Wnt/β-catenin signaling is hyperactivated in systemic sclerosis and induces Smad-dependent fibrotic responses in mesenchymal cells

Drug Discovery Approaches to Target Wnt Signaling in Cancer Stem Cells

(2015)   Oncotarget

Nuclear β-Catenin Is Increased in Systemic Sclerosis Pulmonary Fibrosis and Promotes Lung Fibroblast Migration and Proliferation

(2011) Anna P. Lam et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Inhibition of glycogen synthase kinase 3  induces dermal fibrosis by activation of the canonical Wnt pathway

(2011) C. Bergmann et al.   ANNALS OF THE RHEUMATIC DISEASES

Canonical Wnt signaling induces skin fibrosis and subcutaneous lipoatrophy: A novel mouse model for scleroderma?

(2011) Jun Wei et al.   ARTHRITIS AND RHEUMATISM

Wnt6, Wnt10a and Wnt10b inhibit adipogenesis and stimulate osteoblastogenesis through a β-catenin-dependent mechanism

(2011) William P. Cawthorn et al.   BONE

Bone Metastatic Disease: Taking Aim at New Therapeutic Targets

(2011) F. Coluzzi et al.   CURRENT MEDICINAL CHEMISTRY

β-catenin signaling

(2011) Anna P. Lam et al.   CURRENT OPINION IN RHEUMATOLOGY

Impact of WNT signaling on tissue lineage differentiation in the early mouse embryo

(2011) Satomi S. Tanaka et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

Epigenetic cell fate regulation of hepatic stellate cells

(2011) Hidekazu Tsukamoto et al.   HEPATOLOGY RESEARCH

Targeted Inhibition of  -Catenin/CBP Signaling Ameliorates Renal Interstitial Fibrosis

(2011) S. Hao et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Canonical Wnt/β-catenin signaling mediates transforming growth factor-β1-driven podocyte injury and proteinuria

(2011) Dan Wang et al.   KIDNEY INTERNATIONAL

Understanding fibrosis in systemic sclerosis: shifting paradigms, emerging opportunities

(2011) Swati Bhattacharyya et al.   Nature Reviews Rheumatology

Wnt3a Induces Myofibroblast Differentiation by Upregulating TGF-β Signaling Through SMAD2 in a β-Catenin-Dependent Manner

(2011) Jon M. Carthy et al.   PLoS One

β-Catenin Mediates Mechanically Regulated, Transforming Growth Factor-β1–Induced Myofibroblast Differentiation of Aortic Valve Interstitial Cells

(2010) Jan-Hung Chen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Fibrosis in systemic sclerosis: Emerging concepts and implications for targeted therapy

(2010) Jun Wei et al.   AUTOIMMUNITY REVIEWS

A deep investigation into the adipogenesis mechanism: Profile of microRNAs regulating adipogenesis by modulating the canonical Wnt/β-catenin signaling pathway

(2010) Limei Qin et al.   BMC GENOMICS

Targeting Wnt Signaling: Can We Safely Eradicate Cancer Stem Cells?

(2010) F. Takahashi-Yanaga et al.   CLINICAL CANCER RESEARCH

Epigenetic disruption of the WNT/ß-catenin signaling pathway in human cancers

(2010) Ying Ying et al.   Epigenetics

SPARC Suppresses Apoptosis of Idiopathic Pulmonary Fibrosis Fibroblasts through Constitutive Activation of β-Catenin

(2010) Wenteh Chang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Plasminogen Activator Inhibitor-1 Is a Transcriptional Target of the Canonical Pathway of Wnt/β-Catenin Signaling

(2010) Weichun He et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antagonistic Effect of the Matricellular Signaling Protein CCN3 on TGF-β- and Wnt-Mediated Fibrillinogenesis in Systemic Sclerosis and Marfan Syndrome

(2010) Raphael Lemaire et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Blockade of Wnt/ -Catenin Signaling by Paricalcitol Ameliorates Proteinuria and Kidney Injury

(2010) W. He et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Novel Links among Wnt and TGF-β Signaling and Runx2

(2010) Thomas L. McCarthy et al.   MOLECULAR ENDOCRINOLOGY

PPARγ Downregulation by TGFß in Fibroblast and Impaired Expression and Function in Systemic Sclerosis: A Novel Mechanism for Progressive Fibrogenesis

(2010) Jun Wei et al.   PLoS One

Exogenously administered secreted frizzled related protein 2 (Sfrp2) reduces fibrosis and improves cardiac function in a rat model of myocardial infarction

(2010) W. He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of Wnt/ -catenin/CREB binding protein (CBP) signaling reverses pulmonary fibrosis

(2010) W. R. Henderson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rosiglitazone Abrogates Bleomycin-Induced Scleroderma and Blocks Profibrotic Responses Through Peroxisome Proliferator-Activated Receptor-γ

(2009) Minghua Wu et al.   AMERICAN JOURNAL OF PATHOLOGY

Wnt inhibitory factor 1 is epigenetically silenced in human osteosarcoma, and targeted disruption accelerates osteosarcomagenesis in mice

(2009) Maya Kansara et al.   JOURNAL OF CLINICAL INVESTIGATION

A Wnt Survival Guide: From Flies to Human Disease

(2009) Andy J. Chien et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

COUP-TFII acts downstream of Wnt/ -catenin signal to silence PPAR  gene expression and repress adipogenesis

(2009) M. Okamura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

 -Catenin has sequential roles in the survival and specification of ventral dermis

(2008) J. Ohtola et al.   DEVELOPMENT

Axin and GSK3- control Smad3 protein stability and modulate TGF- signaling

(2008) X. Guo et al.   GENES & DEVELOPMENT

Functional Wnt Signaling Is Increased in Idiopathic Pulmonary Fibrosis

(2008) Melanie Königshoff et al.   PLoS One

Molecular Subsets in the Gene Expression Signatures of Scleroderma Skin

(2008) Ausra Milano et al.   PLoS One

Idiopathic Pulmonary Fibrosis: Aberrant Recapitulation of Developmental Programs?

(2008) Moisés Selman et al.   PLOS MEDICINE