Heat shock proteins in cancer: targeting the ‘chaperones’

Molecular chaperones: Toward new therapeutic tools

(2011) Mauro B. Almeida et al.   BIOMEDICINE & PHARMACOTHERAPY

Heat Shock Proteins: A Potential Anticancer Target

(2011) Kamalesh K. Sankhala et al.   CURRENT DRUG TARGETS

The 90-kDa Heat-shock Protein (Hsp90)-binding Immunophilin FKBP51 Is a Mitochondrial Protein That Translocates to the Nucleus to Protect Cells against Oxidative Stress

(2011) Luciana I. Gallo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multifaceted Intervention by the Hsp90 Inhibitor Ganetespib (STA-9090) in Cancer Cells with Activated JAK/STAT Signaling

(2011) David A. Proia et al.   PLoS One

Death by chaperone: HSP90, HSP70 or both?

(2010) Marissa V. Powers et al.   CELL CYCLE

Targeting heat shock protein 72 enhances Hsp90 inhibitor-induced apoptosis in myeloma

(2010) E L Davenport et al.   LEUKEMIA

Phase I study of the heat shock protein 90 inhibitor alvespimycin (KOS-1022, 17-DMAG) administered intravenously twice weekly to patients with acute myeloid leukemia

(2010) J E Lancet et al.   LEUKEMIA

The Heat Shock Response: Life on the Verge of Death

(2010) Klaus Richter et al.   MOLECULAR CELL

Heat shock factors: integrators of cell stress, development and lifespan

(2010) Malin Åkerfelt et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Protein Kinase A Binds and Activates Heat Shock Factor 1

(2010) Ayesha Murshid et al.   PLoS One

Heat Shock Cognate Protein 70 Is Essential for Akt Signaling in Endothelial Function

(2009) Masayuki Shiota et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Update on Hsp90 Inhibitors in Clinical Trial

(2009) Y. Kim et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Phase I trial of 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG), a heat shock protein inhibitor, administered twice weekly in patients with advanced malignancies

(2009) Shivaani Kummar et al.   EUROPEAN JOURNAL OF CANCER

Retaspimycin hydrochloride (IPI-504): a novel heat shock protein inhibitor as an anticancer agent

(2009) Britt Erika Hanson et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Heat shock proteins, cell survival and drug resistance: The mitochondrial chaperone TRAP1, a potential novel target for ovarian cancer therapy

(2009) Matteo Landriscina et al.   GYNECOLOGIC ONCOLOGY

Detection of gastric carcinoma-associated MG7-Ag by serum immuno-PCR assay in a high-risk Chinese population, with implication for screening

(2009) Lian Zhang et al.   INTERNATIONAL JOURNAL OF CANCER

Combinatorial drug design targeting multiple cancer signaling networks controlled by mitochondrial Hsp90

(2009) Byoung Heon Kang et al.   JOURNAL OF CLINICAL INVESTIGATION

BIIB021, an orally available, fully synthetic small-molecule inhibitor of the heat shock protein Hsp90

(2009) K. Lundgren et al.   MOLECULAR CANCER THERAPEUTICS

Targeting HSP70 for Cancer Therapy

(2009) Lorenzo Galluzzi et al.   MOLECULAR CELL

KU135, a Novel Novobiocin-Derived C-Terminal Inhibitor of the 90-kDa Heat Shock Protein, Exerts Potent Antiproliferative Effects in Human Leukemic Cells

(2009) S. N. Shelton et al.   MOLECULAR PHARMACOLOGY

A purine scaffold Hsp90 inhibitor destabilizes BCL-6 and has specific antitumor activity in BCL-6–dependent B cell lymphomas

(2009) Leandro C Cerchietti et al.   NATURE MEDICINE

Inhibitors of HSP90 block p95-HER2 signaling in Trastuzumab-resistant tumors and suppress their growth

(2009) S Chandarlapaty et al.   ONCOGENE

Compartmentalized cancer drug discovery targeting mitochondrial Hsp90 chaperones

(2009) B H Kang et al.   ONCOGENE

Proteomic profiling of heat shock proteins: An emerging molecular approach with direct pathophysiological and clinical implications

(2009) Patrizia Bottoni et al.   Proteomics Clinical Applications

Dual Targeting of HSC70 and HSP72 Inhibits HSP90 Function and Induces Tumor-Specific Apoptosis

(2008) Marissa V. Powers et al.   CANCER CELL

NVP-AUY922: A Novel Heat Shock Protein 90 Inhibitor Active against Xenograft Tumor Growth, Angiogenesis, and Metastasis

(2008) S. A. Eccles et al.   CANCER RESEARCH

Heat shock proteins in animal neoplasms and human tumours—a comparison

(2008) Mariarita Romanucci et al.   CELL STRESS & CHAPERONES

Inflammation, heat shock proteins, and type 2 diabetes

(2008) Philip L. Hooper et al.   CELL STRESS & CHAPERONES

SNX2112, a Synthetic Heat Shock Protein 90 Inhibitor, Has Potent Antitumor Activity against HER Kinase Dependent Cancers

(2008) S. Chandarlapaty et al.   CLINICAL CANCER RESEARCH

Novobiocin and Additional Inhibitors of the Hsp90 C-Terminal Nucleotide- binding Pocket

(2008) Alison Donnelly et al.   CURRENT MEDICINAL CHEMISTRY

Efficacy of Sunitinib and Sorafenib in Metastatic Papillary and Chromophobe Renal Cell Carcinoma

(2007) Toni K. Choueiri et al.   JOURNAL OF CLINICAL ONCOLOGY