Complementary vascular and matrix regulatory pathways underlie the beneficial mechanism of action of sorafenib in liver fibrosis

Synergistic Antitumor Activity of Sorafenib in Combination with Epidermal Growth Factor Receptor Inhibitors in Colorectal and Lung Cancer Cells

(2010) E. Martinelli et al.   CLINICAL CANCER RESEARCH

Sorafenib: a clinical and pharmacologic review

(2010) Renuka Iyer et al.   EXPERT OPINION ON PHARMACOTHERAPY

Endothelial cell toll-like receptor 4 regulates fibrosis-associated angiogenesis in the liver

(2010) Kumaravelu Jagavelu et al.   HEPATOLOGY

Acute liver failure is associated with elevated liver stiffness and hepatic stellate cell activation

(2010) Alexander Dechêne et al.   HEPATOLOGY

Intrahepatic angiogenesis and sinusoidal remodeling in chronic liver disease: New targets for the treatment of portal hypertension?

(2010) Dominique Thabut et al.   JOURNAL OF HEPATOLOGY

Immortalized liver endothelial cells: a cell culture model for studies of motility and angiogenesis

(2010) Robert C Huebert et al.   LABORATORY INVESTIGATION

Sorafenib targets dysregulated Rho kinase expression and portal hypertension in rats with secondary biliary cirrhosis

(2009) M Hennenberg et al.   BRITISH JOURNAL OF PHARMACOLOGY

Tie2 is tied at the cell-cell contacts and to extracellular matrix by Angiopoietin-1

(2009) Shigetomo Fukuhara et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Pharmacological inhibition of integrin αvβ3 aggravates experimental liver fibrosis and suppresses hepatic angiogenesis

(2009) Eleonora Patsenker et al.   HEPATOLOGY

The Kruppel-Like Factor 6 Genotype Is Associated With Fibrosis in Nonalcoholic Fatty Liver Disease

(2008) Luca Miele et al.   GASTROENTEROLOGY

Hepatic Stellate Cells Secrete Angiopoietin 1 That Induces Angiogenesis in Liver Fibrosis

(2008) Kojiro Taura et al.   GASTROENTEROLOGY

Platelet-Derived Growth Factor Signaling Through Ephrin-B2 Regulates Hepatic Vascular Structure and Function

(2008) David Semela et al.   GASTROENTEROLOGY

Beneficial effects of sorafenib on splanchnic, intrahepatic, and portocollateral circulations in portal hypertensive and cirrhotic rats

(2008) Marc Mejias et al.   HEPATOLOGY

Sorafenib in Advanced Hepatocellular Carcinoma

(2008) Josep M. Llovet et al.   NEW ENGLAND JOURNAL OF MEDICINE