The Ubiquitin-Proteasome System and Molecular Chaperone Deregulation in Alzheimer’s Disease

The amyloid hypothesis, time to move on: Amyloid is the downstream result, not cause, of Alzheimer's disease

(2014) David A. Drachman   Alzheimers & Dementia

Emerging Therapeutics for Alzheimer's Disease

(2014) Karen Chiang et al.   Annual Review of Pharmacology and Toxicology

Hsp90-Tau Complex Reveals Molecular Basis for Specificity in Chaperone Action

(2014) G. Elif Karagöz et al.   CELL

FKBP12 regulates the localization and processing of amyloid precursor protein in human cell lines

(2014) Fan-Lun Liu et al.   JOURNAL OF BIOSCIENCES

Insights into the physiological function of the β-amyloid precursor protein: beyond Alzheimer's disease

(2014) Edgar Dawkins et al.   JOURNAL OF NEUROCHEMISTRY

Impact of RTN3 Deficiency on Expression of BACE1 and Amyloid Deposition

(2014) Q. Shi et al.   JOURNAL OF NEUROSCIENCE

Alzheimer’s disease drug-development pipeline: few candidates, frequent failures

(2014) Jeffrey L Cummings et al.   Alzheimers Research & Therapy

On the origin of Alzheimer's disease. Trials and tribulations of the amyloid hypothesis

(2013) Michael A. Castello et al.   AGEING RESEARCH REVIEWS

2013 Alzheimer's disease facts and figures

(2013)   Alzheimers & Dementia

Link Between Oxidative Stress and Acute Brain Ischemia

(2013) Djordje Radak et al.   ANGIOLOGY

Molecular Chaperone Functions in Protein Folding and Proteostasis

(2013) Yujin E. Kim et al.   Annual Review of Biochemistry

Phosphorylation of Human Tau Protein by Microtubule Affinity-Regulating Kinase 2

(2013) Martin Schwalbe et al.   BIOCHEMISTRY

Prion-like spreading of pathological α-synuclein in brain

(2013) Masami Masuda-Suzukake et al.   BRAIN

Oxidative Stress and Pathophysiology of Ischemic Stroke: Novel Therapeutic Opportunities

(2013) Ramon Rodrigo et al.   CNS & Neurological Disorders-Drug Targets

FKBP14 is an essential gene that regulates Presenilin protein levels and Notch signaling in Drosophila

(2013) D. L. van de Hoef et al.   DEVELOPMENT

Amyloid-β oligomers induce synaptic damage via Tau-dependent microtubule severing by TTLL6 and spastin

(2013) Hans Zempel et al.   EMBO JOURNAL

Spreading of tau pathology in Alzheimer's disease by cell-to-cell transmission

(2013) Nguyen-Vi Mohamed et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Parkin overexpression ameliorates hippocampal long-term potentiation and  -amyloid load in an Alzheimer's disease mouse model

(2013) X. Hong et al.   HUMAN MOLECULAR GENETICS

Accelerated neurodegeneration through chaperone-mediated oligomerization of tau

(2013) Laura J. Blair et al.   JOURNAL OF CLINICAL INVESTIGATION

A novel APP mutation (D678H) in a Taiwanese patient exhibiting dementia and cerebral microvasculopathy

(2013) Min-Yu Lan et al.   JOURNAL OF CLINICAL NEUROSCIENCE

The neuroprotective activity of the amyloid precursor protein against traumatic brain injury is mediated via the heparin binding site in residues 96-110

(2013) Frances Corrigan et al.   JOURNAL OF NEUROCHEMISTRY

Autosomal-dominant Alzheimer's disease mutations at the same codon of amyloid precursor protein differentially alter Aβ production

(2013) Marc Suárez-Calvet et al.   JOURNAL OF NEUROCHEMISTRY

Self-propagation of pathogenic protein aggregates in neurodegenerative diseases

(2013) Mathias Jucker et al.   NATURE

Protein rescue from aggregates by powerful molecular chaperone machines

(2013) Shannon M. Doyle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Alzheimer disease in the United States (2010-2050) estimated using the 2010 census

(2013) L. E. Hebert et al.   NEUROLOGY

The CAMKK2-AMPK Kinase Pathway Mediates the Synaptotoxic Effects of Aβ Oligomers through Tau Phosphorylation

(2013) Georges Mairet-Coello et al.   NEURON

ADAM17, shedding, TACE as therapeutic targets

(2013) Stefan Rose-John   PHARMACOLOGICAL RESEARCH

Poly-Ub-Substrate-Degradative Activity of 26S Proteasome Is Not Impaired in the Aging Rat Brain

(2013) Carolin Giannini et al.   PLoS One

Soluble Alpha-APP (sAPPalpha) Regulates CDK5 Expression and Activity in Neurons

(2013) Daniela Hartl et al.   PLoS One

Soluble β-amyloid Precursor Protein Alpha Binds to p75 Neurotrophin Receptor to Promote Neurite Outgrowth

(2013) Noriko Hasebe et al.   PLoS One

Rapid cell death is preceded by amyloid plaque-mediated oxidative stress

(2013) H. Xie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unique drug screening approach for prion diseases identifies tacrolimus and astemizole as antiprion agents

(2013) Y. E. Karapetyan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Brain homogenates from human tauopathies induce tau inclusions in mouse brain

(2013) Florence Clavaguera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of human peptidyl-prolylcis-transisomerase FKBP22 containing two EF-hand motifs

(2013) Sergei P. Boudko et al.   PROTEIN SCIENCE

Hsp70 chaperone dynamics and molecular mechanism

(2013) Matthias P. Mayer   TRENDS IN BIOCHEMICAL SCIENCES

Prion-like Properties of Pathological TDP-43 Aggregates from Diseased Brains

(2013) Takashi Nonaka et al.   Cell Reports

The Genetics of Alzheimer Disease

(2013) R. E. Tanzi   Cold Spring Harbor Perspectives in Medicine

Epidemiology of Alzheimer Disease

(2013) R. Mayeux et al.   Cold Spring Harbor Perspectives in Medicine

The Ubiquitin-Proteasome System and the Autophagic-Lysosomal System in Alzheimer Disease

(2013) Y. Ihara et al.   Cold Spring Harbor Perspectives in Medicine

Brain Imaging in Alzheimer Disease

(2013) K. A. Johnson et al.   Cold Spring Harbor Perspectives in Medicine

Biochemistry of Amyloid  -Protein and Amyloid Deposits in Alzheimer Disease

(2013) C. L. Masters et al.   Cold Spring Harbor Perspectives in Medicine

The airbag problem–a potential culprit for bench-to-bedside translational efforts: relevance for Alzheimer’s disease

(2013) Dimitrije Krstic et al.   Acta Neuropathologica Communications

A disintegrin and metalloproteases: Molecular scissors in angiogenesis, inflammation and atherosclerosis

(2012) Emiel P.C. van der Vorst et al.   ATHEROSCLEROSIS

AICD Nuclear Signaling and Its Possible Contribution to Alzheimers Disease

(2012) Uwe Konietzko   Current Alzheimer Research

Novel AβIsoforms in Alzheimer's Disease - Their Role in Diagnosis and Treatment

(2012) Erik Portelius et al.   CURRENT PHARMACEUTICAL DESIGN

Spliceosome integrity is defective in the motor neuron diseases ALS and SMA

(2012) Hitomi Tsuiji et al.   EMBO Molecular Medicine

Axonal degeneration in Alzheimer's disease: When signaling abnormalities meet the axonal transport system

(2012) Nicholas M. Kanaan et al.   EXPERIMENTAL NEUROLOGY

Motor Neuron-specific Disruption of Proteasomes, but Not Autophagy, Replicates Amyotrophic Lateral Sclerosis

(2012) Yoshitaka Tashiro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Important functional role of residue x of the presenilin GxGD protease active site motif for APP substrate cleavage specificity and substrate selectivity of γ-secretase

(2012) Benedikt Kretner et al.   JOURNAL OF NEUROCHEMISTRY

Beta-Amyloid Monomer and Insulin/IGF-1 Signaling in Alzheimer's Disease

(2012) Maria Laura Giuffrida et al.   MOLECULAR NEUROBIOLOGY

Amyloid precursor protein (APP) A673T mutation in the elderly Finnish population

(2012) Mia Kero et al.   NEUROBIOLOGY OF AGING

Protein homeostasis and aging: Role of ubiquitin protein ligases

(2012) Nihar Ranjan Jana   NEUROCHEMISTRY INTERNATIONAL

α-Cleavage of cellular prion protein

(2012) Jingjing Liang et al.   Prion

The ubiquitin proteasome system in neurodegenerative diseases: Culprit, accomplice or victim?

(2012) F.J.A. Dennissen et al.   PROGRESS IN NEUROBIOLOGY

A Unifying Role for Prions in Neurodegenerative Diseases

(2012) S. B. Prusiner   SCIENCE

Alzheimer’s pathogenesis: is there neuron-to-neuron propagation?

(2011) Heiko Braak et al.   ACTA NEUROPATHOLOGICA

Insulin-resistant brain state: The culprit in sporadic Alzheimer's disease?

(2011) Sónia C. Correia et al.   AGEING RESEARCH REVIEWS

Observations in APP Bitransgenic Mice Suggest that Diffuse and Compact Plaques Form via Independent Processes in Alzheimer's Disease

(2011) Anna Lord et al.   AMERICAN JOURNAL OF PATHOLOGY

Amyloid Precursor Protein Processing and Alzheimer's Disease

(2011) Richard J. O'Brien et al.   Annual Review of Neuroscience

Nuclear signalling by membrane protein intracellular domains: The AICD enigma

(2011) Caroline Beckett et al.   CELLULAR SIGNALLING

The AICD Interacting Protein DAB1 is Up-Regulated in Alzheimer Frontal Cortex Brain Samples and Causes Deregulation of Proteins Involved in Gene Expression Changes

(2011) T. Muller et al.   Current Alzheimer Research

Targeting FKBP isoforms with small-molecule ligands

(2011) Elizabeth A Blackburn et al.   CURRENT OPINION IN PHARMACOLOGY

Secreted amyloid precursor proteins promote proliferation and glial differentiation of adult hippocampal neural progenitor cells

(2011) Sara Baratchi et al.   HIPPOCAMPUS

A critical role for the PAR-1/MARK-tau axis in mediating the toxic effects of Aβ on synapses and dendritic spines

(2011) Wendou Yu et al.   HUMAN MOLECULAR GENETICS

Comparative Analysis of Different Peptidyl-Prolyl Isomerases Reveals FK506-binding Protein 12 as the Most Potent Enhancer of α-Synuclein Aggregation

(2011) Angélique Deleersnijder et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Seeding of Normal Tau by Pathological Tau Conformers Drives Pathogenesis of Alzheimer-like Tangles

(2011) Jing L. Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FKBP immunophilins and Alzheimer’s disease: A chaperoned affair

(2011) Weihuan Cao et al.   JOURNAL OF BIOSCIENCES

Functions of Aβ, sAPPα and sAPPβ : similarities and differences

(2011) Stéphanie Chasseigneaux et al.   JOURNAL OF NEUROCHEMISTRY

Soluble A  Seeds Are Potent Inducers of Cerebral  -Amyloid Deposition

(2011) F. Langer et al.   JOURNAL OF NEUROSCIENCE

The predator becomes the prey: regulating the ubiquitin system by ubiquitylation and degradation

(2011) Allan M. Weissman et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Prion-like acceleration of a synucleinopathy in a transgenic mouse model

(2011) Anne-Laure Mougenot et al.   NEUROBIOLOGY OF AGING

Autophagy failure in Alzheimer's disease—locating the primary defect

(2011) Ralph A. Nixon et al.   NEUROBIOLOGY OF DISEASE

Oxidative Stress and Cell Membranes in the Pathogenesis of Alzheimer's Disease

(2011) Paul H. Axelsen et al.   PHYSIOLOGY

Secreted Amyloid Precursor Protein β and Secreted Amyloid Precursor Protein α Induce Axon Outgrowth In Vitro through Egr1 Signaling Pathway

(2011) Stéphanie Chasseigneaux et al.   PLoS One

Cytoplasmic Accumulation and Aggregation of TDP-43 upon Proteasome Inhibition in Cultured Neurons

(2011) Janet van Eersel et al.   PLoS One

Prion-like propagation of mutant superoxide dismutase-1 misfolding in neuronal cells

(2011) Christian Münch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Misfolded protein aggregates: Mechanisms, structures and potential for disease transmission

(2011) Ines Moreno-Gonzalez et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

ADAM17: a molecular switch to control inflammation and tissue regeneration

(2011) Jürgen Scheller et al.   TRENDS IN IMMUNOLOGY

The acetylation of tau inhibits its function and promotes pathological tau aggregation

(2011) Todd J. Cohen et al.   Nature Communications

Soluble amyloid precursor protein: a novel proliferation factor of adult progenitor cells of ectodermal and mesodermal origin

(2011) Michael P Demars et al.   Stem Cell Research & Therapy

Blocking ADAM10 synaptic trafficking generates a model of sporadic Alzheimer’s disease

(2010) Roberta Epis et al.   BRAIN

Proposal for a role of the Hsp90/Hsp70-based chaperone machinery in making triage decisions when proteins undergo oxidative and toxic damage

(2010) William B Pratt et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Targeting intrinsically disordered proteins in neurodegenerative and protein dysfunction diseases: another illustration of the D2concept

(2010) Vladimir N Uversky   Expert Review of Proteomics

Calcium Signaling and Amyloid Toxicity in Alzheimer Disease

(2010) Angelo Demuro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Review Article: Genetics of Alzheimer Disease

(2010) Lynn M. Bekris et al.   JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY

Inhibition of FK506 Binding Proteins Reduces  -Synuclein Aggregation and Parkinson's Disease-Like Pathology

(2010) M. Gerard et al.   JOURNAL OF NEUROSCIENCE

A  Oligomers Cause Localized Ca2+ Elevation, Missorting of Endogenous Tau into Dendrites, Tau Phosphorylation, and Destruction of Microtubules and Spines

(2010) H. Zempel et al.   JOURNAL OF NEUROSCIENCE

The Hsp90 Cochaperone, FKBP51, Increases Tau Stability and Polymerizes Microtubules

(2010) U. K. Jinwal et al.   JOURNAL OF NEUROSCIENCE

The Heat Shock Response: Life on the Verge of Death

(2010) Klaus Richter et al.   MOLECULAR CELL

Autophagy gone awry in neurodegenerative diseases

(2010) Esther Wong et al.   NATURE NEUROSCIENCE

Prion-like transmission of protein aggregates in neurodegenerative diseases

(2010) Patrik Brundin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The HSP70 chaperone machinery: J proteins as drivers of functional specificity

(2010) Harm H. Kampinga et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cell-to-cell transmission of non-prion protein aggregates

(2010) Seung-Jae Lee et al.   Nature Reviews Neurology

Acetylation of Tau Inhibits Its Degradation and Contributes to Tauopathy

(2010) Sang-Won Min et al.   NEURON

Neuroprotective effects of FK506 against excitotoxicity in organotypic hippocampal slice culture

(2010) Kyung Hee Lee et al.   NEUROSCIENCE LETTERS

Control of Alzheimer's Amyloid Beta Toxicity by the High Molecular Weight Immunophilin FKBP52 and Copper Homeostasis in Drosophila

(2010) Reiko Sanokawa-Akakura et al.   PLoS One

Peripherally Applied A -Containing Inoculates Induce Cerebral  -Amyloidosis

(2010) Y. S. Eisele et al.   SCIENCE

Decreased Clearance of CNS  -Amyloid in Alzheimer's Disease

(2010) K. G. Mawuenyega et al.   SCIENCE

The propagation of prion-like protein inclusions in neurodegenerative diseases

(2010) Michel Goedert et al.   TRENDS IN NEUROSCIENCES

Calcineurin Inhibition at the Clinical Phase of Prion Disease Reduces Neurodegeneration, Improves Behavioral Alterations and Increases Animal Survival

(2010) Abhisek Mukherjee et al.   PLoS Pathogens

RING Domain E3 Ubiquitin Ligases

(2009) Raymond J. Deshaies et al.   Annual Review of Biochemistry

Lipid Oxidation and Peroxidation in CNS Health and Disease: From Molecular Mechanisms to Therapeutic Opportunities

(2009) Rao Muralikrishna Adibhatla et al.   ANTIOXIDANTS & REDOX SIGNALING

The TRIM-NHL Protein TRIM32 Activates MicroRNAs and Prevents Self-Renewal in Mouse Neural Progenitors

(2009) Jens C. Schwamborn et al.   CELL

ADAM17 as a Therapeutic Target in Multiple Diseases

(2009) Joaquin Arribas et al.   CURRENT PHARMACEUTICAL DESIGN

Tauopathies with parkinsonism: clinical spectrum, neuropathologic basis, biological markers, and treatment options

(2009) A. C. Ludolph et al.   EUROPEAN JOURNAL OF NEUROLOGY

Amyloid beta, mitochondrial structural and functional dynamics in Alzheimer's disease

(2009) P. Hemachandra Reddy   EXPERIMENTAL NEUROLOGY

Deficiency of the E3 ubiquitin ligase TRIM32 in mice leads to a myopathy with a neurogenic component

(2009) Elena Kudryashova et al.   HUMAN MOLECULAR GENETICS

Propagation of Tau Misfolding from the Outside to the Inside of a Cell

(2009) Bess Frost et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Axonal Transport Defects in Neurodegenerative Diseases

(2009) G. A. Morfini et al.   JOURNAL OF NEUROSCIENCE

A Role for Ubiquitin in Selective Autophagy

(2009) Vladimir Kirkin et al.   MOLECULAR CELL

Transmission and spreading of tauopathy in transgenic mouse brain

(2009) Florence Clavaguera et al.   NATURE CELL BIOLOGY

Prions hijack tunnelling nanotubes for intercellular spread

(2009) Karine Gousset et al.   NATURE CELL BIOLOGY

Cytoplasmic penetration and persistent infection of mammalian cells by polyglutamine aggregates

(2009) Pei-Hsien Ren et al.   NATURE CELL BIOLOGY

A peptidyl–prolyl isomerase, FKBP12, accumulates in Alzheimer neurofibrillary tangles

(2009) Hisato Sugata et al.   NEUROSCIENCE LETTERS

Inclusion formation and neuronal cell death through neuron-to-neuron transmission of  -synuclein

(2009) P. Desplats et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alzheimer's disease-like pathological features in transgenic mice expressing the APP intracellular domain

(2009) K. Ghosal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induction of cerebral  -amyloidosis: Intracerebral versus systemic A  inoculation

(2009) Y. S. Eisele et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

 -Secretase Heterogeneity in the Aph1 Subunit: Relevance for Alzheimer's Disease

(2009) L. Serneels et al.   SCIENCE

O1-06-04: Methylthioninium chloride (MTC) acts as a Tau aggregation inhibitor (TAI) in a cellular model and reverses Tau pathology in transgenic mouse models of Alzheimer's disease

(2008) Charles Harrington et al.   Alzheimers & Dementia

O3-04-07: Tau aggregation inhibitor (TAI) therapy with rember™ arrests disease progression in mild and moderate Alzheimer's disease over 50 weeks

(2008) Claude M. Wischik et al.   Alzheimers & Dementia

Intrinsically Disordered Proteins in Human Diseases: Introducing the D2 Concept

(2008) Vladimir N. Uversky et al.   Annual Review of Biophysics

Role of Axonal Transport in Neurodegenerative Diseases

(2008) Kurt J. De Vos et al.   Annual Review of Neuroscience

Autophagy and the ubiquitin-proteasome system: Collaborators in neuroprotection

(2008) Natalia B. Nedelsky et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Aβ40 promotes neuronal cell fate in neural progenitor cells

(2008) Y Chen et al.   CELL DEATH AND DIFFERENTIATION

Assembly, Maturation, and Trafficking of the γ-Secretase Complex in Alzheimers Disease

(2008) Daniel Dries et al.   Current Alzheimer Research

Part-Time α-Secretases: The Functional Biology of ADAM 9, 10 and 17

(2008) Miriam Deuss et al.   Current Alzheimer Research

Hyperphosphorylation of Microtubule-Associated Protein Tau: A Promising Therapeutic Target for Alzheimer Disease

(2008) C.-X. Gong et al.   CURRENT MEDICINAL CHEMISTRY

Activity requires soluble amyloid precursor protein α to promote neurite outgrowth in neural stem cell-derived neurons via activation of the MAPK pathway

(2008) Nidhi Gakhar-Koppole et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

The Ratio of Monomeric to Aggregated Forms of Aβ40 and Aβ42 Is an Important Determinant of Amyloid-β Aggregation, Fibrillogenesis, and Toxicity

(2008) Asad Jan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A TAG1-APP signalling pathway through Fe65 negatively modulates neurogenesis

(2008) Quan-Hong Ma et al.   NATURE CELL BIOLOGY

Amyloid precursor protein increases cortical neuron size in transgenic mice

(2008) Esther S. Oh et al.   NEUROBIOLOGY OF AGING

Endogenous secreted amyloid precursor protein-α regulates hippocampal NMDA receptor function, long-term potentiation and spatial memory

(2008) Chanel J. Taylor et al.   NEUROBIOLOGY OF DISEASE

The intracellular domain of amyloid precursor protein induces neuron-specific apoptosis

(2008) Kohzo Nakayama et al.   NEUROSCIENCE LETTERS

FKBP Family Proteins: Immunophilins with Versatile Biological Functions

(2008) Cong Bao Kang et al.   NEUROSIGNALS

Structure-based classification of 45 FK506-binding proteins

(2008) J. A. Somarelli et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Ubiquitin–proteasome system as a modulator of cell fate

(2007) S THOMPSON et al.   CURRENT OPINION IN PHARMACOLOGY

Aβ inhibits the proteasome and enhances amyloid and tau accumulation

(2007) Bertrand P. Tseng et al.   NEUROBIOLOGY OF AGING