Article
Oncology
Zhuo Xiang, Qing Miao, Jin Zhang, Guoxin Liu, Shuyi Xue, Xu Liu, Zhe Zhang, Lixia Shen, Bangguo Liu, Yu Zhou, Ting Miao, Yang Liu
Summary: The study revealed the anticancer efficacy of AB4, an extract from the herb Pulsatilla chinensis, in liver cancer both in vitro and in vivo by inhibiting cell proliferation and inducing apoptosis through the Notch signaling pathway. The findings were further validated in xenograft tumor-bearing nude mice model, suggesting AB4 as a potential therapeutic agent for liver cancer targeting Notch activity.
Review
Cell Biology
Frederick Allen, Ivan Maillard
Summary: The Notch signaling pathway has been investigated as a therapeutic target for cancers and immune/inflammatory disorders, orchestrating cell fate decisions and regulating immune responses through cell-to-cell contacts. It has shown potential in inhibiting tumor growth and preventing/reversing inflammatory disorders.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Amir Valizadeh, Ali Sayadmanesh, Zatollah Asemi, Forough Alemi, Ata Mahmoodpoor, Bahman Yousefi
Summary: The Notch signaling pathway plays a crucial role in liver development and regeneration, with dysfunction leading to the progression of various liver disorders. Modulation of this pathway may improve cirrhosis in patients with chronic hepatitis B.
CURRENT MEDICINAL CHEMISTRY
(2021)
Article
Engineering, Biomedical
Muhammad Rizwan, Christopher Ling, Chengyu Guo, Tracy Liu, Jia-Xin Jiang, Christine E. Bear, Shinichiro Ogawa, Molly S. Shoichet
Summary: A defined viscoelastic hyaluronan hydrogel is designed to mimic the stress relaxation rate of liver tissue, promoting cholangiocyte organoid growth. Hydrogel viscoelasticity, YAP signaling, and Notch activation play critical roles in cholangiocyte organogenesis.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Immunology
Wenyan Chen, Yining Liu, Jing Chen, Yemei Ma, Yawen Song, Yanli Cen, Mingdan You, Guanghong Yang
Summary: The liver plays a crucial role in metabolism and immune response in the human body. Macrophages are essential for defending against foreign pathogens and can polarize into different states to respond to various invaders. The Notch signaling pathway is believed to regulate the polarization of macrophages in liver diseases, impacting inflammation and tumor growth.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Health Care Sciences & Services
Thomas Iosifidis, Erika N. Sutanto, Samuel T. Montgomery, Patricia Agudelo-Romero, Kevin Looi, Kak-Ming Ling, Nicole C. Shaw, Luke W. Garratt, Jessica Hillas, Kelly M. Martinovich, Elizabeth Kicic-Starcevich, Shyan Vijayasekaran, Francis J. Lannigan, Paul J. Rigby, Darryl A. Knight, Stephen M. Stick, Anthony Kicic
Summary: The study found dysregulation of the Notch pathway in airway epithelial cells of children with wheeze, potentially contributing to defective repair. Primary AEC from children with wheeze showed significantly lower NOTCH2 expression and higher JAG1 expression.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Oncology
Dorota Anusewicz, Magdalena Orzechowska, Andrzej K. Bednarek
Summary: The Notch signaling pathway regulates cell differentiation and is associated with carcinogenesis. Notch pathway members can be either oncogenic or suppressive depending on tissue context, showing promising potential for new treatment strategies.
Review
Oncology
Mingzhou Guo, Yang Niu, Min Xie, Xiansheng Liu, Xiaochen Li
Summary: Notch signaling is important in cell fate determination and dysregulated in human solid tumors. Hypoxia, an important feature of many solid tumors, activates hypoxia-induced factors (HIFs) and their downstream targets to promote tumorigenesis and cancer development. Recently, HIFs have been found to trigger the Notch signaling pathway in various organisms and tissues. This review focuses on the pro- and anti-tumorigenic functions of Notch signaling, discusses the crosstalk between Notch signaling and cellular hypoxic response in cancer pathogenesis, and explores pharmacological strategies targeting Notch signaling and hypoxia in cancer.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Nami Yamashita, Yoshihiro Morimoto, Atsushi Fushimi, Rehan Ahmad, Atrayee Bhattacharya, Tatsuaki Daimon, Naoki Haratake, Yuka Inoue, Satoshi Ishikawa, Masaaki Yamamoto, Tsuyoshi Hata, Sayuri Akiyoshi, Qiang Hu, Tao Liu, Henry Withers, Song Liu, Geoffrey I. Shapiro, Tomoharu Yoshizumi, Mark D. Long, Donald Kufe
Summary: In certain cancer cells, the chromatin remodeling complex SWI/SNF PBAF's subunit polybromo-1 (PBRM1) drives DNA damage resistance and immune evasion through unclear mechanisms. This study found that MUC1-C is necessary for PBRM1 expression in triple-negative breast cancer (TNBC) cells, and the two proteins form a nuclear complex. Transcriptional and chromatin accessibility analysis showed that MUC1-C and PBRM1 increase the expression of STAT1 and IRF1 by enhancing chromatin accessibility on their respective genes, as well as other genes involved in DNA damage resistance and immune evasion.
MOLECULAR CANCER RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Mehrdad Hashemi, Sahar Hasani, Shima Hajimazdarany, Seyed Reza Mirmazloomi, Sara Makvandy, Abbas Zabihi, Yeganeh Goldoost, Nazanin Gholinia, Amirabbas Kakavand, Alireza Tavakolpournegari, Shokooh Salimimoghadam, Noushin Nabavi, Ali Zarrabi, Afshin Taheriazam, Maliheh Entezari, Kiavash Hushmandi
Summary: This article discusses the critical role of non-coding RNAs (ncRNAs) in regulating the Notch signaling pathway in various cancer hallmarks, including proliferation, apoptosis, autophagy, EMT, invasion, metastasis, and resistance to therapies.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Multidisciplinary Sciences
Arushi Jaiswal, Kiichi Murakami, Andrew Elia, Yukiko Shibahara, Susan J. Done, Stephen A. Wood, Nicholas J. Donato, Pamela S. Ohashi, Michael Reedijk
Summary: The study suggests that inhibition of USP9x can treat TNBC by reducing Notch activity, decreasing tumor inflammation, enhancing antitumor immune response, and suppressing tumor growth. Pharmacological inhibition of USP9x can remodel the tumor immune landscape, reduce tumor growth without toxicity, and target Notch in metabolically vulnerable tissues like TNBC.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Immunology
Panagiotis F. Christopoulos, Torleif T. Gjolberg, Stig Kruger, Guttorm Haraldsen, Jan Terje Andersen, Eirik Sundlisaeter
Summary: The Notch signaling pathway plays a supporting role in various inflammation-driven diseases, but targeting this pathway for treatment has proven challenging due to its broad involvement in regenerative and homeostatic processes. Efforts to intervene with the Notch pathway by targeting Notch ligands and/or receptors through distinct therapeutic strategies, including antibody designs, are ongoing. Lessons learned from Notch targeting in cancer treatment may help guide the development of therapeutic strategies for chronic inflammatory diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Lei Qiu, Xiuwei Yang, Jingyu Wu, Changzhi Huang, Yongchang Miao, Zan Fu
Summary: The study reveals that upregulation of HIST2H2BF enhances CSC phenotype, malignancy, and liver metastasis through activating Notch signaling in CRC, shedding light on the mechanism of maintaining stem cell features in CRC and providing new potential therapeutic targets.
FRONTIERS IN ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Antonino Glaviano, Aaron S. C. Foo, Hiu Y. Lam, Kenneth C. H. Yap, William Jacot, Robert H. Jones, Huiyan Eng, Madhumathy G. Nair, Pooyan Makvandi, Birgit Geoerger, Matthew H. Kulke, Richard D. Baird, Jyothi S. Prabhu, Daniela Carbone, Camilla Pecoraro, Daniel B. L. Teh, Gautam Sethi, Vincenzo Cavalieri, Kevin H. Lin, Nathalie R. Javidi-Sharifi, Eneda Toska, Matthew S. Davids, Jennifer R. Brown, Patrizia Diana, Justin Stebbing, David A. Fruman, Alan P. Kumar
Summary: The PI3K/AKT/mTOR (PAM) signaling pathway plays a crucial role in cell survival, growth, and cell cycle progression. Dysregulation of this pathway is associated with cancer development and resistance to therapy. This review focuses on the major dysregulations in the PAM signaling pathway in cancer and discusses strategies for overcoming treatment resistance. The role of PAM signaling in immunology and immunotherapies is also discussed.
Review
Biochemistry & Molecular Biology
Chuanxi Zheng, Jianghong Huang, Gang Xu, Wei Li, Xin Weng, Shiquan Zhang
Summary: Desmoid tumor (DT) is a rare fibroblastic soft-tissue neoplasm that is characterized by local aggressiveness but no metastatic potential. Aberrant activation of Wnt/beta-catenin signaling and Notch pathway is closely associated with the development and progression of DT, suggesting potential therapeutic targets. Two gamma-secretase inhibitors are currently under extensive investigation and have shown potential treatment benefits in clinical trials.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Gastroenterology & Hepatology
Luigi Locatelli, Massimiliano Cadamuro, Carlo Spirli, Romina Fiorotto, Silvia Lecchi, Carola Maria Morell, Yury Popov, Roberto Scirpo, Maria De Matteis, Mariangela Amenduni, Andrea Pietrobattista, Giuliano Torre, Detlef Schuppan, Luca Fabris, Mario Strazzabosco
Article
Multidisciplinary Sciences
Carola M. Morell, Romina Fiorotto, Marica Meroni, Aileen Raizner, Barbara Torsello, Massimiliano Cadamuro, Gaia Spagnuolo, Eleanna Kaffe, Salvatore Sutti, Emanuele Albano, Mario Strazzabosco
Article
Gastroenterology & Hepatology
Charis-Patricia Segeritz, Sheikh Tamir Rashid, Miguel Cardoso de Brito, Maria Paola Serra, Adriana Ordonez, Carola Maria Morell, Joseph E. Kaserman, Pedro Madrigal, Nicholas R. F. Hannan, Laurent Gatto, Lu Tan, Andrew A. Wilson, Kathryn Lilley, Stefan J. Marciniak, Bibek Gooptu, David A. Lomas, Ludovic Vallier
JOURNAL OF HEPATOLOGY
(2018)
Article
Gastroenterology & Hepatology
Carlo Spirli, Luigi Locatelli, Romina Fiorotto, Carola M. Morell, Luca Fabris, Tullio Pozzan, Mario Strazzabosco
Article
Gastroenterology & Hepatology
Carlo Spirli, Carola M. Morell, Luigi Locatelli, Stefano Okolicsanyi, Cecilia Ferrero, Amy K. Kim, Luca Fabris, Romina Fiorotto, Mario Strazzabosco
Article
Gastroenterology & Hepatology
Carlo Spirli, Luigi Locatelli, Carola M. Morell, Romina Fiorotto, Stuart D. Morton, Massimiliano Cadamuro, Luca Fabris, Mario Strazzabosco
Article
Gastroenterology & Hepatology
Carola M. Morell, Luca Fabris, Mario Strazzabosco
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2013)
Article
Gastroenterology & Hepatology
Romina Fiorotto, Aileen Raizner, Carola M. Morell, Barbara Torsello, Roberto Scirpo, Luca Fabris, Carlo Spirlil, Mario Strazzabosco
JOURNAL OF HEPATOLOGY
(2013)
Review
Gastroenterology & Hepatology
Carola Maria Morell, Romina Fiorotto, Luca Fabris, Mario Strazzabosco
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY
(2013)
Article
Cell & Tissue Engineering
Loukia Yiangou, Rodrigo A. Grandy, Carola M. Morell, Rute A. Tomaz, Anna Osnato, Juned Kadiwala, Daniele Muraro, Jose Garcia-Bernardo, Shota Nakanoh, William G. Bernard, Daniel Ortmann, Davis J. McCarthy, Ingrid Simonic, Sanjay Sinha, Ludovic Vallier
Article
Gastroenterology & Hepatology
Casey A. Rimland, Samantha G. Tilson, Carola M. Morell, Rute A. Tomaz, Wei-Yu Lu, Simone E. Adams, Nikitas Georgakopoulos, Francisco Otaizo-Carrasquero, Timothy G. Myers, John R. Ferdinand, Richard L. Gieseck, Fotios Sampaziotis, Olivia C. Tysoe, Alexander Ross, Judith M. Kraiczy, Brandon Wesley, Daniele Muraro, Matthias Zilbauer, Gabriel C. Oniscu, Nicholas R. F. Hannan, Stuart J. Forbes, Kourosh Saeb-Parsy, Thomas A. Wynn, Ludovic Vallier
Summary: Researchers successfully established organoids derived from human gallbladder, common bile duct, pancreatic duct, and IHBDs, expressing stem/progenitor and ductal markers, but conserving only limited regional-specific markers, with differences in response and expression of cell markers between IHBD and EHBD organoids.
Article
Gastroenterology & Hepatology
Samantha G. Tilson, Carola M. Morell, An-Sofie Lenaerts, Seung Bum Park, Zongyi Hu, Benjamin Jenkins, Albert Koulman, T. Jake Liang, Ludovic Vallier
Summary: The study used hiPSCs and CRISPR/CAS9 technology to develop an in vitro model to investigate the impact of the PNPLA3 gene and its variants on NAFLD development, revealing that the I148M variant induces loss of function, making patients more susceptible to fatty liver and liver toxins.