Matricellular Protein CCN1 Promotes Regression of Liver Fibrosis through Induction of Cellular Senescence in Hepatic Myofibroblasts

Cellular senescence controls fibrosis in wound healing

(2016) Joon-Il Jun et al.   Aging-US

Liver fibrosis and hepatocyte apoptosis are attenuated by GKT137831, a novel NOX4/NOX1 inhibitor in vivo

(2012) Joy X. Jiang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Regulation of hepatic stellate cells by connective tissue growth factor

(2012) Guangcun Huang   Frontiers in Bioscience-Landmark

Deactivation of Hepatic Stellate Cells During Liver Fibrosis Resolution in Mice

(2012) Juliane S. Troeger et al.   GASTROENTEROLOGY

Nicotinamide adenine dinucleotide phosphate oxidase in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent

(2012) Tomonori Aoyama et al.   HEPATOLOGY

What's new in liver fibrosis? The origin of myofibroblasts in liver fibrosis

(2012) Keiko Iwaisako et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis

(2012) T. Kisseleva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathogenesis of Liver Fibrosis

(2011) Virginia Hernandez-Gea et al.   Annual Review of Pathology-Mechanisms of Disease

CCN1/CYR61: the very model of a modern matricellular protein

(2011) Lester F. Lau   CELLULAR AND MOLECULAR LIFE SCIENCES

The nicotinamide adenine dinucleotide phosphate oxidase (NOX) homologues NOX1 and NOX2/gp91phox mediate hepatic fibrosis in mice

(2011) Yong-Han Paik et al.   HEPATOLOGY

NOX1/nicotinamide adenine dinucleotide phosphate, reduced form (NADPH) oxidase promotes proliferation of stellate cells and aggravates liver fibrosis induced by bile duct ligation

(2011) Wenhao Cui et al.   HEPATOLOGY

Four faces of cellular senescence

(2011) Francis Rodier et al.   JOURNAL OF CELL BIOLOGY

Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targets

(2011) Joon-Il Jun et al.   NATURE REVIEWS DRUG DISCOVERY

Current status of novel antifibrotic therapies in patients with chronic liver disease

(2011) Michal Cohen-Naftaly et al.   Therapeutic Advances in Gastroenterology

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

The opposing effects of CCN2 and CCN5 on the development of cardiac hypertrophy and fibrosis

(2010) Pyoung Oh Yoon et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Connective tissue growth factor: a fibrogenic master switch in fibrotic liver diseases

(2010) Olav A. Gressner et al.   LIVER INTERNATIONAL

The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing

(2010) Joon-Il Jun et al.   NATURE CELL BIOLOGY

Assessing the Metabolic Competence of Sandwich-Cultured Mouse Primary Hepatocytes

(2009) K. Mathijs et al.   DRUG METABOLISM AND DISPOSITION

Negligible Contribution of Bone Marrow-Derived Cells to Collagen Production During Hepatic Fibrogenesis in Mice

(2009) Reiichi Higashiyama et al.   GASTROENTEROLOGY

Epithelial-to-mesenchymal transitions in the liver

(2009) Steve S. Choi et al.   HEPATOLOGY

Hepatocytes do not undergo epithelial-mesenchymal transition in liver fibrosis in mice

(2009) Kojiro Taura et al.   HEPATOLOGY

Fas-Mediated Apoptosis Is Regulated by the Extracellular Matrix Protein CCN1 (CYR61) In Vitro and In Vivo

(2009) V. Juric et al.   MOLECULAR AND CELLULAR BIOLOGY

Protocols to detect senescence-associated beta-galactosidase (SA-βgal) activity, a biomarker of senescent cells in culture and in vivo

(2009) Florence Debacq-Chainiaux et al.   Nature Protocols

Fibrogenic Potential of Human Multipotent Mesenchymal Stromal Cells in Injured Liver

(2009) Reto M. Baertschiger et al.   PLoS One

Connective tissue growth factor (CCN2, CTGF) and organ fibrosis: lessons from transgenic animals

(2009) David R. Brigstock   Journal of Cell Communication and Signaling

Senescence of Activated Stellate Cells Limits Liver Fibrosis

(2008) Valery Krizhanovsky et al.   CELL

Oxidative stress in alcoholic liver disease: Role of NADPH oxidase complex

(2008) Samuele De Minicis et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Wound repair and regeneration

(2008) Geoffrey C. Gurtner et al.   NATURE

Resolution of liver cirrhosis using vitamin A–coupled liposomes to deliver siRNA against a collagen-specific chaperone

(2008) Yasushi Sato et al.   NATURE BIOTECHNOLOGY

A reproducible and well-tolerated method for 2/3 partial hepatectomy in mice

(2008) Claudia Mitchell et al.   Nature Protocols

NOX enzymes as novel targets for drug development

(2008) J. David Lambeth et al.   Seminars in Immunopathology