Exposed hydrophobicity is a key determinant of nuclear quality control degradation

Nuclear Protein Quality Is Regulated by the Ubiquitin-Proteasome System through the Activity of Ubc4 and San1 in Fission Yeast

(2011) Yuzy Matsuo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Disorder Targets Misorder in Nuclear Quality Control Degradation: A Disordered Ubiquitin Ligase Directly Recognizes Its Misfolded Substrates

(2011) Joel C. Rosenbaum et al.   MOLECULAR CELL

Modularity of the Hrd1 ERAD complex underlies its diverse client range

(2010) Kazue Kanehara et al.   JOURNAL OF CELL BIOLOGY

Ubr1 and Ubr2 Function in a Quality Control Pathway for Degradation of Unfolded Cytosolic Proteins

(2010) Nadinath B. Nillegoda et al.   MOLECULAR BIOLOGY OF THE CELL

Structural characterization of a misfolded intermediate populated during the folding process of a PDZ domain

(2010) Stefano Gianni et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanism of the Orotidine 5′-Monophosphate Decarboxylase-Catalyzed Reaction: Evidence for Substrate Destabilization,

(2009) Kui K. Chan et al.   BIOCHEMISTRY

Intranuclear Degradation of Polyglutamine Aggregates by the Ubiquitin-Proteasome System

(2009) Atsushi Iwata et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Htm1 protein generates the N-glycan signal for glycoprotein degradation in the endoplasmic reticulum

(2009) Simone Clerc et al.   JOURNAL OF CELL BIOLOGY

Quality Control of a Transcriptional Regulator by SUMO-Targeted Degradation

(2009) Z. Wang et al.   MOLECULAR AND CELLULAR BIOLOGY

Intrinsic Conformational Determinants Signal Protein Misfolding to the Hrd1/Htm1 Endoplasmic Reticulum–associated Degradation System

(2009) Wei Xie et al.   MOLECULAR BIOLOGY OF THE CELL

Misfolded Membrane Proteins Are Specifically Recognized by the Transmembrane Domain of the Hrd1p Ubiquitin Ligase

(2009) Brian K. Sato et al.   MOLECULAR CELL

Inefficient Quality Control of Thermosensitive Proteins on the Plasma Membrane

(2009) Michael J. Lewis et al.   PLoS One

Cytoplasmic protein quality control degradation mediated by parallel actions of the E3 ubiquitin ligases Ubr1 and San1

(2009) J. W. Heck et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dissecting the ER-Associated Degradation of a Misfolded Polytopic Membrane Protein

(2008) Kunio Nakatsukasa et al.   CELL

A Genomewide Suppressor and Enhancer Analysis of cdc13-1 Reveals Varied Cellular Processes Influencing Telomere Capping in Saccharomyces cerevisiae

(2008) S. G. Addinall et al.   GENETICS

Degradation of a Cytosolic Protein Requires Endoplasmic Reticulum-associated Degradation Machinery

(2008) Meredith Boyle Metzger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Defining the Glycan Destruction Signal for Endoplasmic Reticulum-Associated Degradation

(2008) Erin M. Quan et al.   MOLECULAR CELL

A genetic screen in Saccharomyces cerevisiae identifies new genes that interact with mex67-5, a temperature-sensitive allele of the gene encoding the mRNA export receptor

(2008) Francisco Estruch et al.   MOLECULAR GENETICS AND GENOMICS

Misfolded proteins partition between two distinct quality control compartments

(2008) Daniel Kaganovich et al.   NATURE

OS-9 and GRP94 deliver mutant α1-antitrypsin to the Hrd1–SEL1L ubiquitin ligase complex for ERAD

(2008) John C. Christianson et al.   NATURE CELL BIOLOGY

One step at a time: endoplasmic reticulum-associated degradation

(2008) Shruthi S. Vembar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Jpred 3 secondary structure prediction server

(2008) C. Cole et al.   NUCLEIC ACIDS RESEARCH

Extrinsic Fluorescent Dyes as Tools for Protein Characterization

(2008) Andrea Hawe et al.   PHARMACEUTICAL RESEARCH