标题
Hepatoprotective and Anti-fibrotic Agents: It's Time to Take the Next Step
作者
关键词
-
出版物
Frontiers in Pharmacology
Volume 6, Issue -, Pages -
出版商
Frontiers Media SA
发表日期
2016-01-07
DOI
10.3389/fphar.2015.00303
参考文献
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- The anti-fibrotic effects of epigallocatechin-3-gallate in bile duct-ligated cholestatic rats and human hepatic stellate LX-2 cells are mediated by the PI3K/Akt/Smad pathway
- (2015) Dong-ke Yu et al. ACTA PHARMACOLOGICA SINICA
- Novel insights into the function and dynamics of extracellular matrix in liver fibrosis
- (2015) Morten A. Karsdal et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Vitamin D inhibits development of liver fibrosis in an animal model but cannot ameliorate established cirrhosis
- (2015) Shirley Abramovitch et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Platelet-derived growth factor-D modulates extracellular matrix homeostasis and remodeling through TIMP-1 induction and attenuation of MMP-2 and MMP-9 gelatinase activities
- (2015) Erawan Borkham-Kamphorst et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Potential Antifibrotic and Angiostatic Impact of Idebenone, Carnosine and Vitamin E in Nano-Sized Titanium Dioxide-Induced Liver Injury
- (2015) Samy A. Abdelazim et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- PDGF-D signaling in portal myofibroblasts and hepatic stellate cells proves identical to PDGF-B via both PDGF receptor type α and β
- (2015) Erawan Borkham-Kamphorst et al. CELLULAR SIGNALLING
- Tranilast reduces serum IL-6 and IL-13 and protects against thioacetamide-induced acute liver injury and hepatic encephalopathy
- (2015) Rania R. Abdelaziz et al. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
- Epigallocatechin gallate attenuated non-alcoholic steatohepatitis induced by methionine- and choline-deficient diet
- (2015) Yi Ding et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Naringenin reduces cholesterol-induced hepatic inflammation in rats by modulating matrix metalloproteinases-2, 9 via inhibition of nuclear factor κB pathway
- (2015) Yassine Chtourou et al. EUROPEAN JOURNAL OF PHARMACOLOGY
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- (2015) Satdarshan Pal Monga GASTROENTEROLOGY
- Nicotinic acid prevents experimental liver fibrosis by attenuating the prooxidant process
- (2015) Jonathan Arauz et al. INTERNATIONAL IMMUNOPHARMACOLOGY
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- (2015) Na-young Yoo et al. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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- (2015) Chiung-Kuei Huang et al. JOURNAL OF HEPATOLOGY
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- (2015) JOURNAL OF HEPATOLOGY
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- (2015) Kelli A. Lytle et al. JOURNAL OF LIPID RESEARCH
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- (2015) Simona Clichici et al. JOURNAL OF MEDICINAL FOOD
- Non-sirtuin histone deacetylases in the control of cardiac aging
- (2015) Bradley S. Ferguson et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Melatonin inhibits autophagy and endoplasmic reticulum stress in mice with carbon tetrachloride-induced fibrosis
- (2015) Beatriz San-Miguel et al. JOURNAL OF PINEAL RESEARCH
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- (2015) F Heymann et al. LABORATORY ANIMALS
- Curcumin regulates cell fate and metabolism by inhibiting hedgehog signaling in hepatic stellate cells
- (2015) Naqi Lian et al. LABORATORY INVESTIGATION
- Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial
- (2015) Brent A Neuschwander-Tetri et al. LANCET
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- (2015) Subhash K. Das et al. LIVER INTERNATIONAL
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- (2015) Iuliana Susnea et al. MASS SPECTROMETRY REVIEWS
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- (2015) Wei-Jian Zhang et al. MEDIATORS OF INFLAMMATION
- Gingerols and shogaols: Important nutraceutical principles from ginger
- (2015) Ruchi Badoni Semwal et al. PHYTOCHEMISTRY
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- (2015) Chien-Yun Hsiang et al. PHYTOMEDICINE
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- (2015) Irene Crespo et al. Translational Research
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- (2014) Erawan Borkham-Kamphorst et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
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- (2014) Fabio Marra et al. GASTROENTEROLOGY
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- (2014) Liu Yang et al. GASTROENTEROLOGY
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- (2014) Raul Lazaro et al. HEPATOLOGY
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- (2014) Carmen Chak-Lui Wong et al. HEPATOLOGY
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- (2014) JS Aher et al. HUMAN & EXPERIMENTAL TOXICOLOGY
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- (2014) Jing Lu et al. INTERNATIONAL IMMUNOPHARMACOLOGY
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- (2014) Feng Zhang et al. INTERNATIONAL IMMUNOPHARMACOLOGY
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- (2014) Lijun Zhang et al. JOURNAL OF HEPATOLOGY
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- (2014) Young Ji Choi et al. LIFE SCIENCES
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- (2014) Fernando Rodríguez-Pascual et al. LIFE SCIENCES
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- (2014) Jie Li et al. LIVER INTERNATIONAL
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- (2014) AKITOSHI DOUHARA et al. Molecular Medicine Reports
- β-catenin is overexpressed in hepatic fibrosis and blockage of Wnt/β-catenin signaling inhibits hepatic stellate cell activation
- (2014) WEN-SONG GE et al. Molecular Medicine Reports
- Effect of zinc on liver cirrhosis with hyperammonemia: A preliminary randomized, placebo-controlled double-blind trial
- (2014) Kazuhiro Katayama et al. NUTRITION
- S-adenosylmethionine mediates inhibition of inflammatory response and changes in DNA methylation in human macrophages
- (2014) Anna C. Pfalzer et al. PHYSIOLOGICAL GENOMICS
- Inhibitory Effects of Japanese Herbal Medicines Sho-saiko-to and Juzen-taiho-to on Nonalcoholic Steatohepatitis in Mice
- (2014) Yoshihisa Takahashi et al. PLoS One
- L-Carnitine Prevents Progression of Non-Alcoholic Steatohepatitis in a Mouse Model with Upregulation of Mitochondrial Pathway
- (2014) Hisashi Ishikawa et al. PLoS One
- Osteopontin deficiency aggravates hepatic injury induced by ischemia–reperfusion in mice
- (2014) S Patouraux et al. Cell Death & Disease
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- (2014) Enting Wang et al. Food & Function
- The Effects of Apigenin on the Expression of Fas/FasL Apoptotic Pathway in Warm Liver Ischemia-Reperfusion Injury in Rats
- (2014) Evanthia G. Tsalkidou et al. Biomed Research International
- Antifibrotic Effects of a Recombinant Adeno-Associated Virus Carrying Small Interfering RNA Targeting TIMP-1 in Rat Liver Fibrosis
- (2013) Min Cong et al. AMERICAN JOURNAL OF PATHOLOGY
- Fluorofenidone attenuates hepatic fibrosis by suppressing the proliferation and activation of hepatic stellate cells
- (2013) Yu Peng et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Combined effects of an antioxidant and caspase inhibitor on the reversal of hepatic fibrosis in rats
- (2013) Do Young Kim et al. APOPTOSIS
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- (2013) Ning Ding et al. CELL
- Gut Microbiota Regulates Bile Acid Metabolism by Reducing the Levels of Tauro-beta-muricholic Acid, a Naturally Occurring FXR Antagonist
- (2013) Sama I. Sayin et al. Cell Metabolism
- Modulation of carbon tetrachloride-induced hepatic oxidative stress, injury and fibrosis by olmesartan and omega-3
- (2013) Ahmed A. Shaaban et al. CHEMICO-BIOLOGICAL INTERACTIONS
- The antihepatic fibrotic effects of fluorofenidone via MAPK signalling pathways
- (2013) Yu Peng et al. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
- Targeted delivery of the RGD-labeled biodegradable polymersomes loaded with the hydrophilic drug oxymatrine on cultured hepatic stellate cells and liver fibrosis in rats
- (2013) Jianhong Yang et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Study of the cellular mechanism of Sunitinib mediated inactivation of activated hepatic stellate cells and its implications in angiogenesis
- (2013) Syamantak Majumder et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Anti-fibrotic effect of Cordyceps sinensis polysaccharide: Inhibiting HSC activation, TGF-β1/Smad signalling, MMPs and TIMPs
- (2013) Jinghua Peng et al. EXPERIMENTAL BIOLOGY AND MEDICINE
- Astragaloside IV suppresses collagen production of activated hepatic stellate cells via oxidative stress-mediated p38 MAPK pathway
- (2013) Xiaoming Li et al. FREE RADICAL BIOLOGY AND MEDICINE
- Epidermal growth factor receptor inhibition attenuates liver fibrosis and development of hepatocellular carcinoma
- (2013) Bryan C. Fuchs et al. HEPATOLOGY
- Hepatic molecular effects of rosiglitazone in human non-alcoholic steatohepatitis suggest long-term pro-inflammatory damage
- (2013) Maud Lemoine et al. HEPATOLOGY RESEARCH
- STAT3-mediated attenuation of CCl4-induced mouse liver fibrosis by the protein kinase inhibitor sorafenib
- (2013) Yan-Ru Deng et al. JOURNAL OF AUTOIMMUNITY
- Caffeine attenuates liver fibrosis via defective adhesion of hepatic stellate cells in cirrhotic model
- (2013) Sung Gon Shim et al. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
- Notch signaling and new therapeutic options in liver disease
- (2013) Carola Maria Morell et al. JOURNAL OF HEPATOLOGY
- Osteopontin delays resolution of liver fibrosis
- (2013) Tung-Ming Leung et al. LABORATORY INVESTIGATION
- Matricellular Protein CCN1 Promotes Regression of Liver Fibrosis through Induction of Cellular Senescence in Hepatic Myofibroblasts
- (2013) K.-H. Kim et al. MOLECULAR AND CELLULAR BIOLOGY
- Bile acid receptors as targets for drug development
- (2013) Frank G. Schaap et al. Nature Reviews Gastroenterology & Hepatology
- Tetrandrine inhibits hepatocellular carcinoma cell growth through the caspase pathway and G2/M phase
- (2013) VIVIAN W.L. YU et al. ONCOLOGY REPORTS
- Lack of the Matricellular Protein SPARC (Secreted Protein, Acidic and Rich in Cysteine) Attenuates Liver Fibrogenesis in Mice
- (2013) Catalina Atorrasagasti et al. PLoS One
- Regression of Fibrosis and Reversal of Cirrhosis in Rats by Galectin Inhibitors in Thioacetamide-Induced Liver Disease
- (2013) Peter G. Traber et al. PLoS One
- Aliskiren Attenuates Steatohepatitis and Increases Turnover of Hepatic Fat in Mice Fed with a Methionine and Choline Deficient Diet
- (2013) Kuei-Chuan Lee et al. PLoS One
- Simvastatin Ameliorates Liver Fibrosis via Mediating Nitric Oxide Synthase in Rats with Non-Alcoholic Steatohepatitis-Related Liver Fibrosis
- (2013) Wei Wang et al. PLoS One
- Atorvastatin and rosuvastatin do not prevent thioacetamide induced liver cirrhosis in rats
- (2013) Haim Shirin WORLD JOURNAL OF GASTROENTEROLOGY
- Protective effects of L-carnitine, N-acetylcysteine and genistein in an experimental model of liver fibrosis
- (2013) Kaan Demiroren et al. Clinics and Research in Hepatology and Gastroenterology
- Platelet-Derived Growth Factor (PDGF)-C Neutralization Reveals Differential Roles of PDGF Receptors in Liver and Kidney Fibrosis
- (2012) Ina V. Martin et al. AMERICAN JOURNAL OF PATHOLOGY
- Drug induced autoimmune hepatitis and TNF-α blocking agents: Is there a real relationship?
- (2012) Cumali Efe AUTOIMMUNITY REVIEWS
- Tyrosine kinase signaling in fibrotic disorders
- (2012) Christian Beyer et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Overview of Pyridine Nucleotides Review Series
- (2012) Michinari Nakamura et al. CIRCULATION RESEARCH
- Thiazolidinediones improve hepatic fibrosis in rats with non-alcoholic steatohepatitis by activating the adenosine monophosphate-activated protein kinase signalling pathway
- (2012) Wei Zhang et al. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
- Role of Oxidative Stress and Molecular Changes in Liver Fibrosis: A Review
- (2012) V. Sanchez-Valle et al. CURRENT MEDICINAL CHEMISTRY
- Fish Omega-3 Fatty Acids Induce Liver Fibrosis in the Treatment of Bile Duct-Ligated Rats
- (2012) Chih-Cheng Chen et al. DIGESTIVE DISEASES AND SCIENCES
- Antifibrotic Activity of Sorafenib in Experimental Hepatic Fibrosis: Refinement of Inhibitory Targets, Dosing, and Window of Efficacy In Vivo
- (2012) Feng Hong et al. DIGESTIVE DISEASES AND SCIENCES
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- (2012) Tai-Long Pan et al. Evidence-based Complementary and Alternative Medicine
- The effects of alpha lipoic acid on liver cells damages and apoptosis induced by polyunsaturated fatty acids
- (2012) Fatma Kaya-Dagistanli et al. FOOD AND CHEMICAL TOXICOLOGY
- Coffee attenuates fibrosis by decreasing the expression of TGF-β and CTGF in a murine model of liver damage
- (2012) Jonathan Arauz et al. JOURNAL OF APPLIED TOXICOLOGY
- Inhibitory effects of salvianolic acid B on CCl4-induced hepatic fibrosis through regulating NF-κB/IκBα signaling
- (2012) Rong Wang et al. JOURNAL OF ETHNOPHARMACOLOGY
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- (2012) Eder Marcolin et al. JOURNAL OF NUTRITION
- Atorvastatin inhibits proliferation and apoptosis, but induces senescence in hepatic myofibroblasts and thereby attenuates hepatic fibrosis in rats
- (2012) Sabine Klein et al. LABORATORY INVESTIGATION
- Rosuvastatin ameliorates high-fat and high-cholesterol diet-induced nonalcoholic steatohepatitis in rats
- (2012) Yoshihisa Okada et al. LIVER INTERNATIONAL
- The Salvia miltiorrhiza monomer IH764-3 induces apoptosis of hepatic stellate cells in vivo in a bile duct ligation-induced model of liver fibrosis
- (2012) LEI LIU et al. Molecular Medicine Reports
- Targeting Fibroblast Growth Factor Receptor Signaling in Hepatocellular Carcinoma
- (2012) Ann-Lii Cheng et al. ONCOLOGY
- Silymarin Decreases Connective Tissue Growth Factor to Improve Liver Fibrosis in Rats Treated with Carbon Tetrachloride
- (2012) Jann-Inn Tzeng et al. PHYTOTHERAPY RESEARCH
- Protective effect of genistein isolated from Hydrocotyle sibthorpioides on hepatic injury and fibrosis induced by chronic alcohol in rats
- (2012) Quanfang Huang et al. TOXICOLOGY LETTERS
- Oxymatrine liposome attenuates hepatic fibrosisviatargeting hepatic stellate cells
- (2012) Ning-Li Chai WORLD JOURNAL OF GASTROENTEROLOGY
- Protective effect of xanthohumol on toxin-induced liver inflammation and fibrosis
- (2012) C Dorn et al. ZEITSCHRIFT FUR GASTROENTEROLOGIE
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- (2012) Guang-Jian Du et al. Nutrients
- Meta-analysis: pioglitazone improves liver histology and fibrosis in patients with non-alcoholic steatohepatitis
- (2011) E. Boettcher et al. ALIMENTARY PHARMACOLOGY & THERAPEUTICS
- SPARC downregulation attenuates the profibrogenic response of hepatic stellate cells induced by TGF-β1 and PDGF
- (2011) Catalina Atorrasagasti et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
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- (2011) Dian J. Chiang et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
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- (2011) Chian Ju Jong et al. AMINO ACIDS
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- (2011) Jeffrey A. Handy et al. BIOCHEMICAL JOURNAL
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- (2011) Yong-Han Paik et al. EXPERIMENTAL AND MOLECULAR MEDICINE
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- (2011) M Kamruzzman Munshi et al. EXPERIMENTAL BIOLOGY AND MEDICINE
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- (2011) Raquel Urtasun et al. HEPATOLOGY
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- (2011) Mario G. Moreno et al. Hepatology International
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- (2011) Jianjun Zhang et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
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- (2011) Hung-Jen Lin et al. JOURNAL OF ETHNOPHARMACOLOGY
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- (2011) Wen-Ling Kuo et al. JOURNAL OF GASTROINTESTINAL SURGERY
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- (2011) Karen Bonefeld et al. LIVER INTERNATIONAL
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- (2011) J.T. Stefano et al. NITRIC OXIDE-BIOLOGY AND CHEMISTRY
- α-Lipoic acid inhibits liver fibrosis through the attenuation of ROS-triggered signaling in hepatic stellate cells activated by PDGF and TGF-β
- (2011) Ning-Ping Foo et al. TOXICOLOGY
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- (2011) Mohamed E. Shaker et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
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- (2010) Sang-Won Hong et al. ARCHIVES OF PHARMACAL RESEARCH
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- (2010) Ae-Kyung Min et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
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- (2010) Jiange Zhang et al. BIOORGANIC & MEDICINAL CHEMISTRY
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- (2010) Shanmugam Lakshmi Devi et al. EUROPEAN JOURNAL OF PHARMACOLOGY
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- (2010) Hung-Jen Lin et al. Evidence-based Complementary and Alternative Medicine
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- (2010) Ralf Weiskirchen Frontiers in Bioscience-Landmark
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- (2010) Samuele De Minicis et al. HEPATOLOGY
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- (2010) Aki Kaimori et al. HEPATOLOGY
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- (2010) Yoshihiro Ikura et al. HEPATOLOGY
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- (2010) Sameer P Junnarkar et al. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
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- (2010) Yuan-Wen Chen et al. JOURNAL OF HEPATOLOGY
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- (2010) Yan Wang et al. JOURNAL OF HEPATOLOGY
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- (2010) Jonel Trebicka et al. JOURNAL OF HEPATOLOGY
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- (2010) Qiong Liu et al. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
- Hepatic and HSC-specific sorafenib effects in rats with established secondary biliary cirrhosis
- (2010) Martin Hennenberg et al. LABORATORY INVESTIGATION
- Disruption of connective tissue growth factor by short hairpin RNA inhibits collagen synthesis and extracellular matrix secretion in hepatic stellate cells
- (2010) Zhu Yuhua et al. LIVER INTERNATIONAL
- Xanthohumol, a chalcon derived from hops, inhibits hepatic inflammation and fibrosis
- (2010) Christoph Dorn et al. MOLECULAR NUTRITION & FOOD RESEARCH
- Allosteric inhibition of lysyl oxidase–like-2 impedes the development of a pathologic microenvironment
- (2010) Vivian Barry-Hamilton et al. NATURE MEDICINE
- Cultivation and Breeding of Chinese Medicinal Plants in Germany
- (2010) Heidi Heuberger et al. PLANTA MEDICA
- Epigallocatechin-3-gallate (EGCG) reduces liver inflammation, oxidative stress and fibrosis in carbon tetrachloride (CCl4)-induced liver injury in mice
- (2010) George L. Tipoe et al. TOXICOLOGY
- Colchicine reduces procollagen III and increases pseudocholinesterase in chronic liver disease
- (2010) Sergio Muntoni WORLD JOURNAL OF GASTROENTEROLOGY
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