Neutrophil-mediated vascular barrier injury: Role of neutrophil extracellular traps

Neutrophil Proteases Promote Experimental Abdominal Aortic Aneurysm via Extracellular Trap Release and Plasmacytoid Dendritic Cell ActivationHighlights

(2016) Huimin Yan et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

DAMP and DIC: The role of extracellular DNA and DNA-binding proteins in the pathogenesis of DIC

(2016) Patricia C. Liaw et al.   BLOOD REVIEWS

Tumor-Induced NETosis as a Risk Factor for Metastasis and Organ Failure

(2016) J. Cedervall et al.   CANCER RESEARCH

Neutrophil Extracellular Traps Promote the Development and Progression of Liver Metastases after Surgical Stress

(2016) Samer Tohme et al.   CANCER RESEARCH

ROS-activated calcium signaling mechanisms regulating endothelial barrier function

(2016) Anke Di et al.   CELL CALCIUM

Histones stimulate von Willebrand factor release in vitro and in vivo

(2016) F. W. Lam et al.   HAEMATOLOGICA

Characterization of neutrophil function in Papillon-Lefèvre syndrome

(2016) Helen Roberts et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Neutrophil elastase-deficient mice form neutrophil extracellular traps in an experimental model of deep vein thrombosis

(2016) K. Martinod et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

The role of neutrophils and NETosis in autoimmune and renal diseases

(2016) Sarthak Gupta et al.   Nature Reviews Nephrology

Histones Induce the Procoagulant Phenotype of Endothelial Cells through Tissue Factor Up-Regulation and Thrombomodulin Down-Regulation

(2016) Ji Eun Kim et al.   PLoS One

Extracellular histones induce tissue factor expression in vascular endothelial cells via TLR and activation of NF-κB and AP-1

(2016) Xinyu Yang et al.   THROMBOSIS RESEARCH

Histones stimulate von Willebrand factor release in vitro and in vivo

(2016) F. W. Lam et al.   HAEMATOLOGICA

Tofacitinib Ameliorates Murine Lupus and Its Associated Vascular Dysfunction

(2016) Yasuko Furumoto et al.   Arthritis & Rheumatology

Inhibitors of Serine Proteases in Regulating the Production and Function of Neutrophil Extracellular Traps

(2016) Pawel Majewski et al.   Frontiers in Immunology

Neutrophil Extracellular Traps Induce Organ Damage during Experimental and Clinical Sepsis

(2016) Paula Giselle Czaikoski et al.   PLoS One

Inter-  inhibitor protein and its associated glycosaminoglycans protect against histone-induced injury

(2015) H. Chaaban et al.   BLOOD

PAD4-deficiency does not affect bacteremia in polymicrobial sepsis and ameliorates endotoxemic shock

(2015) K. Martinod et al.   BLOOD

Neutrophil Extracellular Traps Accumulate in Peripheral Blood Vessels and Compromise Organ Function in Tumor-Bearing Animals

(2015) J. Cedervall et al.   CANCER RESEARCH

Role of extracellular histones in the cardiomyopathy of sepsis

(2015) Miriam Kalbitz et al.   FASEB JOURNAL

Sepsis and ARDS: The Dark Side of Histones

(2015) Zhiheng Xu et al.   MEDIATORS OF INFLAMMATION

Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation

(2015) Huw D Lewis et al.   Nature Chemical Biology

Delayed but not Early Treatment with DNase Reduces Organ Damage and Improves Outcome in a Murine Model of Sepsis

(2015) Safiah H. C. Mai et al.   SHOCK

Molecular mechanisms of NET formation and degradation revealed by intravital imaging in the liver vasculature

(2015) Elzbieta Kolaczkowska et al.   Nature Communications

Virus-Induced NETs – Critical Component of Host Defense or Pathogenic Mediator?

(2015) Craig N. Jenne et al.   PLoS Pathogens

Neutrophil-Derived MMP-8 Drives AMPK-Dependent Matrix Destruction in Human Pulmonary Tuberculosis

(2015) Catherine W. M. Ong et al.   PLoS Pathogens

Nitric oxide,S-Nitrosation, and endothelial permeability

(2015) Walter N. Durán et al.   IUBMB LIFE

Proinflammatory role of neutrophil extracellular traps in abdominal sepsis

(2014) Lingtao Luo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Neutrophil extracellular traps induce endothelial dysfunction in systemic lupus erythematosus through the activation of matrix metalloproteinase-2

(2014) Carmelo Carmona-Rivera et al.   ANNALS OF THE RHEUMATIC DISEASES

von Willebrand Factor Directly Interacts With DNA From Neutrophil Extracellular Traps

(2014) S. Grassle et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Neutrophil Extracellular Traps Promote Thrombin Generation Through Platelet-Dependent and Platelet-Independent Mechanisms

(2014) Travis J. Gould et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Neutrophil extracellular traps in cancer progression

(2014) Jonathan Cools-Lartigue et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Peptidylarginine Deiminase Inhibition Reduces Vascular Damage and Modulates Innate Immune Responses in Murine Models of Atherosclerosis

(2014) Jason S. Knight et al.   CIRCULATION RESEARCH

Protein-based therapies for acute lung injury: targeting neutrophil extracellular traps

(2014) Markus Bosmann et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Papillon-Lefèvre syndrome patient reveals species-dependent requirements for neutrophil defenses

(2014) Ole E. Sørensen et al.   JOURNAL OF CLINICAL INVESTIGATION

Extracellular histones in tissue injury and inflammation

(2014) Ramanjaneyulu Allam et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Leukocyte extravasation and vascular permeability are each controlled in vivo by different tyrosine residues of VE-cadherin

(2014) Florian Wessel et al.   NATURE IMMUNOLOGY

Aggregated neutrophil extracellular traps limit inflammation by degrading cytokines and chemokines

(2014) Christine Schauer et al.   NATURE MEDICINE

In Vivo Characterization of Neutrophil Extracellular Traps in Various Organs of a Murine Sepsis Model

(2014) Koji Tanaka et al.   PLoS One

Presence of Neutrophil Extracellular Traps and Citrullinated Histone H3 in the Bloodstream of Critically Ill Patients

(2014) Tomoya Hirose et al.   PLoS One

NETosis: A New Factor in Tumor Progression and Cancer-Associated Thrombosis

(2014) Melanie Demers et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Neutrophil Extracellular Traps in Sepsis

(2014) Gabriela Camicia et al.   SHOCK

Role of Neutrophil Extracellular Traps Following Injury

(2014) Fu-Chao Liu et al.   SHOCK

Release and activity of histone in diseases

(2014) R Chen et al.   Cell Death & Disease

Phospholipase D Signaling Mediates Reactive Oxygen Species-Induced Lung Endothelial Barrier Dysfunction

(2014) Peter V. Usatyuk et al.   Pulmonary Circulation

Reactive Oxygen Species in Inflammation and Tissue Injury

(2013) Manish Mittal et al.   ANTIOXIDANTS & REDOX SIGNALING

Elevated Levels of Circulating DNA and Chromatin Are Independently Associated With Severe Coronary Atherosclerosis and a Prothrombotic State

(2013) Julian I. Borissoff et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

VWF-mediated leukocyte recruitment with chromatin decondensation by PAD4 increases myocardial ischemia/reperfusion injury in mice

(2013) A. S. Savchenko et al.   BLOOD

How T cells trigger the dissociation of the endothelial receptor phosphatase VE-PTP from VE-cadherin

(2013) M. Vockel et al.   BLOOD

Thrombosis: tangled up in NETs

(2013) K. Martinod et al.   BLOOD

Neutrophils Recruited to Sites of Infection Protect from Virus Challenge by Releasing Neutrophil Extracellular Traps

(2013) Craig N. Jenne et al.   Cell Host & Microbe

Extracellular histones are essential effectors of C5aR- and C5L2-mediated tissue damage and inflammation in acute lung injury

(2013) Markus Bosmann et al.   FASEB JOURNAL

eNOS-derived nitric oxide regulates endothelial barrier function through VE-cadherin and Rho GTPases

(2013) Annarita Di Lorenzo et al.   JOURNAL OF CELL SCIENCE

Neutrophil extracellular traps sequester circulating tumor cells and promote metastasis

(2013) Jonathan Cools-Lartigue et al.   JOURNAL OF CLINICAL INVESTIGATION

Global Substrate Profiling of Proteases in Human Neutrophil Extracellular Traps Reveals Consensus Motif Predominantly Contributed by Elastase

(2013) Anthony J. O’Donoghue et al.   PLoS One

Neutrophil histone modification by peptidylarginine deiminase 4 is critical for deep vein thrombosis in mice

(2013) K. Martinod et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NET balancing: a problem in inflammatory lung diseases

(2013) Olivia Z. Cheng et al.   Frontiers in Immunology

Plasmodium falciparum Histones Induce Endothelial Proinflammatory Response and Barrier Dysfunction

(2012) Mark R. Gillrie et al.   AMERICAN JOURNAL OF PATHOLOGY

Circulating Histones Are Mediators of Trauma-associated Lung Injury

(2012) Simon T. Abrams et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Neutrophil Extracellular Trap (NET) Impact on Deep Vein Thrombosis

(2012) Tobias A. Fuchs et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Extracellular DNA traps are associated with the pathogenesis of TRALI in humans and mice

(2012) G. M. Thomas et al.   BLOOD

ICAM-1-activated Src and eNOS signaling increase endothelial cell surface PECAM-1 adhesivity and neutrophil transmigration

(2012) G. Liu et al.   BLOOD

Intravascular Neutrophil Extracellular Traps Capture Bacteria from the Bloodstream during Sepsis

(2012) Braedon McDonald et al.   Cell Host & Microbe

S-Nitrosation of β-Catenin and p120 Catenin

(2012) Natalie Marín et al.   CIRCULATION RESEARCH

Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury

(2012) Axelle Caudrillier et al.   JOURNAL OF CLINICAL INVESTIGATION

Requirements for NADPH oxidase and myeloperoxidase in neutrophil extracellular trap formation differ depending on the stimulus

(2012) Heather Parker et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Neutrophil Extracellular Traps Directly Induce Epithelial and Endothelial Cell Death: A Predominant Role of Histones

(2012) Mona Saffarzadeh et al.   PLoS One

Stabilizing the VE-cadherin-catenin complex blocks leukocyte extravasation and vascular permeability

(2011) Dörte Schulte et al.   EMBO JOURNAL

Role of reactive oxygen and nitrogen species in the vascular responses to inflammation

(2011) Peter R. Kvietys et al.   FREE RADICAL BIOLOGY AND MEDICINE

Endogenous histones function as alarmins in sterile inflammatory liver injury through Toll-like receptor 9 in mice

(2011) Hai Huang et al.   HEPATOLOGY

Dissociation of VE-PTP from VE-cadherin is required for leukocyte extravasation and for VEGF-induced vascular permeability in vivo

(2011) Andre Broermann et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cortactin deficiency is associated with reduced neutrophil recruitment but increased vascular permeability in vivo

(2011) Michael Schnoor et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Extracellular Histones Are Mediators of Death through TLR2 and TLR4 in Mouse Fatal Liver Injury

(2011) J. Xu et al.   JOURNAL OF IMMUNOLOGY

Neutrophil extracellular traps promote deep vein thrombosis in mice

(2011) A. BRILL et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Neutrophil transmigration, focal adhesion kinase and endothelial barrier function

(2011) Sarah Y. Yuan et al.   MICROVASCULAR RESEARCH

Regulation of Endothelial Permeability via Paracellular and Transcellular Transport Pathways

(2010) Yulia Komarova et al.   Annual Review of Physiology

The NO cascade, eNOS location, and microvascular permeability

(2010) W. N. Duran et al.   CARDIOVASCULAR RESEARCH

Leucocyte/endothelium interactions and microvessel permeability: coupled or uncoupled?

(2010) P. He   CARDIOVASCULAR RESEARCH

Activated endothelial cells induce neutrophil extracellular traps and are susceptible to NETosis-mediated cell death

(2010) Anurag Kumar Gupta et al.   FEBS LETTERS

Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps

(2010) Venizelos Papayannopoulos et al.   JOURNAL OF CELL BIOLOGY

PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps

(2010) Pingxin Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Protein targets of inflammatory serine proteases and cardiovascular disease

(2010) Ram Sharony et al.   Journal of Inflammation-London

Activation of the Raf-MEK-ERK pathway is required for neutrophil extracellular trap formation

(2010) Abdul Hakkim et al.   Nature Chemical Biology

Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases

(2010) Steffen Massberg et al.   NATURE MEDICINE

Neutrophil Elastase, Proteinase 3, and Cathepsin G as Therapeutic Targets in Human Diseases

(2010) B. Korkmaz et al.   PHARMACOLOGICAL REVIEWS

NADPH Oxidase-1 Plays a Crucial Role in Hyperoxia-induced Acute Lung Injury in Mice

(2009) Stéphanie Carnesecchi et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

A double-blind placebo-controlled study to evaluate the safety and efficacy of L-2-oxothiazolidine-4-carboxylic acid in the treatment of patients with acute respiratory distress syndrome*

(2009) Peter E. Morris et al.   CRITICAL CARE MEDICINE

Recent developments and complexities in neutrophil transmigration

(2009) Abigail Woodfin et al.   CURRENT OPINION IN HEMATOLOGY

Molecular mechanisms of endothelial hyperpermeability: implications in inflammation

(2009) Puneet Kumar et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Endothelial signaling in paracellular and transcellular leukocyte transmigration

(2009) Erika et al.   Frontiers in Bioscience-Landmark

Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation

(2009) Yanming Wang et al.   JOURNAL OF CELL BIOLOGY

The clinical value of neutrophil extracellular traps

(2009) Tim Lögters et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

Extracellular histones are major mediators of death in sepsis

(2009) Jun Xu et al.   NATURE MEDICINE

Protease-activated receptors as drug targets in inflammation and pain

(2009) Nathalie Vergnolle   PHARMACOLOGY & THERAPEUTICS

Opening the flood-gates: how neutrophil-endothelial interactions regulate permeability

(2009) Matthew R. DiStasi et al.   TRENDS IN IMMUNOLOGY

Control of granule exocytosis in neutrophils

(2008) Paige Lacy   Frontiers in Bioscience-Landmark

Regulation of endothelial barrier function by reactive oxygen and nitrogen species

(2008) Adel Boueiz et al.   MICROVASCULAR RESEARCH

NEUTROPHIL-DERIVED CIRCULATING FREE DNA (cf-DNA/NETs)

(2008) Stefan Margraf et al.   SHOCK

Phosphorylation of vascular endothelial cadherin controls lymphocyte emigration

(2007) P. Turowski et al.   JOURNAL OF CELL SCIENCE

Focal Adhesion Kinase in Neutrophil-Induced Microvascular Hyperpermeability

(2007) MINGZHANG GUO et al.   MICROCIRCULATION