Repair or destruction-an intimate liaison between ubiquitin ligases and molecular chaperones in proteostasis

The HSP90 chaperone machinery

(2017) Florian H. Schopf et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ubiquitinated proteins promote the association of proteasomes with the deubiquitinating enzyme Usp14 and the ubiquitin ligase Ube3c

(2017) Chueh-Ling Kuo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

How Do J-Proteins Get Hsp70 to Do So Many Different Things?

(2017) Elizabeth A. Craig et al.   TRENDS IN BIOCHEMICAL SCIENCES

Evolution of an intricate J-protein network driving protein disaggregation in eukaryotes

(2017) Nadinath B Nillegoda et al.   eLife

Protein Quality Control by Molecular Chaperones in Neurodegeneration

(2017) Aaron Ciechanover et al.   Frontiers in Neuroscience

The crystal structure of the Sgt1-Skp1 complex: the link between Hsp90 and both SCF E3 ubiquitin ligases and kinetochores

(2017) Oliver Willhoft et al.   Scientific Reports

The E3 ubiquitin ligase CHIP mediates ubiquitination and proteasomal degradation of PRMT5

(2016) Huan-Tian Zhang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mitochondrial quality control by the Pink1/Parkin system

(2016) Cornelia Rüb et al.   CELL AND TISSUE RESEARCH

Chaperone families and interactions in metazoa

(2016) Y. Bar-Lavan et al.   Essays in Biochemistry

Defending the mitochondria: The pathways of mitophagy and mitochondrial-derived vesicles

(2016) Rosalind F. Roberts et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Rqc1 and Ltn1 Prevent C-terminal Alanine-Threonine Tail (CAT-tail)-induced Protein Aggregation by Efficient Recruitment of Cdc48 on Stalled 60S Subunits

(2016) Quentin Defenouillère et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Failure of RQC machinery causes protein aggregation and proteotoxic stress

(2016) Young-Jun Choe et al.   NATURE

The epichaperome is an integrated chaperome network that facilitates tumour survival

(2016) Anna Rodina et al.   NATURE

Heat Shock Proteins Promote Cancer: It's a Protection Racket

(2016) Stuart K. Calderwood et al.   TRENDS IN BIOCHEMICAL SCIENCES

Deubiquitinase activity is required for the proteasomal degradation of misfolded cytosolic proteins upon heat-stress

(2016) Nancy N. Fang et al.   Nature Communications

Degradation Signals for Ubiquitin-Proteasome Dependent Cytosolic Protein Quality Control (CytoQC) in Yeast

(2016) Matthew J. Maurer et al.   G3-Genes Genomes Genetics

A conserved quality-control pathway that mediates degradation of unassembled ribosomal proteins

(2016) Min-Kyung Sung et al.   eLife

The Rqc2/Tae2 subunit of the ribosome-associated quality control (RQC) complex marks ribosome-stalled nascent polypeptide chains for aggregation

(2016) Ryo Yonashiro et al.   eLife

Degradation-mediated protein quality control at the inner nuclear membrane

(2016) Mirta Boban et al.   Nucleus

A Decade of Boon or Burden: What Has the CHIP Ever Done for Cellular Protein Quality Control Mechanism Implicated in Neurodegeneration and Aging?

(2016) Vibhuti Joshi et al.   Frontiers in Molecular Neuroscience

Degradation-mediated protein quality control at the inner nuclear membrane

(2016) Mirta Boban et al.   Nucleus

Bioinformatics analysis identifies several intrinsically disordered human E3 ubiquitin-protein ligases

(2016) Wouter Boomsma et al.   PeerJ

The HECT domain ubiquitin ligase HUWE1 targets unassembled soluble proteins for degradation

(2016) Yue Xu et al.   Cell Discovery

The Biology of Proteostasis in Aging and Disease

(2015) Johnathan Labbadia et al.   Annual Review of Biochemistry

Ubiquitination of newly synthesized proteins at the ribosome

(2015) Feng Wang et al.   BIOCHIMIE

Widespread Proteome Remodeling and Aggregation in Aging C. elegans

(2015) Dirk M. Walther et al.   CELL

The right place at the right time: chaperoning core histone variants

(2015) F. Mattiroli et al.   EMBO REPORTS

A CHIPotle in physiology and disease

(2015) Indranil Paul et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Compartmentalization and Functionality of Nuclear Disorder: Intrinsic Disorder and Protein-Protein Interactions in Intra-Nuclear Compartments

(2015) Fanchi Meng et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Mechanism and Function of Group II Chaperonins

(2015) Tom Lopez et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure and Assembly Pathway of the Ribosome Quality Control Complex

(2015) Sichen Shao et al.   MOLECULAR CELL

The Ubiquitin-Proteasome System and Molecular Chaperone Deregulation in Alzheimer’s Disease

(2015) Yanuar Alan Sulistio et al.   MOLECULAR NEUROBIOLOGY

Crucial HSP70 co-chaperone complex unlocks metazoan protein disaggregation

(2015) Nadinath B. Nillegoda et al.   NATURE

Proteostasis and aging

(2015) Susmita Kaushik et al.   NATURE MEDICINE

Histone exchange, chromatin structure and the regulation of transcription

(2015) Swaminathan Venkatesh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Biochemical and Proteomic Analysis of Ubiquitination of Hsc70 and Hsp70 by the E3 Ligase CHIP

(2015) Sarah E. Soss et al.   PLoS One

Supersaturation is a major driving force for protein aggregation in neurodegenerative diseases

(2015) Prajwal Ciryam et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Active Nuclear Import of Membrane Proteins Revisited

(2015) Justyna Laba et al.   Cells

Autophagic degradation of nuclear components in mammalian cells

(2014) Young-Eun Park et al.   Autophagy

A Quantitative Chaperone Interaction Network Reveals the Architecture of Cellular Protein Homeostasis Pathways

(2014) Mikko Taipale et al.   CELL

The Mechanistic Links Between Proteasome Activity, Aging and Agerelated Diseases

(2014) Isabel Saez et al.   CURRENT GENOMICS

Quality Control of Plasma Membrane Proteins by Saccharomyces cerevisiae Nedd4-Like Ubiquitin Ligase Rsp5p under Environmental Stress Conditions

(2014) Takeki Shiga et al.   EUKARYOTIC CELL

The FACT complex interacts with the E3 ubiquitin ligase Psh1 to prevent ectopic localization of CENP-A

(2014) Gary M.R. Deyter et al.   GENES & DEVELOPMENT

HSP27, 70 and 90, anti-apoptotic proteins, in clinical cancer therapy

(2014) XIAOXIA WANG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

ER-associated degradation: Protein quality control and beyond

(2014) Annamaria Ruggiano et al.   JOURNAL OF CELL BIOLOGY

The requirement for Cdc48/p97 in nuclear protein quality control degradation depends on the substrate and correlates with substrate insolubility

(2014) P. S. Gallagher et al.   JOURNAL OF CELL SCIENCE

Proteostasis and the Aging Proteome in Health and Disease

(2014) R. I. Morimoto et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

The Functional Landscape of Hsp27 Reveals New Cellular Processes such as DNA Repair and Alternative Splicing and Proposes Novel Anticancer Targets

(2014) Maria Katsogiannou et al.   MOLECULAR & CELLULAR PROTEOMICS

Cytosolic Quality Control of Mislocalized Proteins Requires RNF126 Recruitment to Bag6

(2014) Monica C. Rodrigo-Brenni et al.   MOLECULAR CELL

A Cellular System that Degrades Misfolded Proteins and Protects against Neurodegeneration

(2014) Lili Guo et al.   MOLECULAR CELL

Protein quality control at the inner nuclear membrane

(2014) Anton Khmelinskii et al.   NATURE

Rsp5/Nedd4 is the main ubiquitin ligase that targets cytosolic misfolded proteins following heat stress

(2014) Nancy N. Fang et al.   NATURE CELL BIOLOGY

Cleaning up in the endoplasmic reticulum: ubiquitin in charge

(2014) John C Christianson et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

E3 ubiquitin ligase Cullin-5 modulates multiple molecular and cellular responses to heat shock protein 90 inhibition in human cancer cells

(2014) R. S. Samant et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quality control of inner nuclear membrane proteins by the Asi complex

(2014) O. Foresti et al.   SCIENCE

A Chaperome Subnetwork Safeguards Proteostasis in Aging and Neurodegenerative Disease

(2014) Marc Brehme et al.   Cell Reports

STUB1/CHIP is required for HIF1A degradation by chaperone-mediated autophagy

(2013) João Vasco Ferreira et al.   Autophagy

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

SnapShot: Selective Autophagy

(2013) Meiyan Jin et al.   CELL

A Cul4 E3 Ubiquitin Ligase Regulates Histone Hand-Off during Nucleosome Assembly

(2013) Junhong Han et al.   CELL

Selective Autophagy: Talking with the UPS

(2013) Caroline Park et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Chaperone-mediated autophagy: roles in disease and aging

(2013) Ana Maria Cuervo et al.   CELL RESEARCH

Cellular Mechanotransduction Relies on Tension-Induced and Chaperone-Assisted Autophagy

(2013) Anna Ulbricht et al.   CURRENT BIOLOGY

Hsp90, an unlikely ally in the war on cancer

(2013) Jared J. Barrott et al.   FEBS Journal

Hsp70 Targets a Cytoplasmic Quality Control Substrate to the San1p Ubiquitin Ligase

(2013) Christopher J. Guerriero et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The E3 Ubiquitin Ligase UBE3C Enhances Proteasome Processivity by Ubiquitinating Partially Proteolyzed Substrates

(2013) Bernard W. Chu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endoplasmic Reticulum Protein Quality Control Is Determined by Cooperative Interactions between Hsp/c70 Protein and the CHIP E3 Ligase

(2013) Yoshihiro Matsumura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ubiquitin conjugation triggers misfolded protein sequestration into quality control foci when Hsp70 chaperone levels are limiting

(2013) Ayala Shiber et al.   MOLECULAR BIOLOGY OF THE CELL

Principles of Cotranslational Ubiquitination and Quality Control at the Ribosome

(2013) Stefanie Duttler et al.   MOLECULAR CELL

Structural basis of histone H2A–H2B recognition by the essential chaperone FACT

(2013) Maria Hondele et al.   NATURE

Diversity in the origins of proteostasis networks — a driver for protein function in evolution

(2013) Evan T. Powers et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Chaperone machines for protein folding, unfolding and disaggregation

(2013) Helen Saibil   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Type II Hsp40 Sis1 Cooperates with Hsp70 and the E3 Ligase Ubr1 to Promote Degradation of Terminally Misfolded Cytosolic Protein

(2013) Daniel W. Summers et al.   PLoS One

Cdc48/p97 promotes degradation of aberrant nascent polypeptides bound to the ribosome

(2013) Rati Verma et al.   eLife

The ART-Rsp5 ubiquitin ligase network comprises a plasma membrane quality control system that protects yeast cells from proteotoxic stress

(2013) Yingying Zhao et al.   eLife

Ubiquitin and Membrane Protein Turnover: From Cradle to Grave

(2012) Jason A. MacGurn et al.   Annual Review of Biochemistry

The Ubiquitin Code

(2012) David Komander et al.   Annual Review of Biochemistry

A Ribosome-Bound Quality Control Complex Triggers Degradation of Nascent Peptides and Signals Translation Stress

(2012) Onn Brandman et al.   CELL

Heat shock proteins in cancer: targeting the ‘chaperones’

(2012) Z Nahleh et al.   Future Medicinal Chemistry

Heat shock transcription factor 1 inhibits H2O2-induced cardiomyocyte death through suppression of high-mobility group box 1

(2012) Ying Yu et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

RPN-6 determines C. elegans longevity under proteotoxic stress conditions

(2012) David Vilchez et al.   NATURE

Chaperones in autophagy

(2012) Susmita Kaushik et al.   PHARMACOLOGICAL RESEARCH

Novel E3 Ubiquitin Ligases That Regulate Histone Protein Levels in the Budding Yeast Saccharomyces cerevisiae

(2012) Rakesh Kumar Singh et al.   PLoS One

Hul5 ubiquitin ligase

(2012) Nancy N. Fang et al.   Prion

Superior thermotolerance of Saccharomyces cerevisiae for efficient bioethanol fermentation can be achieved by overexpression of RSP5 ubiquitin ligase

(2011) Hosein Shahsavarani et al.   BIOTECHNOLOGY ADVANCES

The chaperone–histone partnership: for the greater good of histone traffic and chromatin plasticity

(2011) Maria Hondele et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

UBR1 promotes protein kinase quality control and sensitizes cells to Hsp90 inhibition

(2011) Rasheda Sultana et al.   EXPERIMENTAL CELL RESEARCH

Cross-functional E3 ligases Parkin and C-terminus Hsp70-interacting protein in neurodegenerative disorders

(2011) Pravir Kumar et al.   JOURNAL OF NEUROCHEMISTRY

Exposed hydrophobicity is a key determinant of nuclear quality control degradation

(2011) Eric K. Fredrickson et al.   MOLECULAR BIOLOGY OF THE CELL

Disorder Targets Misorder in Nuclear Quality Control Degradation: A Disordered Ubiquitin Ligase Directly Recognizes Its Misfolded Substrates

(2011) Joel C. Rosenbaum et al.   MOLECULAR CELL

Protein targeting and degradation are coupled for elimination of mislocalized proteins

(2011) Tara Hessa et al.   NATURE

Molecular chaperones in protein folding and proteostasis

(2011) F. Ulrich Hartl et al.   NATURE

The Machado-Joseph disease deubiquitylase ATX-3 couples longevity and proteostasis

(2011) Kirsten Kuhlbrodt et al.   NATURE CELL BIOLOGY

Misfolded proteins driven to destruction by Hul5

(2011) Daniel Finley   NATURE CELL BIOLOGY

Hul5 HECT ubiquitin ligase plays a major role in the ubiquitylation and turnover of cytosolic misfolded proteins

(2011) Nancy N. Fang et al.   NATURE CELL BIOLOGY

ERAD ubiquitin ligases

(2010) Martin Mehnert et al.   BIOESSAYS

Chaperone-assisted degradation: multiple paths to destruction

(2010) Nadja Kettern et al.   BIOLOGICAL CHEMISTRY

Targeting heat shock proteins in cancer

(2010) Gaëtan Jego et al.   CANCER LETTERS

Distinct Factors Control Histone Variant H3.3 Localization at Specific Genomic Regions

(2010) Aaron D. Goldberg et al.   CELL

Excess histone levels mediate cytotoxicity via multiple mechanisms

(2010) Rakesh Kumar Singh et al.   CELL CYCLE

Chaperone-Assisted Selective Autophagy Is Essential for Muscle Maintenance

(2010) Verena Arndt et al.   CURRENT BIOLOGY

The small heat shock protein B8 (HspB8) promotes autophagic removal of misfolded proteins involved in amyotrophic lateral sclerosis (ALS)

(2010) Valeria Crippa et al.   HUMAN MOLECULAR GENETICS

Versatility of Trigger Factor Interactions with Ribosome-Nascent Chain Complexes

(2010) Sathish Kumar Lakshmipathy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein homeostasis and aging in neurodegeneration

(2010) Peter M. Douglas et al.   JOURNAL OF CELL BIOLOGY

Hsp90–Sgt1 and Skp1 target human Mis12 complexes to ensure efficient formation of kinetochore–microtubule binding sites

(2010) Alexander E. Davies et al.   JOURNAL OF CELL BIOLOGY

Quality control for unfolded proteins at the plasma membrane

(2010) Pirjo M. Apaja et al.   JOURNAL OF CELL BIOLOGY

A Nucleus-based Quality Control Mechanism for Cytosolic Proteins

(2010) Rupali Prasad et al.   MOLECULAR BIOLOGY OF THE CELL

Ubr1 and Ubr2 Function in a Quality Control Pathway for Degradation of Unfolded Cytosolic Proteins

(2010) Nadinath B. Nillegoda et al.   MOLECULAR BIOLOGY OF THE CELL

Network organization of the human autophagy system

(2010) Christian Behrends et al.   NATURE

Enhancement of proteasome activity by a small-molecule inhibitor of USP14

(2010) Byung-Hoon Lee et al.   NATURE

Role of a ribosome-associated E3 ubiquitin ligase in protein quality control

(2010) Mario H. Bengtson et al.   NATURE

The genetics of ageing

(2010) Cynthia J. Kenyon   NATURE

Selective autophagy: ubiquitin-mediated recognition and beyond

(2010) Claudine Kraft et al.   NATURE CELL BIOLOGY

The HSP70 chaperone machinery: J proteins as drivers of functional specificity

(2010) Harm H. Kampinga et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The culprit behind amyloid beta peptide related neurotoxicity in Alzheimer's disease: oligomer size or conformation?

(2010) Kerensa Broersen et al.   Alzheimers Research & Therapy

Biological and Chemical Approaches to Diseases of Proteostasis Deficiency

(2009) Evan T. Powers et al.   Annual Review of Biochemistry

Recognition and Processing of Ubiquitin-Protein Conjugates by the Proteasome

(2009) Daniel Finley   Annual Review of Biochemistry

Interplay between protein homeostasis networks in protein aggregation and proteotoxicity

(2009) Peter M. Douglas et al.   BIOPOLYMERS

Hsp90 and co-chaperones twist the functions of diverse client proteins

(2009) Abbey Zuehlke et al.   BIOPOLYMERS

Defining the Human Deubiquitinating Enzyme Interaction Landscape

(2009) Mathew E. Sowa et al.   CELL

Quantitative Proteomics Reveals the Function of Unconventional Ubiquitin Chains in Proteasomal Degradation

(2009) Ping Xu et al.   CELL

Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3

(2009) Martin Gamerdinger et al.   EMBO JOURNAL

S5a promotes protein degradation by blocking synthesis of nondegradable forked ubiquitin chains

(2009) Hyoung Tae Kim et al.   EMBO JOURNAL

Intranuclear Degradation of Polyglutamine Aggregates by the Ubiquitin-Proteasome System

(2009) Atsushi Iwata et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Ubiquitin Ligase E6-AP Is Induced and Recruited to Aggresomes in Response to Proteasome Inhibition and May Be Involved in the Ubiquitination of Hsp70-bound Misfolded Proteins

(2009) Amit Mishra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Ubiquitin Ligase Hul5 Promotes Proteasomal Processivity

(2009) S. Aviram et al.   MOLECULAR AND CELLULAR BIOLOGY

Histone levels are regulated by phosphorylation and ubiquitylation-dependent proteolysis

(2009) Rakesh Kumar Singh et al.   NATURE CELL BIOLOGY

Cytoplasmic protein quality control degradation mediated by parallel actions of the E3 ubiquitin ligases Ubr1 and San1

(2009) J. W. Heck et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Hsp90 client proteins by a Cullin5-RING E3 ubiquitin ligase

(2009) E. S. Ehrlich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of the aging process by autophagy

(2009) Antero Salminen et al.   TRENDS IN MOLECULAR MEDICINE

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

Function and structure of inherently disordered proteins

(2008) A Keith Dunker et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Molecular mechanism and structure of Trigger Factor bound to the translating ribosome

(2008) Frieder Merz et al.   EMBO JOURNAL

Structural and functional coupling of Hsp90- and Sgt1-centred multi-protein complexes

(2008) Minghao Zhang et al.   EMBO JOURNAL

Degradation of misfolded protein in the cytoplasm is mediated by the ubiquitin ligase Ubr1

(2008) Frederik Eisele et al.   FEBS LETTERS

Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging

(2008) R. I. Morimoto   GENES & DEVELOPMENT

CHIP deletion reveals functional redundancy of E3 ligases in promoting degradation of both signaling proteins and expanded glutamine proteins

(2008) Y. Morishima et al.   HUMAN MOLECULAR GENETICS

Functional Divergence between Co-chaperones of Hsc70

(2008) Stefan Tzankov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Degradation of a Cytosolic Protein Requires Endoplasmic Reticulum-associated Degradation Machinery

(2008) Meredith Boyle Metzger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CHIP promotes Runx2 degradation and negatively regulates osteoblast differentiation

(2008) Xueni Li et al.   JOURNAL OF CELL BIOLOGY

Chaperone signalling complexes in Alzheimer's disease

(2008) John Koren et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

CHIP Deficiency Decreases Longevity, with Accelerated Aging Phenotypes Accompanied by Altered Protein Quality Control

(2008) J.-N. Min et al.   MOLECULAR AND CELLULAR BIOLOGY

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE

In vivo suppression of polyglutamine neurotoxicity by C-terminus of Hsp70-interacting protein (CHIP) supports an aggregation model of pathogenesis

(2008) Aislinn J. Williams et al.   NEUROBIOLOGY OF DISEASE

Contribution of positively charged flanking residues to the insertion of transmembrane helices into the endoplasmic reticulum

(2008) M. Lerch-Bader et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adapting Proteostasis for Disease Intervention

(2008) William E. Balch et al.   SCIENCE

Proteasomal dysfunction activates the transcription factor SKN-1 and produces a selective oxidative-stress response inCaenorhabditis elegans

(2007) Nate W. Kahn et al.   BIOCHEMICAL JOURNAL