Article
Biochemistry & Molecular Biology
Fang Li, Qizhao Tan, Feng Li, Ke Zhang, Zhongjun Liu, Yun Tian, Tengjiao Zhu
Summary: This study reveals that hypoxia in subchondral bone plays a crucial role in the crosstalk between chondrocytes and osteoblasts, and promotes the shift of chondrocytes toward an OA-like phenotype probably by activating the Wnt/beta-catenin signaling pathway in osteoblasts.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Rheumatology
Margo Tuerlings, Marcella van Hoolwerff, Jessica M. van Bokkum, H. Eka D. Suchiman, Nico Lakenberg, Demien Broekhuis, Rob G. H. H. Nelissen, Yolande F. M. Ramos, Hailiang Mei, Davy Cats, Rodrigo Coutinho de Almeida, Ingrid Meulenbelt
Summary: This study identified a dysregulated lncRNA, AC005165.1, in the articular cartilage and subchondral bone of osteoarthritis (OA). Downregulation of AC005165.1 resulted in decreased expression of the OA risk gene FRZB, suggesting that AC005165.1 could be a potential therapeutic target for OA.
Review
Endocrinology & Metabolism
Shihua Zhang, Tingting Li, Yao Feng, Keping Zhang, Jun Zou, Xiquan Weng, Yu Yuan, Lan Zhang
Summary: Articular cartilage degeneration causes various joint diseases, with osteoarthritis being the most typical. Osteoarthritis is characterized by cartilage degeneration and persistent pain, impacting patient's quality of life and placing a burden on society. The occurrence and development of osteoarthritis is connected to subchondral bone microenvironment disorder. Exercise can improve the subchondral bone microenvironment, but the specific mechanism remains unclear.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Biology
Hope C. Ball, Andrew L. Alejo, Trinity K. Samson, Amanda M. Alejo, Fayez F. Safadi
Summary: This review provides an updated overview of the epigenetic factors involved in osteoarthritis, discussing their impact on the onset and development of the disease, and exploring current therapeutic options targeting aberrant epigenetic regulation.
Article
Endocrinology & Metabolism
Hetong Li, Yu Gou, Faming Tian, Ya Zhang, Qiangqiang Lian, Yunpeng Hu, Liu Zhang
Summary: The combined intervention of metformin and exercise showed significant preventative and therapeutic effects on osteoarthritis induced by estrogen deficiency and obesity, improving cartilage lesions and bone degeneration, as well as enhancing bone mass and microarchitecture.
Review
Medicine, General & Internal
Angelos Kaspiris, Argyris C. C. Hadjimichael, Ioanna Lianou, Ilias D. D. Iliopoulos, Dimitrios Ntourantonis, Dimitra Melissaridou, Olga D. D. Savvidou, Evangelia Papadimitriou, Efstathios Chronopoulos
Summary: Osteoarthritis is a degenerative joint disease that primarily affects weight-bearing joints in middle-aged and elderly patients, leading to dysfunction and pain. This study aimed to explore the pathophysiology of subchondral bone cysts (SBCs) in osteoarthritis, as well as their association with disease progression, clinical symptoms, postoperative outcomes, and potential complications. A literature review on PubMed articles revealed theories involving MMPs secretion, angiogenesis, and enhanced bone turnover as responses to abnormal mechanical loads in the development of SBCs. Additionally, novel therapies such as celecoxib-coated microspheres and local administration of IGF-1 and activated chondrocytes showed promise in hindering SBC expansion and preventing osteoarthritis progression if untreated.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Chenyang Zhuang, Zixiang Wang, Weisin Chen, Hanquan Wang, Bo Tian, Hong Lin
Summary: The study demonstrates that Jtg inhibits osteoclast differentiation in subchondral bone and chondrocyte apoptosis in cartilage through the NF-κB signaling pathway, indicating its potential therapeutic value for treating OA. In vivo evaluation shows that Jtg significantly attenuates subchondral bone remodeling and cartilage destruction in ACLT mouse models.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Cell Biology
Ze Du, Xuanhe You, Diwei Wu, Shishu Huang, Zongke Zhou
Summary: Osteoarthritis (OA) is a leading cause of disabilities in older people, and multiple disease-related molecular networks have been identified. Recent research suggests that rhythmic disturbances in the central nervous system and local joint tissues affect joint homeostasis and exacerbate OA progression. However, the mechanisms of rhythm changes in joint tissues remain poorly understood, and studying the impact of rhythmic genes on metabolism and inflammation could enhance our understanding of OA pathology.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Chemistry, Multidisciplinary
Hengli Lu, Jihu Wei, Kaiyuan Liu, Zihua Li, Tianyang Xu, Dong Yang, Qiuming Gao, Huijing Xiang, Guodong Li, Yu Chen
Summary: A dual-functional medication has been developed to protect cartilage and repair subchondral bone simultaneously. Black phosphorus nanosheets (BPNSs) effectively eliminate intracellular reactive oxygen species (ROS), restore chondrocyte function, and regulate inflammation, providing disease-modifying effects on osteoarthritis (OA). In vivo assessments confirm that BPNSs inhibit cartilage degradation and prevent OA progression, making them a competitive candidate for OA treatment.
Article
Immunology
Gundula Roesch, Dominique Muschter, Shahed Taheri, Karima El Bagdadi, Christoph Dorn, Andrea Meurer, Frank Zaucke, Arndt F. Schilling, Susanne Graessel, Rainer H. Straub, Zsuzsa Jenei-Lanzl
Summary: Recent studies have shown that beta 2-adrenoceptors (ARs) contribute to the development of osteoarthritis (OA). In this study, the role of beta 2-AR in knee OA was investigated using beta 2-AR-deficient mice. The results showed that beta 2-AR deficiency led to changes in cartilage degeneration, synovial inflammation, and subchondral bone remodeling in OA. These findings suggest that beta 2-AR plays a significant role in OA-related subchondral bone remodeling and could be a potential target for new therapeutic approaches.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Jiazi Gao, Pengling Ren, He Gong
Summary: This study investigated the morphological and mechanical changes in articular cartilage and subchondral bone during spontaneous hip osteoarthritis in guinea pigs. The results showed that the micromechanical properties of articular cartilage were the lowest at 1 month of age, and the earliest degeneration of articular cartilage occurred at 6 months of age. No degeneration in the micro- or nanostructure of subchondral bone was observed before 9 months. These findings provide valuable insights into the formation and progression of hip osteoarthritis.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Cell Biology
Xiaoxin Wu, Ross Crawford, Yin Xiao, Xinzhan Mao, Indira Prasadam
Summary: The miR-210-5p enriched in exosomes derived from sclerotic subchondral bone osteoblasts of OA plays a critical role in altering the bioenergetic state of chondrocytes, promoting cartilage degeneration. Targeting these exosomes may be a potential therapeutic intervention for OA.
Article
Endocrinology & Metabolism
Zihuan Yang, Qizhao Tan, Zhenda Zhao, Guodong Niu, Siwei Li, Weishi Li, Chunli Song, Huijie Leng
Summary: This study compared the osteochondral changes in post-traumatic OA and ovariectomy-induced OA, and found distinct behaviors in the osteochondral unit. Subchondral bone degradation preceded cartilage degeneration in early OVX-OA, suggesting that inhibiting bone catabolism could be an effective treatment for post-menopausal OA.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Orthopedics
S. Taheri, T. Yoshida, K. O. Boeker, R. H. Foerster, L. Jochim, A. L. Flux, B. Grosskopf, T. Hawellek, W. Lehmann, A. F. Schilling
Summary: We investigated the 3D network of subchondral microchannels (CMMC) connecting the deep zone of cartilage to the bone marrow and its relevance to early idiopathic osteoarthritis (OA). Our quantitative analysis revealed that the number and morphology of CMMC were influenced by the region of the joint, while the size of CMMC was influenced by both the joint location and the cartilage condition. Moreover, we observed an enlargement of the microchannels in early OA, particularly in the non-load-bearing region and the peripheral rim of the femoral head.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Review
Cell Biology
Hongfu Jin, Shigang Jiang, Ruomei Wang, Yi Zhang, Jiangtao Dong, Yusheng Li
Summary: Integrins, a family of transmembrane proteins, play essential roles in osteoarthritis (OA). Dysfunction of integrins has been shown to be involved in the pathogenesis of OA. Understanding the roles of integrins in OA may influence the development of future treatments.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Rheumatology
Margot Van Mechelen, Tobie Martens, Pieter Vanden Berghe, Rik Lories, Giulia R. Gulino
Summary: The study found that local induction of inflammation can trigger a systemic response, leading to splenomegaly, loss of bone mass, and bone marrow changes. Physical activity does not affect the severity of systemic inflammation, but independently impacts joint homeostasis.
Article
Rheumatology
Kevin L. Winthrop, John D. Isaacs, Philip J. Mease, Dimitrios T. Boumpas, Xenofon Baraliakos, Jacques-Eric Gottenberg, Stefan Siebert, Marta Mosca, Neil Basu, Dana Orange, R. Lories, Daniel Aletaha, Iain B. McInnes, Tom W. J. Huizinga, Reinhard E. Voll, Ellen M. Gravallese, Ferry C. Breedveld, Josef S. Smolen
Summary: This article summarizes the unmet clinical and scientific needs in the field of rheumatology. It highlights the importance of clinical trial design innovation and the need to better understand the natural history of rheumatic diseases. The article also identifies the specific unmet needs in different rheumatological disease-specific groups and emphasizes the importance of developing therapies and therapeutic strategies for treatment-refractory disease.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Orthopedics
S. A. Elahi, R. Castro-Vinuelas, P. Tanska, R. K. Korhonen, R. Lories, N. Famaey, I. Jonkers
Summary: In silico approach was used to study the main mechanisms of cartilage degeneration in osteoarthritis. Collagen degradation drives degenerative changes in intact and degenerated cartilage, while mechanical loading initially causes proteoglycans depletion in the presence of a focal cartilage defect.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Article
Orthopedics
J. Quintiens, A. De Roover, F. M. F. Cornelis, A. Escribano-Nun, A. Sermon, S. Pazmino, S. Monteagudo, R. J. Lories
Summary: This study identified the hypoxia and Wnt signaling pathways as regulators of ANP32A expression. Hypoxia increased ANP32A levels, while Wnt hyper-activation decreased ANP32A levels. The modulation of the ATM gene by hypoxia and Wnt was also observed. Maintaining hypoxia and limiting Wnt activation are important for protecting against osteoarthritis.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Review
Rheumatology
Jonas J. W. Kuiper, Joerg C. Prinz, Efstratios Stratikos, Piotr Kusnierczyk, Akiko Arakawa, Sebastian Springer, Dillon Mintoff, Ivan Padjen, Russka Shumnalieva, Secil Vural, Ina Koetter, Marleen G. van de Sande, Ayse Boyvat, Joke H. de Boer, George Bertsias, Niek de Vries, Charlotte L. M. Krieckaert, Ines Leal, Natasa Vidovic Valentincic, Ilknur Tugal-Tutkun, Hanane el Khaldi Ahanach, Felicie Costantino, Simon Glatigny, Danijela Mrazovac Zimak, Fabian Loetscher, Floor G. Kerstens, Marija Bakula, Elsa Viera Sousa, Peter Boehm, Kees Bosman, Tony J. Kenna, Simon J. Powis, Maxime Breban, Ahmet Gul, John Bowes, Rik J. U. Lories, Johannes Nowatzky, Gerrit Jan Wolbink, Dennis G. McGonagle, Franktien Turkstra
Summary: The 'MHC-I-opathy' concept describes a group of inflammatory diseases with overlapping clinical manifestations and a strong genetic link to the MHC-I antigen presentation pathway. However, the understanding and treatment of these disorders is limited due to patient heterogeneity and lack of systematic investigation. Therefore, interdisciplinary collaboration is needed to decipher the underlying disease mechanisms.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Reem Assi, Chahrazad Cherifi, Frederique M. F. Cornelis, Qiongfei Zhou, Lies Storms, Sofia Pazmino, Rodrigo Coutinho de Almeida, Ingrid Meulenbelt, Rik J. J. Lories, Silvia Monteagudo
Summary: The methylation of H3K79me is reduced in osteoarthritis. Histone demethylase families, such as Jumonji-C and KDM2/7, can increase the levels of H3K79me and targeting KDM2/7 can protect joints against osteoarthritis.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Pharmacology & Pharmacy
Reem Assi, Jolien Quintiens, Silvia Monteagudo, Rik J. J. Lories
Summary: Osteoarthritis is a chronic joint disease characterized by progressive damage to the joints, causing pain and loss of function. Intra-articular drug therapy has emerged as a potential treatment option, with drugs being injected directly into affected joints to optimize drug bioavailability and reduce systemic toxicity. This review explores the current landscape of intra-articular drug therapies for osteoarthritis, including established approaches and those in clinical development. Despite challenges in defining outcome measures and optimizing clinical trial set-ups, advancements in drug development and clinical trial design hold promise for successful therapies for this important disease.
Article
Orthopedics
Stijn Arnaert, Paul Byttebier, Sam Van Rossom, Evie Vereecke, Ilse Jonkers, Edwin Oei, Sita M. A. Bierma-Zeinstra, Rik Lories, Marienke van Middelkoop, Stefan Clockaerts
Summary: This study investigates the characteristics of the anterior tibiotalar fat pad (ATFP) in the ankle joint after one year of an ankle sprain and its correlation with systemic factors and local articular pathology. The results suggest that age, body mass index (BMI), and sex are significantly associated with the T1 intensity of ATFP. Age, diffuse cartilage loss in the lateral talus, and Kellgren and Lawrence score in the tibiotalar joint are negatively associated with the area of ATFP. BMI is positively associated with the ATFP area.
Article
Rheumatology
Manouk de Hooge, Alla Ishchenko, Ann-Sophie De Craemer, Serge Steinfeld, Adrien Nzeusseu, Dirk Elewaut, Rik Lories, Kurt de Vlam, Filip van den Bosch
Summary: This study aimed to examine radiographic axial damage of the sacroiliac joints and spine in patients with psoriatic arthritis (PsA) and spondyloarthritis (SpA) in private and academic Belgian practices. The data comparison between the two patient groups found that patients with SpA tend to have more severe spinal damage compared to those with PsA. In patients with PsA, the cervical spine is more often affected, while in patients with SpA, the location of syndesmophytes is more evenly distributed.
Article
Rheumatology
Manouk de Hooge, Alla Ischenko, Serge Steinfeld, Adrien Nzeusseu, Dirk Elewaut, Rik Lories, Filip van den Bosch, Kurt De Vlam
Summary: This study investigates the association between different definitions of axial involvement and syndesmophytes development in patients with Psoriatic Arthritis (PsA). The results show that the probability of developing syndesmophytes is much higher when axial involvement is determined radiographically rather than clinically, particularly in the context of high CRP.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Immunology
Mariia Dzhus, Lisa Ehlers, Marjon Wouters, Katrien Jansen, Rik Schrijvers, Lien De Somer, Steven Vanderschueren, Marco Baggio, Leen Moens, Benjamin Verhaaren, Rik Lories, Giorgia Bucciol, Isabelle Meyts
Summary: Deficiency of human adenosine deaminase type 2 (DADA2) is a rare autoimmune disorder characterized by vasculopathy, immune dysregulation, and hematologic abnormalities. Neurological manifestations, particularly strokes, are a significant feature of DADA2, with brain stem and deep gray matter being commonly affected. Other neurological involvements include neuropathies, focal deficits, ophthalmological findings, convulsions, and headaches. Recognizing the diverse neurological manifestations of DADA2 is crucial for accurate diagnosis and appropriate management.
JOURNAL OF CLINICAL IMMUNOLOGY
(2023)
Review
Rheumatology
Ennio Lubrano, Silvia Scriffignano, Kurt de Vlam, Mario Ronga, Fabio Massimo Perrotta, Rik Lories
Summary: Psoriatic arthritis (PsA) is a complex and chronic inflammatory disease that combines arthritis and psoriasis with other conditions and comorbidities. Non-pharmacological approaches such as diet modifications, improved sleep quality, and physical activity have been shown to improve the quality of life for PsA patients.
Article
Cell & Tissue Engineering
Jeremie Zappia, Qiao Tong, Renee Van der Cruyssen, Frederique M. F. Cornelis, Cecile Lambert, Tiago Pinto Coelho, Juliane Grisart, Erika Kague, Rik J. Lories, Marc Muller, Dirk Elewaut, Chrissy L. Hammond, Christelle Sanchez, Yves Henrotin
Summary: Abnormal subchondral bone remodeling leading to sclerosis is a main feature of osteoarthritis. Osteomodulin (OMD), a proteoglycan, is associated with the sclerotic phenotype. This study found that OMD binds to RANKL and inhibits osteoclastogenesis, thus regulating bone remodeling and contributing to bone and cartilage homeostasis. Targeting OMD may be a promising personalized approach for osteoarthritis.
Meeting Abstract
Orthopedics
J. Quintiens, F. Cornelis, A. De Roover, A. Escribano Nunez, S. Monteagudo, R. J. Lories
OSTEOARTHRITIS AND CARTILAGE
(2022)
Meeting Abstract
Orthopedics
R. Assi, C. Cherifi, F. Cornelis, R. Lories, S. Monteagudo
OSTEOARTHRITIS AND CARTILAGE
(2022)