Reactive Oxygen Species in Inflammation and Tissue Injury

The Fas Death Signaling Pathway Connecting Reactive Oxygen Species Generation and FLICE Inhibitory Protein Down-Regulation

(2014) L. Wang et al.   JOURNAL OF IMMUNOLOGY

Mitochondrial Redox Signaling: Interaction of Mitochondrial Reactive Oxygen Species with Other Sources of Oxidative Stress

(2012) Eberhard Schulz et al.   ANTIOXIDANTS & REDOX SIGNALING

Novel atypical PKC inhibitors prevent vascular endothelial growth factor-induced blood–retinal barrier dysfunction

(2012) Paul M. Titchenell et al.   BIOCHEMICAL JOURNAL

Vascular Nox4

(2012) Rhian M. Touyz et al.   CIRCULATION RESEARCH

PKCα Activation of p120-Catenin Serine 879 Phospho-Switch Disassembles VE-Cadherin Junctions and Disrupts Vascular Integrity

(2012) Emily Vandenbroucke St Amant et al.   CIRCULATION RESEARCH

Evidence That Hyperglycemia After Recovery From Hypoglycemia Worsens Endothelial Function and Increases Oxidative Stress and Inflammation in Healthy Control Subjects and Subjects With Type 1 Diabetes

(2012) A. Ceriello et al.   DIABETES

TRAF6 Protein Couples Toll-like Receptor 4 Signaling to Src Family Kinase Activation and Opening of Paracellular Pathway in Human Lung Microvascular Endothelia

(2012) Anguo Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel Role for Non-muscle Myosin Light Chain Kinase (MLCK) in Hyperoxia-induced Recruitment of Cytoskeletal Proteins, NADPH Oxidase Activation, and Reactive Oxygen Species Generation in Lung Endothelium

(2012) Peter V. Usatyuk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Physiological Relevance of Antioxid/Redox Genes; Learning from Genetically Modified Animals Guest Editor: Junichi Fujii Novel roles of peroxiredoxins in inflammation, cancer and innate immunity

(2012) Tetsuro Ishii et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Chemokine-dependent T cell migration requires aquaporin-3–mediated hydrogen peroxide uptake

(2012) Mariko Hara-Chikuma et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-17 and TNF-  Sustain Neutrophil Recruitment during Inflammation through Synergistic Effects on Endothelial Activation

(2012) G. K. Griffin et al.   JOURNAL OF IMMUNOLOGY

Cdc42-Dependent Activation of NADPH Oxidase Is Involved in Ethanol-Induced Neuronal Oxidative Stress

(2012) Xin Wang et al.   PLoS One

Reactive Oxygen Species Regulate Protrusion Efficiency by Controlling Actin Dynamics

(2012) Nicolas Taulet et al.   PLoS One

Bax regulates primary necrosis through mitochondrial dynamics

(2012) R. S. Whelan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MARCKS protein mediates hydrogen peroxide regulation of endothelial permeability

(2012) B. Y. Jin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of reactive nitrogen species generated via inducible nitric oxide synthase in vesicant-induced lung injury, inflammation and altered lung functioning

(2012) Vasanthi R. Sunil et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Activation of TRPC6 channels is essential for lung ischaemia–reperfusion induced oedema in mice

(2012) Norbert Weissmann et al.   Nature Communications

Arginase II Promotes Macrophage Inflammatory Responses Through Mitochondrial Reactive Oxygen Species, Contributing to Insulin Resistance and Atherogenesis

(2012) Xiu‐Fen Ming et al.   Journal of the American Heart Association

Aggravation of Bleomycin-Induced Pulmonary Inflammation and Fibrosis in Mice Lacking Peroxiredoxin I

(2011) Norihiro Kikuchi et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Macrophages and Tissue Injury: Agents of Defense or Destruction?

(2011) Debra L. Laskin et al.   Annual Review of Pharmacology and Toxicology

Claudins: Control of Barrier Function and Regulation in Response to Oxidant Stress

(2011) Christian E. Overgaard et al.   ANTIOXIDANTS & REDOX SIGNALING

ZO Proteins and Redox-Dependent Processes

(2011) Lorenza González-Mariscal et al.   ANTIOXIDANTS & REDOX SIGNALING

Redox Regulation of Mitochondrial Function

(2011) Diane E. Handy et al.   ANTIOXIDANTS & REDOX SIGNALING

Src Phosphorylation of Endothelial Cell Surface Intercellular Adhesion Molecule-1 Mediates Neutrophil Adhesion and Contributes to the Mechanism of Lung Inflammation

(2011) Guoquan Liu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Leukocyte ligands for endothelial selectins: specialized glycoconjugates that mediate rolling and signaling under flow

(2011) A. Zarbock et al.   BLOOD

Roles of TRPM2 in oxidative stress

(2011) Nobuaki Takahashi et al.   CELL CALCIUM

Lysozyme M–Positive Monocytes Mediate Angiotensin II–Induced Arterial Hypertension and Vascular Dysfunction

(2011) Philip Wenzel et al.   CIRCULATION

Genetic ablation of phagocytic NADPH oxidase in mice limits TNFα-induced inflammation in the lungs but not other tissues

(2011) Wei-Jian Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cross talk between mitochondria and NADPH oxidases

(2011) Sergey Dikalov   FREE RADICAL BIOLOGY AND MEDICINE

Reactive Oxygen Species-mediated TRPC6 Protein Activation in Vascular Myocytes, a Mechanism for Vasoconstrictor-regulated Vascular Tone

(2011) Yanfeng Ding et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The suppression of myosin light chain (MLC) phosphorylation during the response to lipopolysaccharide (LPS): beneficial or detrimental to endothelial barrier?

(2011) Natalia V. Bogatcheva et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Activation of TNFR1 ectodomain shedding by mitochondrial Ca2+ determines the severity of inflammation in mouse lung microvessels

(2011) David J. Rowlands et al.   JOURNAL OF CLINICAL INVESTIGATION

Mitochondrial reactive oxygen species drive proinflammatory cytokine production: Figure 1.

(2011) Edwina Naik et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS)

(2011) Ariel C. Bulua et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Innate Immune Function of the Adherens Junction Protein p120-Catenin in Endothelial Response to Endotoxin

(2011) Y.-l. Wang et al.   JOURNAL OF IMMUNOLOGY

Protein kinase C-α signals P115RhoGEF phosphorylation and RhoA activation in TNF-α-induced mouse brain microvascular endothelial cell barrier dysfunction

(2011) Jing Peng et al.   Journal of Neuroinflammation

The redox-sensitive cation channel TRPM2 modulates phagocyte ROS production and inflammation

(2011) Anke Di et al.   NATURE IMMUNOLOGY

NOX-4 is expressed in thickened pulmonary arteries in idiopathic pulmonary fibrosis

(2011) Jean-Claude Pache et al.   NATURE MEDICINE

Targeting Vascular NADPH Oxidase 1 Blocks Tumor Angiogenesis through a PPARα Mediated Mechanism

(2011) Sarah Garrido-Urbani et al.   PLoS One

Proteomic Analysis Shows Synthetic Oleanane Triterpenoid Binds to mTOR

(2011) Mark M. Yore et al.   PLoS One

Intracellular Redox Compartments: Mechanisms and Significances

(2010) Thomas Kietzmann   ANTIOXIDANTS & REDOX SIGNALING

Lipopolysaccharide-induced hepatic oxidative injury is not potentiated by knockout of GPX1 and SOD1 in mice

(2010) Jian-Hong Zhu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Redox signaling (cross-talk) from and to mitochondria involves mitochondrial pores and reactive oxygen species

(2010) Andreas Daiber   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

CD99 and CD99L2 act at the same site as, but independently of, PECAM-1 during leukocyte diapedesis

(2010) M. G. Bixel et al.   BLOOD

Nox2 NADPH Oxidase Promotes Pathologic Cardiac Remodeling Associated with Doxorubicin Chemotherapy

(2010) Y. Zhao et al.   CANCER RESEARCH

Role of GTPases in control of microvascular permeability

(2010) V. Spindler et al.   CARDIOVASCULAR RESEARCH

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Nicotinamide Adenine Dinucleotide Phosphate Reduced Oxidase 5 (Nox5) Regulation by Angiotensin II and Endothelin-1 Is Mediated via Calcium/Calmodulin-Dependent, Rac-1-Independent Pathways in Human Endothelial Cells

(2010) Augusto C. Montezano et al.   CIRCULATION RESEARCH

Nox4 is a Novel Inducible Source of Reactive Oxygen Species in Monocytes and Macrophages and Mediates Oxidized Low Density Lipoprotein–Induced Macrophage Death

(2010) Chi Fung Lee et al.   CIRCULATION RESEARCH

Upregulation of Nox4 by Hypertrophic Stimuli Promotes Apoptosis and Mitochondrial Dysfunction in Cardiac Myocytes

(2010) Tetsuro Ago et al.   CIRCULATION RESEARCH

Zona occludens proteins modulate podosome formation and function

(2010) Joachim Kremerskothen et al.   FASEB JOURNAL

Xanthine oxidase-induced oxidative stress causes activation of NF-κB and inflammation in the liver of type I diabetic rats

(2010) Marco Romagnoli et al.   FREE RADICAL BIOLOGY AND MEDICINE

Reactive oxygen species, cellular redox systems, and apoptosis

(2010) Magdalena L. Circu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Settings and mechanisms for trans-cellular diapedesis

(2010) Peter et al.   Frontiers in Bioscience-Landmark

The Ly49Q Receptor Plays a Crucial Role in Neutrophil Polarization and Migration by Regulating Raft Trafficking

(2010) Shigemi Sasawatari et al.   IMMUNITY

Neutrophils, from Marrow to Microbes

(2010) Niels Borregaard   IMMUNITY

Human neutrophil integrin  9 1: up-regulation by cell activation and synergy with  2 integrins during adhesion to endothelium under flow

(2010) A. Mambole et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Role of protein kinase Cζ in thrombin-induced RhoA activation and inter-endothelial gap formation of human dermal microvessel endothelial cell monolayers

(2010) Richard D. Minshall et al.   MICROVASCULAR RESEARCH

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

Aquaporin-3 mediates hydrogen peroxide uptake to regulate downstream intracellular signaling

(2010) E. W. Miller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Redox regulation of Nox proteins

(2010) Srikanth Pendyala et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

NOX4/NADPH oxidase expression is increased in pulmonary fibroblasts from patients with idiopathic pulmonary fibrosis and mediates TGF 1-induced fibroblast differentiation into myofibroblasts

(2010) N. Amara et al.   THORAX

Post-Stroke Inhibition of Induced NADPH Oxidase Type 4 Prevents Oxidative Stress and Neurodegeneration

(2010) Christoph Kleinschnitz et al.   PLOS BIOLOGY

Nox4 NADPH oxidase mediates oxidative stress and apoptosis caused by TNF-α in cerebral vascular endothelial cells

(2009) Shyamali Basuroy et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

NADPH Oxidase-1 Plays a Crucial Role in Hyperoxia-induced Acute Lung Injury in Mice

(2009) Stéphanie Carnesecchi et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The Oligomerization of the Coiled Coil-domain of Occluddin Is Redox Sensitive

(2009) Juliane K. Walter et al.   Annals of the New York Academy of Sciences

Regulation Mechanisms and Signaling Pathways of Autophagy

(2009) Congcong He et al.   Annual Review of Genetics

The Inflammasomes: Guardians of the Body

(2009) Fabio Martinon et al.   Annual Review of Immunology

NOX Enzymes and Pulmonary Disease

(2009) Brian Griffith et al.   ANTIOXIDANTS & REDOX SIGNALING

Endothelial cell activation leads to neutrophil transmigration as supported by the sequential roles of ICAM-2, JAM-A, and PECAM-1

(2009) A. Woodfin et al.   BLOOD

Redox-sensitivity of the dimerization of occludin

(2009) J. K. Walter et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

NADPH Oxidase-derived ROS Contributes to Upregulation of TRPC6 Expression in Puromycin Aminonucleoside-induced Podocyte Injury

(2009) Ziying Wang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Poldip2, a Novel Regulator of Nox4 and Cytoskeletal Integrity in Vascular Smooth Muscle Cells

(2009) Alicia N. Lyle et al.   CIRCULATION RESEARCH

Recent developments and complexities in neutrophil transmigration

(2009) Abigail Woodfin et al.   CURRENT OPINION IN HEMATOLOGY

Patients with severe psoriasis are at increased risk of cardiovascular mortality: cohort study using the General Practice Research Database

(2009) N. N. Mehta et al.   EUROPEAN HEART JOURNAL

Histamine acting on H1 receptor promotes inhibition of proliferation via PLC, RAC, and JNK-dependent pathways

(2009) Cintia Notcovich et al.   EXPERIMENTAL CELL RESEARCH

Peroxiredoxin I is a negative regulator of Th2-dominant allergic asthma

(2009) Ken-ichiro Inoue et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Oxidative Stress Decreases Phosphatidylinositol 4,5-Bisphosphate Levels by Deactivating Phosphatidylinositol- 4-phosphate 5-Kinase β in a Syk-dependent Manner

(2009) Mark Z. Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Regulation of Vascular Endothelial Growth Factor-induced Microvascular Permeability Requires Rac and Reactive Oxygen Species

(2009) Elizabeth Monaghan-Benson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Integrins in immunity

(2009) R. Evans et al.   JOURNAL OF CELL SCIENCE

Disruption of Nrf2 Impairs the Resolution of Hyperoxia-Induced Acute Lung Injury and Inflammation in Mice

(2009) N. M. Reddy et al.   JOURNAL OF IMMUNOLOGY

Regulation of Mature ADAM17 by Redox Agents for L-Selectin Shedding

(2009) Y. Wang et al.   JOURNAL OF IMMUNOLOGY

Elevated Mitochondrial Reactive Oxygen Species Generation Affects the Immune Response via Hypoxia-Inducible Factor-1  in Long-Lived Mclk1+/- Mouse Mutants

(2009) D. Wang et al.   JOURNAL OF IMMUNOLOGY

Occludin oligomeric assemblies at tight junctions of the blood-brain barrier are altered by hypoxia and reoxygenation stress

(2009) Gwen McCaffrey. et al.   JOURNAL OF NEUROCHEMISTRY

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

Direct Activation of RhoA by Reactive Oxygen Species Requires a Redox-Sensitive Motif

(2009) Amir Aghajanian et al.   PLoS One

Subcellular localization of Nox4 and regulation in diabetes

(2009) K. Block et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Driving Rho GTPase activity in endothelial cells regulates barrier integrity

(2009) C. M. L. Beckers et al.   THROMBOSIS AND HAEMOSTASIS

Mechanisms of nitric oxide synthase uncoupling in endotoxin-induced acute lung injury: Role of asymmetric dimethylarginine

(2009) Shruti Sharma et al.   VASCULAR PHARMACOLOGY

Critical role of Cdc42 in mediating endothelial barrier protection in vivo

(2008) Ramaswamy Ramchandran et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

NOX4 mediates hypoxia-induced proliferation of human pulmonary artery smooth muscle cells: the role of autocrine production of transforming growth factor-β1 and insulin-like growth factor binding protein-3

(2008) Saleh Ismail et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

NOX4 Regulates ROS Levels Under Normoxic and Hypoxic Conditions, Triggers Proliferation, and Inhibits Apoptosis in Pulmonary Artery Adventitial Fibroblasts

(2008) Shu Li et al.   ANTIOXIDANTS & REDOX SIGNALING

Regulation of NADPH Oxidase in Vascular Endothelium: The Role of Phospholipases, Protein Kinases, and Cytoskeletal Proteins

(2008) Srikanth Pendyala et al.   ANTIOXIDANTS & REDOX SIGNALING

Role of Nox4 and Nox2 in Hyperoxia-Induced Reactive Oxygen Species Generation and Migration of Human Lung Endothelial Cells

(2008) Srikanth Pendyala et al.   ANTIOXIDANTS & REDOX SIGNALING

Is there a role for supplemented antioxidants in the prevention of atherosclerosis?

(2008) Niki Katsiki et al.   CLINICAL NUTRITION

Glutathione peroxidase family - an evolutionary overview

(2008) Rogerio Margis et al.   FEBS Journal

Nox5 mediates PDGF-induced proliferation in human aortic smooth muscle cells

(2008) Desmond B. Jay et al.   FREE RADICAL BIOLOGY AND MEDICINE

Genetic deficiency of NADPH oxidase does not diminish, but rather enhances, LPS-induced acute inflammatory responses in vivo

(2008) Wei-Jian Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Involvement of Nox2 NADPH Oxidase in Adverse Cardiac Remodeling After Myocardial Infarction

(2008) Yee H. Looi et al.   HYPERTENSION

TLR4 Signaling Is Coupled to SRC Family Kinase Activation, Tyrosine Phosphorylation of Zonula Adherens Proteins, and Opening of the Paracellular Pathway in Human Lung Microvascular Endothelia

(2008) Ping Gong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation of Tyr-398 and Tyr-402 in Occludin Prevents Its Interaction with ZO-1 and Destabilizes Its Assembly at the Tight Junctions

(2008) Bertha C. Elias et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endothelial adhesion receptors are recruited to adherent leukocytes by inclusion in preformed tetraspanin nanoplatforms

(2008) Olga Barreiro et al.   JOURNAL OF CELL BIOLOGY

Toll-like receptors, wound healing, and carcinogenesis

(2008) Johannes Kluwe et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Occludin oligomeric assembly at tight junctions of the blood-brain barrier is disrupted by peripheral inflammatory hyperalgesia

(2008) Gwen McCaffrey et al.   JOURNAL OF NEUROCHEMISTRY

Calcium-Dependent NOX5 Nicotinamide Adenine Dinucleotide Phosphate Oxidase Contributes to Vascular Oxidative Stress in Human Coronary Artery Disease

(2008) Tomasz J. Guzik et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

(2008) Tatsuya Saitoh et al.   NATURE

From endoplasmic-reticulum stress to the inflammatory response

(2008) Kezhong Zhang et al.   NATURE

ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration

(2008) Zhihui Zhong et al.   NATURE NEUROSCIENCE

Structural Basis of Protein Kinase C Isoform Function

(2008) Susan F. Steinberg   PHYSIOLOGICAL REVIEWS

Endothelial Domes Encapsulate Adherent Neutrophils and Minimize Increases in Vascular Permeability in Paracellular and Transcellular Emigration

(2008) Mia Phillipson et al.   PLoS One

Targeting Nrf2 with the triterpenoid CDDO- imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice

(2008) T. E. Sussan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

(2008) C. Dostert et al.   SCIENCE

Contribution of xanthine oxidase-derived superoxide to chronic hypoxic pulmonary hypertension in neonatal rats

(2007) Robert P. Jankov et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Endothelial MnSOD overexpression prevents retinal VEGF expression in diabetic mice

(2007) Hideo Goto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Role of TRPM2 Channel in Mediating H 2 O 2 -Induced Ca 2+ Entry and Endothelial Hyperpermeability

(2007) Claudie M. Hecquet et al.   CIRCULATION RESEARCH

Molecular Mechanisms of Angiotensin II–Mediated Mitochondrial Dysfunction

(2007) Abdulrahman K. Doughan et al.   CIRCULATION RESEARCH

Phosphorylation of vascular endothelial cadherin controls lymphocyte emigration

(2007) P. Turowski et al.   JOURNAL OF CELL SCIENCE