标题
Synthesis of lysine methyltransferase inhibitors
作者
关键词
-
出版物
Frontiers in Chemistry
Volume 3, Issue -, Pages -
出版商
Frontiers Media SA
发表日期
2015-07-23
DOI
10.3389/fchem.2015.00044
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Small-Molecule Inhibitors of SETD8 with Cellular Activity
- (2014) Gil Blum et al. ACS Chemical Biology
- Development and classes of epigenetic drugs for cancer
- (2014) Dashyant Dhanak et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Nonclinical pharmacokinetics and metabolism of EPZ-5676, a novel DOT1L histone methyltransferase inhibitor
- (2014) Aravind Basavapathruni et al. BIOPHARMACEUTICS & DRUG DISPOSITION
- Mind the Methyl: Methyllysine Binding Proteins in Epigenetic Regulation
- (2014) Tobias Wagner et al. ChemMedChem
- A Chemical Tool for In Vitro and In Vivo Precipitation of Lysine Methyltransferase G9a
- (2014) Kyle D. Konze et al. ChemMedChem
- SET8 methyltransferase activity during the DNA double-strand break response is required for recruitment of 53BP1
- (2014) S. Dulev et al. EMBO REPORTS
- Discovery of a Selective, Substrate-Competitive Inhibitor of the Lysine Methyltransferase SETD8
- (2014) Anqi Ma et al. JOURNAL OF MEDICINAL CHEMISTRY
- Selective Inhibition of EZH2 by EPZ-6438 Leads to Potent Antitumor Activity in EZH2-Mutant Non-Hodgkin Lymphoma
- (2014) S. K. Knutson et al. MOLECULAR CANCER THERAPEUTICS
- Structure–activity relationship studies of SETD8 inhibitors
- (2014) Anqi Ma et al. MedChemComm
- Identification of 2,4-diamino-6,7-dimethoxyquinoline derivatives as G9a inhibitors
- (2014) Nitipol Srimongkolpithak et al. MedChemComm
- Discovery and Development of Potent and Selective Inhibitors of Histone Methyltransferase G9a
- (2014) Ramzi F. Sweis et al. ACS Medicinal Chemistry Letters
- Discovery and Optimization of Tetramethylpiperidinyl Benzamides as Inhibitors of EZH2
- (2014) Christopher G. Nasveschuk et al. ACS Medicinal Chemistry Letters
- An Orally Bioavailable Chemical Probe of the Lysine Methyltransferases EZH2 and EZH1
- (2013) Kyle D. Konze et al. ACS Chemical Biology
- Bromo-deaza-SAH: A potent and selective DOT1L inhibitor
- (2013) Wenyu Yu et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Design of small molecule epigenetic modulators
- (2013) Boobalan Pachaiyappan et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Potent inhibition of DOT1L as treatment of MLL-fusion leukemia
- (2013) S. R. Daigle et al. BLOOD
- The promise and failures of epigenetic therapies for cancer treatment
- (2013) Pasano Bojang et al. CANCER TREATMENT REVIEWS
- Identification of EZH2 and EZH1 Small Molecule Inhibitors with Selective Impact on Diffuse Large B Cell Lymphoma Cell Growth
- (2013) Shivani Garapaty-Rao et al. CHEMISTRY & BIOLOGY
- Small-Molecule Modulators for Epigenetics Targets
- (2013) Stefan Knapp et al. ChemMedChem
- Histone Lysine-Specific Methyltransferases and Demethylases in Carcinogenesis: New Targets for Cancer Therapy and Prevention
- (2013) Xuejiao Tian et al. CURRENT CANCER DRUG TARGETS
- On the Histone Lysine Methyltransferase Activity of Fungal Metabolite Chaetocin
- (2013) Fanny L. Cherblanc et al. JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of an in Vivo Chemical Probe of the Lysine Methyltransferases G9a and GLP
- (2013) Feng Liu et al. JOURNAL OF MEDICINAL CHEMISTRY
- Small-molecular modulators of cancer-associated epigenetic mechanisms
- (2013) Yukihiro Itoh et al. Molecular BioSystems
- Chromatin proteins and modifications as drug targets
- (2013) Kristian Helin et al. NATURE
- Chaetocin is a nonspecific inhibitor of histone lysine methyltransferases
- (2013) Fanny L Cherblanc et al. Nature Chemical Biology
- Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2
- (2013) S. K. Knutson et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Small molecule epigenetic inhibitors targeted to histone lysine methyltransferases and demethylases
- (2013) Zhanxin Wang et al. QUARTERLY REVIEWS OF BIOPHYSICS
- Erratum: Corrigendum: Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors
- (2013) Wenyu Yu et al. Nature Communications
- A Small-Molecule Probe of the Histone Methyltransferase G9a Induces Cellular Senescence in Pancreatic Adenocarcinoma
- (2012) Yuan Yuan et al. ACS Chemical Biology
- Epidithiodiketopiperazine as a pharmacophore for protein lysine methyltransferase G9a inhibitors: Reducing cytotoxicity by structural simplification
- (2012) Shinya Fujishiro et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Histone Lysine Methyltransferase SETD8 Promotes Carcinogenesis by Deregulating PCNA Expression
- (2012) M. Takawa et al. CANCER RESEARCH
- Conformational Adaptation Drives Potent, Selective and Durable Inhibition of the Human Protein Methyltransferase DOT1L
- (2012) Aravind Basavapathruni et al. Chemical Biology & Drug Design
- PR-Set7 and H4K20me1: at the crossroads of genome integrity, cell cycle, chromosome condensation, and transcription
- (2012) D. B. Beck et al. GENES & DEVELOPMENT
- Correction to Selective Inhibitors of Histone Methyltransferase DOT1L: Design, Synthesis, and Crystallographic Studies
- (2012) Yuan Yao et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations
- (2012) Michael T. McCabe et al. NATURE
- A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells
- (2012) Sarah K Knutson et al. Nature Chemical Biology
- Epigenetic protein families: a new frontier for drug discovery
- (2012) Cheryl H. Arrowsmith et al. NATURE REVIEWS DRUG DISCOVERY
- Nahuoic Acid A Produced by a Streptomyces sp. Isolated From a Marine Sediment Is a Selective SAM-Competitive Inhibitor of the Histone Methyltransferase SETD8
- (2012) David E. Williams et al. ORGANIC LETTERS
- Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation
- (2012) W. Qi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Synthesis and biological activities of chaetocin and its derivatives
- (2012) Mikiko Sodeoka et al. PURE AND APPLIED CHEMISTRY
- Identification of Potent, Selective, Cell-Active Inhibitors of the Histone Lysine Methyltransferase EZH2
- (2012) Sharad K. Verma et al. ACS Medicinal Chemistry Letters
- Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors
- (2012) Wenyu Yu et al. Nature Communications
- Targeting protein lysine methylation and demethylation in cancers
- (2011) Yunlong He et al. ACTA BIOCHIMICA ET BIOPHYSICA SINICA
- Selective Killing of Mixed Lineage Leukemia Cells by a Potent Small-Molecule DOT1L Inhibitor
- (2011) Scott R. Daigle et al. CANCER CELL
- SET8 promotes epithelial-mesenchymal transition and confers TWIST dual transcriptional activities
- (2011) Fen Yang et al. EMBO JOURNAL
- H3K9 methyltransferase G9a and the related molecule GLP
- (2011) Y. Shinkai et al. GENES & DEVELOPMENT
- The diverse functions of Dot1 and H3K79 methylation
- (2011) A. T. Nguyen et al. GENES & DEVELOPMENT
- Epipolythiodiketopiperazine Alkaloids: Total Syntheses and Biological Activities
- (2011) Eriko Iwasa et al. ISRAEL JOURNAL OF CHEMISTRY
- Optimization of Cellular Activity of G9a Inhibitors 7-Aminoalkoxy-quinazolines
- (2011) Feng Liu et al. JOURNAL OF MEDICINAL CHEMISTRY
- Selective Inhibitors of Histone Methyltransferase DOT1L: Design, Synthesis, and Crystallographic Studies
- (2011) Yuan Yao et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- The Polycomb complex PRC2 and its mark in life
- (2011) Raphaël Margueron et al. NATURE
- A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells
- (2011) Masoud Vedadi et al. Nature Chemical Biology
- Histone H4 Lys 20 monomethylation by histone methylase SET8 mediates Wnt target gene activation
- (2011) Z. Li et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Total syntheses of chaetocin and ent-chaetocin
- (2011) Eriko Iwasa et al. TETRAHEDRON
- H3K9 Histone Methyltransferase G9a Promotes Lung Cancer Invasion and Metastasis by Silencing the Cell Adhesion Molecule Ep-CAM
- (2010) M.-W. Chen et al. CANCER RESEARCH
- Dynamic regulation of the PR-Set7 histone methyltransferase is required for normal cell cycle progression
- (2010) S. Wu et al. GENES & DEVELOPMENT
- PR-Set7-mediated monomethylation of histone H4 lysine 20 at specific genomic regions induces transcriptional repression
- (2010) Lauren M. Congdon et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Protein Lysine Methyltransferase G9a Inhibitors: Design, Synthesis, and Structure Activity Relationships of 2,4-Diamino-7-aminoalkoxy-quinazolines.
- (2010) Feng Liu et al. JOURNAL OF MEDICINAL CHEMISTRY
- Adding a Lysine Mimic in the Design of Potent Inhibitors of Histone Lysine Methyltransferases
- (2010) Yanqi Chang et al. JOURNAL OF MOLECULAR BIOLOGY
- General Approach to Epipolythiodiketopiperazine Alkaloids: Total Synthesis of (+)-Chaetocins A and C and (+)-12,12′-Dideoxychetracin A
- (2010) Justin Kim et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Total Synthesis of (+)-Chaetocin and its Analogues: Their Histone Methyltransferase G9a Inhibitory Activity
- (2010) Eriko Iwasa et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- CRL4Cdt2-Mediated Destruction of the Histone Methyltransferase Set8 Prevents Premature Chromatin Compaction in S Phase
- (2010) Richard C. Centore et al. MOLECULAR CELL
- CRL4Cdt2 Regulates Cell Proliferation and Histone Gene Expression by Targeting PR-Set7/Set8 for Degradation
- (2010) Tarek Abbas et al. MOLECULAR CELL
- The Emerging Therapeutic Potential of Histone Methyltransferase and Demethylase Inhibitors
- (2009) Astrid Spannhoff et al. ChemMedChem
- New Insights into the Design of Inhibitors of HumanS-Adenosylmethionine Decarboxylase: Studies of Adenine C8Substitution in Structural Analogues ofS-Adenosylmethionine†
- (2009) Diane E. McCloskey et al. JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of a 2,4-Diamino-7-aminoalkoxyquinazoline as a Potent and Selective Inhibitor of Histone Lysine Methyltransferase G9a
- (2009) Feng Liu et al. JOURNAL OF MEDICINAL CHEMISTRY
- Monomethylation of Histone H4-Lysine 20 Is Involved in Chromosome Structure and Stability and Is Essential for Mouse Development
- (2009) H. Oda et al. MOLECULAR AND CELLULAR BIOLOGY
- Protein methyltransferases as a target class for drug discovery
- (2009) Robert A. Copeland et al. NATURE REVIEWS DRUG DISCOVERY
- Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294
- (2009) Yanqi Chang et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Total Synthesis of (+)-11,11'-Dideoxyverticillin A
- (2009) J. Kim et al. SCIENCE
- Concise Total Synthesis of (+)-WIN 64821 and (−)-Ditryptophenaline
- (2008) Mohammad Movassaghi et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Catalytic Function of the PR-Set7 Histone H4 Lysine 20 Monomethyltransferase Is Essential for Mitotic Entry and Genomic Stability
- (2008) Sabrina I. Houston et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Discovery of Quinazolines as Histamine H4Receptor Inverse Agonists Using a Scaffold Hopping Approach
- (2008) Rogier A. Smits et al. JOURNAL OF MEDICINAL CHEMISTRY
- Nonprocessive methylation by Dot1 leads to functional redundancy of histone H3K79 methylation states
- (2008) Floor Frederiks et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
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