Article
Biochemistry & Molecular Biology
Silvia Marchiano, Michele Biagioli, Rosalinda Roselli, Angela Zampella, Cristina Di Giorgio, Martina Bordoni, Rachele Bellini, Ginevra Urbani, Elva Morretta, Maria Chiara Monti, Eleonora Distrutti, Stefano Fiorucci
Summary: The study compared the pharmacological effects of UDCA and norUDCA in a mouse model of NAFLD/NASH, finding that both protected against liver steatosis and fibrosis development, improved lipid metabolism and insulin sensitivity, with UDCA acting as a GPBAR1 agonist, while norUDCA had no effect on GPBAR1 signaling.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2022)
Review
Pharmacology & Pharmacy
Changchao Huan, Yao Xu, Wei Zhang, Tingting Guo, Haochun Pan, Song Gao
Summary: Liquorice, a traditional medicine, contains triterpenoids such as glycyrrhizin and glycyrrhetinic acid which have inhibitory effects on various viruses, including SARS-CoV-2. These compounds work through mechanisms such as inhibition of virus replication, direct inactivation of viruses, and inhibition of inflammation. Further research on unknown antiviral mechanisms, structural modifications, and drug combinations is emphasized for future studies.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Jenessa A. Winston, Alissa Rivera, Jingwei Cai, Andrew D. Patterson, Casey M. Theriot
Summary: Ursodeoxycholic acid, also known as ursodiol, is a naturally occurring bile acid used to treat hepatic and gastrointestinal diseases. This study reveals how exogenously administered ursodiol shapes the healthy gastrointestinal ecosystem in conventional mice, with significant contributions from members of the Lachnospiraceae Family. Further research is needed to understand how these changes impact the host's physiological response.
Article
Chemistry, Medicinal
Xiaosu Zou, Chang Liu, Congcong Li, Rong Fu, Wei Xu, Hongzhu Bian, Xun Dong, Xiaozhen Zhao, Zhenye Xu, Jinghua Zhang, Zhengwu Shen
Summary: A series of dihydroartemisinin derivatives with anti-proliferation activity against cancer cells were synthesized, and the dihydroartemisinin-ursodeoxycholic acid conjugate showed the most potent activity. In vivo experiments confirmed its effectiveness in suppressing tumor growth in different cell models.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Gastroenterology & Hepatology
Yuki Yamashita, Takeji Umemura, Takefumi Kimura, Satoru Joshita, Junko Hirohara, Toshiaki Nakano, Atsumasa Komori, Atsushi Tanaka
Summary: This study showed that baseline ALBI grade is a simple non-invasive predictor for prognosis in PBC, and it is significantly associated with histological stage and disease progression. ALBI score/grade can be used to assess liver function and predict mortality and the need for liver transplantation in PBC patients.
Review
Chemistry, Medicinal
Fahimeh Zamani-Garmsiri, Solaleh Emamgholipour, Soheil Rahmani Fard, Ghasem Ghasempour, Roya Jahangard Ahvazi, Reza Meshkani
Summary: Polyphenols have potential benefits in health status, especially in obesity-related metabolic disorders, but further high-quality research is needed to establish their clinical efficacy.
PHYTOTHERAPY RESEARCH
(2022)
Review
Immunology
Fei Huang, Carmine M. Pariante, Alessandra Borsini
Summary: Studies have shown that UDCA, GUDCA, and TUDCA can reduce cell apoptosis, oxidative stress, and inflammation in pre-clinical models of neurological, neurodegenerative, and neuropsychiatric disorders. The three bile acids have slightly different effects in different models, but overall they demonstrate promising therapeutic potential.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Multidisciplinary Sciences
Julian Stuerznickel, Friederike Behler-Janbeck, Anke Baranowsky, Tobias Schmidt, Dorothee Schwinge, Clara John, Ansgar W. Lohse, Christoph Schramm, Joerg Heeren, Thorsten Schinke, Michael Amling
Summary: Primary sclerosing cholangitis (PSC) often leads to bone health issues, and the study found heterogeneity in bone mineral density among patients with PSC. Although the study did not confirm that an increase in circulating bile levels is the primary cause of PSC-associated osteoporosis, significant differences in serum bile acid concentrations were identified.
SCIENTIFIC REPORTS
(2022)
Article
Gastroenterology & Hepatology
Omar Y. Mousa, Brian D. Juran, Bryan M. McCauley, Mette N. Vesterhus, Trine Folseraas, Coleman T. Turgeon, Ahmad H. Ali, Erik M. Schlicht, Elizabeth J. Atkinson, Chang Hu, Denise Harnois, Elizabeth J. Carey, Andrea A. Gossard, Devin Oglesbee, John E. Eaton, Nicholas F. LaRusso, Gregory J. Gores, Tom H. Karlsen, Konstantinos N. Lazaridis
Summary: In patients with PSC, alterations in plasma BA consistent with cholestasis, UDCA treatment, and IBD were observed. BA profiles were able to predict future hepatic decompensation, demonstrating the clinical potential of BA profiling for use in clinical trials.
Article
Surgery
Intekhab Hossain, Jane Brodie, Erin O'Brien, Katherine Tedman-Aucoin, Diana Lawlor, Raleen Murphy, Laurie Twells, David Pace, Bradley Evans, James Ellsmere
Summary: This study assessed the effect of routine UDCA administration following LSG on symptomatic gallstone disease. The results showed that patients who received UDCA had lower rates of cholecystectomy and ERCP, supporting the effectiveness of the ASMBS 2019 guidelines for preventing gallstone disease after LSG.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Environmental Sciences
Sukumaran Gheena, Devaraj Ezhilarasan, Karthik Shree Harini, Shanmugam Rajeshkumar
Summary: The study revealed that syringic acid has a hepatoprotective effect against sodium valproate-induced liver injury in rats, reducing oxidative stress and inflammation in the liver.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Obstetrics & Gynecology
J. Fleminger, P. T. Seed, A. Smith, E. Juszczak, P. H. Dixon, J. Chambers, J. Dorling, C. Williamson, J. G. Thornton, L. C. Chappell
Summary: The study found that there was no specific group of women with intrahepatic cholestasis of pregnancy who would benefit from treatment with ursodeoxycholic acid, indicating that its routine use for improvement of bile acid concentration or itch score should be reconsidered.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2021)
Review
Surgery
Amit Sharma, Hiba Shanti, Haritharan Nageswaran, Lawrence M. J. Best, Ameet G. Patel
Summary: This meta-analysis examines the efficacy of ursodeoxycholic acid (UDCA) treatment in reducing gallstone formation in postoperative bariatric patients. The results indicate that oral UDCA treatment significantly reduces the risks of developing gallstones and symptomatic gallstone disease in these patients. A dosage of 500 to 600 mg UDCA for 6 months is recommended.
Article
Biochemistry & Molecular Biology
Federico Zappaterra, Stefania Costa, Daniela Summa, Bruno Semeraro, Virginia Cristofori, Claudio Trapella, Elena Tamburini
Summary: Bile acids, specifically ursodeoxycholic acid (UDCA), are effective in treating certain conditions but have poor solubility, impacting their bioavailability. Researchers explored enzymatic esterification as a method to enhance the water solubility of UDCA for better absorption.
Article
Pharmacology & Pharmacy
Rifika Jain, Mohamed Ali Hussein, Shannon Pierce, Chad Martens, Preksha Shahagadkar, Gnanasekar Munirathinam
Summary: Licorice, a natural herb used for centuries, contains compounds like glycyrrhizin and glycyrrhetinic acid which have various pharmacological effects, including anti-inflammatory, anticancer, antiviral properties. Studies show that licorice is effective against the replication of SARS-CoV-2 and has potential in cancer prevention and treatment.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Plant Sciences
Vinayak Nayak, Sushmita Patra, Shrushti Rout, Atala Bihari Jena, Rohit Sharma, Kali Prasad Pattanaik, Jay Singh, Shyam S. Pandey, Ravindra Pratap Singh, Sanatan Majhi, Kshitij R. B. Singh, Rout George Kerry
Summary: This study introduces a customized engineering and designing approach for novel nanotherapeutics, which involves the use of polymeric nanoparticles loaded with specific phytocompounds and coated with an antibody targeting the transferrin receptor. This approach aims to effectively tackle AD-related neuroinflammation by crossing the Blood-Brain Barrier and interacting with target molecules within the brain.
Article
Plant Sciences
Zhi Shang, Yating Gao, Yan Xue, Congcong Zhang, Jiahao Qiu, Yihan Qian, Miao Fang, Xin Zhang, Xuehua Sun, Xiaoni Kong, Yueqiu Gao
Summary: This study investigated the mechanism of Shenge Formula (SGF) in the treatment of nonalcoholic fatty liver disease (NAFLD) using proteomics strategy. The results revealed that SGF could regulate the lipid metabolism and energy consumption process of hepatocytes to treat NAFLD.
Article
Plant Sciences
Long You, Ting Shen, Weicheng Hu, Jae Youl Cho
Summary: By activating growth factor receptors such as EGFR and HER2, protopanaxatriol (PPT) can regulate skin moisturizing factors and multiple signaling pathways, thereby protecting and moisturizing the skin.
Article
Plant Sciences
Lingmei Li, Lei Li, Ce Cao, Fan Guo, Aoao Wang, Li Lin, Zixin Liu, Hongxu Meng, Peng Zhang, Gaojie Xin, Jianxun Liu, Junguo Ren, Jianhua Fu
Summary: The study found that Shuangshen Ningxin Capsule (SSNX) has a protective effect against myocardial ischemia-reperfusion injury. It works by correcting abnormal myocardial energy metabolism, changing the levels and distribution patterns of phospholipids, and stabilizing the structure of the myocardial cell membrane. Matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) can be used to detect the spatial distribution of small molecule metabolites in the myocardium.
Article
Plant Sciences
Nidhi Sharma, Ramakrishna Sistla, Sai Balaji Andugulapati
Summary: The study investigates the anti-fibrotic activity of Yohimbine hydrochloride (YHC) in chronic liver injury. The results show that YHC can reduce inflammation and fibrosis, potentially making it a potential lead compound for liver fibrosis treatment.
Article
Plant Sciences
Tao-tao Wang, Cheng-yong Yang, Li Peng, Li Li, Nan-ting Chen, Xue Feng, Jing Xie, Ting-chun Wu, Tao Xu, Yun-zhi Chen
Summary: QSYQ has been found to have an anti-atherosclerotic effect by targeting TTC39B-LXR mediated reverse cholesterol transport in the liver. QSYQ not only promotes reverse cholesterol transport, but also improves fatty liver and protects liver function.
Article
Plant Sciences
Zhuo Liu, Yuli Geng, Yanjing Huang, Runan Hu, Fan Li, Jiahui Ding, Wenwen Ma, Haoxu Dong, Kunkun Song, Xiaohu Xu, Xiao Wu, Yufan Song, Mingmin Zhang
Summary: This study investigated the therapeutic efficacy of the Bushen Antai recipe (BAR) in abortion-prone mice and explored its potential mechanisms related to myeloid-derived suppressor cells (MDSCs). The results showed that BAR improved embryo absorption rate and increased the number of MDSCs, promoting normal pregnancy processes.
Article
Plant Sciences
Xue-Ping Yang, Jia-Hua Huang, Fan-Long Ye, Qing-Yun Yv, Sheng Chen, Wen-Wei Li, Min Zhu
Summary: This study found that ECH exerts neuroprotective effects on Parkinson's disease (PD) by regulating the expression of the TLR2/NF-kappa B/NLRP3 axis and reducing the expression of alpha-syn.
Article
Plant Sciences
Lihui Qian, Sirui Huang, Xiaoli Liu, Yongxia Jiang, Yongqu Jiang, Yue Hu, Zhou Yang
Summary: This study highlights the potential use of morroniside in treating post-stroke depression (PSD) by activating the MiR-409-3p-mediated BDNF/TrkB signaling pathway.
Article
Plant Sciences
Jiahui Wu, Hoi Lam Zhang, Suisui Guo, Xin Li, Tingxia Dong, Yue Zhu, Karl Wah Keung Tsim
Summary: This study revealed the significant MDR-preventing effects of Acori Tatarinowii Rhizoma (ATR) in fluoxetine-induced Escherichia coli (E. coli). ATR reduced the accumulation of fluoxetine in bacteria and reversed the fluoxetine-induced membrane damage and superoxide response. The polysaccharide fraction of ATR exhibited the most significant anti-MDR activity.
Article
Plant Sciences
Chao-Sheng Lu, Chen-Yu Wu, Yi-Hong Wang, Qing-Qing Hu, Rong-Yue Sun, Min-Jie Pan, Xin-Yu Lu, Ting Zhu, Shuang Luo, Hong-Jing Yang, Dan Wang, Hong-Wei Wang
Summary: This study demonstrates the potential of icariin in alleviating testicular dysfunction induced by T1D, with the involvement of AMPK-mediated Nrf2 activation and NF-kappa B p65 inhibition.
Article
Plant Sciences
Hongkang Zhu, Fanglin Shen, Xiaochen Wang, He Qian, Yu Liu
Summary: This study explores the therapeutic effect and underlying mechanism of chlorogenic acid (CGA) in alleviating sleep deprivation-induced cognitive deficits and neuroinflammation. By interacting with the gut microbiota, CGA improves intestinal barrier, regulates immune function, and enhances hippocampal-dependent spatial memory via Nrf2/PPAR signaling pathways. This research provides important insights into the clinical application of CGA in sleep-related disorders.
Article
Plant Sciences
Meng Liu, Pengli Guo, Mengnan Zeng, Yuhan Zhang, Jufang Jia, Yanling Liu, Xu Chen, Haixue Kuang, Weisheng Feng, Xiaoke Zheng
Summary: This study found that Fre D and Reh C improved S-AKI through the ER-TLR4-IL-1β pathway, and ERα and ERβ may have direct or indirect interactions with TLR4.
Review
Plant Sciences
Puja Ghosh, Niloy Patari, Chennu Manisha, Duraiswamy Basavan, Velammal Petchiappan, Antony Justin
Summary: This article reviews the possible mechanisms of alternative treatment using lectins for cancer, particularly MDRC cancer. Lectins have the ability to reverse drug resistance mechanisms and show synergistic effects when combined with complementary medicine. They can also serve as nano drug carriers for targeted delivery.
Article
Plant Sciences
Tian Lan, Xiao-juan Geng, Si-jia Zhang, Xi-xi Zeng, Jun-jie Ying, Yi Xu, Shi-yu Liu, Ping Li, Yu-hua Tong, Wen Wang, Zhu-jun Mao, Si-wei Wang
Summary: This study investigates the impact of SNS on MAFLD in mice and explores its underlying molecular mechanisms. The results show that SNS effectively reduces lipid accumulation and improves MAFLD through the activation of AMPK and the modulation of lipid metabolism-related proteins.