Scleroderma pathogenesis: a pivotal role for fibroblasts as effector cells

Interspecies Comparison of Human and Murine Scleroderma Reveals IL-13 and CCL2 as Disease Subset-Specific Targets

(2012) Matthew B. Greenblatt et al.   AMERICAN JOURNAL OF PATHOLOGY

Inhibition of hedgehog signalling prevents experimental fibrosis and induces regression of established fibrosis

(2012) Angelika Horn et al.   ANNALS OF THE RHEUMATIC DISEASES

Hedgehog signaling controls fibroblast activation and tissue fibrosis in systemic sclerosis

(2012) Angelika Horn et al.   ARTHRITIS AND RHEUMATISM

Wnt/β-catenin signaling is hyperactivated in systemic sclerosis and induces Smad-dependent fibrotic responses in mesenchymal cells

(2012) Jun Wei et al.   ARTHRITIS AND RHEUMATISM

Targeting TGFβ superfamily ligand accessory proteins as novel therapeutics for chronic lung disorders

(2012) David C. Budd et al.   PHARMACOLOGY & THERAPEUTICS

The Role of Fibrocytes in Sickle Cell Lung Disease

(2012) Joshua J. Field et al.   PLoS One

Focal adhesion kinase and reactive oxygen species contribute to the persistent fibrotic phenotype of lesional scleroderma fibroblasts

(2012) X. Shi-wen et al.   RHEUMATOLOGY

Gut fibrosis with altered colonic contractility in a mouse model of scleroderma

(2012) N. M. Thoua et al.   RHEUMATOLOGY

Canonical Wnt signaling induces skin fibrosis and subcutaneous lipoatrophy: A novel mouse model for scleroderma?

(2011) Jun Wei et al.   ARTHRITIS AND RHEUMATISM

Inhibition of activator protein 1 signaling abrogates transforming growth factor β-mediated activation of fibroblasts and prevents experimental fibrosis

(2011) Jérôme Avouac et al.   ARTHRITIS AND RHEUMATISM

Circulating fibrocytes are increased in children and young adults with pulmonary hypertension

(2011) M. E. Yeager et al.   EUROPEAN RESPIRATORY JOURNAL

An Essential Role for Resident Fibroblasts in Experimental Lung Fibrosis Is Defined by Lineage-Specific Deletion of High-Affinity Type II Transforming Growth Factor β Receptor

(2010) Rachel K. Hoyles et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Involvement of functional autoantibodies against vascular receptors in systemic sclerosis

(2010) G. Riemekasten et al.   ANNALS OF THE RHEUMATIC DISEASES

Targeting ADAM-17/notch signaling abrogates the development of systemic sclerosis in a murine model

(2010) Niloufar Kavian et al.   ARTHRITIS AND RHEUMATISM

Selective expression of connective tissue growth factor in fibroblasts in vivo promotes systemic tissue fibrosis

(2010) Sonali Sonnylal et al.   ARTHRITIS AND RHEUMATISM

Systemic vasculopathy with altered vasoreactivity in a transgenic mouse model of scleroderma

(2010) Emma C Derrett-Smith et al.   ARTHRITIS RESEARCH & THERAPY

Endothelial–Mesenchymal Transition in Bleomycin-Induced Pulmonary Fibrosis

(2009) Naozumi Hashimoto et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

EMT: When epithelial cells decide to become mesenchymal-like cells

(2009) Raghu Kalluri   JOURNAL OF CLINICAL INVESTIGATION

A TGFβ-Responsive Gene Signature Is Associated with a Subset of Diffuse Scleroderma with Increased Disease Severity

(2009) Jennifer L. Sargent et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Scleroderma

(2009) Armando Gabrielli et al.   NEW ENGLAND JOURNAL OF MEDICINE

Fibroblast-specific perturbation of transforming growth factor β signaling provides insight into potential pathogenic mechanisms of scleroderma-associated lung fibrosis: Exaggerated response to alveolar epithelial injury in a novel mouse model

(2008) Rachel K. Hoyles et al.   ARTHRITIS AND RHEUMATISM

Adenosine A2A Receptor Blockade or Deletion Diminishes Fibrocyte Accumulation in the Skin in a Murine Model of Scleroderma, Bleomycin-induced Fibrosis

(2008) Majid Katebi et al.   INFLAMMATION

Fibrocytes are a potential source of lung fibroblasts in idiopathic pulmonary fibrosis

(2008) Annika Andersson-Sjöland et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Development of pulmonary fibrosis through a pathway involving the transcription factor Fra-2/AP-1

(2008) R. Eferl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA