, Gang Liu, Weiding Cui, Zhongjie Yu, Wei Chen, Yao Qin, Jiuxiang Liu, Yaojun Lu, Weimin Fan, Wenwei Liang
Summary: The Rspo2 gene is elevated in synovial tissues of osteoarthritis (OA) patients. In this study, we found that astaxanthin and Rspo2 have therapeutic effects on OA. Astaxanthin can reverse the increase in inflammatory factors and decrease in anabolic markers, as well as suppress the secretion of Rspo2.
Article
Biochemistry & Molecular Biology
Ahmed A. Raslan, Youn Jeong Oh, Yong Ri Jin, Jeong Kyo Yoon
Summary: The lungs have the ability to regenerate damaged tissues caused by acute injury, but many lung diseases are associated with reduced regeneration potential. This study investigates the role of R-spondin2 (RSPO2) in adult lung homeostasis and regeneration. The findings suggest that RSPO2 plays a key role in promoting the regeneration of lung epithelial stem/progenitor cells, and could be a potential therapeutic target for chronic lung diseases with reduced regenerative capability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell & Tissue Engineering
Xuan Wang, Tianwei He, Lei He, Bu Yang, Zhongyu Liu, Mao Pang, Peigen Xie, Liangming Zhang, Limin Rong
Summary: The study demonstrates that melatonin enhances the hypertrophic differentiation of MSC-derived chondrocytes through the Wnt signaling pathway, increasing chondrocyte cell volume and type X collagen expression while decreasing type II collagen expression.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Medicine, Research & Experimental
Xiaohui Chen, Shengxing Wang, Zhan Cui, Yutong Gu
Summary: Muscle and adipose tissue-derived mesenchymal stem cells have high osteogenic potentials and can modulate osteoblast function through releasing extracellular vesicles containing miRNAs. This study found that BMSC-EVs enriched with miR-497-5p could accelerate ossification of the posterior longitudinal ligament (OPLL) by delivering miRNAs to ligament fibroblasts and modulating the RSPO2-mediated Wnt/β-catenin pathway.
Article
Oncology
Kun Chen, Zheng Wang, Qi-Bei Zong, Meng-Ying Zhou, Qing-Fa Chen
Summary: Numerous studies have found a relationship between cancer formation and aberrant microRNA expression. This study found that miR-497-5p expression was significantly lower in GBM tissues compared to normal brain glial cells. Mechanistic investigations revealed that miR-497-5p suppresses the Wnt/beta-catenin signaling pathway by targeting RSPO2, leading to reduced cell proliferation, migration, and invasion in GBM.
Article
Oncology
Morgan K. K. Penny, Antonio M. M. Lerario, Kaitlin J. J. Basham, Sahiti Chukkapalli, Dipika R. R. Mohan, Chris LaPensee, Kimber Converso-Baran, Mark J. J. Hoenerhoff, Laura Suarez-Fernandez, Carmen Gonzalez del Rey, Thomas J. J. Giordano, Ruolan Han, Erika A. A. Newman, Gary D. D. Hammer
Summary: Adrenocortical carcinoma (ACC) is a rare and aggressive cancer with limited treatment options. This study identified a novel Wnt/β-catenin-associated signature enriched in ECM, which was predictive of poor survival in ACC patients. Inhibition of Wnt/β-catenin signaling reduced ECM expression and cancer cell viability, suggesting it as a potential therapeutic strategy for ACC.
Article
Cell Biology
Renee F. C. Hein, Joshua H. Wu, Emily M. Holloway, Tristan Frum, Ansley S. Conchola, Yu-Hwai Tsai, Angeline Wu, Alexis S. Fine, Alyssa J. Miller, Emmanuelle Szenker-Ravi, Kelley S. Yan, Calvin J. Kuo, Ian Glass, Tristan Frum, Ian Glass, Bruno Reversade, Jason R. Spence
Summary: During human lung development, there is a population of mesenchymal cells highly enriched for the RSPO2 gene expression, which plays a critical role in supporting the maintenance and multipotency of the nearby bud tip progenitor cells through enhancing WNT signaling.
DEVELOPMENTAL CELL
(2022)
Review
Genetics & Heredity
Yiqian Zhang, Xenab Ahmadpoor, Hang Lin
Summary: The growth plate is a cartilaginous tissue that contributes to bone lengthening during development. Injury to the growth plate can result in growth arrest or disorder, affecting leg length and causing deformity. This review explores the regulatory network of the growth plate, the roles of specific factors, and potential engineering approaches for this unique tissue.
Article
Multidisciplinary Sciences
Rulu Pan, Yan Yu, Haiyan Zhu, Wenyi Zhang, Yuan Qin, Lin Ye, Juji Dai, Ren Huang, Xinyan Peng, Siqi Ye, Ziqi Lin, Shishun Huang, Shuyi Chong, Liting Lu, Xincheng Lu
Summary: RSPO2 promotes the growth and metastasis of ovarian cancer through the activation of FAK/Src signaling cascades. It prevents the endocytic degradation of LGR4 and promotes LGR4-mediated translocation of Src to the plasma membrane. In addition, it directly binds to integrin beta 3 and enhances the stability of integrins. High expression of RSPO2 is associated with poor prognosis in ovarian tumors.
Article
Cell Biology
Marta Marchini, Mitchell R. Ashkin, Melina Bellini, Margaret Man-Ger Sun, Matthew Lloyd Workentine, Hamza Malik Okuyan, Roman Krawetz, Frank Beier, Campbell Rolian
Summary: The genetic and developmental mechanisms of limb formation are well understood, but how chondrocyte physiology modulates these mechanisms to produce differences in limb bone length is unclear. Through RNA sequencing and cell culture experiments, it was found that NKA plays a key role in chondrocyte differentiation and regulation of bone length, with implications for limb length diversity.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Orthopedics
Yutaro Kuwahara, Yasuhiko Takegami, Katsuhiro Tokutake, Yotaro Yamada, Kentaro Komaki, Shiro Imagama
Summary: This study investigated whether low body mass index (BMI) can predict the risk of mortality in elderly patients with distal femur fractures within 18 months after injury, and evaluated its impact on postoperative clinical outcomes and mortality. The results showed that low BMI was an independent risk factor for increased mortality and impaired postoperative functional recovery.
JOURNAL OF ORTHOPAEDIC SCIENCE
(2023)
Article
Orthopedics
Kosuke Bando, Yasuhiko Takegami, Toshihiro Ando, Takayuki Sugino, Toshifumi Sato, Tomoki Fujita, Shiro Imagama
Summary: This study compared early weight bearing with delayed weight bearing after surgical repair for ankle fractures. The findings showed that there were no significant differences in functional outcomes between the two groups, but the early weight bearing group had lower rates of deep infection and reoperation. Therefore, early postoperative weight bearing is recommended for patients with surgically treated ankle fractures.
JOURNAL OF ORTHOPAEDIC SCIENCE
(2023)
Article
Orthopedics
Daisaku Kato, Yasuhiko Takegami, Taisuke Seki, Yusuke Osawa, Genta Takemoto, Masanori Okamoto, Hiroki Iida, Shiro Imagama
Summary: The aim of this study was to evaluate the impact of different types of cementless stems on patient quality of life and patient-reported outcomes (PRO), and to clarify the relationship between PRO and stem-cortical bone contact. The study included 138 patients undergoing cementless total hip arthroplasty. The results showed no significant differences in PRO between stem types according to the JHEQ and patient's joint perception. Patients with a taper wedge stem had a higher frequency of peri-hip articular joint pain (PHAP) compared to those with a fit-and-fill stem. Distal contact was associated with PHAP in both groups, but not with JHEQ results and patient's joint perception.
JOURNAL OF ORTHOPAEDICS
(2023)
Article
Orthopedics
Saki Sakurai, Yasuhiko Takegami, Katsuhiro Tokutake, Yutaro Kuwahara, Ryutaro Shibata, Hideyuki Ota, Hiroaki Kumagai, Shiro Imagama
Summary: This study compared the postoperative clinical and radiographic outcomes between super-elderly and middle-elderly patients with distal radius fractures treated with volar locking plate fixation, and found comparable results between the two groups.
INDIAN JOURNAL OF ORTHOPAEDICS
(2023)
Article
Orthopedics
Keita Naruse, Yasuhiko Takegami, Katsuhiro Tokutake, Keita Shimizu, Yoshito Sudo, Takaaki Shinohara, Shiro Imagama
Summary: The purpose of this study was to investigate the rate of surgical treatment for lateral meniscal injury in patients with tibial plateau fracture (TPF) and to clarify the explanatory radiographic factors associated with meniscal injury. The results showed that 27.7% of TPF cases required repair for lateral meniscal injury, and bone fragment size and the location of fracture line on radiographs were associated with meniscus injuries requiring surgery.
INDIAN JOURNAL OF ORTHOPAEDICS
(2023)
Article
Critical Care Medicine
Ken Sato, Yasuhiko Takegami, Katsuhiro Tokutake, Yuya Shimamoto, Hiroki Ueno, Toshihiro Ando, Shiro Imagama
Summary: This study aimed to examine the mortality rate and predictors associated with mortality in elderly patients who have sustained humeral shaft fragility fractures (HSFF). Retrospective data from a TRON database was analyzed using multivariable Cox regression analysis. The results showed a mortality rate of 15.7% at 1 year and 24.6% at 2 years for HSFF in the elderly. Factors such as older age, underweight, severe illness, limited mobility, dominant-side injury, and nonoperative treatment were significant predictors of mortality.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2023)
Review
Biochemistry & Molecular Biology
Kinji Ohno, Bisei Ohkawara, Xin-Ming Shen, Duygu Selcen, Andrew G. Engel
Summary: Congenital myasthenic syndromes (CMS) are a group of heterogeneous disorders characterized by impaired neuromuscular signal transmission due to germline pathogenic variants in genes expressed at the neuromuscular junction (NMJ). A total of 35 genes have been reported in CMS, which can be classified into 14 groups based on the pathomechanical, clinical, and therapeutic features of CMS patients. Diagnosing CMS requires measurement of compound muscle action potentials elicited by repetitive nerve stimulation, and accurate diagnosis always requires genetic studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Orthopedics
Yasutaka Oshika, Yasuhiko Takegami, Katsuhiro Tokutake, Hiroki Yokoyama, Takeshi Oguchi, Shiro Imagama
Summary: The purpose of the study was to identify the incidence and factors associated with postoperative ulnar nerve neuropathy in patients who underwent open reduction and internal fixation for intraarticular distal humerus fractures. A retrospective review of 116 patients was conducted, and it was found that olecranon osteotomy was the only independent factor associated with preventing ulnar nerve neuropathy.
JOURNAL OF HAND SURGERY-AMERICAN VOLUME
(2023)
Article
Endocrinology & Metabolism
Yutaro Fuse, Kazuhito Takeuchi, Hiroshi Nishiwaki, Takahiro Imaizumi, Yuichi Nagata, Kinji Ohno, Ryuta Saito
Summary: This study aimed to develop tools for predicting delayed hyponatremia (DHN) in patients undergoing endoscopic transsphenoidal surgery (eTSS) for pituitary neuroendocrine tumors (PitNETs). Machine learning models using pre- and post-operative clinical variables were able to accurately predict the occurrence of DHN.
Article
Environmental Sciences
Zhizhou Huang, Mikako Ito, Shaochuan Zhang, Takuro Toda, Jun-ichi Takeda, Tomoo Ogi, Kinji Ohno
Summary: This study found that exposure to ELF-EMF for 3 hours can activate acetylation of HSPs, enhance protein folding, and have positive effects on cells.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Orthopedics
Yutaro Kuwahara, Yasuhiko Takegami, So Mitsuya, Katsuhiro Tokutake, Kenichi Yamauchi, Shiro Imagama
Summary: Locked tension band wiring (LTBW) is a modified technique developed to reduce implant-related complications in the treatment of olecranon fractures. This retrospective study compared LTBW with conventional tension band wiring (CTBW) and found that LTBW had a significantly lower complication rate and removal rate, with equivalent functional outcomes. However, LTBW did have a longer operation time compared to CTBW.
INDIAN JOURNAL OF ORTHOPAEDICS
(2023)
Article
Biochemistry & Molecular Biology
Samira Bushra, Ying-Ni Lin, Atefeh Joudaki, Mikako Ito, Bisei Ohkawara, Kinji Ohno, Akio Masuda
Summary: Agrin is a crucial heparan sulfate proteoglycan that clusters acetylcholine receptors at the neuromuscular junction. The inclusion of Y and Z exons in neuronal isoforms of agrin is regulated by binding sites for PTBP1, which were found to be enriched in the human AGRN gene. PTBP1-silencing enhanced the coordinated inclusion of Y and Z exons, while deletion analysis identified five PTBP1-binding sites with significant splicing repression activities. Neuronal differentiation downregulates PTBP1 expression and promotes the coordinated inclusion of Y and Z exons, suggesting that the reduction of the PTBP1-RNA network is essential for generating neuron-specific agrin isoforms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Bisei Ohkawara, Masaomi Kurokawa, Akinori Kanai, Kiyomi Imamura, Guiying Chen, Ruchen Zhang, Akio Masuda, Koichi Higashi, Hiroshi Mori, Yutaka Suzuki, Ken Kurokawa, Kinji Ohno
Summary: During embryonic development, the formation of the neuromuscular junction is regulated by a series of genes. Analysis of embryonic and neonatal mouse diaphragms reveals distinct gene expression patterns in each muscle nucleus during the formation of the neuromuscular junction. Some of these genes play important roles in the process.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
