Article
Chemistry, Medicinal
Huiqiang Wei, Wenfeng Gou, Jun Gao, Hongxin Ning, Yang Song, Deguan Li, Yong Qin, Wenbin Hou, Yiliang Li
Summary: A novel therapeutic, compound 31c, that targets PHD2 and HDACs simultaneously has been developed to prevent AKI progression. The compound exhibited potent renoprotective effects in cellular and animal models, suggesting its potential as a clinical agent for the treatment/prevention of cisplatin-induced AKI in various cancers.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Immunology
Marietta Z. Poles, Anna Naszai, Levente Gulacsi, Balint L. Czako, Krisztian G. Gal, Romy J. Glenz, Dishana Dookhun, Attila Rutai, Szabolcs P. Tallosy, Andrea Szabo, Balint Lorinczi, Istvan Szatmari, Ferenc Fulop, Laszlo Vecsei, Mihaly Boros, Laszlo Juhasz, Jozsef Kaszaki
Summary: KYNA and its synthetic analogues have been found to be potential neuroprotective agents in sepsis by reducing peripheral formation of NETs, lowering BBB permeability changes, and alleviating mitochondrial dysfunction in the CNS.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Louise D. McCullough, Meaghan Roy-O'Reilly, Yun-Ju Lai, Anthony Patrizz, Yan Xu, Juneyoung Lee, Aleah Holmes, Daniel C. Kraushaar, Anjali Chauhan, Lauren H. Sansing, Barbara S. Stonestreet, Liang Zhu, Julia Kofler, Yow-Pin Lim, Venugopal Reddy Venna
Summary: IAIPs have shown significant therapeutic effects in ischemic stroke, especially in delayed treatment, with potential benefits in different age groups of experimental animals. The therapeutic effects of IAIPs in ischemic stroke are mediated through mechanisms such as inhibiting C5aR1. These results suggest that IAIPs are a potential candidate for the treatment of ischemic stroke.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Urology & Nephrology
Jennifer S. Y. Li, Harry Robertson, Katie Trinh, Arti M. Raghubar, Quan Nguyen, Nicholas Matigian, Ellis Patrick, Angus W. Thomson, Andrew J. Mallett, Natasha M. Rogers
Summary: Ischemia reperfusion injury is a common cause of acute kidney injury. Adoptively transferred tolerogenic dendritic cells can successfully limit kidney injury and provide protection against ischemia reperfusion injury.
KIDNEY INTERNATIONAL
(2023)
Article
Multidisciplinary Sciences
Yi-En Liao, Yongmei Xu, Katelyn Arnold, Fuming Zhang, Jine Li, Rani Sellers, Chaoyin Yin, Vijayakanth Pagadala, Anna Marie Inman, Robert J. Linhardt, Ding Xu, Rafal Pawlinski, Jian Liu
Summary: This study discovered that a synthetic heparan sulfate octadecasaccharide (18-mer) can effectively prevent sepsis and reduce related injuries and inflammation. The 18-mer inhibits the pro-inflammatory activity of histone H3 and HMGB1, while eliciting the anti-inflammatory effect of ApoA-I. By directly interacting with proteins, the 18-mer neutralizes cytotoxic histone H3 and separates HMGB1 and lipopolysaccharide complex, thereby reducing cell death and tissue damage in sepsis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Pharmacology & Pharmacy
Yue Chen, Xin Yi, Bo Huo, Yi He, Xian Guo, Zihao Zhang, Xiaoxuan Zhong, Xin Feng, Ze-Min Fang, Xue-Hai Zhu, Xiang Wei, Ding-Sheng Jiang
Summary: Smooth muscle cell loss and aortic dissection (AD) development are associated with ferroptosis, a novel iron-dependent regulated cell death driven by lipid peroxidation accumulation. This study found that the ferroptosis-related molecules and lipid peroxidation product were increased in the aorta of AD. The histone methyltransferase inhibitor BRD4770 showed a protective effect on ferroptosis of smooth muscle cells (SMCs) and attenuated aortic dilation and mortality in a mouse AD model.
PHARMACOLOGICAL RESEARCH
(2022)
Review
Cell Biology
Bingyi Zhou, Deliang Liu, Yuyong Tan
Summary: Cancer is the second leading cause of death worldwide, with digestive system cancers being a primary contributor. Acetylation and deacetylation play crucial roles in cancer development, with HDAC6 being a widely studied enzyme that is upregulated in various tumors and associated with clinicopathological characteristics. There is ongoing research on HDAC6 inhibitors and their potential in inhibiting tumor growth.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medicine, Research & Experimental
Astrid De Roover, Ana Escribano Nunez, Frederique M. F. Cornelis, Chahrazad Cherifi, Leire Casas-Fraile, An Sermon, Frederic Cailotto, Rik J. Lories, Silvia Monteagudo
Summary: Osteoarthritis is a prevalent joint disease with no curative treatment available, but research shows that DOT1L plays a crucial role in protecting against it, and hypoxia may enhance DOT1L expression through HIF1A to combat osteoarthritis.
Article
Multidisciplinary Sciences
Su Jin Lee, Jueng Soo You, Amal Gharbi, Yong Joo Kim, Mi Suk Lee, Dong Hwan Kim, Keun Woo Lee, In Duk Jung, Yeong Min Park
Summary: The study shows that lysine demethylase (Kdm) plays a key role in sepsis regulation, while 8-hydroxyquinoline-5-carboxylic acid (IOX1) has a significant impact on controlling endotoxemia and bacterial sepsis, as well as suppressing multidrug-resistant bacterial growth through the inhibition of DNA Gyrase.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
David Bajusz, Zsolt Bognar, Jessica Ebner, Florian Grebien, Gyorgy M. Keseru
Summary: In this study, first-generation cell-permeable non-nucleoside inhibitors of SETD2 were identified, showing dose-dependent inhibition of the enzymatic activity of SETD2. The correlation between AML cell lines with MLL rearrangements and decreased H3K36me3 levels prioritizes the further development of these compounds as potential drug candidates.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Jing Meng, Kai Deng, Na Hu, Honglun Wang
Summary: The polysaccharides derived from Nitraria tangutorum Bobr. show anti-inflammatory and protective effects in lipopolysaccharide-induced acute lung injury in mice. The main monosaccharide components of these polysaccharides include mannose, rhamnose, glucuronic acid, etc.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Pharmacology & Pharmacy
Shijie Qiu, Xuyi Li, Jingyan Zhang, Pilong Shi, Yonggang Cao, Yongzhi Zhuang, Liquan Tong
Summary: The study prepared nano-taurine by coating taurine with neutrophil membranes, and demonstrated that nano-taurine can treat hepatic ischemia-reperfusion injury by inhibiting inflammation, oxidative stress, and ferroptosis.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Hematology
Julie A. Peterson, Susan A. Maroney, Nicholas D. Martinez, Alan E. Mast
Summary: This study identified the primary source of heparin-releasable TFPI alpha in the extracellular matrix (ECM) rather than on the cell surface, suggesting its role in inhibiting procoagulant activity surrounding the vasculature. TFPI alpha was shown to interact with specific ECM proteins and glycosaminoglycans, potentially modulating VEGF responses. The study provides important insights into the function of TFPI alpha within cells and its interactions with specific proteins.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Magda C. Diaz-Vesga, Ursula Zuniga-Cuevas, Andres Ramirez-Reyes, Nicolas Herrera-Zelada, Ivan Palomo, Roberto Bravo-Sagua, Jaime A. Riquelme
Summary: Despite advances in treating myocardial infarction, limiting infarct size after reperfusion to prevent heart failure remains a challenge, with factors such as comorbidities and experimental models needing to be considered for effective cardioprotection studies. Studies show that current therapeutic strategies may not fully protect the aging heart from myocardial infarction, prompting the need for potential new cardioprotective strategies targeting the aging heart.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cell Biology
Xin Kang, Ying Chen, Xiaohong Xin, Menghan Liu, Yuan Ma, Yifei Ren, Jing Ji, Qi Yu, Lei Qu, Suxia Wang, Gang Liu, Chengang Xiang, Li Yang
Summary: The study demonstrates that hAECs and their derived EXOs have nephro-protective effects in cisplatin-induced acute kidney injury (cisplatin-AKI) in vivo, without compromising the anti-tumor activity of cisplatin.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Immunology
Cristina Puy, Jiaqing Pang, Stephanie E. Reitsma, Christina U. Lorentz, Erik Tucker, David Gailani, Andras Gruber, Florea Lupu, Owen J. T. McCarty
Summary: The study found that FXIa directly interacts with CFH and neutralizes CFH by cleaving the R341/R342 bonds, reducing its function and enhancing the activity of the complement system. Additionally, the generation of FXIa promotes the cleavage of CFH in plasma. These results reveal a novel link between the contact pathway of coagulation and the complement system.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Yuji Kondo, Jason L. Larabee, Liang Gao, Huiping Shi, Bojing Shao, Christopher M. Hoover, J. Michael McDaniel, Yen-Chun Ho, Robert Silasi-Mansat, Stephanie A. Archer-Hartmann, Parastoo Azadi, R. Sathish Srinivasan, Alireza R. Rezaie, Alain Borczuk, Jeffrey C. Laurence, Florea Lupu, Jasimuddin Ahamed, Rodger P. McEver, James F. Papin, Zhongxin Yu, Lijun Xia
Summary: The study found that the C-type lectin receptor L-SIGN acts as a receptor for SARS-CoV-2 infection, predominantly expressed in human liver sinusoidal endothelial cells (LSECs) and lymph node lymphatic endothelial cells. These endothelial cells showed increased levels of clotting factors after SARS-CoV-2 infection, potentially contributing to COVID-19-associated coagulopathy.
Article
Obstetrics & Gynecology
Aarthi Gunasekaran, Christa Devette, Samuel Levin, Hala Chaaban
Summary: Necrotizing enterocolitis (NEC) is the most common gastrointestinal emergency in the neonatal intensive care unit, but the understanding and reliable biomarkers for accurate diagnosis of this disease are still unclear. Despite extensive studies on biomarkers, there is currently a lack of biomarkers with sufficient sensitivity and specificity for use.
CLINICS IN PERINATOLOGY
(2022)
Article
Pharmacology & Pharmacy
Rebecca A. Mayes, Peter N. Johnson, Bryan P. White, Stephen B. Neely, Hala Chaaban, Jamie L. Miller
Summary: This retrospective study found that the duration of ceftazidime use was associated with an increased risk of P aeruginosa resistance in neonatal intensive care unit patients. Further studies are needed to confirm these findings.
ANNALS OF PHARMACOTHERAPY
(2022)
Article
Nutrition & Dietetics
Kathryn Burge, Jeffrey Eckert, Adam Wilson, MaJoi Trammell, Shiloh R. Lueschow, Steven J. McElroy, David Dyer, Hala Chaaban
Summary: This study found that hyaluronic acid 35 kDa (HA35) can reduce the pathological damage and mortality of necrotizing enterocolitis, potentially providing new translational targets for preventing premature infant diseases by activating protective and reparative mechanisms in the small intestine.
Article
Microbiology
Hala Chaaban, Maulin M. Patel, Kathryn Burge, Jeffrey Eckert, Cristina Lupu, Ravi S. Keshari, Robert Silasi, Girija Regmi, MaJoi Trammell, David Dyer, Steven J. McElroy, Florea Lupu
Summary: Increasing evidence suggests a correlation between prolonged antibiotic therapy in preterm infants and increased mortality and morbidities such as NEC. This study used neonatal mice to test the effects of systemic antibiotic treatment on intestinal development and found that it impaired intestinal development and increased the risk of intestinal injury.
Article
Pediatrics
David M. Box, Abhishek Makkar, Zhongxin Yu, Hala Chaaban, Henry H. Tran, Kathryn Y. Burge, Jeffrey Eckert
Summary: Maternal tobacco exposure during pregnancy is associated with increased placental neutrophil infiltration and upregulated inflammatory gene expression, but is not associated with bronchopulmonary dysplasia in preterm infants.
Article
Multidisciplinary Sciences
Adam Wilson, Kathryn Burge, Jeffrey Eckert, Hala Chaaban
Summary: In this study, a protocol to generate a two-dimensional monolayer from non-human primate enteroids was described. The enteroid-derived monolayers were then used in an in vitro scratch wound assay to investigate the effects of HA35 on cell migration and proliferation. The results showed that HA35 could accelerate wound healing by promoting cell proliferation and migration.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2022)
Review
Medicine, General & Internal
Kathryn Y. Burge, Aarthi Gunasekaran, Marjorie M. Makoni, Arshid M. Mir, Harold M. Burkhart, Hala Chaaban
Summary: This review discusses the risk factors, pathogenesis, and treatment strategies of necrotizing enterocolitis in neonates with congenital heart disease. Understanding the mechanisms underlying cardiac NEC may aid in future diagnosis and treatment of this condition.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Microbiology
Adam Wilson, Brett Bogie, Hala Chaaban, Kathryn Burge
Summary: The intestinal microbiome is implicated in NEC pathogenesis, but research has mainly focused on bacteria and ignored other microorganisms such as fungi and viruses. The role of fungi and viruses in preterm intestinal development and NEC pathogenesis is not well understood. Host and environmental factors, interkingdom interactions, and human milk also influence the abundance, diversity, and function of fungal and viral microbes in the preterm intestinal ecosystem.
Article
Cardiac & Cardiovascular Systems
Yen-Chun Ho, Xin Geng, Anna O'Donnell, Jaime Ibarrola, Amaya Fernandez-Celis, Rohan Varshney, Kumar Subramani, Zheila J. Azartash-Namin, Jang Kim, Robert Silasi, Jill Wylie-Sears, Zahra Alvandi, Lijuan Chen, Boksik Cha, Hong Chen, Lijun Xia, Bin Zhou, Florea Lupu, Harold M. Burkhart, Elena Aikawa, Lorin E. Olson, Jasimuddin Ahamed, Natalia Lopez-Andres, Joyce Bischoff, Katherine E. Yutzey, R. Sathish Srinivasan
Summary: PROX1 and FOXC2 are involved in the development and disease of cardiac valves. Deletion of PROX1 leads to thickening and myxomatous degeneration of valves, while abnormal expression of FOXC2 and PDGF-B is related to valve prolapse and valve insufficiency. Pharmacological inhibition of PDGF-B signaling can partially correct valve defects.
CIRCULATION RESEARCH
(2023)
Letter
Infectious Diseases
Rebecca A. Mayes, Peter N. Johnson, Bryan P. White, Stephen B. Neely, Hala Chaaban, Jamie L. Miller
JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY
(2022)
Meeting Abstract
Medicine, General & Internal
A. Wilson, K. Y. Burge, J. Eckert, H. Chaaban
JOURNAL OF INVESTIGATIVE MEDICINE
(2022)
Meeting Abstract
Medicine, General & Internal
K. Y. Burge, M. A. Trammell, J. Eckert, A. Wilson, S. R. Lueschow, S. J. McElroy, D. W. Dyer, H. Chaaban
JOURNAL OF INVESTIGATIVE MEDICINE
(2022)
Meeting Abstract
Medicine, General & Internal
C. DeVette, K. Y. Burge, A. Wilson, H. Chaaban
JOURNAL OF INVESTIGATIVE MEDICINE
(2022)