Deficiency of NOX1 or NOX4 Prevents Liver Inflammation and Fibrosis in Mice through Inhibition of Hepatic Stellate Cell Activation

The inhibition of activated hepatic stellate cells proliferation by arctigenin through G0/G1 phase cell cycle arrest: Persistent p27Kip1 induction by interfering with PI3K/Akt/FOXO3a signaling pathway

(2015) Ao Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Inhibitory Effect of Tanshinone IIA on Rat Hepatic Stellate Cells

(2014) Ya-Wei Liu et al.   PLoS One

The antihepatic fibrotic effects of fluorofenidone via MAPK signalling pathways

(2013) Yu Peng et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Thymoquinone attenuates liver fibrosis via PI3K and TLR4 signaling pathways in activated hepatic stellate cells

(2013) Ting Bai et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Hepatic stellate cells in liver development, regeneration, and cancer

(2013) Chunyue Yin et al.   JOURNAL OF CLINICAL INVESTIGATION

Liver fibrosis and hepatocyte apoptosis are attenuated by GKT137831, a novel NOX4/NOX1 inhibitor in vivo

(2012) Joy X. Jiang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hedgehog Controls Hepatic Stellate Cell Fate by Regulating Metabolism

(2012) Yuping Chen et al.   GASTROENTEROLOGY

Nicotinamide adenine dinucleotide phosphate oxidase in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent

(2012) Tomonori Aoyama et al.   HEPATOLOGY

NADPH Oxidase NOX4 Mediates Stellate Cell Activation and Hepatocyte Cell Death during Liver Fibrosis Development

(2012) Patricia Sancho et al.   PLoS One

Gli Proteins in Development and Disease

(2011) Chi-chung Hui et al.   Annual Review of Cell and Developmental Biology

Design, synthesis and biological activity of original pyrazolo-pyrido-diazepine, -pyrazine and -oxazine dione derivatives as novel dual Nox4/Nox1 inhibitors

(2011) Francesca Gaggini et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The nicotinamide adenine dinucleotide phosphate oxidase (NOX) homologues NOX1 and NOX2/gp91phox mediate hepatic fibrosis in mice

(2011) Yong-Han Paik et al.   HEPATOLOGY

NOX1/nicotinamide adenine dinucleotide phosphate, reduced form (NADPH) oxidase promotes proliferation of stellate cells and aggravates liver fibrosis induced by bile duct ligation

(2011) Wenhao Cui et al.   HEPATOLOGY

Control of Hepatic Nuclear Superoxide Production by Glucose 6-Phosphate Dehydrogenase and NADPH Oxidase-4

(2011) Netanya Y. Spencer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Myofibroblast differentiation during fibrosis: role of NAD(P)H oxidases

(2011) Jeffrey L. Barnes et al.   KIDNEY INTERNATIONAL

Targeting Vascular NADPH Oxidase 1 Blocks Tumor Angiogenesis through a PPARα Mediated Mechanism

(2011) Sarah Garrido-Urbani et al.   PLoS One

Linking oxidative stress to inflammation: Toll-like receptors

(2010) Roop Gill et al.   FREE RADICAL BIOLOGY AND MEDICINE

Signals from dying hepatocytes trigger growth of liver progenitors

(2010) Y. Jung et al.   GUT

Hepatocyte NAD(P)H oxidases as an endogenous source of reactive oxygen species during hepatitis C virus infection

(2010) Nabora Soledad Reyes de Mochel et al.   HEPATOLOGY

Leptin Promotes the Myofibroblastic Phenotype in Hepatic Stellate Cells by Activating the Hedgehog Pathway

(2010) Steve S. Choi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

First in Class, Potent, and Orally Bioavailable NADPH Oxidase Isoform 4 (Nox4) Inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis

(2010) Benoı̂t Laleu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Toll-Like Receptor Signaling and Liver Fibrosis

(2010) Tomonori Aoyama et al.   Gastroenterology Research and Practice

Effects of losartan on hepatic expression of nonphagocytic NADPH oxidase and fibrogenic genes in patients with chronic hepatitis C

(2009) Jordi Colmenero et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

NADPH oxidase-4 mediates myofibroblast activation and fibrogenic responses to lung injury

(2009) Louise Hecker et al.   NATURE MEDICINE

Mechanisms of Hepatic Fibrogenesis

(2008) Scott L. Friedman   GASTROENTEROLOGY

Sonic hedgehog is an autocrine viability factor for myofibroblastic hepatic stellate cells

(2007) Liu Yang et al.   JOURNAL OF HEPATOLOGY