标题
DOT1L Inhibition Sensitizes MLL-Rearranged AML to Chemotherapy
作者
关键词
Cancer treatment, Apoptosis, Leukemia cells, DNA damage, Acute myeloid leukemia, Leukemias, Cell differentiation, Chemotherapy
出版物
PLoS One
Volume 9, Issue 5, Pages e98270
出版商
Public Library of Science (PLoS)
发表日期
2014-05-24
DOI
10.1371/journal.pone.0098270
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Potent inhibition of DOT1L as treatment of MLL-fusion leukemia
- (2013) S. R. Daigle et al. BLOOD
- Leukemic transformation by the MLL-AF6 fusion oncogene requires the H3K79 methyltransferase Dot1l
- (2013) A. J. Deshpande et al. BLOOD
- Recent progress toward epigenetic therapies: the example of mixed lineage leukemia
- (2013) T. Neff et al. BLOOD
- The trithorax protein partner menin acts in tandem with EZH2 to suppress C/EBP and differentiation in MLL-AF9 leukemia
- (2013) A. T. Thiel et al. HAEMATOLOGICA
- Synthesis, activity and metabolic stability of non-ribose containing inhibitors of histone methyltransferase DOT1L
- (2013) Lisheng Deng et al. MedChemComm
- FACS analysis of Stat3/5 signaling reveals sensitivity to G-CSF and IL-6 as a significant prognostic factor in pediatric AML: a Children's Oncology Group report
- (2012) M. S. Redell et al. BLOOD
- Dysregulation of the Repressive H3K27 Trimethylation Mark in Head and Neck Squamous Cell Carcinoma Contributes to Dysregulated Squamous Differentiation
- (2012) O. M. Gannon et al. CLINICAL CANCER RESEARCH
- Bat3 facilitates H3K79 dimethylation by DOT1L and promotes DNA damage-induced 53BP1 foci at G1/G2 cell-cycle phases
- (2012) Timothy P Wakeman et al. EMBO JOURNAL
- Synthesis and Structure–Activity Relationship Investigation of Adenosine-Containing Inhibitors of Histone Methyltransferase DOT1L
- (2012) Justin L. Anglin et al. JOURNAL OF MEDICINAL CHEMISTRY
- Abrogation of MLL–AF10 and CALM–AF10-mediated transformation through genetic inactivation or pharmacological inhibition of the H3K79 methyltransferase Dot1l
- (2012) L Chen et al. LEUKEMIA
- DOT1L, the H3K79 methyltransferase, is required for MLL-AF9-mediated leukemogenesis
- (2011) A. T. Nguyen et al. BLOOD
- Selective Killing of Mixed Lineage Leukemia Cells by a Potent Small-Molecule DOT1L Inhibitor
- (2011) Scott R. Daigle et al. CANCER CELL
- The heterogeneity of pediatric MLL-rearranged acute myeloid leukemia
- (2011) B V Balgobind et al. LEUKEMIA
- Analysis of the Role of Hematopoietic Stem-Cell Transplantation in Infants With Acute Lymphoblastic Leukemia in First Remission andMLLGene Rearrangements: A Report From the Children's Oncology Group
- (2010) ZoAnn E. Dreyer et al. JOURNAL OF CLINICAL ONCOLOGY
- Histone H3 lysine 4 (H3K4) methylation in development and differentiation
- (2009) Joel C. Eissenberg et al. DEVELOPMENTAL BIOLOGY
- Molecular disruption of RAD50 sensitizes human tumor cells to cisplatin-based chemotherapy
- (2009) Waleed M. Abuzeid et al. JOURNAL OF CLINICAL INVESTIGATION
- ERCC1 and BRCA1 mRNA expression levels in metastatic malignant effusions is associated with chemosensitivity to cisplatin and/or docetaxel
- (2008) Lifeng Wang et al. BMC CANCER
- H3K79 Methylation Profiles Define Murine and Human MLL-AF4 Leukemias
- (2008) Andrei V. Krivtsov et al. CANCER CELL
- Aberrant chromatin at genes encoding stem cell regulators in human mixed-lineage leukemia
- (2008) M. G. Guenther et al. GENES & DEVELOPMENT
- DOT1L/KMT4 Recruitment and H3K79 Methylation Are Ubiquitously Coupled with Gene Transcription in Mammalian Cells
- (2008) D. J. Steger et al. MOLECULAR AND CELLULAR BIOLOGY
- Bcl-2 family proteins and cancer
- (2008) K W Yip et al. ONCOGENE
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started