Stromal response to Hedgehog signaling restrains pancreatic cancer progression

Ectopic Overexpression of Sonic Hedgehog (Shh) Induces Stromal Expansion and Metaplasia in the Adult Murine Pancreas

(2015) Volker Fendrich et al.   NEOPLASIA

Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival

(2014) Berna C. Özdemir et al.   CANCER CELL

Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma

(2014) Andrew D. Rhim et al.   CANCER CELL

Hyaluronan, fluid pressure and stromal resistance in pancreas cancer

(2013) P P Provenzano et al.   BRITISH JOURNAL OF CANCER

Detection of Pancreatic Ductal Adenocarcinoma in Mice by Ultrasound Imaging of Thymocyte Differentiation Antigen 1

(2013) Kira Foygel et al.   GASTROENTEROLOGY

Increased Survival in Pancreatic Cancer with nab-Paclitaxel plus Gemcitabine

(2013) Daniel D. Von Hoff et al.   NEW ENGLAND JOURNAL OF MEDICINE

Enzymatic Targeting of the Stroma Ablates Physical Barriers to Treatment of Pancreatic Ductal Adenocarcinoma

(2012) Paolo P. Provenzano et al.   CANCER CELL

Identification of Sox9-Dependent Acinar-to-Ductal Reprogramming as the Principal Mechanism for Initiation of Pancreatic Ductal Adenocarcinoma

(2012) Janel L. Kopp et al.   CANCER CELL

Sonic Hedgehog in pancreatic cancer: From bench to bedside, then back to the bench

(2012) David E. Rosow et al.   SURGERY

FOLFIRINOX versus Gemcitabine for Metastatic Pancreatic Cancer

(2011) Thierry Conroy et al.   NEW ENGLAND JOURNAL OF MEDICINE

Loss of Indian Hedgehog Activates Multiple Aspects of a Wound Healing Response in the Mouse Intestine

(2010) Willemijn A. van Dop et al.   GASTROENTEROLOGY

Indian Hedgehog Regulates Intestinal Stem Cell Fate Through Epithelial−Mesenchymal Interactions During Development

(2010) Cynthia Kosinski et al.   GASTROENTEROLOGY

StatBite U.S. Pancreatic Cancer Rates

(2010)   JNCI-Journal of the National Cancer Institute

Potent agonists of the Hedgehog signaling pathway

(2009) Shirley A. Brunton et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Pancreatic Duct Glands Are Distinct Ductal Compartments That React to Chronic Injury and Mediate Shh-Induced Metaplasia

(2009) Oliver Strobel et al.   GASTROENTEROLOGY

GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation

(2009) O. Nolan-Stevaux et al.   GENES & DEVELOPMENT

Sonic hedgehog paracrine signaling regulates metastasis and lymphangiogenesis in pancreatic cancer

(2009) J M Bailey et al.   ONCOGENE

Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis

(2009) H. Tian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer

(2009) K. P. Olive et al.   SCIENCE

Sonic Hedgehog Promotes Desmoplasia in Pancreatic Cancer

(2008) J. M. Bailey et al.   CLINICAL CANCER RESEARCH

Hedgehog Signaling Is Required for Effective Regeneration of Exocrine Pancreas

(2008) Volker Fendrich et al.   GASTROENTEROLOGY

Hedgehog inhibition prolongs survival in a genetically engineered mouse model of pancreatic cancer

(2008) G Feldmann et al.   GUT

An orally bioavailable small-molecule inhibitor of Hedgehog signaling inhibits tumor initiation and metastasis in pancreatic cancer

(2008) G. Feldmann et al.   MOLECULAR CANCER THERAPEUTICS

A paracrine requirement for hedgehog signalling in cancer

(2008) Robert L. Yauch et al.   NATURE