Low-density lipoprotein receptor–related protein 5 governs Wnt-mediated osteoarthritic cartilage destruction

Heterozygosity for an inactivating mutation in low-density lipoprotein-related receptor 6 (Lrp6) increases osteoarthritis severity in mice after ligament and meniscus injury

(2013) D.M. Joiner et al.   OSTEOARTHRITIS AND CARTILAGE

Lrp5 and Lrp6 Exert Overlapping Functions in Osteoblasts during Postnatal Bone Acquisition

(2013) Ryan C. Riddle et al.   PLoS One

Dkk-1 expression in chondrocytes inhibits experimental osteoarthritic cartilage destruction in mice

(2012) Hwanhee Oh et al.   ARTHRITIS AND RHEUMATISM

Genetic deletion of low-density lipoprotein receptor-related protein 5 increases cartilage degradation in instability-induced osteoarthritis

(2012) L. Lodewyckx et al.   RHEUMATOLOGY

Bone morphogenetic protein-2-induced Wnt/beta-catenin signaling pathway activation through enhanced low-density-lipoprotein receptor-related protein 5 catabolic activity contributes to hypertrophy in osteoarthritic chondrocytes

(2012) Ioanna Papathanasiou et al.   ARTHRITIS RESEARCH & THERAPY

Hypoxia-inducible factor-2α regulates Fas-mediated chondrocyte apoptosis during osteoarthritic cartilage destruction

(2011) J-H Ryu et al.   CELL DEATH AND DIFFERENTIATION

To Seek Shelter from the Wnt in Osteoarthritis? Wnt-Signaling as a Target for Osteoarthritis Therapy

(2010) Arjen B. Blom et al.   CURRENT DRUG TARGETS

Hypoxia-inducible factor-2α is a catabolic regulator of osteoarthritic cartilage destruction

(2010) Siyoung Yang et al.   NATURE MEDICINE

Matrix metalloproteinase 13–deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development

(2009) C. B. Little et al.   ARTHRITIS AND RHEUMATISM

Esophageal cancer related gene 4 (ECRG4) is a marker of articular chondrocyte differentiation and cartilage destruction

(2009) Yun Hyun Huh et al.   GENE

Inhibition of β‐catenin signaling in articular chondrocytes results in articular cartilage destruction

(2008) Mei Zhu et al.   ARTHRITIS AND RHEUMATISM

Lrp5 Controls Bone Formation by Inhibiting Serotonin Synthesis in the Duodenum

(2008) Vijay K. Yadav et al.   CELL

Activation of β-Catenin Signaling in Articular Chondrocytes Leads to Osteoarthritis-Like Phenotype in Adult β-Catenin Conditional Activation Mice

(2008) Mei Zhu et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Molecular network of cartilage homeostasis and osteoarthritis

(2007) Megumi Hashimoto et al.   MEDICINAL RESEARCH REVIEWS