Endothelial to Mesenchymal Transition (EndoMT) in the Pathogenesis of Human Fibrotic Diseases

Response to Letter Regarding Article, “MiR-125b Is Critical for Fibroblast-to-Myofibroblast Transition and Cardiac Fibrosis”

(2016) Varun Nagpal et al.   CIRCULATION

In Brief: Endothelial-to-mesenchymal transition

(2016) Gonzalo Sanchez-Duffhues et al.   JOURNAL OF PATHOLOGY

Canonical Wnt signaling in systemic sclerosis

(2016) Christina Bergmann et al.   LABORATORY INVESTIGATION

Endothelial to mesenchymal transition (EndoMT) in the pathogenesis of Systemic Sclerosis-associated pulmonary fibrosis and pulmonary arterial hypertension. Myth or reality?

(2016) Sergio A. Jimenez et al.   MATRIX BIOLOGY

Identification of Endothelial-to-Mesenchymal Transition as a Potential Participant in Radiation Proctitis

(2015) Elodie Mintet et al.   AMERICAN JOURNAL OF PATHOLOGY

Endothelial to Mesenchymal Transition Contributes to Endothelial Dysfunction in Pulmonary Arterial Hypertension

(2015) Robert B. Good et al.   AMERICAN JOURNAL OF PATHOLOGY

Novel insights into the function and dynamics of extracellular matrix in liver fibrosis

(2015) Morten A. Karsdal et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Sonic Hedgehog Signaling in the Lung. From Development to Disease

(2015) Matthias C. Kugler et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Idiopathic pulmonary fibrosis: An update

(2015) Paolo Spagnolo et al.   ANNALS OF MEDICINE

MicroRNA regulatory networks in idiopathic pulmonary fibrosis

(2015) Kusum V. Pandit et al.   Biochemistry and Cell Biology

Epigenetic balance of aberrant Rasal1 promoter methylation and hydroxymethylation regulates cardiac fibrosis

(2015) Xingbo Xu et al.   CARDIOVASCULAR RESEARCH

Perivascular Gli1+ Progenitors Are Key Contributors to Injury-Induced Organ Fibrosis

(2015) Rafael Kramann et al.   Cell Stem Cell

Endothelial-to-Mesenchymal Transition in Pulmonary Hypertension

(2015) B. Ranchoux et al.   CIRCULATION

Getting to the Heart of the Matter

(2015) Andrew Leask   CIRCULATION RESEARCH

A Hypoxia-Induced Vascular Endothelial-to-Mesenchymal Transition in Development of Radiation-Induced Pulmonary Fibrosis

(2015) S.-H. Choi et al.   CLINICAL CANCER RESEARCH

Contemporary Assessment of Hepatic Fibrosis

(2015) Alan Bonder et al.   Clinics in Liver Disease

Kallistatin inhibits TGF-β-induced endothelial–mesenchymal transition by differential regulation of microRNA-21 and eNOS expression

(2015) Youming Guo et al.   EXPERIMENTAL CELL RESEARCH

High reactive oxygen species in fibrotic and nonfibrotic skin of patients with diffuse cutaneous systemic sclerosis

(2015) Khalil Bourji et al.   FREE RADICAL BIOLOGY AND MEDICINE

MicroRNA-31 is a positive modulator of endothelial-mesenchymal transition and associated secretory phenotype induced by TGF-β

(2015) Akihiro Katsura et al.   GENES TO CELLS

Snail Is a Direct Target of Hypoxia-inducible Factor 1α (HIF1α) in Hypoxia-induced Endothelial to Mesenchymal Transition of Human Coronary Endothelial Cells

(2015) Xingbo Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Endothelial-mesenchymal Transition in Systemic Sclerosis Is Induced by Endothelin-1 and Transforming Growth Factor-  and May Be Blocked by Macitentan, a Dual Endothelin-1 Receptor Antagonist

(2015) P. Cipriani et al.   JOURNAL OF RHEUMATOLOGY

Interactions of DPP-4 and integrin β1 influences endothelial-to-mesenchymal transition

(2015) Sen Shi et al.   KIDNEY INTERNATIONAL

IgG4-related disease

(2015) Terumi Kamisawa et al.   LANCET

C3a and C5a receptor antagonists ameliorate endothelial-myofibroblast transition via the Wnt/β-catenin signaling pathway in diabetic kidney disease

(2015) Ling Li et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Snail1-induced partial epithelial-to-mesenchymal transition drives renal fibrosis in mice and can be targeted to reverse established disease

(2015) M Teresa Grande et al.   NATURE MEDICINE

Epithelial-to-mesenchymal transition induces cell cycle arrest and parenchymal damage in renal fibrosis

(2015) Sara Lovisa et al.   NATURE MEDICINE

Diverse origins of the myofibroblast—implications for kidney fibrosis

(2015) Lucas L. Falke et al.   Nature Reviews Nephrology

Fibrosis — A Common Pathway to Organ Injury and Failure

(2015) Don C. Rockey et al.   NEW ENGLAND JOURNAL OF MEDICINE

Relaxin inhibits cardiac fibrosis and endothelial–mesenchymal transition via the Notch pathway

(2015) Xi Zhou et al.   Drug Design Development and Therapy

Increased Expression of NAPDH Oxidase 4 in Systemic Sclerosis Dermal Fibroblasts: Regulation by Transforming Growth Factor β

(2015) Sonsoles Piera-Velazquez et al.   Arthritis & Rheumatology

Endothelial Cells Expressing Endothelial and Mesenchymal Cell Gene Products in Lung Tissue From Patients With Systemic Sclerosis-Associated Interstitial Lung Disease

(2015) Fabian A. Mendoza et al.   Arthritis & Rheumatology

A Reactive Oxygen Species-Mediated Loop Maintains Increased Expression of NADPH Oxidases 2 and 4 in Skin Fibroblasts From Patients With Systemic Sclerosis

(2015) Tatiana Spadoni et al.   Arthritis & Rheumatology

Redox-fibrosis: Impact of TGFβ1 on ROS generators, mediators and functional consequences

(2015) Kati Richter et al.   Redox Biology

Reciprocal regulation of TGF-β and reactive oxygen species: A perverse cycle for fibrosis

(2015) Rui-Ming Liu et al.   Redox Biology

Matrix Biology of Idiopathic Pulmonary Fibrosis

(2014) Victor J. Thannickal et al.   AMERICAN JOURNAL OF PATHOLOGY

Combined inhibition of morphogen pathways demonstrates additive antifibrotic effects and improved tolerability

(2014) Alfiya Distler et al.   ANNALS OF THE RHEUMATIC DISEASES

Role of Flow-Sensitive microRNAs in Endothelial Dysfunction and Atherosclerosis

(2014) Sandeep Kumar et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Emerging cellular and molecular targets in fibrosis

(2014) Flavia V. Castelino et al.   CURRENT OPINION IN RHEUMATOLOGY

Linagliptin-Mediated DPP-4 Inhibition Ameliorates Kidney Fibrosis in Streptozotocin-Induced Diabetic Mice by Inhibiting Endothelial-to-Mesenchymal Transition in a Therapeutic Regimen

(2014) Keizo Kanasaki et al.   DIABETES

Increased concentration of circulating angiogenesis and nitric oxide inhibitors induces endothelial to mesenchymal transition and myocardial fibrosis in patients with chronic kidney disease

(2014) David M. Charytan et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Cellular and molecular mechanisms in kidney fibrosis

(2014) Jeremy S. Duffield   JOURNAL OF CLINICAL INVESTIGATION

Resident fibroblast lineages mediate pressure overload–induced cardiac fibrosis

(2014) Thomas Moore-Morris et al.   JOURNAL OF CLINICAL INVESTIGATION

Curtailing Endothelial TGF-  Signaling Is Sufficient to Reduce Endothelial-Mesenchymal Transition and Fibrosis in CKD

(2014) S. Xavier et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Human schistosomiasis

(2014) Daniel G Colley et al.   LANCET

Chagas Disease Cardiomyopathy: Immunopathology and Genetics

(2014) Edecio Cunha-Neto et al.   MEDIATORS OF INFLAMMATION

Noncoding RNAs and myocardial fibrosis

(2014) Thomas Thum   Nature Reviews Cardiology

Molecular mechanisms of epithelial–mesenchymal transition

(2014) Samy Lamouille et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Fibrosis—a lethal component of systemic sclerosis

(2014) Yuen Yee Ho et al.   Nature Reviews Rheumatology

Transforming growth factor β—at the centre of systemic sclerosis

(2014) Robert Lafyatis   Nature Reviews Rheumatology

Signaling mechanisms of the epithelial-mesenchymal transition

(2014) D. M. Gonzalez et al.   Science Signaling

TGF-  Signaling Mediates Endothelial-to-Mesenchymal Transition (EndMT) During Vein Graft Remodeling

(2014) B. C. Cooley et al.   Science Translational Medicine

N-acetyl-seryl-aspartyl-lysyl-proline Inhibits Diabetes-Associated Kidney Fibrosis and Endothelial-Mesenchymal Transition

(2014) Takako Nagai et al.   Biomed Research International

Fibroblasts in fibrosis: novel roles and mediators

(2014) Ryan T. Kendall et al.   Frontiers in Pharmacology

NADPH oxidase-dependent redox signaling in TGF-β-mediated fibrotic responses

(2014) Fan Jiang et al.   Redox Biology

Narrative Review: Fibrotic Diseases: Cellular and Molecular Mechanisms and Novel Therapies

(2013) Joel Rosenbloom   ANNALS OF INTERNAL MEDICINE

The Epidemiology, Diagnosis, and Management of Aristolochic Acid Nephropathy

(2013) M. Refik Gökmen et al.   ANNALS OF INTERNAL MEDICINE

Role of NADPH Oxidases in Liver Fibrosis

(2013) Yong-Han Paik et al.   ANTIOXIDANTS & REDOX SIGNALING

Myofibroblast Differentiation: Main Features, Biomedical Relevance, and the Role of Reactive Oxygen Species

(2013) Alessandro Siani et al.   ANTIOXIDANTS & REDOX SIGNALING

The role of microRNAs in skin fibrosis

(2013) Olubukola Babalola et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Dkk1 and Msx2–Wnt7b Signaling Reciprocally Regulate the Endothelial–Mesenchymal Transition in Aortic Endothelial Cells

(2013) Su-Li Cheng et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Role of the endothelial-to-mesenchymal transition in renal fibrosis of chronic kidney disease

(2013) Jianhua He et al.   Clinical and Experimental Nephrology

Molecular Mechanisms and Treatment of Radiation-Induced Lung Fibrosis

(2013) Nian-Hua Ding et al.   CURRENT DRUG TARGETS

Cytokine-induced Chromatin Modifications of the Type I Collagen Alpha 2 Gene during Intestinal Endothelial-to-Mesenchymal Transition

(2013) Tammy Sadler et al.   INFLAMMATORY BOWEL DISEASES

Interferon-γ promotes vascular remodeling in human microvascular endothelial cells by upregulating endothelin (ET)-1 and transforming growth factor (TGF) β2

(2013) Izabela Chrobak et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Role of caveolin-1 in fibrotic diseases

(2013) David Gvaramia et al.   MATRIX BIOLOGY

Origin and function of myofibroblasts in kidney fibrosis

(2013) Valerie S LeBleu et al.   NATURE MEDICINE

microRNA 126 Inhibits the Transition of Endothelial Progenitor Cells to Mesenchymal Cells via the PIK3R2-PI3K/Akt Signalling Pathway

(2013) Junfeng Zhang et al.   PLoS One

Scleroderma pathogenesis: a pivotal role for fibroblasts as effector cells

(2013) Adrian J Gilbane et al.   ARTHRITIS RESEARCH & THERAPY

MicroRNAs in Kidney Fibrosis and Diabetic Nephropathy: Roles on EMT and EndMT

(2013) Swayam Prakash Srivastava et al.   Biomed Research International

Recent Developments in Myofibroblast Biology

(2012) Boris Hinz et al.   AMERICAN JOURNAL OF PATHOLOGY

Hedgehog-Gli Pathway Activation during Kidney Fibrosis

(2012) Steven L. Fabian et al.   AMERICAN JOURNAL OF PATHOLOGY

Caveolin-1 Deficiency Induces Spontaneous Endothelial-to-Mesenchymal Transition in Murine Pulmonary Endothelial Cells in Vitro

(2012) Zhaodong Li et al.   AMERICAN JOURNAL OF PATHOLOGY

Cellular Mechanisms of Tissue Fibrosis. 1. Common and organ-specific mechanisms associated with tissue fibrosis

(2012) Michael Zeisberg et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Role of Sonic Hedgehog in idiopathic pulmonary fibrosis

(2012) Alfredo Lozano Bolaños et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

β-catenin is a central mediator of pro-fibrotic Wnt signaling in systemic sclerosis

(2012) Christian Beyer et al.   ANNALS OF THE RHEUMATIC DISEASES

Hedgehog signaling controls fibroblast activation and tissue fibrosis in systemic sclerosis

(2012) Angelika Horn et al.   ARTHRITIS AND RHEUMATISM

Wnt/β-catenin signaling is hyperactivated in systemic sclerosis and induces Smad-dependent fibrotic responses in mesenchymal cells

(2012) Jun Wei et al.   ARTHRITIS AND RHEUMATISM

Strategies for anti-fibrotic therapies

(2012) Joel Rosenbloom et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Hypoxia-Inducible Factors in Physiology and Medicine

(2012) Gregg L. Semenza   CELL

Wnt/β-Catenin Signaling and Disease

(2012) Hans Clevers et al.   CELL

Molecular basis of cardiac endothelial-to-mesenchymal transition (EndMT): Differential expression of microRNAs during EndMT

(2012) Asish K. Ghosh et al.   CELLULAR SIGNALLING

The potential of microRNAs in liver fibrosis

(2012) Yong He et al.   CELLULAR SIGNALLING

Myofibroblasts

(2012) Biao Hu et al.   CURRENT OPINION IN RHEUMATOLOGY

The role of endothelial-mesenchymal transition in development and pathological process

(2012) Feng Lin et al.   IUBMB LIFE

MicroRNAs, transforming growth factor beta-1, and tissue fibrosis

(2012) Timothy Bowen et al.   JOURNAL OF PATHOLOGY

Sonic Hedgehog Signaling Mediates Epithelial-Mesenchymal Communication and Promotes Renal Fibrosis

(2012) H. Ding et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

miRNAs regulate expression and function of extracellular matrix molecules

(2012) Zina Jeyapalan Rutnam et al.   MATRIX BIOLOGY

The complex world of WNT receptor signalling

(2012) Christof Niehrs   NATURE REVIEWS MOLECULAR CELL BIOLOGY

IgG4-Related Disease

(2012) John H. Stone et al.   NEW ENGLAND JOURNAL OF MEDICINE

NADPH Oxidase NOX4 Mediates Stellate Cell Activation and Hepatocyte Cell Death during Liver Fibrosis Development

(2012) Patricia Sancho et al.   PLoS One

Notch and disease: A growing field

(2012) Angeliki Louvi et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

FGF Regulates TGF-β Signaling and Endothelial-to-Mesenchymal Transition via Control of let-7 miRNA Expression

(2012) Pei-Yu Chen et al.   Cell Reports

Role of Endothelial-Mesenchymal Transition (EndoMT) in the Pathogenesis of Fibrotic Disorders

(2011) Sonsoles Piera-Velazquez et al.   AMERICAN JOURNAL OF PATHOLOGY

Inflammation-Induced Endothelial-to-Mesenchymal Transition

(2011) Florian Rieder et al.   AMERICAN JOURNAL OF PATHOLOGY

Nuclear β-Catenin Is Increased in Systemic Sclerosis Pulmonary Fibrosis and Promotes Lung Fibroblast Migration and Proliferation

(2011) Anna P. Lam et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Transforming Growth Factor-β–Induced Endothelial-to-Mesenchymal Transition Is Partly Mediated by MicroRNA-21

(2011) Regalla Kumarswamy et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Protein kinase Cδ and c-Abl kinase are required for transforming growth factor β induction of endothelial-mesenchymal transition in vitro

(2011) Zhaodong Li et al.   ARTHRITIS AND RHEUMATISM

Transforming growth factor-β2 promotes Snail-mediated endothelial–mesenchymal transition through convergence of Smad-dependent and Smad-independent signalling

(2011) Damian Medici et al.   BIOCHEMICAL JOURNAL

Regulation of endothelial cell plasticity by TGF-β

(2011) Laurens A. van Meeteren et al.   CELL AND TISSUE RESEARCH

Notch Initiates the Endothelial-to-Mesenchymal Transition in the Atrioventricular Canal through Autocrine Activation of Soluble Guanylyl Cyclase

(2011) Alex C.Y. Chang et al.   DEVELOPMENTAL CELL

Experimental myocardial infarction triggers canonical Wnt signaling and endothelial-to-mesenchymal transition

(2011) O. Aisagbonhi et al.   Disease Models & Mechanisms

Myofibroblast differentiation and survival in fibrotic disease

(2011) Kornelia Kis et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

TGF-β signaling in fibrosis

(2011) Anna Biernacka et al.   GROWTH FACTORS

Signalling pathways from NADPH oxidase-4 to idiopathic pulmonary fibrosis

(2011) Bruno Crestani et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Myofibroblast differentiation during fibrosis: role of NAD(P)H oxidases

(2011) Jeffrey L. Barnes et al.   KIDNEY INTERNATIONAL

Endothelial Cell–Derived Endothelin-1 Promotes Cardiac Fibrosis in Diabetic Hearts Through Stimulation of Endothelial-to-Mesenchymal Transition

(2010) Bambang Widyantoro et al.   CIRCULATION

Fibrocytes in health and disease

(2010) Erica L. Herzog et al.   EXPERIMENTAL HEMATOLOGY

MicroRNAs and the regulation of fibrosis

(2010) Xiaoying Jiang et al.   FEBS Journal

Oxidative stress, extracellular matrix targets, and idiopathic pulmonary fibrosis

(2010) Corrine R. Kliment et al.   FREE RADICAL BIOLOGY AND MEDICINE

Review Article: Review: Endothelial-myofibroblast transition, a new player in diabetic renal fibrosis

(2010) JINHUA LI et al.   NEPHROLOGY

NOX4/NADPH oxidase expression is increased in pulmonary fibroblasts from patients with idiopathic pulmonary fibrosis and mediates TGF 1-induced fibroblast differentiation into myofibroblasts

(2010) N. Amara et al.   THORAX

Endothelial to Mesenchymal Transition via Transforming Growth Factor-β1/Smad Activation Is Associated with Portal Venous Stenosis in Idiopathic Portal Hypertension

(2009) Azusa Kitao et al.   AMERICAN JOURNAL OF PATHOLOGY

Endothelial-Myofibroblast Transition Contributes to the Early Development of Diabetic Renal Interstitial Fibrosis in Streptozotocin-Induced Diabetic Mice

(2009) Jinhua Li et al.   AMERICAN JOURNAL OF PATHOLOGY

Fate Tracing Reveals the Pericyte and Not Epithelial Origin of Myofibroblasts in Kidney Fibrosis

(2009) Benjamin D. Humphreys et al.   AMERICAN JOURNAL OF PATHOLOGY

Endothelial–Mesenchymal Transition in Bleomycin-Induced Pulmonary Fibrosis

(2009) Naozumi Hashimoto et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Pathophysiological Consequences of HIF Activation

(2009) Volker H. Haase   Annals of the New York Academy of Sciences

TGF-β and fibrosis in different organs — molecular pathway imprints

(2009) Dirk Pohlers et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Hedgehog-Mediated Epithelial-to-Mesenchymal Transition and Fibrogenic Repair in Nonalcoholic Fatty Liver Disease

(2009) Wing–Kin Syn et al.   GASTROENTEROLOGY

Differential Regulation of Transforming Growth Factor β Signaling Pathways by Notch in Human Endothelial Cells

(2009) YangXin Fu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of circulating mesenchymal progenitor cells (fibrocytes) in the pathogenesis of pulmonary fibrosis

(2009) Robert M. Strieter et al.   JOURNAL OF LEUKOCYTE BIOLOGY

NADPH oxidase-4 mediates myofibroblast activation and fibrogenic responses to lung injury

(2009) Louise Hecker et al.   NATURE MEDICINE

Scleroderma

(2009) Armando Gabrielli et al.   NEW ENGLAND JOURNAL OF MEDICINE

Transforming Growth Factor β–Induced Endothelial-to-Mesenchymal Transition: A Switch to Cardiac Fibrosis?

(2009) Marie-José Goumans et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Hypoxia. Hypoxia in the pathogenesis of systemic sclerosis

(2009) Christian Beyer et al.   ARTHRITIS RESEARCH & THERAPY

Tissue stiffness, latent TGF-β1 Activation, and mechanical signal transduction: Implications for the pathogenesis and treatment of fibrosis

(2009) Boris Hinz   Current Rheumatology Reports

Antifibrotic properties of caveolin-1 scaffolding domain in vitro and in vivo

(2008) Elena Tourkina et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Decreased expression of caveolin 1 in patients with systemic sclerosis: Crucial role in the pathogenesis of tissue fibrosis

(2008) Francesco Del Galdo et al.   ARTHRITIS AND RHEUMATISM

TGF-β signaling in vascular biology and dysfunction

(2008) Marie-José Goumans et al.   CELL RESEARCH

The role of the ZEB family of transcription factors in development and disease

(2008) C. Vandewalle et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Caveolin-1, transforming growth factor-β receptor internalization, and the pathogenesis of systemic sclerosis

(2008) Francesco Del Galdo et al.   CURRENT OPINION IN RHEUMATOLOGY

Slug is a direct Notch target required for initiation of cardiac cushion cellularization

(2008) Kyle Niessen et al.   JOURNAL OF CELL BIOLOGY

Fibroblasts in Kidney Fibrosis Emerge via Endothelial-to-Mesenchymal Transition

(2008) E. M. Zeisberg et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Matrix Elasticity, Cytoskeletal Tension, and TGF- : The Insoluble and Soluble Meet

(2008) R. G. Wells et al.   Science Signaling