Cellular and molecular mechanisms in kidney fibrosis

Translational Profiles of Medullary Myofibroblasts during Kidney Fibrosis

(2014) I. Grgic et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Cellular Mechanisms of Tissue Fibrosis. 3. Novel mechanisms of kidney fibrosis

(2013) Gabriela Campanholle et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Role of Lung Pericytes and Resident Fibroblasts in the Pathogenesis of Pulmonary Fibrosis

(2013) Chi Hung et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Pericyte Progenitors at the Crossroads Between Fibrosis and Regeneration

(2013) Matthew L. Steinhauser et al.   CIRCULATION RESEARCH

M2-like macrophages are responsible for collagen degradation through a mannose receptor–mediated pathway

(2013) Daniel H. Madsen et al.   JOURNAL OF CELL BIOLOGY

EphrinB2 Reverse Signaling Protects against Capillary Rarefaction and Fibrosis after Kidney Injury

(2013) Y. Kida et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Fibrocytes develop outside the kidney but contribute to renal fibrosis in a mouse model

(2013) Barbara Reich et al.   KIDNEY INTERNATIONAL

The contentious ontogeny of fibrosis in the kidney

(2013) Peter J. Nelson   KIDNEY INTERNATIONAL

Origin and function of myofibroblasts in kidney fibrosis

(2013) Valerie S LeBleu et al.   NATURE MEDICINE

TLR-2/TLR-4 TREM-1 Signaling Pathway Is Dispensable in Inflammatory Myeloid Cells during Sterile Kidney Injury

(2013) Gabriela Campanholle et al.   PLoS One

LRP-6 is a coreceptor for multiple fibrogenic signaling pathways in pericytes and myofibroblasts that are inhibited by DKK-1

(2013) Shuyu Ren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Therapy for Fibrotic Diseases: Nearing the Starting Line

(2013) S. L. Friedman et al.   Science Translational Medicine

Transforming Growth Factor β-1 Stimulates Profibrotic Epithelial Signaling to Activate Pericyte-Myofibroblast Transition in Obstructive Kidney Fibrosis

(2012) Ching-Fang Wu et al.   AMERICAN JOURNAL OF PATHOLOGY

Host Responses in Tissue Repair and Fibrosis

(2012) Jeremy S. Duffield et al.   Annual Review of Pathology-Mechanisms of Disease

The bHLH transcription factor Tcf21 is required for lineage-specific EMT of cardiac fibroblast progenitors

(2012) A. Acharya et al.   DEVELOPMENT

Pericytes support neutrophil subendothelial cell crawling and breaching of venular walls in vivo

(2012) Doris Proebstl et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pericyte TIMP3 and ADAMTS1 Modulate Vascular Stability after Kidney Injury

(2012) C. Schrimpf et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Subtotal Ablation of Parietal Epithelial Cells Induces Crescent Formation

(2012) E.-M. Sicking et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Sonic Hedgehog Signaling Mediates Epithelial-Mesenchymal Communication and Promotes Renal Fibrosis

(2012) H. Ding et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Learning in motion: pericytes instruct migrating innate leukocytes

(2012) Ronen Alon et al.   NATURE IMMUNOLOGY

Lineage tracing and genetic ablation of ADAM12+ perivascular cells identify a major source of profibrotic cells during acute tissue injury

(2012) Sophie Dulauroy et al.   NATURE MEDICINE

Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis

(2012) T. Kisseleva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differentiation of vascular smooth muscle cells from local precursors during embryonic and adult arteriogenesis requires Notch signaling

(2012) L. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting Endothelium-Pericyte Cross Talk by Inhibiting VEGF Receptor Signaling Attenuates Kidney Microvascular Rarefaction and Fibrosis

(2011) Shuei-Liong Lin et al.   AMERICAN JOURNAL OF PATHOLOGY

Role of Urokinase Plasminogen Activator Receptor–Associated Protein in Mouse Lung

(2011) Michael M. Bundesmann et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Epithelial-mesenchymal transition (EMT) in kidney fibrosis: fact or fantasy?

(2011) Wilhelm Kriz et al.   JOURNAL OF CLINICAL INVESTIGATION

Dysfunction of fibroblasts of extrarenal origin underlies renal fibrosis and renal anemia in mice

(2011) Nariaki Asada et al.   JOURNAL OF CLINICAL INVESTIGATION

Mannose Receptor 2 Attenuates Renal Fibrosis

(2011) J. M. Lopez-Guisa et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Parietal Epithelial Cells Participate in the Formation of Sclerotic Lesions in Focal Segmental Glomerulosclerosis

(2011) B. Smeets et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Distinct Macrophage Phenotypes Contribute to Kidney Injury and Repair

(2011) S. Lee et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Platelet-derived growth factor receptor signaling activates pericyte–myofibroblast transition in obstructive and post-ischemic kidney fibrosis

(2011) Yi-Ting Chen et al.   KIDNEY INTERNATIONAL

The origin of interstitial myofibroblasts in chronic kidney disease

(2011) Ivica Grgic et al.   PEDIATRIC NEPHROLOGY

Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition

(2011) J. R. Rock et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Pericyte Origin of Spinal Cord Scar Tissue

(2011) C. Goritz et al.   SCIENCE

Autophagy Is a Component of Epithelial Cell Fate in Obstructive Uropathy

(2010) Ling Li et al.   AMERICAN JOURNAL OF PATHOLOGY

Tubular Overexpression of Transforming Growth Factor-β1 Induces Autophagy and Fibrosis but Not Mesenchymal Transition of Renal Epithelial Cells

(2010) Robert Koesters et al.   AMERICAN JOURNAL OF PATHOLOGY

Epithelial Notch signaling regulates interstitial fibrosis development in the kidneys of mice and humans

(2010) Bernhard Bielesz et al.   JOURNAL OF CLINICAL INVESTIGATION

Origin of new cells in the adult kidney: results from genetic labeling techniques

(2010) Jeremy S. Duffield et al.   KIDNEY INTERNATIONAL

Methylation determines fibroblast activation and fibrogenesis in the kidney

(2010) Wibke Bechtel et al.   NATURE MEDICINE

Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury

(2010) Li Yang et al.   NATURE MEDICINE

Allosteric inhibition of lysyl oxidase–like-2 impedes the development of a pathologic microenvironment

(2010) Vivian Barry-Hamilton et al.   NATURE MEDICINE

Macrophage Wnt7b is critical for kidney repair and regeneration

(2010) S.-L. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fate Tracing Reveals the Pericyte and Not Epithelial Origin of Myofibroblasts in Kidney Fibrosis

(2009) Benjamin D. Humphreys et al.   AMERICAN JOURNAL OF PATHOLOGY

Mfge8 diminishes the severity of tissue fibrosis in mice by binding and targeting collagen for uptake by macrophages

(2009) Kamran Atabai et al.   JOURNAL OF CLINICAL INVESTIGATION

Bone Marrow Ly6Chigh Monocytes Are Selectively Recruited to Injured Kidney and Differentiate into Functionally Distinct Populations

(2009) S. L. Lin et al.   JOURNAL OF IMMUNOLOGY

Cellular Origins of Type IV Collagen Networks in Developing Glomeruli

(2009) D. R. Abrahamson et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Prevalence of CKD in the United States: A Sensitivity Analysis Using the National Health and Nutrition Examination Survey (NHANES) 1999-2004

(2008) Jon J. Snyder et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Pericytes and Perivascular Fibroblasts Are the Primary Source of Collagen-Producing Cells in Obstructive Fibrosis of the Kidney

(2008) Shuei-Liong Lin et al.   AMERICAN JOURNAL OF PATHOLOGY

Intrinsic Epithelial Cells Repair the Kidney after Injury

(2008) Benjamin D. Humphreys et al.   Cell Stem Cell

A Wnt7b-dependent pathway regulates the orientation of epithelial cell division and establishes the cortico-medullary axis of the mammalian kidney

(2008) J. Yu et al.   DEVELOPMENT

Osr1 expression demarcates a multi-potent population of intermediate mesoderm that undergoes progressive restriction to an Osr1-dependent nephron progenitor compartment within the mammalian kidney

(2008) Joshua W. Mugford et al.   DEVELOPMENTAL BIOLOGY

Kidney injury molecule–1 is a phosphatidylserine receptor that confers a phagocytic phenotype on epithelial cells

(2008) Takaharu Ichimura et al.   JOURNAL OF CLINICAL INVESTIGATION

Fibroblasts in Kidney Fibrosis Emerge via Endothelial-to-Mesenchymal Transition

(2008) E. M. Zeisberg et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY